184 results match your criteria extracts andrographolide

Anti-SARS-CoV-2 Activity of Extract and Its Major Component Andrographolide in Human Lung Epithelial Cells and Cytotoxicity Evaluation in Major Organ Cell Representatives.

J Nat Prod 2021 04 12;84(4):1261-1270. Epub 2021 Apr 12.

Excellent Center for Drug Discovery (ECDD), Faculty of Science, Mahidol University, Bangkok 10400, Thailand.

The coronaviruses disease 2019 (COVID-19) caused by a novel coronavirus (SARS-CoV-2) has become a major health problem, affecting more than 50 million people with over one million deaths globally. Effective antivirals are still lacking. Here, we optimized a high-content imaging platform and the plaque assay for viral output study using the legitimate model of human lung epithelial cells, Calu-3, to determine the anti-SARS-CoV-2 activity of extract and its major component, andrographolide. Read More

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Andrographis paniculata (Burm.f.) Nees: Traditional uses, phytochemistry, pharmacological properties and quality control/quality assurance.

J Ethnopharmacol 2021 Apr 6;275:114054. Epub 2021 Apr 6.

Sophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute, Lucknow, 226031, Uttar Pradesh, India. Electronic address:

Ethnopharmacological Relevance: Andrographis paniculata (Burm.f.) Nees is a medicinal herb of the Asian countries used in many traditional medicinal systems for the treatment of diarrhea, flu, leprosy, leptospirosis, malaria, rabies, upper respiratory infections, sinusitis, syphilis, tuberculosis and HIV/AIDS etc. Read More

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Comparing the pharmacokinetics of 13α,21-dihydroeurycomanone and eurycomanone exclusively enriched in Eurycoma longifolia extracts and their spermatogenesis enhancement in andrographolide-induced oligospermia in rats.

J Pharm Pharmacol 2021 Mar;73(2):161-168

School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.

Objectives: The quassinoids eurycomanone (EN) and 13α,21-dihydroeurycomanone (DHY) of Eurycoma longifolia Jack are reported to enhance spermatogenesis. This study aims to profile the pharmacokinetics of DHY, a minor and hitherto unstudied constituent, evaluate its spermatogenesis enhancement property and compare these attributes with that of the predominant EN.

Methods: Crude Eurycoma longifolia extract was chromatographed into a DHY-enriched extract (DHY-F) and an EN-enriched extract (EN-F). Read More

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Estimation of drug-likeness properties of GC-MS separated bioactive compounds in rare medicinal using molecular docking technique and SwissADME in silico tools.

Hakani D Sympli

Netw Model Anal Health Inform Bioinform 2021 24;10(1):14. Epub 2021 Feb 24.

Department of Biotechnology, School of Biosciences, Assam Don Bosco University, Tapesia, Kamarkuchi, Sonapur, Assam 782402 India.

The main aim of the paper was to determine bioactive compounds in extracts using gas chromatographic technique and to investigate their drug-likeness potential using molecular docking algorithm and ADME studies on the recent intractable disease, for example, SARS-CoV-2. sample was prepared for GC-MS analysis. The peak components were identified based on the NIST Library. Read More

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February 2021

Andrographolide, an Antioxidant, Counteracts Paraquat- Induced Mutagenesis in Mammalian Cells.

Asian Pac J Cancer Prev 2021 Feb 1;22(S1):3-8. Epub 2021 Feb 1.

Laboratory of Pharmacology, Chulabhorn Research Institute, Bangkok 10210, Thailand.

Paraquat (1,1'-dimethyl, 4,4'-bipyridinium dichloride; PQ), a commonly used herbicide worldwide, is both toxic and mutagenic. The mutagenic effect of PQ stems from its ability to redox-cycle, generating oxidative stress and subsequently oxidative DNA damage, which miscodes when replication is attempted. Andrographolide (AP1), the major constituent in the leaves of the herbaceous plant Andrographis paniculata, is a diterpenoid with reported antioxidant activity. Read More

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February 2021

Nanoencapsulation of Andrographolide Rich Extract for the Inhibition of Cervical and Neuroblastoma Cancer Cells.

J Biomed Nanotechnol 2020 Sep;16(9):1370-1380

Andrographis paniculata is traditionally used for many diseases and scientifically proven for anti-cancer property. Andrographolide which is the marker compound is believed to be the main contributor to the pharmacological activities. The poor solubility and bioavailability of this diterpenoid lactone could be overcome by nanoencapsulation. Read More

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September 2020

Andrographis paniculata and Its Main Bioactive Ingredient Andrographolide Decrease Alcohol Drinking and Seeking in Rats Through Activation of Nuclear PPARγ Pathway.

Alcohol Alcohol 2021 Feb;56(2):240-249

School of Pharmacy, Pharmacology Unit, University of Camerino, Via Madonna delle Carceri, 62032 Camerino, Italy.

Background And Aims: Andrographis paniculata is an annual herbaceous plant which belongs to the Acanthaceae family. Extracts from this plant have shown hepatoprotective, anti-inflammatory and antidiabetic properties, at least in part, through activation of the nuclear receptor Peroxisome Proliferator-Activated Receptor-gamma (PPAR γ). Recent evidence has demonstrated that activation of PPARγ reduces alcohol drinking and seeking in Marchigian Sardinian (msP) alcohol-preferring rats. Read More

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February 2021

Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular Metabolism.

Molecules 2020 Dec 22;26(1). Epub 2020 Dec 22.

Laboratory of Inflammation Pharmacology, Faculty of Veterinary Sciences, Institute of Pharmacology and Morphophysiology, Universidad Austral de Chile, Valdivia 5090000, Chile.

Andrographolide is a labdane diterpene and the main active ingredient isolated from the herb . Andrographolide possesses diverse biological effects including anti-inflammatory, antioxidant, and antineoplastic properties. Clinical studies have demonstrated that andrographolide could be useful in therapy for a wide range of diseases such as osteoarthritis, upper respiratory diseases, and multiple sclerosis. Read More

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December 2020

A Review of Malaysian Herbal Plants and Their Active Constituents with Potential Therapeutic Applications in Sepsis.

Evid Based Complement Alternat Med 2020 28;2020:8257817. Epub 2020 Oct 28.

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, Malaysia.

Sepsis refers to organ failure due to uncontrolled body immune responses towards infection. The systemic inflammatory response triggered by pathogen-associated molecular patterns (PAMPs), such as lipopolysaccharide (LPS) from Gram-negative bacteria, is accompanied by the release of various proinflammatory mediators that can lead to organ damage. The progression to septic shock is even more life-threatening due to hypotension. Read More

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October 2020

Identification and characterization of new potent inhibitors of dengue virus NS5 proteinase from Andrographis paniculata supercritical extracts on in animal cell culture and in silico approaches.

J Ethnopharmacol 2021 Mar 2;267:113541. Epub 2020 Nov 2.

Department of Genetics, Maharshi Dayanand University, Rohtak, 124001, Haryana, India. Electronic address:

Ethnopharmacological Relevance: About 2.5 billion peoples are at risk of dengue virus and the majority of people, use traditional plant-based medicines to combat dengue. The whole plant of Andrographis paniculata used traditionally over past decades for health promotion. Read More

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Plants as source of new therapies for endometriosis: a review of preclinical and clinical studies.

Hum Reprod Update 2021 Feb;27(2):367-392

Institute for Clinical & Experimental Surgery, Saarland University, 66421 Homburg, Germany.

Background: Given the disadvantages and limitations of current endometriosis therapy, there is a progressive increase in studies focusing on plant-derived agents as a natural treatment option with the intention of achieving high efficiency, avoiding adverse effects and preserving the chance for successful pregnancy. The heterogeneity of these studies in terms of evaluated agents, applied approaches and outcomes illustrates the need for an up-to-date summary and critical view on this rapidly growing field in endometriosis research.

Objective And Rationale: This review provides a comprehensive overview of plant-derived agents and natural treatment strategies that are under preclinical or clinical investigation and critically evaluates their potential for future endometriosis therapy. Read More

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February 2021

Improves Insulin Resistance in High-Fat Diet-Induced Obese Mice and TNFα-Treated 3T3-L1 Adipocytes.

Am J Chin Med 2020 ;48(5):1073-1090

Department of Nutrition, China Medical University, Taichung, Taiwan.

Pro-inflammatory cytokines interfere with blood glucose homeostasis, which leads to hyperglycemia. (AP) has been shown to possess anti-inflammatory activity and to reduce blood glucose levels in diabetes. The two major bioactive diterpenoids in AP, andrographolide (AND) and 14-deoxy-11,12-didehydroandrographolide (deAND), have potent anti-inflammatory activity. Read More

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October 2020

Electrochemical Assessment of Anticancer Compounds on the Human Tongue Squamous Carcinoma Cells.

Sensors (Basel) 2020 May 5;20(9). Epub 2020 May 5.

Department of Biomedical Engineering, National Yang-Ming University, Taipei 11221, Taiwan.

The most common oral cancer is squamous cell carcinoma (SCC) and its highest occurrence is in the tongue. Almost 30% of patients with one primary head and neck tumor will have a second primary malignancy. In recent studies, two novel plant extracts, andrographolide and cannabidiol (CBD), have been exploited for their anticancer effects. Read More

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A Review on Natural Products and Herbs Used in the Management of Diabetes.

Curr Diabetes Rev 2021 ;17(2):186-197

Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar- Delhi G.T. Road, Phagwara, Punjab, 144411, India.

Aim: We aimed to review the importance of the natural products and herbs used in the management of diabetes mellitus (DM) as medicinal agents.

Background: Naturally occuring phytoactive compounds and herbs are very important because they are found to be effective against several diseases. DM is a commonly occurring endocrinological disorder, with the incidences increased four times in the last 34 years. Read More

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Semisynthesis and Pesticidal Activities of Derivatives of the Diterpenoid Andrographolide and Investigation on the Stress Response of Van der Goot (Homoptera: Aphididae).

J Agric Food Chem 2020 Apr 25;68(14):4131-4143. Epub 2020 Mar 25.

College of Plant Protection, Northwest A&F University, Yangling, Shaanxi Province 712100, China.

To discover natural-product-based pesticides, 7β-oxycarbonylandrographolide derivatives were stereoselectively constructed from a labdane diterpenoid andrographolide. Among them, 2'-()Pr-1',3'-dioxin-7β-oxy(-Cl)benzoylandrographolide (), 2'-()Pr-1',3'-dioxin-7β-oxyacetylandrographolide (), 2'-(Me)Ph-1',3'-dioxin-7β-oxy(-Cl)benzoylandrographolide (), and 2'-(Me)Ph-1',3'-dioxin-7β-oxy(-Cl)benzoylandrographolide () against displayed the most promising growth inhibitory activity; 2'-()Pr-1',3'-dioxin-7β-oxy(-Cl)benzoylandrographolide (: LC = 0.406 mg/mL) and (LC = 0. Read More

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Classification of Andrographis paniculata extracts by solvent extraction using HPLC fingerprint and chemometric analysis.

BMC Res Notes 2020 Feb 4;13(1):56. Epub 2020 Feb 4.

Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.

Objective: Andrographis paniculata, widely used as an antidiabetic in Indonesian traditional medicines (jamu), contains chemical compounds whose concentration is related to its therapeutic effects. The concentration of solvents used for extraction will also affect the number of compounds extracted. Therefore, a quality control method is needed to ensure consistency in quantifying these compounds in A. Read More

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February 2020

Cytotoxicity and Synergistic Effect of Biogenically Synthesized Ternary Therapeutic Nano Conjugates Comprising Plant Active Principle, Silver and Anticancer Drug on MDA-MB-453 Breast Cancer Cell Line.

Asian Pac J Cancer Prev 2020 Jan 1;21(1):195-204. Epub 2020 Jan 1.

Department of Pharmacognosy, PSG College of Pharmacy, Coimbatore, Tamil Nadu, India.

Drug delivery through biogenically synthesized silver nanoparticles (AgNPs) in cancer treatment is exerted by smaller size entailing high surface area and synergistic effects of embedded biomolecules.  In this study, prepared ternary conjugates of silver with plant active compound and anticancer drug towards reducing the dose through synergy, rendered by Electrostatic Attraction (EA) of functionalized drug on to the surface of biogenically synthesized AgNPs. The biogenic synthesis resulted in particles of nanometer range as well as serving reducing and capping agents. Read More

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January 2020

Anti-obesity effect of plant diterpenes and their derivatives: A review.

Phytother Res 2020 Jun 24;34(6):1216-1225. Epub 2020 Jan 24.

Department of Chemistry, The University of Jordan, Amman, Jordan.

Obesity is a medical condition in which excess body fat is accumulated by a combination of excessive food intake, lack of physical activity, and genetic susceptibility. Obesity increases the risk of various diseases and conditions, including cardiovascular diseases, diabetes, cancer, and depression. This review focuses on most recent reports pertaining to the antiobesity activity of plant-derived diterpenes in different databases. Read More

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Improvement of Oxazolone-Induced Ulcerative Colitis in Rats Using Andrographolide.

Molecules 2019 Dec 24;25(1). Epub 2019 Dec 24.

Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, The MOE Key Laboratory for Standardization of Chinese Medicines, Shanghai R&D Centre for Standardization of Chinese Medicines, 1200 Cailun Road, Shanghai 201203, China.

Ulcerative colitis (UC) is usually accompanied with symptoms of abdominal pain, diarrhea, and bloody stool, which impair the quality of life of patients. Previous studies have shown that extracts, which have andrographolide (AND) as their main compound, can relieve UC symptoms in patients. The aim of the study was to investigate the alleviating effect of AND on UC using the oxazolone (OXZ)-induced UC rat model. Read More

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December 2019

Quantitative Determination of Andrographolide and Related Compounds in Extracts and Biological Evaluation of Their Anti-Inflammatory Activity.

Foods 2019 Dec 14;8(12). Epub 2019 Dec 14.

Institut de Chimie Organique et Analytique, Université d'Orléans, UMR CNRS 7311, BP 6759, 45067 Orléans CEDEX 2, France.

Extraction, isolation and characterization of () products were developed. Three natural diterpenes compounds were obtained and one was used for chemical modifications. Evaluation of their inhibition of TNFα induced NFκB transcriptional activity. Read More

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December 2019

Metabolite profiling of Andrographis paniculata (Burm. f.) Nees. young and mature leaves at different harvest ages using H NMR-based metabolomics approach.

Sci Rep 2019 11 14;9(1):16766. Epub 2019 Nov 14.

Department of Crop Science, Faculty of Agriculture, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia.

Andrographis paniculata (Burm. F.) Nees. Read More

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November 2019

Piriformospora indica promotes the growth of the in-vitro-raised Cymbidium aloifolium plantlet and their acclimatization.

Plant Signal Behav 2019 16;14(6):1596716. Epub 2019 Apr 16.

a Central Department of Botany , Tribhuvan University , Kathmandu , Nepal.

Cymbidium aloifolium is known for its ornamental and medicinal values. It has been listed as threatened orchid species. In this study, in vitro propagated C. Read More

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A double-blind, randomized, placebo-controlled study to assess the efficacy of Andrographis paniculata standardized extract (ParActin®) on pain reduction in subjects with knee osteoarthritis.

Phytother Res 2019 May 10;33(5):1469-1479. Epub 2019 Apr 10.

Institute of Pharmacology and Morphophysiology, Facultad de Ciencias Veterinarias Universidad Austral de Chile, Valdivia, Chile.

Andrographis paniculata Wall (Acanthaceae) is becoming more recognized for its anti-inflammatory and antioxidant properties. A randomized, double-blind, placebo-controlled study was conducted to assess the efficacy of an andrographolide-containing supplement, ParActin® (300 and 600 mg daily), on Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain reduction in patients with knee osteoarthritis. Joint stiffness, physical function, changes in the SF-36 quality of life questionnaire, a fatigue scale, and safety were also evaluated. Read More

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Adaptogens in chemobrain (Part II): Effect of plant extracts on chemotherapy-induced cytotoxicity in neuroglia cells.

Phytomedicine 2019 May 6;58:152743. Epub 2018 Nov 6.

Phytomed AB, Vaxtorp, Halland, Sweden; EuroPharma USA Inc., 955 Challenger Dr., Green Bay, WI 54311, USA. Electronic address:

Background: Cancer chemotherapy-induced cognitive impairments are apparently associated with harmful effects on physiological functions of brain cells. Adaptogens, are known to exhibit neuroprotective effects and to increase cognitive functions in clinical studies. In our previous study (Seo et al. Read More

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Andrographolide binds to ATP-binding pocket of VEGFR2 to impede VEGFA-mediated tumor-angiogenesis.

Sci Rep 2019 03 11;9(1):4073. Epub 2019 Mar 11.

Division of Molecular Medicine, Bose Institute, P-1/12, Calcutta Improvement Trust Scheme VII M, Kolkata, 700054, India.

Vasculogenesis and angiogenesis are process of formation of blood vessels. Blood vessels are evolved to distribute nutrients and oxygen to distant organs. These vessels are crucial for growth and repair of wounded tissue. Read More

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Ovicidal and larvicidal effects of extracts from leaves of Andrographis paniculata (Burm. f.) Wall.ex Nees against field isolates of human hookworm (Ancylostoma duodenale).

J Ethnopharmacol 2019 May 11;235:489-500. Epub 2019 Feb 11.

Department of Biological Science, Adamawa State University, P.M.B. 25, Mubi, Nigeria. Electronic address:

Ethnopharmacological Relevance: The whole plant of Andrographis paniculata (Burm. f.) Wall. Read More

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Preparative Separation of Diterpene Lactones and Flavones from Using Off-Line Two-Dimensional High-Speed Counter-Current Chromatography.

Molecules 2019 Feb 11;24(3). Epub 2019 Feb 11.

Shandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China.

Seven diterpene lactones, andrographolide (), isoandrographolide (), neo-andrographolide (), 14-deoxy-11,12-didehydroandrographolide (), 14-deoxyandrographiside (), 14-deoxy-11,12-didehydroandrographiside (), 3,14-dideoxyandrographolide (), and three flavones, andrographidine C (), andrographidine A (), 5-hydroxy-7,8-dimethoxyflavanone () have been successfully and efficiently isolated from using an off-line two dimensional (2D) high-speed counter-current chromatography (HSCCC) method for the first time. For the first dimension HSCCC separation, petroleum ether-ethyl acetate-methanol-water 3:7:5:5 (/) was employed to isolate 14.4 mg of compound , 3. Read More

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February 2019

Amido surface-functionalized magnetic molecularly imprinted polymers for the efficient extraction of Sibiskoside from Sibiraea angustata.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Mar 18;1109:90-98. Epub 2019 Jan 18.

School of Chemical Engineering and Technology, Harbin Institute of Technology, Harbin 150090, China. Electronic address:

A general method for efficient and selective extraction of a target compound from complex natural products remains elusive, despite decades of research. By introducing a functional amido group on the surface of dispersity-enhanced magnetic nanoparticles, a nanoparticle receptor to selectively recognize Sibiskoside (a monoterpene) from the aerial portion of Sibiraea angustata by hydrogen bond interaction was synthesized. The superparamagnetic FeO nanoparticles were successively modified with tetraethyl orthosilicate (TEOS), amino and amido functional groups, and 4-vinylbenzoic acid (VBZA) was used as the functional monomer. Read More

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Adaptogens in chemobrain (Part I): Plant extracts attenuate cancer chemotherapy-induced cognitive impairment - Transcriptome-wide microarray profiles of neuroglia cells.

Phytomedicine 2019 Mar 19;55:80-91. Epub 2018 Oct 19.

EuroPharma USA Inc., 955 Challenger Dr., Green Bay, Wisconsin 54311 United States; Phytomed AB, Vaxtorp, Sweden. Electronic address:

Background: Cancer chemotherapy-induced cognitive impairments are presumably associated with undesirable effects of chemotherapy on physiological functions of brain cells. Adaptogens are natural compounds or plant extracts increasing an organism's adaptability and survival in stress. They exhibited neuroprotective effects and increased cognitive functions in clinical studies in human beings. Read More

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Adaptogens in chemobrain (Part III): Antitoxic effects of plant extracts towards cancer chemotherapy-induced toxicity - transcriptome-wide microarray analysis of neuroglia cells.

Phytomedicine 2019 Mar 9;56:246-260. Epub 2018 Nov 9.

EuroPharma USA Inc., 955 Challenger Dr., Green Bay, WI 54311; Phytomed AB, Vaxtorp, Halland, Sweden. Electronic address:

Background: Toxicity of chemotherapeutics is a serious problem in cancer therapy. Adaptogens are known to increase adaptability and survival organisms.

Aim: The aim of this study was to assess the effects of selected adaptogenic herbal extracts on FEC (fixed combination of 5-fluorouracil, epirubicin and cyclophosphamide) induced changes in transcriptome-wide microarray profiles of neuroglia cells. Read More

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