305,238 results match your criteria extraction


Rectal foreign body, an impacted plastic ball: A case report and review of literature.

Int J Surg Case Rep 2021 Sep 16;87:106404. Epub 2021 Sep 16.

Department of General Surgery, Princess Basma Teaching Hospital, Irbid, Jordan.

View Article and Full-Text PDF
September 2021

Recent sample pretreatment methods for determination of selective serotonin reuptake inhibitors (SSRIs) in biological samples.

J Pharm Biomed Anal 2021 Sep 8;206:114364. Epub 2021 Sep 8.

Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China. Electronic address:

Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (FLU), sertraline (SER), paroxetine (PAR), fluvoxamine (FLV) and citalopram (CIT) have been the first treatment drugs for pregnant and breastfeeding women. Quantitative analysis of SSRIs in biological samples is extremely needed in public health and clinical practice. During the analysis, sample pretreatment is an important step that can obtain an accurate quantitative analysis of SSRIs in the complex samples. Read More

View Article and Full-Text PDF
September 2021

A concise review towards defining the exposome of oesophageal cancer in sub-Saharan Africa.

Environ Int 2021 Sep 17;157:106880. Epub 2021 Sep 17.

Department of Bioanalysis, Centre of Excellence in Mycotoxicology and Public Health, Ghent University, Ghent, Belgium; MYTOX-SOUTH, International Thematic Network, Ghent University, Ghent, Belgium; CRIG, Cancer Research Institute Ghent, Ghent, Belgium.

Context: Oesophageal cancer (EC) is among the common causes of illness and death among all cancers worldwide. Advanced EC has a poor prognosis, with worse outcomes observed in low-income settings. Oesophageal squamous cell carcinoma (ESCC) is the most common EC histology reported globally, with the highest ESCC incidence rates in the 'Asian Belt' and the African EC corridor. Read More

View Article and Full-Text PDF
September 2021

PrimePatNet87: Prime pattern and tunable q-factor wavelet transform techniques for automated accurate EEG emotion recognition.

Comput Biol Med 2021 Sep 16;138:104867. Epub 2021 Sep 16.

Ngee Ann Polytechnic, Department of Electronics and Computer Engineering, 599489, Singapore; Department of Biomedical Engineering, School of Science and Technology, SUSS University, Singapore; Department of Biomedical Informatics and Medical Engineering, Asia University, Taichung, Taiwan. Electronic address:

Nowadays, many deep models have been presented to recognize emotions using electroencephalogram (EEG) signals. These deep models are computationally intensive, it takes a longer time to train the model. Also, it is difficult to achieve high classification performance using for emotion classification using machine learning techniques. Read More

View Article and Full-Text PDF
September 2021

Amplification-free smartphone-based attomolar HBV detection.

Biosens Bioelectron 2021 Sep 11;194:113622. Epub 2021 Sep 11.

Joint International Research Laboratory of Animal Health and Food Safety of Ministry of Education & Single Molecule Nanometry Laboratory (Sinmolab), Nanjing Agricultural University, Nanjing, Jiangsu, 210095, China. Electronic address:

Classical gold standard HBV detection relies on expensive devices and complicated procedures, thus is always restricted in large-scale hospitals and centers for disease control and prevention. To extend HBV detection to primary clinics especially in underdeveloped areas, we design amplification-free smartphone-based attomolar HBV detecting technique based on single molecule sensing. Verified by synthesized HBV target DNA, this technique reaches a detection limit at attomolar concentration (100 aM); and verified by 110 clinical samples, it also reaches a rather high sensitivity of 10 copy/mL (≈2000 IU/mL) with a high accuracy of 93. Read More

View Article and Full-Text PDF
September 2021

An improved sample extraction method reveals that plasma receptor for advanced glycation end-products (RAGE) modulates circulating free oxytocin in mice.

Peptides 2021 Sep 17:170649. Epub 2021 Sep 17.

Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan. Electronic address:

The receptor for advanced glycation end-products (RAGE) binds oxytocin (OT) and transports it from the blood to the brain. As RAGE's OT-binding capacity was lost in RAGE knockout (KO) mice, we predicted that circulating concentrations of unbound (free) OT should be elevated compared to wild-type (WT) mice. However, this hypothesis has not yet been investigated. Read More

View Article and Full-Text PDF
September 2021

Evaluation of targets for Strongyloides genus specific molecular diagnosis in experimental strongyloidiasis.

Exp Parasitol 2021 Sep 17:108157. Epub 2021 Sep 17.

Laboratório de Investigação Médica (LIM-06) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil; Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, Brazil. Electronic address:

Strongyloides venezuelensis has been used in different experimental studies, such as those aimed at the evaluation of diagnostic techniques for human strongyloidiasis, mainly the molecular diagnosis. In this study, three regions (genus, 18S and 28S targets) of Strongyloides ribosomal DNA were evaluated for the molecular diagnosis of experimental strongyloidiasis. Rats were infected subcutaneously with 400 or 4000 S. Read More

View Article and Full-Text PDF
September 2021

Single-crystal ordered macroporous metal-organic framework as support for molecularly imprinted polymers and their integration in membrane formant for the specific recognition of zearalenone.

J Sep Sci 2021 Sep 20. Epub 2021 Sep 20.

Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, Hunan, 412007, China.

Zearalenone is a fungal contaminant that is widely present in grains. Here, a novel molecularly imprinted membrane based on SOM-ZIF-8 was developed for the rapid and highly selective identification of zearalenone in grain samples. The molecularly imprinted membrane was prepared using polyvinylidene fluoride, cyclododecyl 2,4-dihydroxybenzoate as a template and SOM-ZIF-8 as a carrier. Read More

View Article and Full-Text PDF
September 2021

Assessing direct analysis in real time mass spectrometry for the identification and serotyping of Legionella pneumophila.

J Appl Microbiol 2021 Sep 20. Epub 2021 Sep 20.

Department of Food Safety, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.

Aims: The efficacy of ambient mass spectrometry to identify and serotype Legionella pneumophila was assessed. To this aim, isolated waterborne colonies were submitted to a rapid extraction method and analysed by direct analysis in real time mass spectrometry (DART-HRMS).

Methods And Results: The DART-HRMS profiles, coupled with partial least squares discriminant analysis (PLS-DA), were first evaluated for their ability to differentiate Legionella spp. Read More

View Article and Full-Text PDF
September 2021

DHNLDA: A novel deep hierarchical network based method for predicting lncRNA-disease associations.

IEEE/ACM Trans Comput Biol Bioinform 2021 Sep 20;PP. Epub 2021 Sep 20.

Recent studies have found that lncRNA (long non-coding RNA) in ncRNA (non-coding RNA) is not only involved in many biological processes, but also abnormally expressed in many complex diseases. Identification of lncRNA-disease associations accurately is of great significance for understanding the function of lncRNA and disease mechanism. In this paper, a deep learning framework consisting of stacked autoencoder(SAE), multi-scale ResNet and stacked ensemble module, named DHNLDA, was constructed to predict lncRNA-disease associations, which integrates multiple biological data sources and constructing feature matrices. Read More

View Article and Full-Text PDF
September 2021

Satisfaction, Preference and Injection Habits of Switching to 200 Units/ml Insulin Lispro Pen from 100 Units/ml: A Patient Survey in Germany.

Diabetes Ther 2021 Sep 20. Epub 2021 Sep 20.

Klinik und Poliklinik für Endokrinologie, Nephrologie, Rheumatologie, Universitätsklinikum Leipzig, Liebigstr. 20, 04103, Leipzig, Germany.

Introduction: The study was designed to assess patient satisfaction, preferences and injection habits for patients using insulin lispro 200 units/ml pen (IL200) compared to their previously used disposable 100 units/ml mealtime insulin pen ("MTI-100 pen") in Germany.

Methods: A site-based, cross-sectional study involving a self-reported survey and medical record extraction in patients with diabetes currently using IL200 for between 3 and 12 months and had previously used any disposable MTI-100 pen.

Results: Of 114 patients included, 83. Read More

View Article and Full-Text PDF
September 2021

Purification of Cytoskeletal Proteins by Fast Protein Liquid Chromatography (FPLC) Using an ÄKTA Start System.

Methods Mol Biol 2022 ;2364:237-249

Protein Purification, Kemp Proteins, Frederick, MD, USA.

Actin, myosin, and tubulin are ubiquitous components of the fibrous network known as the cytoskeleton. Cytoskeletal proteins are involved in a plethora of intracellular processes such as maintenance of cellular organization, organelle translocation, and various nuclear roles including chromosome separation during mitosis. Early methods for protein extraction primarily relied on the salting-out method which was performed in conjunction with biochemical assays. Read More

View Article and Full-Text PDF
January 2022

Imaging Cytoskeleton Components by Electron Microscopy.

Authors:
Tatyana Svitkina

Methods Mol Biol 2022 ;2364:25-52

Department of Biology, University of Pennsylvania, Philadelphia, PA, USA.

The cytoskeleton is a complex of detergent-insoluble components of the cytoplasm playing critical roles in cell motility, shape generation, and mechanical properties of a cell. Fibrillar polymers-actin filaments, microtubules, and intermediate filaments-are major constituents of the cytoskeleton, which constantly change their organization during cellular activities. The actin cytoskeleton is especially polymorphic, as actin filaments can form multiple higher-order assemblies performing different functions. Read More

View Article and Full-Text PDF
January 2022

Self-supervised representation learning for surgical activity recognition.

Int J Comput Assist Radiol Surg 2021 Sep 20. Epub 2021 Sep 20.

Department of Computer Science, ETH Zurich, Zurich, Switzerland.

Purpose: Virtual reality-based simulators have the potential to become an essential part of surgical education. To make full use of this potential, they must be able to automatically recognize activities performed by users and assess those. Since annotations of trajectories by human experts are expensive, there is a need for methods that can learn to recognize surgical activities in a data-efficient way. Read More

View Article and Full-Text PDF
September 2021

Microplastics in Tissues (Brain, Gill, Muscle and Gastrointestinal) of Mullus barbatus and Alosa immaculata.

Arch Environ Contam Toxicol 2021 Sep 20. Epub 2021 Sep 20.

Department of Seafood Processing Technology, Faculty of Fisheries, Ataturk University, 25030, Erzurum, Turkey.

The researches on MPs in commercial marine fish are very limited although in marine environments microplastic (MPs) pollution is a global problem. In this study, the presence, composition, and characterization of MPs in different tissues (brain, gill, muscle, and gastrointestinal tract) of commercial fish species [red mullet (Mullus barbatus) and pontic shad (Alosa immaculata Bennett 1835)] from the Black Sea were investigated. M. Read More

View Article and Full-Text PDF
September 2021

Interventions to Reduce Hospital Length of Stay in High-risk Populations: A Systematic Review.

JAMA Netw Open 2021 Sep 1;4(9):e2125846. Epub 2021 Sep 1.

ECRI Evidence-based Practice Center, Center for Clinical Evidence and Guidelines, Plymouth Meeting, Pennsylvania.

Importance: Many strategies to reduce hospital length of stay (LOS) have been implemented, but few studies have evaluated hospital-led interventions focused on high-risk populations. The Agency for Healthcare Research and Quality (AHRQ) Learning Health System panel commissioned this study to further evaluate system-level interventions for LOS reduction.

Objective: To identify and synthesize evidence regarding potential systems-level strategies to reduce LOS for patients at high risk for prolonged LOS. Read More

View Article and Full-Text PDF
September 2021

Use and Safety of Immunotherapeutic Management of N-Methyl-d-Aspartate Receptor Antibody Encephalitis: A Meta-analysis.

JAMA Neurol 2021 Sep 20. Epub 2021 Sep 20.

Children's National Medical Center, Washington, DC.

Importance: Overall, immunotherapy has been shown to improve outcomes and reduce relapses in individuals with N-methyl-d-aspartate receptor (NMDAR) antibody encephalitis (NMDARE); however, the superiority of specific treatments and combinations remains unclear.

Objective: To map the use and safety of immunotherapies in individuals with NMDARE, identify early predictors of poor functional outcome and relapse, evaluate changes in immunotherapy use and disease outcome over the 14 years since first reports of NMDARE, and assess the Anti-NMDAR Encephalitis One-Year Functional Status (NEOS) score.

Data Sources: Systematic search in PubMed from inception to January 1, 2019. Read More

View Article and Full-Text PDF
September 2021

Computational elucidation of the aging time effect on zeolite synthesis selectivity in the presence of water and diquaternary ammonium iodide.

Phys Chem Chem Phys 2021 Sep 20. Epub 2021 Sep 20.

Research Institute of Petroleum Industry, West Blvd. of Azadi Complex, Tehran 1485733111, Iran.

An example of zeolite selectivity (MFI → MOR) driven by synthesis aging time has been studied. Using ,,','-tetramethyl-,'-dipropyl-ethylenediammonium diiodide (TMDP) as an organic structure-directing agent (OSDA), the zeolite phases obtained at 2 h (MFI 97%), 8 h (MFI 84%, MOR 16%) and 24 h (MFI 43%, MOR 57%) have been characterized by powder X-ray diffraction. The results suggest that at intermediate aging time, namely 8 h and 24 h, the dominant phase (MFI) is displaced by MOR. Read More

View Article and Full-Text PDF
September 2021

Current Evidence and Directions for Future Research in eHealth Physical Activity Interventions for Adults Affected by Cancer: Systematic Review.

JMIR Cancer 2021 Sep 20;7(3):e28852. Epub 2021 Sep 20.

Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada.

Background: Physical activity (PA) interventions can increase PA and improve well-being among adults affected by cancer; however, most adults do not meet cancer-specific PA recommendations. Lack of time, facility access, and travel distances are barriers to participation in PA interventions. eHealth technologies may address some of these barriers, serving as a viable way to promote PA behavior change in this population. Read More

View Article and Full-Text PDF
September 2021

Three-Port with Natural Orifice Specimen Extraction versus Conventional Laparoscopic Anterior Resection for Rectal-Sigmoid Cancer: A Matched Pair Analysis.

J Invest Surg 2021 Sep 20:1-5. Epub 2021 Sep 20.

Division of Colorectal Surgery, Changzheng Hospital, Shanghai, P.R. China.

Background: The conventional laparoscopic colorectal surgery requires four or more ports to accomplish the laparoscopic dissection, and a mini-laparotomy to remove the specimen, which is a main cause of postoperative pain and incision complications, and compromise the cosmetic results. Reduced port surgery and natural orifice specimen extraction (NOSE) surgery hold the promise to overcome these drawbacks. This study planned to compare peri-operative outcomes of patients with rectal-sigmoid cancer undergoing three-port laparoscopic anterior resection with NOSE (three-port NOSE LAR) to those of patients receiving conventional LAR. Read More

View Article and Full-Text PDF
September 2021

Development and validation of a multi-residue method for the simultaneous analysis of brominated and organophosphate flame retardants, organochlorine pesticides, and polycyclic aromatic compounds in household dust.

Anal Methods 2021 Sep 20. Epub 2021 Sep 20.

Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou 510006, P. R. China.

Household dust is a sink for multiple toxic chemicals with known or suspected potential health effects. However, most dust exposure studies focus on a few chemicals, which may limit overall understanding of human exposure characteristics because people spend most of their time indoors. This paper describes the development and evaluation of a multi-residue analysis of 20 organochlorine pesticides (OCPs), 15 polycyclic aromatic hydrocarbons (PAHs), 8 polybrominated diphenyl ether congeners (PBDEs), 3 hexabromocyclododecane (HBCDs), 8 synthetic musks (Musks), and 7 organophosphate esters (OPEs) in indoor dusts. Read More

View Article and Full-Text PDF
September 2021

Aidi injection as adjunctive treatment to gemcitabine-based chemotherapy for advanced non-small cell lung cancer: a systematic review and meta-analysis.

Pharm Biol 2021 Dec;59(1):1260-1275

Department of Pharmacy, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.

Context: Aidi injection is one of the most commonly use antitumor Chinese medicine injections for advanced non-small cell lung cancer (NSCLC). It is made from the extraction of , and

Objective: To evaluate the efficacy and safety of Aidi injection in combination with gemcitabine-based chemotherapy (GBC) for advanced NSCLC.

Materials And Methods: PubMed, Embase, Cochrane Library, Chinese Biological Medicine, China National Knowledge Infrastructure, Wanfang, and VIP were searched for relevant randomised controlled trials (RCTs) comparing Aidi injection plus GBC treatment with GBC alone in NSCLC, from inception up to October 2020. Read More

View Article and Full-Text PDF
December 2021

A Review of Selumetinib in the Treatment of Neurofibromatosis Type 1-Related Plexiform Neurofibromas.

Ann Pharmacother 2021 Sep 18:10600280211046298. Epub 2021 Sep 18.

Union University College of Pharmacy, Jackson, TN, USA.

Objective: To evaluate the safety and efficacy of selumetinib, a novel MEK inhibitor, for the treatment of plexiform neurofibromas (PN) in patients with neurofibromatosis type 1 (NF1).

Data Sources: An English-based literature search of PubMed, EMBASE, and ClinicalTrials.gov was conducted using the terms AND from inception to August 1, 2021. Read More

View Article and Full-Text PDF
September 2021

Diagnostic test accuracy of artificial intelligence analysis of cross-sectional imaging in pulmonary hypertension: a systematic literature review.

Br J Radiol 2021 Sep 19:20210332. Epub 2021 Sep 19.

Royal United Hospitals Bath NHS Foundation Trust, Bath, UK.

Objectives: To undertake the first systematic review examining the performance of artificial intelligence (AI) applied to cross-sectional imaging for the diagnosis of acquired pulmonary arterial hypertension (PAH).

Methods: Searches of Medline, Embase and Web of Science were undertaken on July 1 2020. Original publications studying AI applied to cross-sectional imaging for the diagnosis of acquired PAH in adults were identified through two-staged double-blinded review. Read More

View Article and Full-Text PDF
September 2021

Literature Retrieval for Precision Medicine with Neural Matching and Faceted Summarization.

Proc Conf Empir Methods Nat Lang Process 2020 Nov;2020:3389-3399

Division of Biomedical Informatics, University of Kentucky, Kentucky, USA.

Information retrieval (IR) for precision medicine (PM) often involves looking for multiple pieces of evidence that characterize a patient case. This typically includes at least the name of a condition and a genetic variation that applies to the patient. Other factors such as demographic attributes, comorbidities, and social determinants may also be pertinent. Read More

View Article and Full-Text PDF
November 2020

Assigning ICD-O-3 Codes to Pathology Reports using Neural Multi-Task Training with Hierarchical Regularization.

ACM BCB 2021 Aug;2021

Division of Biomedical Informatics (Internal Medicine), University of Kentucky, Lexington, Kentucky, USA.

Tracking population-level cancer information is essential for researchers, clinicians, policymakers, and the public. Unfortunately, much of the information is stored as unstructured data in pathology reports. Thus, too process the information, we require either automated extraction techniques or manual curation. Read More

View Article and Full-Text PDF

Attention-Gated Graph Convolutions for Extracting Drug Interaction Information from Drug Labels.

ACM Trans Comput Healthc 2021 Mar;2(2)

National Library of Medicine, United States.

Preventable adverse events as a result of medical errors present a growing concern in the healthcare system. As drug-drug interactions (DDIs) may lead to preventable adverse events, being able to extract DDIs from drug labels into a machine-processable form is an important step toward effective dissemination of drug safety information. Herein, we tackle the problem of jointly extracting mentions of drugs and their interactions, including interaction , from drug labels. Read More

View Article and Full-Text PDF

Morphological and molecular characterization of n. sp. (Tylenchida: Paratylenchidae) from the rhizosphere of pine tree ( Mill) in Maryland, USA.

J Nematol 2021 7;53. Epub 2021 Sep 7.

Electron and Confocal Microscopy, USDA, ARS, Northeast Area, Beltsville, MD, 20705.

The pin nematode, n. sp. collected from rhizosphere soil of a Virginia pine tree ( Mill) growing in Little Paint Branch Park, Beltsville, Prince George's County, Maryland, USA, is described and illustrated along with light and scanning electron photomicrographs. Read More

View Article and Full-Text PDF
September 2021

Water footprint in gold extraction: A case-study in Suárez, Cauca, Colombia.

Heliyon 2021 Sep 6;7(9):e07949. Epub 2021 Sep 6.

Instituto Cinara, Universidad del Valle, Cali, Colombia.

This research deepens the analysis of the mineral water footprint, especially that of gold, in regions that are understudied and where mining has been an intensified extractive activity since the colonial era, as is the case in the northern part of department of Cauca in Colombia. Thus, the purpose was to estimate the water footprint indicators in gold mining in Suárez (Cauca, Colombia), to quantify the impacts generated by the non-returned water in the production process and the levels of pollutants in the wastewater, aimed to strength public policies, control strategies and mitigation that generates reductions in the impacts from mining activities on the environment. The blue water footprint was estimated in 79. Read More

View Article and Full-Text PDF
September 2021

SSMFN: a fused spatial and sequential deep learning model for methylation site prediction.

PeerJ Comput Sci 2021 26;7:e683. Epub 2021 Aug 26.

Bioinformatics and Data Science Research Center, Bina Nusantara University, West Jakarta, Jakarta, Indonesia.

Background: Conventional methods for post-translational modification site prediction such as spectrophotometry, Western blotting, and chromatin immune precipitation can be very expensive and time-consuming. Neural networks (NN) are one of the computational approaches that can predict effectively the post-translational modification site. We developed a neural network model, namely the Sequential and Spatial Methylation Fusion Network (SSMFN), to predict possible methylation sites on protein sequences. Read More

View Article and Full-Text PDF