28,215 results match your criteria extracts inhibited


Pumpkin Seed Extracts Inhibit Proliferation and Induce Autophagy in PC-3 Androgen Insensitive Prostate Cancer Cells.

J Med Food 2021 May 11. Epub 2021 May 11.

Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University, Athens, Greece.

Pumpkin seed is a rich source of polyphenols and other bioactive compounds that may act as chemopreventive agents against cancer. In this study, five different extracts of pumpkin seeds were evaluated for their ability to affect proliferation and autophagy on PC-3 prostate cancer cells. All extracts (water [W], methanolic, acetone, ethylacetate, and polar lipid [PL]) inhibited cell proliferation in a dose-dependent manner. Read More

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Chemical Analysis of the Ingredients of 20% Aqueous Ethanol Extract of through Phytochemical Study and Evaluation of Anti-Neuroinflammatory Component.

Evid Based Complement Alternat Med 2021 22;2021:5901653. Epub 2021 Apr 22.

Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 54538, Republic of Korea.

spp. have been widely used in Asia as a folk medicine. In particular, the extracts of , a species that grows in China, India, and Tibet, have been used to treat mental disorders, hyperlipidemia, hypertension, and convulsions. Read More

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Oxygen radical antioxidant capacity (ORAC) and antibacterial properties of Melicope glabra bark extracts and isolated compounds.

PLoS One 2021 10;16(5):e0251534. Epub 2021 May 10.

Department of Chemistry, Faculty of Science, Universiti Malaya, Kuala Lumpur, Malaysia.

Melicope glabra (Blume) T. G. Hartley from the Rutaceae family is one of the richest sources of plant secondary metabolites, including coumarins and flavanoids. Read More

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Mitochondrial damage produced by phytotoxic chromenone and chromanone derivatives from endophytic fungus Daldinia eschscholtzii strain GsE13.

Appl Microbiol Biotechnol 2021 May 10. Epub 2021 May 10.

Instituto de Química, Departamento de Productos Naturales, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Delegación Coyoacán, 04510, Mexico City, Mexico.

Bioassay-guided fractionation of the organic extracts of the endophyte Daldinia eschscholtzii strain GsE13 led to the isolation of several phytotoxic compounds, including two chromenone and two chromanone derivatives: 5-hydroxy-8-methoxy-2-methyl-4H-chromen-4-one, 1; 5-hydroxy-2-methyl-4H-chromen-4-one, 2; 5-methoxy-2-methyl-chroman-4-one, 3; and 5-methoxy-2-methyl-chroman-4-ol, 4; as well as other aromatic compounds: 4,8-dihydroxy-1-tetralone, 5; 1,8-dimethoxynaphthalene, 6; and 4,9-dihydroxy-1,2,11,12-tetrahydroperyl-ene-3,10-quinone, 7. Compounds 1, 4, and 7 were isolated for the first time from D. eschscholtzii. Read More

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Soybean extract modified by Aspergillus awamori stimulates a greater collagen-I synthesis in the intracellular matrix of human fibroblasts.

J Cosmet Dermatol 2021 May 10. Epub 2021 May 10.

Laboratory of Clinical Cytology, Department of Clinical Analyses, Toxicology and Food Science. School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil.

Aglycone isoflavones are estrogen-like bioactive compounds found in low amounts in soybean, which are increased by biotransformation processes. This study investigated two biotransformation processes of soybean extracts with Aspergillus awamori fungus, evaluating aglycone content and capability of stimulation of collagen-I deposition. Isoflavones were quantified via HPLC; cytotoxicity of biotransformed extracts towards mouse and human fibroblasts was evaluated via NRU and apoptosis/necrosis assays; and collagen-I deposition was measured through Western Blot, immunofluorescence, and immunoassay. Read More

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from fungus gardens of fungus-growing ants produce antifungals that inhibit the specialized parasite .

Appl Environ Microbiol 2021 May 7. Epub 2021 May 7.

Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA

Within animal associated microbiomes, the functional roles of specific microbial taxa are often uncharacterized. Here, we use the fungus-growing ant system, a model for microbial symbiosis, to determine the potential defensive roles of key bacterial taxa present in the ants' fungus gardens. Fungus gardens serve as an external digestive system for the ants, with mutualistic fungi in the genus spp. Read More

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In vitro studies of Annona muricata L. extract-loaded electrospun scaffolds for localized treatment of breast cancer.

J Biomed Mater Res B Appl Biomater 2021 May 7. Epub 2021 May 7.

Department of Mechanical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts, USA.

This paper presents in vitro studies of the sustained release of Annona muricata leaf extracts (AME) from hybrid electrospun fibers for breast cancer treatment. Electrospun hybrid scaffolds were fabricated from crude AME extracts, poly(lactic-co-glycolic acid)/gelatin (PLGA/Ge) and pluronic F127. The physicochemical properties of the AME extract and scaffolds were studied. Read More

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Natural products targeting the synthesis of β(1,3)-D-glucan and chitin of the fungal cell wall. Existing drugs and recent findings.

Phytomedicine 2021 Mar 27:153556. Epub 2021 Mar 27.

Instituto de Biología Funcional y Genómica and Departamento de Microbiología y Genética, Consejo Superior de Investigaciones Científicas (CSIC)/Universidad de Salamanca, Salamanca, Spain. Electronic address:

Background: During the last three decades systemic fungal infections associated to immunosuppressive therapies have become a serious healthcare problem. Clinical development of new antifungals is an urgent requirement. Since fungal but not mammalian cells are encased in a carbohydrate-containing cell wall, which is required for the growth and viability of fungi, the inhibition of cell wall synthesizing machinery, such as β(1,3)-D-glucan synthases (GS) and chitin synthases (CS) that catalyze the synthesis of β(1-3)-D-glucan and chitin, respectively, represent an ideal mode of action of antifungal agents. Read More

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Antibacterial and antioxidant activities of extracts and isolated compounds from the roots extract of Cucumis prophetarum and in silico study on DNA gyrase and human peroxiredoxin 5.

BMC Chem 2021 May 6;15(1):32. Epub 2021 May 6.

Department of Applied Chemistry, School of Applied Natural Science, Adama Science and Technology University, P.O.Box 1888, Adama, Ethiopia.

Background: Cucumis prophetarum is traditionally used to treat liver and lung disorders, heart failure, diarrhea, gonorrhea, skin infections, intestinal problems and cancer. In the present work, the isolation of two novel compounds along with their antibacterial and antioxidant activities is reported for the first time.

Methods: Silica gel column chromatography was applied to separate constituents of the roots of C. Read More

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The entry reaction of the plant shikimate pathway is subjected to highly complex metabolite-mediated regulation.

Plant Cell 2021 May;33(3):671-696

Department of Botany, University of Wisconsin-Madison, 430 Lincoln Dr. Madison, WI 53706, USA.

The plant shikimate pathway directs bulk carbon flow toward biosynthesis of aromatic amino acids (AAAs, i.e. tyrosine, phenylalanine, and tryptophan) and numerous aromatic phytochemicals. Read More

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Evaluation of Antibacterial Activity of Aqueous, Ethanolic and Methanolic Extracts Areca Nut Fruit on Selected Bacteria.

Biomed Res Int 2021 16;2021:6663399. Epub 2021 Apr 16.

Department of Chemistry, Tabriz Branch, Islamic Azad University, Tabriz, Iran.

Today, the tendency to use of natural preservatives to increase food security has expanded. In the present study, antibacterial effects of Areca Nut fruit extracts were evaluated against , , , and bacteria using agar disc diffusion technique. Methanol, ethanol, and water were used as solvents for extraction by maceration method, and extracts were analyzed by GC-MS. Read More

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Periplocin and cardiac glycosides suppress the unfolded protein response.

Sci Rep 2021 May 4;11(1):9528. Epub 2021 May 4.

Department of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, 467-8603, Japan.

The unfolded protein response (UPR) controls protein homeostasis through transcriptional and translational regulation. However, dysregulated UPR signaling has been associated with the pathogenesis of many human diseases. Therefore, the compounds modulating UPR may provide molecular insights for these pathologies in the context of UPR. Read More

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Hemistepsin a Induces Apoptosis of Hepatocellular Carcinoma Cells by Downregulating STAT3.

Int J Mol Sci 2021 Apr 29;22(9). Epub 2021 Apr 29.

College of Korean Medicine, Daegu Haany University, Gyeongsan 38610, Korea.

(Bunge) Bunge is a biennial medicinal plant possessing beneficial effects including anti-inflammation, and hemistepsin A (HsA) isolated from has been known as a hepatoprotective sesquiterpene lactone. In this report, we explored the cytotoxic effects of on hepatocellular carcinoma (HCC) cells and investigated the associated bioactive compounds and their relevant mechanisms. From the viability results of HCC cells treated with various extracts, HsA was identified as the major compound contributing to the -mediated cytotoxicity. Read More

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Extracts Stimulate IAA Biosynthesis in ZZ21 via the Indole-3-pyruvic Acid Pathway.

Microorganisms 2021 Apr 30;9(5). Epub 2021 Apr 30.

College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China.

Inter-organismal metabolites play important roles in regulating organism behavior and the communication between organisms. Nematodes, the most abundant animals on earth, are crucial participants in soil ecosystems through their interactions with microbes. For example, bacterial-feeding nematodes increase the activity of indole-3-acetic acid (IAA)-producing bacteria and the IAA content in soil. Read More

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Anti-Inflammatory and Anti-Vascular Leakage Effects by Combination of and L. Leaf Extracts.

Evid Based Complement Alternat Med 2021 14;2021:7381620. Epub 2021 Apr 14.

Department of Histology, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea.

Venous insufficiency results from several factors responsible for the progression of inflammation and oxidative damage of veins. Recently, natural extracts have been proposed for the treatment of venous insufficiency, but their efficacies have not been fully elucidated. In the present study, we evaluate the combinatorial effects on anti-inflammatory and anti-vascular leakage potential of mixed compositions containing different proportions of extract (CE) and L. Read More

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8-hydroxypinoresinol-4-O-β-D-glucoside from Valeriana officinalis L. Is a Novel Kv1.5 Channel Blocker.

J Ethnopharmacol 2021 Apr 28;276:114168. Epub 2021 Apr 28.

The Macrohard Institute of Health, 231 North Ave, Battle Creek, MI, 49017, USA; The American Academy of Tradition Chinese Medicine Inc., 1925 W County Rd B2, Roseville, MN, 55113, USA. Electronic address:

Ethnopharmacology Relevance: In folkloric medicine of many cultures, one of the medical uses of Valeriana officinalis Linn is to treat heart-related disease. Recently, it was shown that the ethanol extracts from V. officinalis could effectively prevent auricular fibrillation, and 8-hydroxypinoresinol-4-O-β-D-glucoside (HPG) from the extracts is one of the two active compounds showing antiarrhythmia activities. Read More

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.

J Pharmacol Exp Ther 2021 Apr 30. Epub 2021 Apr 30.

Gavin Herbert Eye Institute, Dept. of Ophthalmology, University of California, Irvine, United States

CB-5083 is an inhibitor of p97/valosin-containing protein (VCP), for which Phase I trials for cancer were terminated due to adverse effects on vision, such as photophobia and dyschromatopsia. Lower dose CB-5083 could combat inclusion body myopathy with early-onset Paget disease; and frontotemporal dementia or multisystem proteinopathy, caused by gain-of-function mutations in VCP. We hypothesized that the visual impairment in the cancer trial was due to CB-5083's inhibition of phosphodiesterase-6 (PDE6), which mediates signal transduction in photoreceptors. Read More

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Anticholinesterase Activities of Different Solvent Extracts of Brewer's Spent Grain.

Foods 2021 Apr 23;10(5). Epub 2021 Apr 23.

Department of Food BioSciences, Teagasc Food Research Centre Ashtown, D15KN3K Dublin, Ireland.

Cholinesterases, involved in acetylcholine catabolism in the central and peripheral nervous system, have been strongly linked with neurodegenerative diseases. Current therapeutic approaches using synthetic drugs present several side effects. Hence, there is an increasing research interest in naturally-occurring dietary polyphenols, which are also considered efficacious. Read More

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In Vitro Antifungal Activity of Plant Extracts on Pathogenic Fungi of Blueberry ( sp.).

Plants (Basel) 2021 Apr 23;10(5). Epub 2021 Apr 23.

Instituto Politécnico Nacional, Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional Unidad Michoacán, Jiquilpan, MI 59510, Mexico.

Three pathogenic fungi of blueberry ( spp.) responsible for dieback disease, identified as , and , were isolated in the northwestern region of the state of Michoacán, Mexico. The mycelial growth in vitro of these fungi was inhibited by extracts from , and , medicinal plants collected in Sahuayo, Michoacán, Mexico. Read More

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Nest Carton as a Source of New Promising Bioactive Extracts with Chemopreventive Potential.

Int J Mol Sci 2021 Apr 22;22(9). Epub 2021 Apr 22.

Isobolographic Analysis Laboratory, Institute of Rural Health, Jaczewskiego 2, 20-090 Lublin, Poland.

Six new water extracts (E1-E6) were obtained from nest carton produced by jet black ants and tested for their biochemical and bioactive properties, including antioxidative and anticancer effects. The present study demonstrated significant qualitative and quantitative differences in the content of individual biochemical constituents, as well as bioactive properties between the investigated samples. All tested extracts demonstrated antioxidant properties (determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) methods), and the highest antioxidative potential was recorded in extracts E1 and E2 (188. Read More

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Chemical Characterization of Plant Extracts and Evaluation of their Nematicidal and Phytotoxic Potential.

Molecules 2021 Apr 12;26(8). Epub 2021 Apr 12.

Instituto de Agroindustrias, Universidad Tecnológica de la Mixteca, Acatlima, Huajuapan de León, Oaxaca 69000, Mexico.

ranks among the "top ten" plant-parasitic nematodes of phytosanitary importance. It causes significant losses in commercial interest crops in America and is a potential risk in the European Union. The nematicidal and phytotoxic activities of seven plant extracts against and were evaluated in vitro, respectively. Read More

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Enhanced Recovery of Phenolic and Tocopherolic Compounds from Walnut ( L.) Male Flowers Based on Process Optimization of Ultrasonic Assisted-Extraction: Phytochemical Profile and Biological Activities.

Antioxidants (Basel) 2021 Apr 15;10(4). Epub 2021 Apr 15.

Department of Toxicology, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, 8 Victor Babes, 400012 Cluj-Napoca, Romania.

The extraction of bioactive compounds present in walnut ( L.) male flowers (WMFs) was performed based on an experimental design using ultrasonic-assisted extraction. Solvent nature, extraction time, and water content were selected as experimental variables, and phenolic, flavonoidic, and condensed tannins contents and antioxidant properties were evaluated. Read More

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Inhibitory Effects of Brassicaceae Cover Crop on Germination and Early Growth.

Plants (Basel) 2021 Apr 17;10(4). Epub 2021 Apr 17.

Institute for Pesticide and Environmental Protection, Banatska 31 b, 11080 Belgrade, Serbia.

Several cover crops (CCs) exert allelopathic effects that suppress weed growth. The aim of the present study was to evaluate the effects of aqueous extracts containing different concentrations [0, 0.5, 1, 2. Read More

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Isolation, Structure Elucidation and In Silico Prediction of Potential Drug-Like Flavonoids from Targeted towards Functionally Important Proteins of Drug-Resistant Bad Bugs.

Molecules 2021 Apr 2;26(7). Epub 2021 Apr 2.

Basic Science Department, College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.

Admittedly, the disastrous emergence of drug resistance in prokaryotic and eukaryotic human pathogens has created an urgent need to develop novel chemotherapeutic agents. is a source of traditional medicine with cooling, laxative, and anthelmintic effects. The objective of the current research was to analyze the biological potential of and to isolate and characterize the chemical constituents of the plant. Read More

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Synergistic Protection by Isoquercitrin and Quercetin against Glutamate-Induced Oxidative Cell Death in HT22 Cells via Activating Nrf2 and HO-1 Signaling Pathway: Neuroprotective Principles and Mechanisms of Leaves.

Antioxidants (Basel) 2021 Apr 2;10(4). Epub 2021 Apr 2.

College of Pharmacy and Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, Suwon 16499, Korea.

leaves (DML) have long been used as traditional medicine to treat diverse symptoms in Korea. Ethyl acetate-soluble extracts of DML (DMLE) rescued HT22 mouse hippocampal neuronal cells from glutamate (Glu)-induced oxidative cell death; however, the protective compounds and mechanisms remain unknown. Here, we aimed to identify the neuroprotective ingredients and mechanisms of DMLE in the Glu-HT22 cell model. Read More

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Hill Extracts Exhibits Antioxidant Effects and Attenuates Melanogenesis in B16-F10 Cells via Downregulating CREB/MITF/Tyrosinase and Upregulating p-ERK and p-JNK.

Plants (Basel) 2021 Apr 8;10(4). Epub 2021 Apr 8.

School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.

Hill is a perennial herb traditionally used to alleviate inflammatory complications. This study investigated the antioxidant and anti-melanogenic activities of . The methanolic extract (OLM) of and its different fractions, including ethyl acetate (OLEF), -butanol (OLBF), and water (OLWF) fractions, were prepared. Read More

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Simultaneous Quantitative Analysis of Ginsenosides Isolated from the Fruit of C.A. Meyer and Regulation of HO-1 Expression through EGFR Signaling Has Anti-Inflammatory and Osteogenic Induction Effects in HPDL Cells.

Molecules 2021 Apr 6;26(7). Epub 2021 Apr 6.

College of Pharmacy, Keimyung University, 1095 Dalgubeol-daero, Daegu 42601, Korea.

Periodontitis is a set of chronic inflammatory diseases caused by the accumulation of Gram-negative bacteria on teeth, resulting in gingivitis, pocket formation, alveolar bone loss, tissue destruction, and tooth loss. In this study, the contents of ginsenosides isolated from fruit extract were quantitatively analyzed, and the anti-inflammatory effects were evaluated in human periodontal ligament cells. The major ginsenosides, Re, Ra8, and Rf, present in ginseng fruit were simultaneously analyzed by a validated method using high-performance liquid chromatography with a diode-array detector; Re, Ra8, and Rf content per 1 g of fruit extract was 1. Read More

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Simultaneous Quantification of Four Marker Compounds in Extract and Their Potential Inhibitory Effects on Alzheimer's Disease Biomarkers.

Plants (Basel) 2021 Apr 6;10(4). Epub 2021 Apr 6.

Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea.

is a tropical woody plant widely distributed in Vietnam and Unnan in southern China. Although many studies have shown the biological activities of extracts from various other species in the genus, no studies have investigated the effects of extracts on biological systems. In the present study, a quantitative analysis of four marker compounds of ethanol extracts of branches (EEBC) was performed using the high performance liquid chromatography (HPLC)-photodiode array (PDA) method. Read More

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Activation of Hair Cell Growth Factors by Linoleic Acid in Seed.

Molecules 2021 Apr 7;26(8). Epub 2021 Apr 7.

College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 28644, Korea.

Hair loss by excessive stress from work and lifestyle changes has become a growing concern, particularly among young individuals. However, most drugs for alopecia impose a plethora of side effects. We have found the powerful impact of seed extracts on alleviating hair loss. Read More

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Comparative Evaluation of Chemical Composition, Phenolic Compounds, and Antioxidant and Antimicrobial Activities of Tropical Black Bolete Mushroom Using Different Preservation Methods.

Foods 2021 Apr 5;10(4). Epub 2021 Apr 5.

Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.

Tropical black bolete, , provides various nutritional benefits and natural antioxidants to humans. In this study, the chemical composition, phenolic compounds, and antioxidant and antimicrobial activities of fresh mushroom samples and samples stored for a period of one year using different preservation methods (drying, brining, and frozen) were investigated. The results indicated that the brining method significantly reduced the protein and fat contents of the mushrooms. Read More

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