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Clinoptilolite Microparticles as Carriers of Catechin-Rich Extracts: Microencapsulation and In Vitro Release Study.

Molecules 2021 Mar 16;26(6). Epub 2021 Mar 16.

Mineralagro-Z Ltd., 1000 Sofia, Bulgaria.

The main goal of the present study was to investigate the microencapsulation, in vitro release capacity and efficiency of catechin-rich extract by Clinosorbent-5 (CLS-5) microparticles by in-depth detailed analyses and mathematical modelling of the encapsulation and in vitro release kinetics behaviour of the polyphenol-mineral composite system. The bioflavanol encapsulation and release efficiency on/from the mineral matrix were assessed by sorption experiments and interpretative modelling of the experimental data. The surface and spectral characteristics of the natural bioactive substance and the inorganic microcarrier were determined by Fourier Transform Infrared Spectroscopy (FTIR) and Ultraviolet/Visible (UV/Vis) spectrophotometric analyses. Read More

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Triptolide laden reduced graphene oxide transdermal hydrogel to manage knee arthritis: and studies.

J Biomater Sci Polym Ed 2021 Apr 2:1-11. Epub 2021 Apr 2.

Department of Orthopedics combined TCM with Western Medicine, Xi'an Honghui Hospital, No. 555 Youyi East Road, Beilin, Xi'an, Shaanxi, 710054, China.

Triptolide (extract of herb ) is widely used in rheumatoid arthritis due to its potent immunosuppressant effect. The marketed oral (tablet dosage forms) and parenteral injections have short duration of action (half-life =38 min) and not limited to multiorgan toxicity, which restrict the use of triptolide in clinical practice. In this study, a triptolide-loaded Pluronic® F68-reduced graphene oxide transdermal (non-invasive) hydrogel was developed to achieve sustained release of triptolide. Read More

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Ecological variation and institutionalized inequality in hunter-gatherer societies.

Proc Natl Acad Sci U S A 2021 Mar;118(13)

Department of Anthropology, University of Utah, Salt Lake City, UT 84112

Research examining institutionalized hierarchy tends to focus on chiefdoms and states, while its emergence among small-scale societies remains poorly understood. Here, we test multiple hypotheses for institutionalized hierarchy, using environmental and social data on 89 hunter-gatherer societies along the Pacific coast of North America. We utilize statistical models capable of identifying the main correlates of sustained political and economic inequality, while controlling for historical and spatial dependence. Read More

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Identifying Healthcare Professional Roles in Developing Palliative Care: A Mixed Method.

Authors:
Wadi B Alonazi

Front Public Health 2021 3;9:615111. Epub 2021 Mar 3.

King Saud University, Health Administration Department, Riyadh, Saudi Arabia.

Creating a holistic approach in healthcare services is the ultimate aim for the integrated healthcare system. Theoretically, healthcare policy makers constantly expected optimal operations within the hospitals through capitalizing the maximum potential of healthcare expertise, professionals, practitioners, and supporting staff. The objective of this study is to explore the role of healthcare individuals to sustain effective palliative care programs in a safe environment with high-quality of care. Read More

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Persistent Uncontrolled Asthma: Long-Term Impact on Physical Activity and Body Composition.

J Asthma Allergy 2021 12;14:229-240. Epub 2021 Mar 12.

Pulmonary Research Institute at the LungenClinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany.

Rationale: Asthma, obesity and physical activity (PA) are interrelated. However, longitudinal data with objective PA measures and direct assessment of body composition are still lacking.

Objective: To study the impact of symptom control on PA and body composition. Read More

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Content analysis of reported activities of the United Nations Road Safety Collaboration Members during the Decade of Action for Road Safety 2011-2020.

BMJ Open 2021 Mar 5;11(3):e042409. Epub 2021 Mar 5.

Department of Social Determinants of Health, World Health Organization, Geneva, Switzerland.

Objective: Several activities were planned for the Decade of Action (DOA) for Road Safety 2011-2020, covering key policies and interventions on road safety. Knowledge of the activities implemented by key actors is currently lacking in the literature. This study answers the question: what activities were implemented during the DOA by the United Nations Road Safety Collaboration (UNRSC) members?

Design: The study used content analysis techniques to extract and analyse information from five United Nations Secretary General's reports, which summarise the activities reported by UNRSC members. Read More

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Linear and non linear measures of pupil size as a function of hypnotizability.

Sci Rep 2021 Mar 4;11(1):5196. Epub 2021 Mar 4.

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via San Zeno, 31, 56127, Pisa, Italy.

Higher arousal and cortical excitability have been observed in high hypnotizable individuals (highs) with respect to low hypnotizables (lows), which may be due to differences in the activation of ascending activating systems. The present study investigated the possible hypnotizability-related difference in the cortical noradrenergic tone sustained by the activity of the Locus Coeruleus which is strongly related to pupil size. This was measured during relaxation in three groups of participants-highs (N = 15), lows (N = 15) and medium hypnotizable individuals (mediums, N = 11)-in the time and frequency domains and through the Recurrence Quantification Analysis. Read More

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Role of the Ipsilateral Primary Motor Cortex in the Visuo-Motor Network During Fine Contractions and Accurate Performance.

Int J Neural Syst 2021 Feb 18:2150011. Epub 2021 Feb 18.

Centre for Human Brain Health and School of Psychology, University of Birmingham, Birmingham, UK.

It is widely recognized that continuous sensory feedback plays a crucial role in accurate motor control in everyday life. Feedback information is used to adapt force output and to correct errors. While primary motor cortex contralateral to the movement (cM1) plays a dominant role in this control, converging evidence supports the idea that ipsilateral primary motor cortex (iM1) also directly contributes to hand and finger movements. Read More

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February 2021

Utilization of Machine Learning-Based Computer Vision and Voice Analysis to Derive Digital Biomarkers of Cognitive Functioning in Trauma Survivors.

Digit Biomark 2021 Jan-Apr;5(1):16-23. Epub 2020 Dec 30.

Department of Psychiatry, New York University School of Medicine, New York, New York, USA.

Background: Alterations in multiple domains of cognition have been observed in individuals who have experienced a traumatic stressor. These domains may provide important insights in identifying underlying neurobiological dysfunction driving an individual's clinical response to trauma. However, such assessments are burdensome, costly, and time-consuming. Read More

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December 2020

5-HT3/7 and GABA receptors mediate inhibition of trigeminal nociception by dietary supplementation of grape seed extract.

Nutr Neurosci 2021 Feb 5:1-12. Epub 2021 Feb 5.

Missouri State University, Springfield, MO, USA.

Temporomandibular joint disorder is a prevalent orofacial pain condition involving sensitization and activation of trigeminal nociceptive neurons. Dietary supplementation with a proanthocyanin-enriched grape seed extract (GSE) was found to inhibit trigeminal nociception in a chronic TMD model. In this study, the cellular mechanisms by which GSE inhibits sustained trigeminal nociception in male and female Sprague Dawley rats were investigated. Read More

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February 2021

Long-Term Bacterial and Fungal Dynamics following Oral Lyophilized Fecal Microbiota Transplantation in Clostridioides difficile Infection.

mSystems 2021 Feb 2;6(1). Epub 2021 Feb 2.

School of Medical Sciences, University of New South Wales, Sydney, Australia

Oral lyophilized fecal microbiota transplantation (FMT) is effective in recurrent infection (CDI); however, limited data exist on its efficacy in primary CDI and long-term microbial engraftment. Patients with primary or recurrent CDI were prospectively enrolled to receive oral FMT. Changes in the bacterial and fungal communities were characterized prior to and up to 6 months following treatment. Read More

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February 2021

Cinnamon extract loaded electrospun chitosan/gelatin membrane with antibacterial activity.

Int J Biol Macromol 2021 Mar 26;173:580-590. Epub 2021 Jan 26.

Institute of Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.

This study develops chitosan/gelatin nanofiber membranes with sustained release capacity to prevent infection by delivering cinnamon extract (CE) in the implanted site. The effects of the incorporation of CE content (2-6%) on the properties of the nanofibers were evaluated. Morphological studies using SEM indicated that loading the extract did not affect the average diameter of nanofiber mats, which remained around 140-170 nm. Read More

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Neurophysiological Effects of Whole Coffee Cherry Extract in Older Adults with Subjective Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Pilot Study.

Antioxidants (Basel) 2021 Jan 20;10(2). Epub 2021 Jan 20.

Initiative for the Center for Neuroscience, Auburn University, AL 36849, USA.

Bioactive plant-based compounds have shown promise as protective agents across multiple domains including improvements in neurological and psychological measures. Methodological challenges have limited our understanding of the neurophysiological changes associated with polyphenol-rich supplements such as whole coffee cherry extract (WCCE). In the current study, we (1) compared 100 mg of WCCE to a placebo using an acute, randomized, double-blind, within-subject, cross-over design, and we (2) conducted a phytochemical analysis of WCCE. Read More

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January 2021

Flaxseed Lignans and Polyphenols Enhanced Activity in Streptozotocin-Induced Diabetic Rats.

Biology (Basel) 2021 Jan 11;10(1). Epub 2021 Jan 11.

Faculty of Chemical Engineering and Environmental Protection, Gheorghe Asachi Technical University of Iasi, 700050 Iasi, Romania.

Flaxseeds play an important role in human health due to their chemical composition and recognized beneficial outcomes. This study investigated the antidiabetic effects of present lignans and polyphenols found in the flaxseed extract on streptozotocin (STZ)-induced diabetic rats. The flaxseed administration produced favorable changes in body weight, food and water intake, and glycosylated hemoglobin and blood glucose quantities in the treated diabetic rats. Read More

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January 2021

Maxillofacial trauma in children: Association between age and mandibular fracture site.

Am J Otolaryngol 2021 Mar-Apr;42(2):102874. Epub 2020 Dec 29.

Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States; Department of Otolaryngology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States. Electronic address:

Purpose: To describe the association between age and location of facial fractures in the pediatric population.

Materials And Methods: A retrospective analysis of the Healthcare Cost and Utilization Project (HCUP) from the 2016 Kids' Inpatient Database (KID) in children aged ≤18 years was conducted. International Statistical Classification of Diseases, 10th Revision (ICD-10) codes were used to extract facial fracture diagnoses. Read More

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December 2020

Self-determination theory interventions versus usual care in people with diabetes: a protocol for a systematic review with meta-analysis and trial sequential analysis.

Syst Rev 2021 Jan 7;10(1):12. Epub 2021 Jan 7.

Department of Anaesthesiology, Herlev University Hospital, Herlev, Denmark.

Background: Existing self-management and behavioural interventions for diabetes vary widely in their content, and their sustained long-term effectiveness is uncertain. Autonomy supporting interventions may be a prerequisite to achieve 'real life' patient engagement and more long-term improvement through shared decision-making and collaborative goal setting. Autonomy supportive interventions aim to promote that the person with diabetes' motivation is autonomous meaning that the person strives for goals they themselves truly believe in and value. Read More

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January 2021

Identification of the laterality of motor unit behavior in female patients with parkinson's disease using high-density surface electromyography.

Eur J Neurosci 2021 Mar 12;53(6):1938-1949. Epub 2021 Jan 12.

Faculty of Frontier Engineering, Institute of Science & Engineering, Kanazawa University, Kanazawa, Japan.

Patients with Parkinson's disease (PD) have greater laterality of muscle contraction properties than other people with parkinsonism diseases. However, few studies have reported the laterality of MU activation properties of the lower extremity muscles in patients with PD. The aim of the present study was to identify the laterality of MU behavior in PD patients using high-density surface electromyography (HD-SEMG). Read More

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Pharmacological Management of Diabetes for Reducing Glucose Levels and Cardiovascular Disease Risk: What Evidence in South Asians?

Curr Diabetes Rev 2020 Dec 28. Epub 2020 Dec 28.

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow. United Kingdom.

Introduction/aims: South Asians experience more type 2 diabetes, which is earlier in onset and with more rapid glycaemic deterioration, although average body mass indices are lower than in whites. Cardiovascular outcomes from diabetes drug trials are now reported as standard, with data from newer therapies influencing patient management. However, less is known of the effect of such therapies in South Asians. Read More

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December 2020

Biocompatibility improvement of artificial cornea using chitosan-dextran nanoparticles containing bioactive macromolecules obtained from human amniotic membrane.

Int J Biol Macromol 2021 Feb 28;169:492-499. Epub 2020 Dec 28.

Nanobiotechnology Department, New Technologies Research Group, Pasteur Institute of Iran, Tehran, Iran. Electronic address:

Corneal transplantation, by which the damaged cornea is replaced by a new one, suffers from limited access to HLA-compatible-donors and high maintenance and surgical costs. Therefore, artificial corneas are considered as alternative tools with promising prospects. In our previous study, a two-part-polymeric artificial cornea was composed of enhanced hydrophilic surface electrospun poly(ε-caprolactone) nanofibrous scaffold that is thermally connected to a polyvinyl alcohol-based hydrogel disk was prepared. Read More

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February 2021

The preventive and therapeutic effects of AAV1-KLF4-shRNA in cigarette smoke-induced pulmonary hypertension.

J Cell Mol Med 2021 Jan 20;25(2):1238-1251. Epub 2020 Dec 20.

Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

We found previously that KLF4 expression was up-regulated in cultured rat and human pulmonary artery smooth muscle cells (PASMCs) exposed to cigarette smoke (CS) extract and in pulmonary artery from rats with pulmonary hypertension induced by CS. Here, we aim to investigate whether CS-induced pulmonary hypertension (PH) is prevented and ameliorated by targeted pulmonary vascular gene knockdown of KLF4 via adeno-associated virus 1 (AAV1)-KLF4-shRNA in vivo in rat model. The preventive and therapeutic effects were observed according to the different time-point of AAV1-KLF4-shRNA intratracheal administration. Read More

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January 2021

Co-Delivery of Docetaxel and Curcumin via Nanomicelles for Enhancing Anti-Ovarian Cancer Treatment.

Int J Nanomedicine 2020 3;15:9703-9715. Epub 2020 Dec 3.

Department of Neurosurgery and Institute of Neurosurgery, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu 610041, People's Republic of China.

Introductions: Ovarian cancer is a stubborn malignancy of gynecological system with a high mortality rate. Docetaxel (DTX), the second-generation of anti-tumor drug Taxane, has shown superior efficacy over classic paclitaxel (PTX) in certain cancers. However, its clinical application is hindered by poor bioavailability. Read More

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December 2020

Dandelion extract relaxes mouse airway smooth muscle by blocking VDLCC and NSCC channels.

Cell Biosci 2020 Oct 28;10(1):125. Epub 2020 Oct 28.

School of Pharmaceutical Sciences, South-Central University for Nationalities, 182 Min-Zu Road, Wuhan, 430074, China.

Background: Asthma is one of the main intractable diseases recognized by the international medical community. The current widely used bronchodilators for asthma-β2-adrenal receptor agonists-have limited therapeutic effects, necessitating the development of novel antiasthma drugs with increased efficacy and fewer adverse effects. In this study, we investigated the relaxant effects and underlying mechanism of an ethyl acetate extract from dandelion (EAED) on mouse airway smooth muscle. Read More

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October 2020

Cardioprotective Activities of Ethanolic Extract Root of on Alloxan-Induced Cardiotoxicity in Diabetic Rats.

Biomed Res Int 2020 19;2020:3189672. Epub 2020 Nov 19.

Department of Anatomy, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Bushenyi, Uganda.

Diabetes mellitus has developed into one of the debilitating diseases disturbing the health of many people living with cardiovascular diseases in modern times. The root of was investigated for its effects on alloxan-induced diabetic Wistar rats' cardiac tissues. Thirty-two (32) Wistar rats weighing between 180 and 190 g were randomly divided into four groups. Read More

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November 2020

Nanomaterial Lipid-Based Carrier for Non-Invasive Capsaicin Delivery; Manufacturing Scale-Up and Human Irritation Assessment.

Molecules 2020 Nov 27;25(23). Epub 2020 Nov 27.

Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.

Capsaicin is an active compound in chili peppers () that has been approved for chronic pain treatment. The topical application of high-strength capsaicin has been proven to reduce pain; however, skin irritation is a major drawback. The aim of this study was to investigate an appropriate and scalable technique for preparing nanostructured lipid carriers (NLCs) containing 0. Read More

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November 2020

Mg-protoporphyrin IX monomethyl ester cyclase from Rhodobacter capsulatus: radical SAM-dependent synthesis of the isocyclic ring of bacteriochlorophylls.

Biochem J 2020 12;477(23):4635-4654

Braunschweig Centre of Integrated Systems Biology, Technische Universität Braunschweig, Rebenring 56, D-38106 Braunschweig, Germany.

During bacteriochlorophyll a biosynthesis, the oxygen-independent conversion of Mg-protoporphyrin IX monomethyl ester (Mg-PME) to protochlorophyllide (Pchlide) is catalyzed by the anaerobic Mg-PME cyclase termed BchE. Bioinformatics analyses in combination with pigment studies of cobalamin-requiring Rhodobacter capsulatus mutants indicated an unusual radical S-adenosylmethionine (SAM) and cobalamin-dependent BchE catalysis. However, in vitro biosynthesis of the isocyclic ring moiety of bacteriochlorophyll using purified recombinant BchE has never been demonstrated. Read More

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December 2020

Impacts of zinc oxide nano and bulk particles on redox-enzymes of the Punica granatum callus.

Sci Rep 2020 11 12;10(1):19722. Epub 2020 Nov 12.

Botany and Microbiology Department, Faculty of Science, Assiut University, Assiut, 71516, Egypt.

The structure and function of cellular membranes were sustained by redox-enzymes. We studied the interaction between the oxidative stress caused by excessive accumulation of ZnO-nanoparticles (ZnO-NPs) in plants and the role of redox-enzymes that can alleviate this stress. The crude callus extract from pomegranate, which was treated with 0, 10, and 150 µg mL ZnO-NPs or bulk particles (ZnO-BPs), was applied to study the activity and kinetics of redox-enzymes. Read More

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November 2020

Preparation and Evaluation of Sustained Release Platelet-Rich Plasma-Loaded Gelatin Microspheres Using an Emulsion Method.

ACS Omega 2020 Oct 13;5(42):27113-27118. Epub 2020 Oct 13.

Department of Blood Transfusion, General Hospital of Southern Theatre Command of PLA, Guangzhou 510010, China.

The management and treatment of chronic wounds or acute wounds remain a major challenge in modern medicine. The application of autologous platelet-rich plasma (PRP) has become a promising adjuvant therapy to promote wound healing. PRP is derived from centrifuged whole blood to extract concentrated platelets, and a large amount of cytokines and growth factors are released upon activation. Read More

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October 2020

Dandelion extract relaxes mouse airway smooth muscle by blocking VDLCC and NSCC channels.

Cell Biosci 2020 28;10:125. Epub 2020 Oct 28.

School of Pharmaceutical Sciences, South-Central University for Nationalities, 182 Min-Zu Road, Wuhan, 430074 China.

Background: Asthma is one of the main intractable diseases recognized by the international medical community. The current widely used bronchodilators for asthma-β2-adrenal receptor agonists-have limited therapeutic effects, necessitating the development of novel antiasthma drugs with increased efficacy and fewer adverse effects. In this study, we investigated the relaxant effects and underlying mechanism of an ethyl acetate extract from dandelion (EAED) on mouse airway smooth muscle. Read More

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October 2020

State of the Art in the Culture of the Human Microbiota: New Interests and Strategies.

Clin Microbiol Rev 2020 Dec 28;34(1). Epub 2020 Oct 28.

Aix-Marseille Université, IRD, MEPHI, AP-HM, Institut Hospitalo-Universitaire Méditerranée-Infection, Marseille, France

SUMMARYThe last 5 years have seen a turning point in the study of the gut microbiota with a rebirth of culture-dependent approaches to study the gut microbiota. High-throughput methods have been developed to study bacterial diversity with culture conditions aimed at mimicking the gut environment by using rich media such as YCFA (yeast extract, casein hydrolysate, fatty acids) and Gifu anaerobic medium in an anaerobic workstation, as well as media enriched with rumen and blood and coculture, to mimic the symbiosis of the gut microbiota. Other culture conditions target phenotypic and metabolic features of bacterial species to facilitate their isolation. Read More

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December 2020

Paternal cannabis extract exposure in rats: Preconception timing effects on neurodevelopmental behavior in offspring.

Neurotoxicology 2020 12 19;81:180-188. Epub 2020 Oct 19.

Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA. Electronic address:

Maternal toxicant exposure during gestation can have deleterious effects on neurobehavioral development of the offspring. The potential risks engendered by paternal toxicant exposure prior to conception have been largely understudied. Recently, we found that chronic THC exposure prior to conception in male rats causes long-lasting behavioral impairment in their offspring. Read More

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December 2020