106 results match your criteria extents invasion

Staphylococcus aureus ST228 and ST239 as models for expression studies of diverse markers during osteoblast infection and persistence.

Microbiologyopen 2021 03;10(2):e1178

Department of Biomedical and Biotechnological Sciences (BIOMETEC), Medical Molecular Microbiology and Antibiotic Resistance laboratory (MMARLab, University of Catania, Catania, Italy.

The ability of S. aureus to infect bone and osteoblasts is correlated with its incredible virulence armamentarium that can mediate the invasion/internalization process, cytotoxicity, membrane damage, and intracellular persistence. We comparatively analyzed the interaction, persistence, and modulation of expression of selected genes and cell viability in an ex vivo model using human MG-63 osteoblasts of two previously studied and well-characterized S. Read More

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Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2.

bioRxiv 2021 Apr 16. Epub 2021 Apr 16.

Infection by SARS-CoV-2 generally causes mild symptoms but can lead to severe disease and death in certain populations, including the immunocompromised. Drug repurposing efforts are underway to identify compounds that interfere with SARS-CoV-2 replication or the immunopathology it can elicit. Rapamycin is among those being currently tested in clinical trials for impacts on COVID-19 severity. Read More

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Advantageous factors of R0 curative conversion esophagectomy and the optimal extent of lymphadenectomy after induction therapy for cT4b thoracic esophageal cancer.

Ann Gastroenterol Surg 2021 Mar 11;5(2):204-214. Epub 2020 Dec 11.

Department of Gastroenterological Surgery Toranomon Hospital Okinaka Memorial Institute for Medical Research Tokyo Japan.

Aim: This study aimed to clarify the prognostic factors, the advantageous factors of R0 curative resection, and optimal extents of lymph node dissection for conversion esophagectomy after induction therapy.

Methods: Among 1903 patients with esophageal cancer at Toranomon Hospital between January 2006 to May 2020, 151 patients with locally advanced T4b thoracic esophageal cancer were divided into two groups according to treatment: conversion surgery group (n = 54) and non-surgical treatment group (n = 97) for comparison.

Results: The patients who underwent R0 curative resection showed preferable survival comparable to the survival rate of patients with cCR in the non-surgical treatment group (1-, 3- and 5-year survival: 96. Read More

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GPR37 promotes the malignancy of lung adenocarcinoma via TGF-β/Smad pathway.

Open Med (Wars) 2021 5;16(1):24-32. Epub 2020 Dec 5.

Department of Respiration, Midong Branch of People's Hospital of Xinjiang Autonomous Region, 1302-17 Midong South Road, Urumqi, Xinjiang, People's Republic of China.

This paper aimed to research the function and in-depth mechanism of GPR37 in lung adenocarcinoma (LUAD). Herein, based on TCGA and Oncomine databases, we revealed that GPR37 was expressed at high levels in LUAD, and upregulation of GPR37 was related to the poor outcomes. Furthermore, biological function experiments were utilized to assess whether GPR37 impacts malignant phenotype of LUAD cells. Read More

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December 2020

[Clinicopathological characterization of primary pulmonary and tracheal glomus tumors].

Zhonghua Bing Li Xue Za Zhi 2020 Dec;49(12):1282-1287

Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.

To investigate the clinical pathological features of primary pulmonary and tracheal glomus tumors. The clinical and pathological features of 11 cases (4 cases from Shanghai Pulmonary Hospital, Tongji University School of Medicine, China and 7 cases from Fudan University Shanghai Cancer Center, China) of respiratory glomus tumor diagnosed from 2010 to 2019 were analyzed, and reviewed in light of the relevant literature. In the 11 cases, there were 5 males and 6 females, with the onset ages of 29‒66 years (median age of 43). Read More

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December 2020

Mechanism of action of Panax notoginoside against lung cancer in mice based on response to CTSB gene.

BMC Complement Med Ther 2020 Nov 25;20(1):367. Epub 2020 Nov 25.

Internal Medicine of Traditional Chinese Medicine, Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medicine University, No. 9 Jiaowei Road, Lucheng District, Wenzhou, China.

Background: This study aimed to investigate the mechanism of action of Panax notoginoside (PNS) against lung cancer and inhibition of lung cancer cell proliferation by the drug at different concentrations in a mouse model, considering the cathepsin B (CTSB) gene as a target.

Methods: The mice were randomly assigned into the following five groups: normal control, tumor-bearing, low-dose Panax notoginoside (TSPN), medium-dose TSPN, and high-dose TSPN. All mice were treated with physiological saline or TSPN at different concentrations for 28 days consecutively by gavage. Read More

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November 2020

What Is the Spatial Extent of a Population?

Insects 2020 Nov 18;11(11). Epub 2020 Nov 18.

Department of Entomology, University of Georgia, Athens, GA 30602, USA.

Effective pest management depends on basic knowledge about insect dispersal patterns and gene flow in agroecosystems. The globally invasive sweet potato whitefly (Gennadius) (Hemiptera: Aleyrodidae) is considered a weak flier whose life history nonetheless predisposes it to frequent dispersal, but the scale over which populations exchange migrants, and should therefore be managed, is uncertain. In this review, we synthesize the emergent literature on population genetics to address the question: What spatial scales define populations? We find that within-species genetic differentiation among sites is often low, and evidence of population structuring by host plant or geography is rare. Read More

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November 2020

Comprehensive Exome Analysis of Immunocompetent Metastatic Head and Neck Cancer Models Reveals Patient Relevant Landscapes.

Cancers (Basel) 2020 Oct 12;12(10). Epub 2020 Oct 12.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.

Immunocompetent metastatic head and neck cancer (HNC) models, although scarce, can help understanding cancer progression and therapy responses in vivo. Their comprehensive genome characterizations are essential for translational research. We first exome-sequenced the two most widely used spontaneous metastatic immunocompetent models, namely AT-84 and SCC VII, followed by comprehensive genomic analyses with three prior-sequenced models (MOC2, MOC2-10, and 4MOSC2), together with patient tumors for utility assessment. Read More

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October 2020

Realised rather than fundamental thermal niches predict site occupancy: Implications for climate change forecasting.

J Anim Ecol 2020 12 12;89(12):2863-2875. Epub 2020 Oct 12.

DSI-NRF Centre of Excellence for Invasion Biology, Department of Botany and Zoology, Stellenbosch University, Matieland, South Africa.

Thermal performance traits are regularly used to make forecasts of the responses of ectotherms to anthropogenic environmental change, but such forecasts do not always differentiate between fundamental and realised thermal niches. Here we determine the relative extents to which variation in the fundamental and realised thermal niches accounts for current variation in species abundance and occupancy and assess the effects of niche-choice on future-climate response estimations. We investigated microclimate and macroclimate temperatures alongside abundance, occupancy, critical thermal limits and foraging activity of 52 ant species (accounting for >95% individuals collected) from a regional assemblage from across the Western Cape Province, South Africa, between 2003 and 2014. Read More

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December 2020

Hyperglycemia during Adjuvant Chemotherapy as a Prognostic Factor in Breast Cancer Patients without Diabetes.

J Breast Cancer 2020 Aug 5;23(4):398-409. Epub 2020 Aug 5.

Department of Surgery, Research Institute of Clinical Medicine, Jeonbuk National University Hospital, Jeonbuk National University and Biomedical Research Institute, Jeonju, Korea.

Purpose: Breast cancer treatments, including chemotherapy, administered in combination with glucocorticoids can induce hyperglycemia. This study aimed to investigate the effect of hyperglycemia during adjuvant chemotherapy on the prognosis of breast cancer patients without a known history of diabetes.

Methods: In this study, 936 patients who underwent breast cancer surgery from 2010 to 2015 were initially selected as participants. Read More

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Morinda citrifolia (Noni) Juice Suppresses A549 Human Lung Cancer Cells via Inhibiting AKT/Nuclear Factor-κ B Signaling Pathway.

Chin J Integr Med 2020 Jul 9. Epub 2020 Jul 9.

Laboratory Center, the Third People's Hospital of Huizhou, Affiliated Hospital of Guangzhou Medical University, Huizhou, Guangdong Province, 516002, China.

Objective: To study the mechanism of the anti-tumor effect of Morinda citrifolia (noni).

Methods: The influences of noni juice on cell proliferation, apoptosis, invasion, migration and the activity of AKT/nuclear factor- κ B (NF- κ B) signaling pathway in A549 human lung cancer cells were detected by MTT, cell counting kit-8, colony formation, Annexin V/PI double labeling, transwell, scratch test and immunoblotting assay, respectively. A549 cells were inoculated into the right axilla of nude mice, followed by noni juice treatment. Read More

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In vivo and in vitro Pathogenesis and Virulence Factors of Candida albicans Strains Isolated from Cutaneous Candidiasis.

Iran Biomed J 2020 09 19;24(5):324-32. Epub 2020 Feb 19.

Department of Medical Mycology, Pasteur Institute of Iran, Tehran 1316943551, Iran.

Background: The Candida albicans is one of the most important global opportunistic pathogens, and the incidence of candidiasis has increased over the past few decades. Despite the established role of skin in defense against fungal invasion, little has been documented about the pathogenesis of Candida species when changing from normal flora to pathogens of vaginal and gastrointestinal epithelia. This study was carried out to determine the in vivo and in vitro pathogenesis of clinical C. Read More

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September 2020

Mapping the global potential transmission hotspots for severe fever with thrombocytopenia syndrome by machine learning methods.

Emerg Microbes Infect 2020 Dec;9(1):817-826

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, People's Republic of China.

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with increasing spread. Currently SFTS transmission has expanded beyond Asian countries, however, with definitive global extents and risk patterns remained obscure. Here we established an exhaustive database that included globally reported locations of human SFTS cases and the competent vector, (), as well as the explanatory environmental variables, based on which, the potential geographic range of and risk areas for SFTS were mapped by applying two machine learning methods. Read More

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December 2020

Anticancer effects of n-3 EPA and DHA and their endocannabinoid derivatives on breast cancer cell growth and invasion.

Prostaglandins Leukot Essent Fatty Acids 2020 05 16;156:102024. Epub 2019 Oct 16.

Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK. Electronic address:

The anticancer effects of the omega-3 long chain polyunsaturated fatty acids (LCPUFA), EPA and DHA may be due, at least in part, to conversion to their respective endocannabinoid derivatives, eicosapentaenoyl-ethanolamine (EPEA) and docosahexaenoyl-ethanolamine (DHEA). Here, the effects of EPEA and DHEA and their parent compounds, EPA and DHA, on breast cancer (BC) cell function was examined. EPEA and DHEA exhibited greater anti-cancer effects than EPA and DHA in two BC cells (MCF-7 and MDA-MB-231) whilst displaying no effect in non-malignant breast cells (MCF-10a). Read More

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Downregulation of long noncoding RNA LINC01419 inhibits cell migration, invasion, and tumor growth and promotes autophagy inactivation of the PI3K/Akt1/mTOR pathway in gastric cancer.

Ther Adv Med Oncol 2019 24;11:1758835919874651. Epub 2019 Sep 24.

Department of Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Street, Changchun, Jilin Province 130033, China.

Background: Accumulating evidence has highlighted the crucial role of long noncoding RNAs (lncRNAs) in the tumorigenesis of gastric cancer (GC), which is the most common gastrointestinal malignancy. The present study aimed to identify the capacity of lncRNA LINC01419 (LINC01419) in GC progression, with the potential mechanism explored.

Methods: Highly expressed lncRNAs were identified by analysis, with the LINC01419 expression in GC tissues measured using reverse transcription-quantitative PCR (RT-qPCR). Read More

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September 2019

Plasticity and genetic variation in traits underpinning asexual replication of the rodent malaria parasite, Plasmodium chabaudi.

Malar J 2019 Jul 1;18(1):222. Epub 2019 Jul 1.

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Charlotte Auerbach Road, Edinburgh, EH9 3FL, UK.

Background: The ability of malaria (Plasmodium) parasites to adjust investment into sexual transmission stages versus asexually replicating stages is well known, but plasticity in other traits underpinning the replication rate of asexual stages in the blood has received less attention. Such traits include burst size (the number of merozoites produced per schizont), the duration of the asexual cycle, and invasion preference for different ages of red blood cell (RBC).

Methods: Here, plasticity [environment (E) effects] and genetic variation [genotype (G) effects] in traits relating to asexual replication rate are examined for 4 genotypes of the rodent malaria parasite Plasmodium chabaudi. Read More

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Not Responding Consecutively to Proliferation Caused Replant Disease Formation of .

Int J Mol Sci 2019 Jun 29;20(13). Epub 2019 Jun 29.

Key Laboratory of Ministry of Education for Genetics, Breeding and Multiple Utilization of Crops, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

Consecutive monoculture practice facilitates enrichment of rhizosphere pathogenic microorganisms and eventually leads to the emergence of replant disease. However, little is known about the interaction relationship among pathogens enriched in rhizosphere soils, Nucleotide binding-leucine-rich repeats (NB-LRR) receptors that specifically recognize pathogens in effector-triggered immunity (ETI) and physiological indicators under replant disease stress in . In this study, a controlled experiment was performed using different kinds of soils from sites never planted (NP), replanted (TP) and mixed by different ration of TP soils (1/3TP and 2/3TP), respectively. Read More

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Dating and localizing an invasion from post-introduction data and a coupled reaction-diffusion-absorption model.

J Math Biol 2019 07 16;79(2):765-789. Epub 2019 May 16.

BioSP, INRA, 84914, Avignon, France.

Invasion of new territories by alien organisms is of primary concern for environmental and health agencies and has been a core topic in mathematical modeling, in particular in the intents of reconstructing the past dynamics of the alien organisms and predicting their future spatial extents. Partial differential equations offer a rich and flexible modeling framework that has been applied to a large number of invasions. In this article, we are specifically interested in dating and localizing the introduction that led to an invasion using mathematical modeling, post-introduction data and an adequate statistical inference procedure. Read More

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Characterizing tumor invasiveness of glioblastoma using multiparametric magnetic resonance imaging.

J Neurosurg 2019 Apr 26;132(5):1465-1472. Epub 2019 Apr 26.

1Cambridge Brain Tumor Imaging Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences.

Objective: The objective of this study was to characterize the abnormalities revealed by diffusion tensor imaging (DTI) using MR spectroscopy (MRS) and perfusion imaging, and to evaluate the prognostic value of a proposed quantitative measure of tumor invasiveness by combining contrast-enhancing (CE) and DTI abnormalities in patients with glioblastoma.

Methods: Eighty-four patients with glioblastoma were recruited preoperatively. DTI was decomposed into isotropic (p) and anisotropic (q) components. Read More

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Resolving the invasion paradox: pervasive scale and study dependence in the native-alien species richness relationship.

Ecol Lett 2019 Jun 28;22(6):1038-1046. Epub 2019 Mar 28.

Bio-Protection Research Centre, Lincoln University, PO Box 84, Lincoln, 7647, New Zealand.

The degree to which plant communities are vulnerable to invasion by alien species has often been assessed using the relationship between native and alien plant species richness (NAR). Variation in the direction and strength of the NAR tends to be negative for small plot sizes and study extents, but positive for large plots and extents. This invasion paradox has been attributed to different processes driving species richness at different spatial scales. Read More

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Correlation of native and exotic species richness: a global meta-analysis finds no invasion paradox across scales.

Ecology 2019 01;100(1):e02552

State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China.

Support for the "biotic resistance hypothesis," that species-rich communities are more successful at resisting invasion by exotic species than are species-poor communities, has long been debated. It has been argued that native-exotic richness relationships (NERR) are negative at small spatial scales and positive at large scales, but evidence for the role of spatial scale on NERR has been contradictory. However, no formal quantitative synthesis has previously examined whether NERR is scale-dependent across multiple studies, and previous studies on NERR have not distinguished spatial grain and extent, which may drive very different ecological processes. Read More

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January 2019

Multiple drivers of contrasting diversity-invasibility relationships at fine spatial grains.

Ecology 2019 02 4;100(2):e02573. Epub 2019 Jan 4.

Earth to Oceans Research Group, Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, V5A 1S6, Canada.

The diversity-invasibility hypothesis and ecological theory predict that high-diversity communities should be less easily invaded than species-poor communities, but empirical evidence does not consistently support this prediction. While fine-scale experiments tend to yield the predicted negative association between diversity and invasibility, broad-scale observational surveys generally report a positive correlation. This conflicting pattern between experiments and observational studies is referred to as the invasion paradox and is thought to arise because different processes control species composition at different spatial scales. Read More

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February 2019

Mammary fibroblasts remodel fibrillar collagen microstructure in a biomimetic nanocomposite hydrogel.

Acta Biomater 2019 01 7;83:221-232. Epub 2018 Nov 7.

Department of Chemical Engineering and Materials Science, Michigan State University, United States. Electronic address:

Architecture and microstructure of type I collagen fibers constitute central regulators of tumor invasion with aligned fibers providing a route for migration of stromal and cancer cells. Several different aspects of fibrillar collagen, such as stiffness, density, thickness, and pore size, may regulate migration of cancer cells, but determining effects of any one parameter requires clear decoupling of physical properties of collagen networks. The objective of this work is to develop and apply an in vitro three-dimensional (3D) tumor-extra cellular matrix (ECM) model with tunable physical parameters to define how stromal fibroblasts modulate collagen microstructure to control migration of breast cancer cells. Read More

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January 2019

Dextran sulfate inhibition on human gastric cancer cells invasion, migration and epithelial-mesenchymal transformation.

Oncol Lett 2018 Oct 2;16(4):5041-5049. Epub 2018 Aug 2.

Department of Pathology, Ningxia People's Hospital, Yinchuan, Ningxia Hui Autonomous Region 750021, P.R. China.

The objective of the present study was to observe the influence of dextran sulfate (DS) on the proliferation, invasion and migration of AGS, BGC-23, GES-1, MGC-803 and SGC-7901 cells. Additionally, the possible inhibition mechanism of DS on BGC-823 cells epithelial-mesenchymal transition (EMT) was explored. The cells in the control and experimental group were treated with PBS and DS respectively. Read More

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October 2018

Methionine and choline supply during the peripartal period alter polymorphonuclear leukocyte immune response and immunometabolic gene expression in Holstein cows.

J Dairy Sci 2018 Nov 29;101(11):10374-10382. Epub 2018 Aug 29.

Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana 61801.

Polymorphonuclear leukocytes (PMNL) are the first responders upon pathogen invasion and hence play an important role in inflammatory and immune responses. Rumen-protected methionine (MET) and choline (CHOL) during the peripartal period affect the immune response and inflammatory status in dairy cows to different extents. We aimed to examine the effect of MET and CHOL supply on expression of genes regulating key PMNL functions and associations with whole-blood immune challenge. Read More

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November 2018

Iterative Surgical Resections of Diffuse Glioma With Awake Mapping: How to Deal With Cortical Plasticity and Connectomal Constraints?

Neurosurgery 2019 07;85(1):105-116

Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, Montpellier, France.

Background: In diffuse glioma, a multistage approach with iterative tailored surgical resections can be considered.

Objective: To compare results of iterative intrasurgical brain mappings to investigate the potential and limitation of neuroplasticity at the individual stage, and to highlight to what extent it can influence the therapeutic strategy.

Methods: Glioma patients who underwent 2 consecutive awake surgeries with cortical and subcortical stimulation were classified into group 1 (n = 23) if cortical mappings exhibited high level of plasticity (displacement of ≥2 sites) or into group 2 (n = 19) with low level of plasticity. Read More

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Giant viruses as protein-coated amoeban mitochondria?

Hervé Seligmann

Virus Res 2018 07 18;253:77-86. Epub 2018 Jun 18.

Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR MEPHI, Aix-Marseille Université, IRD, Assistance Publique-Hôpitaux de Marseille, Institut Hospitalo-Universitaire Méditerranée-Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France; The National Natural History Collections, The Hebrew University of Jerusalem, 91904, Jerusalem, Israel. Electronic address:

Mimivirus' genome includes parts of 5S, 16S and 23S ribosomal RNAs encoded by Acanthamoeba's mitogenome, the giant virus' host. Two non-exclusive hypotheses for rRNA remnants in giant viruses are examined: 1. mitogenomes invade viral genomes as they do for nuclear chromosomes (producing numts); 2. Read More

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Livelihood benefits and costs from an invasive alien tree (Acacia dealbata) to rural communities in the Eastern Cape, South Africa.

J Environ Manage 2019 Jan 1;229:158-165. Epub 2018 Jun 1.

Department of Environmental Science, Rhodes University, Grahamstown 6140, South Africa. Electronic address:

The negative effects of invasive alien species (IAS) are increasingly invoked to justify widespread and usually top-down approaches for their management or eradication. However, very little of the research or discourse is based on investigating local perceptions, uses and struggles with IAS, and how their presence influences and changes local livelihoods. The objective of this study was to assess the perceptions and livelihood uses of Acacia dealbata by local communities at three localities in the montane grasslands of the Eastern Cape, South Africa, using a combination of random household interviews, focus group discussions and participatory tools. Read More

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January 2019

Shared and independent functions of aPKCλ and Par3 in skin tumorigenesis.

Oncogene 2018 09 23;37(37):5136-5146. Epub 2018 May 23.

Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Köln, Germany.

The polarity proteins Par3 and aPKC are key regulators of processes altered in cancer. Par3/aPKC are thought to dynamically interact with Par6 but increasing evidence suggests that aPKC and Par3 also exert complex-independent functions. Whereas aPKCλ serves as tumor promotor, Par3 can either promote or suppress tumorigenesis. Read More

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September 2018

Doublethink and scale mismatch polarize policies for an invasive tree.

PLoS One 2018 7;13(3):e0189733. Epub 2018 Mar 7.

Department of Agronomy & Horticulture, University of Nebraska, Lincoln, NE, United States of America.

Mismatches between invasive species management policies and ecological knowledge can lead to profound societal consequences. For this reason, natural resource agencies have adopted the scientifically-based density-impact invasive species curve to guide invasive species management. We use the density-impact model to evaluate how well management policies for a native invader (Juniperus virginiana) match scientific guidelines. Read More

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