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Primary Septic Arthritis in Children Demonstrates Presumed and Confirmed Varieties Which Require Age-specific Evaluation and Treatment Strategies.

J Pediatr Orthop 2021 Sep 27. Epub 2021 Sep 27.

Children's Health System of Texas Department of Orthopedics, Texas Scottish Rite Hospital for Children Department of Orthopedics and Pediatrics, University of Texas Southwestern, Dallas, TX.

Background: There is uncertainty involved in the evaluation and treatment of children suspected to have septic arthritis particularly when no causative pathogen is confirmed. This study evaluates children with primary septic arthritis to refine the processes of evaluation and treatment and improve the rate of pathogen confirmation.

Methods: Children suspected to have septic arthritis from 2009 to 2019 were retrospectively studied. Read More

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September 2021

The assessment of emerging data-intelligence technologies for modeling Mg and SO surface water quality.

J Environ Manage 2021 Sep 21;300:113774. Epub 2021 Sep 21.

New era and Development in Civil engineering Research Group, Scientific Research Center, Al-Ayen University, Thi-Qar, 64001, Iraq; College of Creative Design, Asia University, Taichung City, Taiwan. Electronic address:

The concentration of soluble salts in surface water and rivers such as sodium, sulfate, chloride, magnesium ions, etc., plays an important role in the water salinity. Therefore, accurate determination of the distribution pattern of these ions can improve better management of drinking water resources and human health. Read More

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September 2021

Does drainage or resection predict subsequent interventions and long-term quality of life in patients with Grade IV pancreatic injuries: A population-based analysis.

J Trauma Acute Care Surg 2021 Oct;91(4):708-715

From the Department of Surgery (C.G.B., A.W.K.), University of Calgary, Calgary, Alberta, Canada; Department of Surgery (W.L.B.), Scripps Clinic Medical Group, La Jolla, California; Department of Surgery (S.M.H.), University of British Columbia, Vancouver, BC, Canada; Department of Surgery (K.V., N.G.P.), Western University, London, Ontario, Canada; and Department of Surgery (M.K.), Cook County Hospital, Chicago, Illinois.

Background: Clinical equipoise remains significant for the treatment of Grade IV pancreatic injuries in stable patients (i.e., drainage vs. Read More

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October 2021

Treatment of tibial plateau fractures involving the posterolateral column using the extended anterolateral approach.

Medicine (Baltimore) 2021 Sep;100(38):e27316

Yangzhou Jiangdu People's Hospital, 9 Dongfanghong Road, Jiangdu District, Yangzhou City, Jiangsu Province, China.

Abstract: To summarize the surgical technique and clinical effects of the extended anterolateral approach for the treatment of Schatzker type II and Schatzker type V/VI involving the posterolateral column tibial plateau.From January 2015 through December 2018, 28 patients with tibial plateau fractures involving the posterolateral column were included in the study. Among them, 16 patients were Schatzker type II treated using an extended anterolateral approach with lateral tibial locking compression plate fixation. Read More

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September 2021

Inhibitory effect of polyunsaturated fatty acids alone or in combination with fluconazole on Candida krusei biofilms in vitro and in Caenorhabditis elegans.

Med Mycol 2021 Sep 24. Epub 2021 Sep 24.

Pathogenic Yeast Research Group, Department of Microbiology and Biochemistry, University of the Free State, Bloemfontein, South Africa.

The incidence of infections by non-albicans Candida species, including Candida krusei, is increasing. Candida krusei exhibits intrinsic resistance to fluconazole and rapidly develops acquired resistance to other antifungals. Moreover, this yeast can form biofilm with increased resistance. Read More

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September 2021

Correlations between hippocampal functional connectivity, structural changes, and clinical data in patients with relapsing-remitting multiple sclerosis: a case-control study using multimodal magnetic resonance imaging.

Neural Regen Res 2022 May;17(5):1115-1124

First Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.

Multiple sclerosis is associated with structural and functional brain alterations leading to cognitive impairments across multiple domains including attention, memory, and the speed of information processing. The hippocampus, which is a brain important structure involved in memory, undergoes microstructural changes in the early stage of multiple sclerosis. In this study, we analyzed hippocampal function and structure in patients with relapsing-remitting multiple sclerosis and explored correlations between the functional connectivity of the hippocampus to the whole brain, changes in local brain function and microstructure, and cognitive function at rest. Read More

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Comparative analyses of aging-related genes in long-lived mammals provide insights into natural longevity.

Innovation (N Y) 2021 May 29;2(2):100108. Epub 2021 Apr 29.

Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China.

Extreme longevity has evolved multiple times during the evolution of mammals, yet its underlying molecular mechanisms remain largely underexplored. Here, we compared the evolution of 115 aging-related genes in 11 long-lived species and 25 mammals with non-increased lifespan (control group) in the hopes of better understanding the common molecular mechanisms behind longevity. We identified 16 unique positively selected genes and 23 rapidly evolving genes in long-lived species, which included nine genes involved in regulating lifespan through the insulin/IGF-1 signaling (IIS) pathway and 11 genes highly enriched in immune-response-related pathways, suggesting that the IIS pathway and immune response play a particularly important role in exceptional mammalian longevity. Read More

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Fracture Resistance of Equine Cheek Teeth With and Without Occlusal Fissures: A Standardized Model.

Front Vet Sci 2021 7;8:699940. Epub 2021 Sep 7.

Department of Surgery and Anaesthesiology of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium.

fracture models are frequently used in human dentistry to provide insights in the fracture mechanisms of teeth. Equine cheek teeth fractures are an important dental pathology, but there has been no research performed to examine the fracture resistance . To evaluate the fracture resistance of equine cheek teeth and identify anatomical predictors that might influence fracture resistance in healthy teeth. Read More

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September 2021

Optimized nerve block techniques while performing percutaneous hepatic ablation: .

J Interv Med 2020 Dec 12;3(4):161-166. Epub 2020 Aug 12.

Assistant Professor, Faculty of Medicine, McGill University, Department of Radiology, Division of Interventional Radiology, McGill University Health Centre, Montreal, Canada.

Percutaneous image guided thermal ablation has become a cornerstone of therapy for patients with oligometastatic disease and primary liver malignancies. Evolving from percutaneous ethanol injection (PEI), thermal ablation utilizing radiofrequency ablation (RFA) and microwave ablation (MWA) have become the standard approach in the treatment of isolated lesions that fit within the size criteria for curative intent therapy (typically 3-4cm). With the evolution of more intense thermal ablation, such as MWA, the dramatic increase in both the size of ablation zone and intensity of heat generation have extended the limits of this technique. Read More

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December 2020

Vaginal microbiome as a tool for prediction of chorioamnionitis in preterm labor: a pilot study.

Sci Rep 2021 Sep 23;11(1):18971. Epub 2021 Sep 23.

Department of Obstetrics and Gynecology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan.

Intra-amniotic infection (IAI) is a major cause of preterm birth with a poor perinatal prognosis. We aimed to determine whether analyzing vaginal microbiota can evaluate the risk of chorioamnionitis (CAM) in preterm labor cases. Vaginal discharge samples were collected from 83 pregnant women admitted for preterm labor. Read More

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September 2021

'It was hell in the community': a qualitative study of maternal and child health care during health care worker strikes in Kenya.

Int J Equity Health 2021 Sep 23;20(1):210. Epub 2021 Sep 23.

Academic Model Providing Access to Healthcare (AMPATH), Eldoret, Kenya.

Background: Health care workers in Kenya have launched major strikes in the public health sector in the past decade but the impact of strikes on health systems is under-explored. We conducted a qualitative study to investigate maternal and child health care and services during nationwide strikes by health care workers in 2017 from the perspective of pregnant women, community health volunteers (CHVs), and health facility managers.

Methods: We conducted in-depth interviews and focus group discussions (FGDs) with three populations: women who were pregnant in 2017, CHVs, and health facility managers. Read More

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September 2021

Interindividual and intraindividual variability in amnestic mild cognitive impairment (aMCI) measured with an online cognitive assessment.

J Clin Exp Neuropsychol 2021 Sep 24:1-17. Epub 2021 Sep 24.

Rotman Research Institute, Baycrest (Fully Affiliated with the University of Toronto), Toronto, Canada.

Introduction: Mean cognitive performance is worse in amnestic mild cognitive impairment (aMCI) compared to control groups. However, studies on variability of cognitive performance in aMCI have yielded inconclusive results, with many differences in variability measures and samples from one study to another.

Methods: We examined variability in aMCI using an existing older adult sample ( = 91; 51 with aMCI, 40 with normal cognition for age), measured with an online self-administered computerized cognitive assessment (Cogniciti's Brain Health Assessment). Read More

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September 2021

Kinetic changes associated with extended knee landings following anterior cruciate ligament reconstruction in females.

Phys Ther Sport 2021 Sep 13;52:180-188. Epub 2021 Sep 13.

La Crosse Institute for Movement Science, University of Wisconsin-La Crosse, La Crosse, WI, USA; Health Professions Department, University of Wisconsin-La Crosse, La Crosse, WI, USA.

Objectives: To determine the relationship between knee flexion excursion symmetry and lower extremity kinematics, kinetics, and muscle, joint, and ligament forces in females 1-3 years after ACL reconstruction.

Design: Cross-sectional.

Setting: Laboratory. Read More

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September 2021

Suhuang antitussive capsule ameliorates post-infectious cough in mice through AhR-Nrf2 pathway.

J Ethnopharmacol 2021 Sep 20:114664. Epub 2021 Sep 20.

Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, PR China. Electronic address:

Ethnopharmacological Relevance: Suhuang antitussive capsule (SH capsule), a typical traditional Chinese medicines (TCMs) compound, is widely used for the treatment of post-infectious cough (PIC) in the clinic. Our previous studies have demonstrated that SH capsule possesses significant ameliorative effects on cough variant asthma (CVA), sputum obstruction and airway remodeling.

Aim Of The Study: This study is designed to investigate the ameliorative effects and potential mechanisms of SH capsule on PIC in mice. Read More

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September 2021

Revelations of service-learning project: Multiple perspectives of college students' reflection.

Authors:
Ting-Hua Lin

PLoS One 2021 23;16(9):e0257754. Epub 2021 Sep 23.

Department of Early Childhood Care and Education, Cheng Shiu University, Kaohsiung, Taiwan.

This study explored the reflections of college students at different stages of their service provided to preschoolers and proposed recommendations on service-learning curricula according to the research findings. Thirty-six college juniors enrolled in an academic service-learning course were asked to complete a service-learning project, to undertake service activities in the form of eight storytelling sessions at preschools. This storytelling plan was 1. Read More

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September 2021

SERS Chemical Enhancement of 2,4,5-Trichlorophenoxyacetic Acid Adsorbed on Silver Substrate.

J Phys Chem A 2021 Sep 23. Epub 2021 Sep 23.

Institute for Computational Science and Technology (ICST), Ho Chi Minh City 700000, Vietnam.

Surface-enhanced Raman spectroscopy (SERS) was employed to gain an understanding of the chemical enhancement mechanism of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), an Agent Orange, adsorbed on a silver substrate surface. Experimental measurements were performed using a micro-Raman spectrophotometer with an excitation wavelength of 532 nm and successfully detected 2,4,5-T at a relatively low concentration of 0.4 nM. Read More

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September 2021

In Vivo Near-Infrared Imaging Using Ternary Selenide Semiconductor Nanoparticles with an Uncommon Crystal Structure.

Small 2021 Sep 23:e2103505. Epub 2021 Sep 23.

Nanomaterials for Bioimaging Group (NanoBIG), Facultad de Ciencias, Universidad Autónoma de Madrid, C/Francisco Tomás y Valiente 7, Madrid, 28049, Spain.

The implementation of in vivo fluorescence imaging as a reliable diagnostic imaging modality at the clinical level is still far from reality. Plenty of work remains ahead to provide medical practitioners with solid proof of the potential advantages of this imaging technique. To do so, one of the key objectives is to better the optical performance of dedicated contrast agents, thus improving the resolution and penetration depth achievable. Read More

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September 2021

Insight into the hidden bacterial diversity of Lake Balaton, Hungary.

Biol Futur 2020 Dec 7;71(4):383-391. Epub 2020 Sep 7.

MTA Centre for Ecological Research, Danube Research Institute, Budapest, Hungary.

In the present study, the prokaryotic community structure of the water of Lake Balaton was investigated at the littoral region of three different points (Tihany, Balatonmáriafürdő and Keszthely) by cultivation independent methods [next-generation sequencing (NGS), specific PCRs and microscopy cell counting] to check the hidden microbial diversity of the lake. The taxon-specific PCRs did not show pathogenic bacteria but at Keszthely and Máriafürdő sites extended spectrum beta-lactamase-producing microorganisms could be detected. The bacterial as well as archaeal diversity of the water was high even when many taxa are still uncultivable. Read More

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December 2020

Synthesis and fluorescence properties of red-to-near-infrared-emitting push-pull dyes based on benzodioxazole scaffolds.

J Mater Chem B 2021 Sep 23. Epub 2021 Sep 23.

Department of Chemistry and COSDAF (Centre of super-Diamond and Advanced Films), City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, China.

Fluorescence imaging with high temporal and spatial resolution has emerged as one of the most promising techniques to monitor biomolecules and biological processes in living systems. Among many kinds of small molecular fluorescent dyes, 2,1,3-benzoxadiazole (BD) derivatives have been widely applied in many chemical and biological applications due to their excellent photophysical properties. However, only a limited number of BD dyes with long emission wavelengths were reported. Read More

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September 2021

Is there still a role for a cleavage-stage embryo transfer?

F S Rep 2021 Sep 29;2(3):269-274. Epub 2021 Jun 29.

Division of Reproductive Endocrinology and Infertility, Mayo Clinic, Rochester, Minnesota.

Objective: To determine whether pregnancy outcomes are poor or futile when an intended day 5 transfer is converted to a cleavage-stage transfer because of poor embryo development or a lower number of embryos.

Design: Retrospective cohort study.

Setting: Academic medical center. Read More

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September 2021

A gene expression-based immune content predictor for survival and postoperative radiotherapy response in head and neck cancer.

Mol Ther Oncolytics 2021 Sep 10;22:380-387. Epub 2021 Jul 10.

Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510060, China.

The immune infiltration in the tumor microenvironment has been demonstrated to be relevant to radiotherapy response. Here, we sought to understand the immune infiltration in head and neck cancer (HNC) and evaluate its significance in predicting prognosis and radiotherapy response. Using RNA sequencing data of 522 retrospective head and neck squamous cell carcinomas (HNSCCs), we constructed an immune content score based on genes related to 6 prognostic infiltrating cell types. Read More

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September 2021

Use of metformin to prolong gestation in preterm pre-eclampsia: randomised, double blind, placebo controlled trial.

BMJ 2021 Sep 22;374:n2103. Epub 2021 Sep 22.

Translational Obstetrics Group, Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia.

Objective: To evaluate whether extended release metformin could be used to prolong gestation in women being expectantly managed for preterm pre-eclampsia.

Design: Randomised, double blind, placebo controlled trial.

Setting: Referral hospital in Cape Town, South Africa. Read More

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September 2021

Freedom within a cage: how patriarchal gender norms limit women's use of mobile phones in rural central India.

BMJ Glob Health 2021 Sep;6(Suppl 5)

Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.

Introduction: India has one of the highest gender gaps in mobile phone access in the world. As employment opportunities, health messaging (mHealth), access to government entitlements, banking, civic participation and social engagement increasingly take place in the digital sphere, this gender gap risks further exacerbating women's disadvantage in Indian society. This study identifies the factors driving women's unequal use of phones in rural Madhya Pradesh, India. Read More

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September 2021

Liposomal bupivacaine addition versus standard bupivacaine alone for colorectal surgery: a randomized controlled trial.

Pain Manag 2021 Sep 23. Epub 2021 Sep 23.

Indiana University School of Medicine, 340 W 10th Street, Fairbanks Hall 6200, Indianapolis, IN 46202, USA.

This study evaluated use of liposomal bupivacaine (LB) versus standard bupivacaine (SB) alone in quadratus lumborum (QL) blocks for laparoscopic colorectal surgery. In this prospective, randomized controlled trial, patients received QL1 blocks with either LB (40 ml 0.125% SB plus 20 ml of LB) or SB (60 ml of 0. Read More

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September 2021

ArGSLab: a tool for analyzing experimental or simulated particle networks.

Soft Matter 2021 Sep 22;17(36):8354-8362. Epub 2021 Sep 22.

Division of Physical Chemistry, Lund University, Lund, Sweden.

Microscopy and particle-based simulations are both powerful techniques to study aggregated particulate matter such as colloidal gels. The data provided by these techniques often contains information on a wide array of length scales, but structural analysis methods typically focus on the local particle arrangement, even though the data also contains information about the particle network on the mesoscopic length scale. In this paper, we present a MATLAB software package for quantifying mesoscopic network structures in colloidal samples. Read More

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September 2021

Treatment with doxorubicin-based protocol in cardiac involvement diffuse large B-cell lymphoma: A case report.

J Oncol Pharm Pract 2021 Sep 22:10781552211035120. Epub 2021 Sep 22.

Department of Internal Medicine Division of Hematology Konya, 427826Necmettin Erbakan University Meram Faculty of Medicine, Turkey.

Introduction: Cardiac involvement in diffuse large B-cell lymphoma is a rare entity in non-Hodgkin lymphomas. Symptoms are usually related to heart failure. Patients who are severely symptomatic due to cardiac mass could be considered treatment as soon as possible. Read More

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September 2021

The role of laparoscopic management in perforated gastric cancer.

Ann Surg Treat Res 2021 Sep 31;101(3):151-159. Epub 2021 Aug 31.

Department of Surgery, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Purpose: Perforated gastric cancer is an extremely rare condition and usually presents in advanced stage with poor prognosis. Surgical strategies are still controversial regarding the extent to which complete resection or primary repair is performed and the application of laparoscopic techniques. We aim to determine the role of laparoscopic 2-stage approach in perforated gastric cancer. Read More

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September 2021

Reconstructing aspects of human embryogenesis with pluripotent stem cells.

Nat Commun 2021 Sep 21;12(1):5550. Epub 2021 Sep 21.

Plasticity and Self-Organization Group, Division of Biology and Biological Engineering, Caltech, Pasadena, CA, 91125, USA.

Understanding human development is of fundamental biological and clinical importance. Despite its significance, mechanisms behind human embryogenesis remain largely unknown. Here, we attempt to model human early embryo development with expanded pluripotent stem cells (EPSCs) in 3-dimensions. Read More

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September 2021

High-efficiency broadband achromatic metalens for near-IR biological imaging window.

Nat Commun 2021 Sep 21;12(1):5560. Epub 2021 Sep 21.

State Key Laboratory on Tunable laser Technology, Ministry of Industry and Information Technology Key Lab of Micro-Nano Optoelectronic Information System, Harbin Institute of Technology (Shenzhen), Shenzhen, 518055, P. R. China.

Over the past years, broadband achromatic metalenses have been intensively studied due to their great potential for applications in consumer and industry products. Even though significant progress has been made, the efficiency of technologically relevant silicon metalenses is limited by the intrinsic material loss above the bandgap. In turn, the recently proposed achromatic metalens utilizing transparent, high-index materials such as titanium dioxide has been restricted by the small thickness and showed relatively low focusing efficiency at longer wavelengths. Read More

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September 2021

Extending the straight leg raise test for improved clinical evaluation of sciatica: validity and diagnostic performance with reference to the magnetic resonance imaging.

BMC Musculoskelet Disord 2021 Sep 21;22(1):808. Epub 2021 Sep 21.

Department of Rehabilitation, Kuopio University Hospital, PL 100, 70029, KYS / Kuopio, Finland.

Background: The straight leg raise test (SLR) is one of the most utilized and studied physical tests in patients with low back pain (LBP) for the detection of lumbar disc herniation (LDH), showing high sensitivity and heterogeneous or low specificity. The high incidence of asymptomatic 'pathologic' findings in the magnetic resonance imaging (MRI) scans may cause verification bias to these results. We studied an extended SLR (ESLR) by adding location-specific structural differentiation movements (hip internal rotation or ankle dorsiflexion) to the traditional SLR for it to better differentiate neural symptoms from musculoskeletal. Read More

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September 2021