16,594 results match your criteria external validation


Strategic infarct locations for post-stroke depressive symptoms: a lesion- and disconnection-symptom mapping study.

Biol Psychiatry Cogn Neurosci Neuroimaging 2021 Sep 18. Epub 2021 Sep 18.

Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, Utrecht, the Netherlands.

Background: Depression is the most common neuropsychiatric complication after stroke. Infarct location is associated with post-stroke depressive symptoms (PSDS), but it remains debated which brain structures are critically involved. We performed a large-scale lesion-symptom mapping study to identify infarct locations, and white matter disconnections, associated with PSDS. Read More

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September 2021

Real-time artificial intelligence for detecting focal lesions and diagnosing neoplasms of the stomach by white-light endoscopy (with videos).

Gastrointest Endosc 2021 Sep 18. Epub 2021 Sep 18.

Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China; Key Laboratory of Hubei Province for Digestive System Disease, Renmin Hospital of Wuhan University, Wuhan, China; Hubei Provincial Clinical Research Center for Digestive Disease Minimally Invasive Incision, Renmin Hospital of Wuhan University, Wuhan, China. Electronic address:

Background And Aims: White-light endoscopy (WLE) is the most pivotal tool to detect gastric cancer in the early stage. However, the skill among endoscopists varies greatly. Here, we aim to develop a deep learning-based system named ENDOANGEL-LD (lesion detection) to assist in detecting all focal gastric lesions and predicting neoplasms by WLE. Read More

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September 2021

A Novel Physical Examination Test for Ischiofemoral Impingement: Validation With Magnetic Resonance Imaging Correlation.

J Comput Assist Tomogr 2021 Sep-Oct 01;45(5):722-727

Department of Radiology, Hacettepe University School of Medicine, Sıhhiye, Ankara, Turkey.

Objective: The purpose of this study was to propose and validate a novel physical examination test for ischiofemoral impingement with magnetic resonance imaging (MRI) correlation.

Methods: We prospectively studied 24 women with buttock (deep gluteal) pain and 27 asymptomatic women. Each group underwent a 2-stage physical examination test that featured hip adduction-external rotation-extension and knee flexion. Read More

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September 2021

The estimation of a preference-based single index for the IBS-QoL by mapping to the EQ-5D-5L in patients with irritable bowel syndrome.

Qual Life Res 2021 Sep 21. Epub 2021 Sep 21.

Department of Clinical Epidemiology and Medical Technology Assessment, CAPHRI Care and Public Health Research Institute, Maastricht University Medical Center, Maastricht, The Netherlands.

Purpose: The Irritable Bowel Syndrome Quality of Life (IBS-QoL) questionnaire is a commonly used and validated IBS-specific QoL instrument. However, this questionnaire is in contrast to the EQ-5D-5L, not preference-based and as such does not allow calculation of QALYs. The objective of this study was to describe the convergent- and known-group validity of both questionnaires and to develop a mapping algorithm from EQ-5D-5L which enable IBS-QoL scores to be transformed into utility scores for use in economic evaluations. Read More

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September 2021

Multi-Disease Detection in Retinal Imaging Based on Ensembling Heterogeneous Deep Learning Models.

Stud Health Technol Inform 2021 Sep;283:23-31

IT-Infrastructure for Translational Medical Research, University of Augsburg, Augsburg, Germany.

Preventable or undiagnosed visual impairment and blindness affect billion of people worldwide. Automated multi-disease detection models offer great potential to address this problem via clinical decision support in diagnosis. In this work, we proposed an innovative multi-disease detection pipeline for retinal imaging which utilizes ensemble learning to combine the predictive capabilities of several heterogeneous deep convolutional neural network models. Read More

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September 2021

Immune and cellular damage biomarkers to predict COVID-19 mortality in hospitalized patients.

Curr Res Immunol 2021 Sep 16. Epub 2021 Sep 16.

Department of Pulmonary Medicine, Thoracic Disease Research Unit, Mayo Clinic, Rochester, USA.

Early prediction of COVID-19 in-hospital mortality relies usually on patients' preexisting comorbidities and is rarely reproducible in independent cohorts. We wanted to compare the role of routinely measured biomarkers of immunity, inflammation, and cellular damage with preexisting comorbidities in eight different machine-learning models to predict mortality, and evaluate their performance in an independent population. We recruited and followed-up consecutive adult patients with SARS-Cov-2 infection in two different Italian hospitals. Read More

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September 2021

External validation of the 4C mortality score among COVID-19 patients admitted to hospital in Ontario, Canada: a retrospective study.

Sci Rep 2021 Sep 20;11(1):18638. Epub 2021 Sep 20.

Waterloo Regional Campus, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Canada.

Risk prediction scores are important tools to support clinical decision-making for patients with coronavirus disease (COVID-19). The objective of this paper was to validate the 4C mortality score, originally developed in the United Kingdom, for a Canadian population, and to examine its performance over time. We conducted an external validation study within a registry of COVID-19 positive hospital admissions in the Kitchener-Waterloo and Hamilton regions of southern Ontario between March 4, 2020 and June 13, 2021. Read More

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September 2021

External validation of Chronic Pancreatitis Prognosis Score(COPPS): A prospective cohort study.

Dig Liver Dis 2021 Sep 17. Epub 2021 Sep 17.

Divisions of Gastroenterology, School of Digestive and Liver Disease, IPGME&R, Kolkata, India. Electronic address:

Background: Prognostic stratification in ChronicPancreatitis(CP) remains suboptimal and cumbersome. Chronic Pancreatitis Prognostic Score(COPPS) was recently developed to predict one-year hospitalisations in CP.

Aim: External validation of COPPS in a geographically divergent patient population. Read More

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September 2021

External validation of the REMARCC model for the selection of cytoreductive nephrectomy in patients with primary metastatic renal cell carcinoma: A multicenter retrospective study.

Urol Oncol 2021 Sep 17. Epub 2021 Sep 17.

Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

Objectives: This study aims to evaluate the utility of the scoring system of the Registry for Metastatic Renal Cell Carcinoma (REMARCC) model on the overall survival (OS) of patients undergoing cytoreductive nephrectomy (CN).

Methods: A total of 278 patients with primary metastatic renal cell carcinoma (mRCC) treated with first-line tyrosine kinase inhibitors (TKIs) between January 2008 and November 2019 were identified. The c-index and net benefit between the REMARCC score were compared with the International mRCC Database Consortium (IMDC) score in patients with CN (CN group, n = 146). Read More

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September 2021

Identification and validation of a novel immune-related signature associated with macrophages and CD8 T cell infiltration predicting overall survival for hepatocellular carcinoma.

BMC Med Genomics 2021 Sep 20;14(1):232. Epub 2021 Sep 20.

Liver Disease Center, The Affiliated Hospital of Qingdao University, No. 59 Haier Road, Qingdao, 266003, China.

Background: Although the effects of macrophages and CD8 T cell infiltration on clinical outcome have been widely reported, the association between immunity-associated gene with them for hepatocellular carcinoma (HCC) remains unclear.

Materials And Methods: The ssGSEA served for quantifying the macrophages as well as CD8 T cell infiltration in the HCC samples obtained from TCGA database. Kaplan-Meier (KM) survival assay was used to determine the associations between macrophages and CD8 T cell infiltration with OS. Read More

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September 2021

Estimating Bleeding Risk in Patients with Cancer-Associated Thrombosis: Evaluation of Existing Risk Scores and Development of a New Risk Score.

Thromb Haemost 2021 Sep 20. Epub 2021 Sep 20.

Department of Acute Internal Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.

Background:  Bleeding risk is highly relevant for treatment decisions in cancer-associated thrombosis (CAT). Several risk scores exist, but have never been validated in patients with CAT and are not recommended for practice.

Objectives:  To compare methods of estimating clinically relevant (major and clinically relevant nonmajor) bleeding risk in patients with CAT: (1) existing risk scores for bleeding in venous thromboembolism, (2) pragmatic classification based on cancer type, and (3) new prediction model. Read More

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September 2021

ProFitFun: A Protein Tertiary Structure Fitness Function for Quantifying the Accuracies of Model Structures.

Bioinformatics 2021 Sep 20. Epub 2021 Sep 20.

Laboratory for Structural Bioinformatics, Center for Biosystems Dynamics Research, RIKEN, 1-7-22 Suehiro, Yokohama, Kanagawa, 230-0045, Japan.

Motivation: An accurate estimation of the quality of protein model structures typifies as a cornerstone in protein structure prediction regimes. Despite the recent groundbreaking success in the field of protein structure prediction, there are certain prospects for the improvement in model quality estimation at multiple stages of protein structure prediction and thus, to further push the prediction accuracy. Here, a novel approach, named ProFitFun, for assessing the quality of protein models is proposed by harnessing the sequence and structural features of experimental protein structures in terms of the preferences of backbone dihedral angles and relative surface accessibility of their amino acid residues at the tripeptide level. Read More

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September 2021

Development and Validation of the Social Network Addiction Scale (SNAddS-6S).

Eur J Investig Health Psychol Educ 2020 Jul 26;10(3):763-778. Epub 2020 Jul 26.

Maimonides Biomedical Research Institute of Cordoba (IMIBIC), 14004 Córdoba, Spain.

The use of social networks has increased exponentially, especially among youth. These tools offer many advantages but also carry some risks such as addiction. This points to the need for a valid multifactorial instrument to measure social network addiction, focusing on the core components of addiction that can serve researchers and practitioners. Read More

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The English Version of the Health Profession Communication Collective Efficacy Scale (HPCCE Scale) by Capone and Petrillo, 2012.

Eur J Investig Health Psychol Educ 2020 Nov 13;10(4):1065-1079. Epub 2020 Nov 13.

Department of Humanities, University of Naples Federico II, 80100 Naples, Italy.

Communication is a crucial component in all steps of the health care process. Therefore, it is important to have knowledge about the communication skills of the whole health organization. From the socio-cognitive perspective, collective efficacy beliefs are the main indicators of the capacity of functioning of the system. Read More

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November 2020

Predictive models for independence after stroke rehabilitation: Maugeri external validation and development of a new model.

NeuroRehabilitation 2021 Sep 13. Epub 2021 Sep 13.

Department of Research and Innovation, Institut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, Badalona, Barcelona, Spain.

Background: Many efforts have been devoted to identify predictors of functional outcomes after stroke rehabilitation. Though extensively recommended, there are very few external validation studies.

Objective: To externally validate two predictive models (Maugeri model 1 and model 2) and to develop a new model (model 3) that estimate the probability of achieving improvement in physical functioning (primary outcome) and a level of independence requiring no more than supervision (secondary outcome) after stroke rehabilitation. Read More

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September 2021

Assessing Extensive Cow-Calf Welfare in Namibia: Feasibility of Adapting a New Zealand Beef Cow Welfare Assessment Protocol.

J Appl Anim Welf Sci 2021 Sep 20:1-11. Epub 2021 Sep 20.

School of Agriculture and Environmental Management, Massey University, Palmerston North, New Zealand.

Namibia needs a robust welfare assessment protocol for beef cattle for benchmarking and trade. As there is presently no such protocol, one was developed for Namibian conditions based on one designed for extensive beef cattle in New Zealand which had been derived from the Welfare Quality and UC Davis Cow-Calf protocols, the modified protocol was evaluated in a semi-commercial farming village during the pregnancy testing of 141 cows from 5 herds of different households. Animal- and stockperson-based measures were assessed directly, cows were observed at grazing, and a questionnaire-guided interview was conducted. Read More

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September 2021

How to identify the most suitable questionnaires and rating scales for your research and clinical practice?

Int J Clin Pract 2021 Sep 19:e14895. Epub 2021 Sep 19.

Center of primary care and public health (Unisanté), University of Lausanne, Lausanne, Switzerland.

Background: Selection of the most suitable instrument for a health outcome or exposure assessment is challenging, as there are many different instruments and their versions, most with unknown validity.

Aims: To develop guidelines facilitating the search for the most suitable instrument.

Materials And Methods: Based on our experience, we formalized a five-step process. Read More

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September 2021

Development and Validation of a Clinical Prognostic Nomogram for Esophageal Adenocarcinoma Patients.

Front Oncol 2021 2;11:736573. Epub 2021 Sep 2.

Department of Cardiothoracic Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

Background: Clinical staging is essential for clinical decisions but remains imprecise. We purposed to construct a novel survival prediction model for improving clinical staging system (cTNM) for patients with esophageal adenocarcioma (EAC).

Methods: A total of 4180 patients diagnosed with EAC were extracted from the Surveillance, Epidemiology, and End Results (SEER) database and included as the training cohort. Read More

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September 2021

Computed Tomography-Based Radiomics Nomogram: Potential to Predict Local Recurrence of Gastric Cancer After Radical Resection.

Front Oncol 2021 2;11:638362. Epub 2021 Sep 2.

Department of Radiology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Objective: Accurate prediction of postoperative recurrence risk of gastric cancer (GC) is critical for individualized precision therapy. We aimed to investigate whether a computed tomography (CT)-based radiomics nomogram can be used as a tool for predicting the local recurrence (LR) of GC after radical resection.

Materials And Methods: 342 patients (194 in the training cohort, 78 in the internal validation cohort, and 70 in the external validation cohort) with pathologically proven GC from two centers were included. Read More

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September 2021

The Development and Validation of the Health Behavior Motivation Scale.

Front Psychol 2021 3;12:706495. Epub 2021 Sep 3.

Institute of Psychology, The Maria Grzegorzewska University, Warsaw, Poland.

The article presents the construction and validation process of the (HBMS), which measures the motivation toward pro-health behaviors in population of healthy adults. The tool is conceptually based on Self-Determination Theory (SDT) and more precisely on one of its subtheories-Organismic Integration Theory (OIT). In the first stage of the construction, the linguistic validation with competent judges procedure allowed to eliminate the items which were not correctly formulated. Read More

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September 2021

A Novel Physical Examination Test for Ischiofemoral Impingement: Validation With Magnetic Resonance Imaging Correlation.

J Comput Assist Tomogr 2021 Sep 17. Epub 2021 Sep 17.

From the Departments of Radiology Physical Medicine and Rehabilitation, İnönü University School of Medicine, Malatya Department of Radiology, Hacettepe University School of Medicine, Sıhhiye, Ankara, Turkey.

Objective: The purpose of this study was to propose and validate a novel physical examination test for ischiofemoral impingement with magnetic resonance imaging (MRI) correlation.

Methods: We prospectively studied 24 women with buttock (deep gluteal) pain and 27 asymptomatic women. Each group underwent a 2-stage physical examination test that featured hip adduction-external rotation-extension and knee flexion. Read More

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September 2021

Radiomics, machine learning, and artificial intelligence-what the neuroradiologist needs to know.

Neuroradiology 2021 Sep 18. Epub 2021 Sep 18.

Division of Neuroradiology, The Hospital for Sick Children, Toronto, Canada.

Purpose: Artificial intelligence (AI) is playing an ever-increasing role in Neuroradiology.

Methods: When designing AI-based research in neuroradiology and appreciating the literature, it is important to understand the fundamental principles of AI. Training, validation, and test datasets must be defined and set apart as priorities. Read More

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September 2021

Validation and Public Health Modelling of Risk Prediction Models for Kidney Cancer using UK Biobank.

BJU Int 2021 Sep 19. Epub 2021 Sep 19.

Department of Public health and Primary Care, University of Cambridge, Cambridge, UK.

Objectives: Early detection of kidney cancer improves survival; however, low prevalence means that population-wide screening based on age alone is inefficient. Stratifying the population, using risk models, could enable an individually tailored screening program. Risk models exist but very few have been externally validated. Read More

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September 2021

Transcultural adaptation and validation of the Spanish-language version of ACTIVLIM in adults with inherited myopathies using the Rasch model.

Neurologia (Engl Ed) 2021 Sep 29;36(7):514-524. Epub 2020 May 29.

Instituto de Investigación Sanitaria de Navarra, Pamplona, Navarra, Spain; Navarrabiomed-Departamento de Salud-UPNA. Red de Investigación en Servicios Sanitarios y Enfermedades Crónicas (REDISSEC), Pamplona, Navarra, Spain.

Introduction: ACTIVLIM is an instrument for the measurement of activity limitations in patients with neuromuscular disorders. The aim of this study is to establish a transcultural adaptation and psychometric validation of the Spanish-language version of ACTIVLIM in a sample of Spanish patients with inherited myopathies.

Patients And Method: A Spanish-language version of ACTIVLIM was developed using the translation/back translation method. Read More

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September 2021

Magnetic resonance imaging radiomics signatures for predicting endocrine resistance in hormone receptor-positive non-metastatic breast cancer.

Breast 2021 Sep 11;60:90-97. Epub 2021 Sep 11.

Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, China; Department of Medical Oncology, Phase I Clinical Trial Centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, China. Electronic address:

Background: One-third of patients with hormone receptor (HR)-positive breast cancers fail to respond to hormone therapy, and some patients even progress within two years of adjuvant endocrine therapy (ET) toward primary endocrine resistance. However, there is no effective way to predict endocrine resistance.

Objective: To build a model that incorporates the radiomic signature of pretreatment magnetic resonance imaging (MRI) with clinical information to predict endocrine resistance. Read More

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September 2021

Identification of a novel immune-related prognostic signature associated with tumor microenvironment for breast cancer.

Int Immunopharmacol 2021 Sep 15;100:108122. Epub 2021 Sep 15.

Department of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address:

Background: In the view that immune-related genes play a crucial role in breast cancer progression and long-term patient outcomes, we aimed to identify a novel gene signature based on immune-related genes to improve the prognostic prediction of breast cancer.

Methods: RNA sequencing data and clinical information were obtained from The Cancer Genome Atlas (TCGA). Univariate and multivariate Cox regression analyses were conducted to establish the immune-related prognostic signature (IRPS). Read More

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September 2021

Pre-transplant morphometry by computed tomography scan and post-transplant dialysis risk in overweight or obese kidney transplant recipients.

Int Urol Nephrol 2021 Sep 18. Epub 2021 Sep 18.

Department of Urology and Transplantation Surgery, Hôpital de Bicêtre, AP-HP. Université Paris Saclay, 78 rue du général Leclerc, Le Kremlin-Bicêtre, 94270, Paris, France.

Purpose: Adipose distribution and sarcopenia could better assess kidney transplantation outcomes than body mass index (BMI) and have been poorly evaluated among obese and overweight recipients. We aimed to evaluate morphometric radiologic markers to predict post-operative dialysis within this population.

Methods: We conducted a retrospective study including patients with a BMI > 25 kg/m undergoing kidney transplantation during 5 years. Read More

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September 2021

Artificial intelligence for detecting superficial esophageal squamous cell carcinoma under multiple endoscopic imaging modalities: a multicenter study.

J Gastroenterol Hepatol 2021 Sep 17. Epub 2021 Sep 17.

Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Background And Aim: Diagnosis of esophageal squamous cell carcinoma (ESCC) is complicated and requires substantial expertise and experience. This study aimed to develop an artificial intelligence (AI) system for detecting superficial ESCC under multiple endoscopic imaging modalities.

Methods: Endoscopic images were retrospectively collected from West China Hospital, Sichuan University as a training dataset and an independent internal validation dataset. Read More

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September 2021

Independent External Validation of FRAX and Garvan Fracture Risk Calculators: A Sub-Study of the FRISBEE Cohort.

JBMR Plus 2021 Sep 6;5(9):e10532. Epub 2021 Aug 6.

Department of Endocrinology, CHU Brugmann Université Libre de Bruxelles Brussels Belgium.

Probabilistic models including clinical risk factors with or without bone mineral density (BMD) have been developed to estimate the 5- or 10-year absolute fracture risk. We investigated the performance of the FRAX and Garvan tools in a well-characterized population-based cohort of 3560 postmenopausal, volunteer women, aged 60 to 85 years at baseline, included in the Fracture Risk Brussels Epidemiological Enquiry (FRISBEE) cohort, during 5 years of follow-up. Baseline data were used to calculate the estimated 10-year risk of hip and major osteoporotic fractures (MOFs) for each participant using FRAX (Belgium). Read More

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September 2021

Best Practices for Technical Reproducibility Assessment of Multiplex Immunofluorescence.

Front Mol Biosci 2021 31;8:660202. Epub 2021 Aug 31.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Multiplex immunofluorescence (mIF) tyramide signal amplification is a new and useful tool for the study of cancer that combines the staining of multiple markers in a single slide. Several technical requirements are important to performing high-quality staining and analysis and to obtaining high internal and external reproducibility of the results. This review manuscript aimed to describe the mIF panel workflow and discuss the challenges and solutions for ensuring that mIF panels have the highest reproducibility possible. Read More

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