Gastroenterology 2021 Sep 24. Epub 2021 Sep 24.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA;; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, MA, USA; Gastrointestinal Cancer Center, Dana-Farber Cancer Institute, Boston, MA, USA;; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA;. Electronic address:
Background And Aims: Genomic alterations that encourage stem cell activity and hinder proper maturation are central to the development of colorectal cancer (CRC). Key molecular mediators that promote these malignant properties require further elucidation to galvanize translational advances. We therefore aimed to characterize a key factor that blocks intestinal differentiation, define its transcriptional and epigenetic program, and provide preclinical evidence for therapeutic targeting in CRC. Read More