82,317 results match your criteria expression profiles

Exosome-shuttled miR-7162-3p from human umbilical cord derived mesenchymal stem cells repair endometrial stromal cell injury by restricting APOL6.

Arch Biochem Biophys 2021 Apr 17:108887. Epub 2021 Apr 17.

Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong, 226000, China. Electronic address:

Background: Recent studies have shown that exosomes (Exos) derived from stem cells can be used as paracrine factors to regenerate cells and tissues via shuttling miRNAs. Exos derived from human umbilical cord derived mesenchymal stem cells (UCMSCs) have been found to alleviate mifepristone-induced endometrial stromal cell (ESC) injury in vitro. Information on the functions and mechanisms of Exos from UCMSC-induced endometrial repair is limited and requires more study. Read More

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Leaf powder supplementation of Senna alexandrina ameliorates oxidative stress, inflammation, and hepatic steatosis in high-fat diet-fed obese rats.

PLoS One 2021 20;16(4):e0250261. Epub 2021 Apr 20.

Department of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh.

Obesity is an enduring medical issue that has raised concerns around the world. Natural plant extracts have shown therapeutic potential in preventing oxidative stress and inflammation related to obesity complications. In this study, Senna alexandrina Mill. Read More

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Identification of hub prognosis-associated oxidative stress genes in skin cutaneous melanoma using integrated bioinformatic analysis.

Eur Rev Med Pharmacol Sci 2021 Apr;25(7):2927-2940

Department of Spine and Joint Surgery, Guilin Peoples' Hospital, Guilin, China.

Objective: Oxidative stress (OS) significantly correlates with cancer progression. However, targeting OS has not been considered as a therapeutic strategy in skin cutaneous melanoma (SKCM) due to a lack of systematical studies on validated biomarkers. The work presented here aimed to identify hub prognosis-associated OS genes in SKCM and generated an effective predictive model. Read More

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Use of RNA Sequencing to Perform Comprehensive Analysis of Long Noncoding RNA Expression Profiles in Macrophages Infected with Trichosporon asahii.

Mycopathologia 2021 Apr 20. Epub 2021 Apr 20.

Department of Dermatology, The Seventh Medical Center of PLA General Hospital, Beijing, 100700, China.

Trichosporon asahii (T. asahii) is a clinically important opportunistic pathogenic fungus capable of causing systemic lethal infection in immunosuppressive and immunodeficient hosts. However, the mechanism of the host immune response upon T. Read More

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Global Shifts in Gene Expression Profiles Accompanied with Environmental Changes in Cnidarian-Dinoflagellate Endosymbiosis.

G3 (Bethesda) 2019 Jul;9(7):2337-2347

Department of Basic Biology, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), Okazaki, Aichi, Japan.

Stable endosymbiotic relationships between cnidarian animals and dinoflagellate algae are vital for sustaining coral reef ecosystems. Recent studies have shown that elevated seawater temperatures can cause the collapse of their endosymbiosis, known as 'bleaching', and result in mass mortality. However, the molecular interplay between temperature responses and symbiotic states still remains unclear. Read More

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Genomic and proteomic profiles of biofilms on microplastics are decoupled from artificial surface properties.

Environ Microbiol 2021 Apr 19. Epub 2021 Apr 19.

University of Greifswald, Institute of Pharmacy, Greifswald, Germany.

Microplastics in marine ecosystems are colonized by diverse prokaryotic and eukaryotic communities. How these communities and their functional profiles are shaped by the artificial surfaces remains broadly unknown. In order to close this knowledge gap, we set up an in situ experiment with pellets of the polyolefin polymer polyethylene (PE), the aromatic hydrocarbon polymer polystyrene (PS), and wooden beads along a coastal to estuarine gradient in the Baltic Sea, Germany. Read More

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Correction to: Gene expression profiles of pro-inflammatory mediators in the conjunctiva of patients with epiblepharon.

Graefes Arch Clin Exp Ophthalmol 2021 Apr 19. Epub 2021 Apr 19.

Department of Ophthalmology, Severance Hospital, The Institute of Vision Research, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

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Dimethyl fumarate induces ferroptosis and impairs NF-κB/STAT3 signaling in DLBCL.

Blood 2021 Apr 19. Epub 2021 Apr 19.

University of Tuebingen, Tübingen, Germany.

Despite the development of novel targeted drugs, the molecular heterogeneity of diffuse large B-cell lymphoma (DLBCL) still poses a major therapeutic challenge. DLBCL can be classified into at least two major subtypes, i.e. Read More

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Deep learning of gene relationships from single cell time-course expression data.

Brief Bioinform 2021 Apr 20. Epub 2021 Apr 20.

FORE Systems Professor of Computational Biology and Machine Learning at CMU, USA.

Time-course gene-expression data have been widely used to infer regulatory and signaling relationships between genes. Most of the widely used methods for such analysis were developed for bulk expression data. Single cell RNA-Seq (scRNA-Seq) data offer several advantages including the large number of expression profiles available and the ability to focus on individual cells rather than averages. Read More

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The adipokine orosomucoid alleviates adipose tissue fibrosis via the AMPK pathway.

Acta Pharmacol Sin 2021 Apr 19. Epub 2021 Apr 19.

School of Pharmacy, Second Military Medical University/Naval Medical University, Shanghai, 200433, China.

The excess deposition of underlying extracellular matrix (ECM) in adipose tissue is defined as adipose tissue fibrosis that is a major contributor to metabolic disorder such as obesity and type 2 diabetes. Anti-fibrosis therapy has received much attention in the treatment of metabolic disorders. Orosomucoid (ORM) is an acute-phase protein mainly produced by liver, which is also an adipokine. Read More

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Identification of differentially expressed genes and signaling pathways in human conjunctiva and reproductive tract infected with Chlamydia trachomatis.

Hum Genomics 2021 Apr 19;15(1):22. Epub 2021 Apr 19.

Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.

Background: Currently, Chlamydia trachomatis-specific host defense mechanisms in humans remain poorly defined. To study the characteristics of host cells infected early with Chlamydia trachomatis, we used bioinformatics methods to analyze the RNA transcription profiles of the conjunctiva, fallopian tubes, and endometrium in humans infected with Chlamydia trachomatis.

Method: The gene expression profiles of GSE20430, GSE20436, GSE26692, and GSE41075 were downloaded from the Gene Expression Synthesis (GEO) database. Read More

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Comprehensive analysis of IgA nephropathy expression profiles: identification of potential biomarkers and therapeutic agents.

BMC Nephrol 2021 Apr 19;22(1):137. Epub 2021 Apr 19.

Regenerative medicine research center, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: IgA nephropathy (IgAN) is a kidney disease recognized by the presence of IgA antibody depositions in kidneys. The underlying mechanisms of this complicated disease are remained to be explored and still, there is an urgent need for the discovery of noninvasive biomarkers for its diagnosis. In this investigation, an integrative approach was applied to mRNA and miRNA expression profiles in PBMCs to discover a gene signature and novel potential targets/biomarkers in IgAN. Read More

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Identification of the specific long-noncoding RNAs involved in night-break mediated flowering retardation in Chenopodium quinoa.

BMC Genomics 2021 Apr 19;22(1):284. Epub 2021 Apr 19.

Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Sichuan Engineering & Technology Research Center of Coarse Cereal Industralization, School of Food and Biological Engineering, Chengdu University, Chengluo road 2025, Shiling town, Longquanyi District, Chengdu, 610106, Sichuan Province, P.R. China.

Background: Night-break (NB) has been proven to repress flowering of short-day plants (SDPs). Long-noncoding RNAs (lncRNAs) play key roles in plant flowering. However, investigation of the relationship between lncRNAs and NB responses is still limited, especially in Chenopodium quinoa, an important short-day coarse cereal. Read More

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Genome-wide analysis of SET-domain group histone methyltransferases in apple reveals their role in development and stress responses.

BMC Genomics 2021 Apr 19;22(1):283. Epub 2021 Apr 19.

State Key Laboratory of Crop Stress Biology for Arid Areas/Shaanxi Key Laboratory of Apple, College of Horticulture, Northwest A&F University, Yangling, 712100, Shaanxi, China.

Background: Histone lysine methylation plays an important role in plant development and stress responses by activating or repressing gene expression. Histone lysine methylation is catalyzed by a class of SET-domain group proteins (SDGs). Although an increasing number of studies have shown that SDGs play important regulatory roles in development and stress responses, the functions of SDGs in apple remain unclear. Read More

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Fibroblast-Specific Proteo-Transcriptomes Reveal Distinct Fibrotic Signatures of Human Sinoatrial Node in Non-Failing and Failing Hearts.

Circulation 2021 Apr 20. Epub 2021 Apr 20.

Department of Physiology & Cell Biology; Bob and Corrine Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart & Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH.

Up to fifty percent of the adult human sinoatrial node (SAN), is composed of dense connective tissue. Cardiac diseases including heart failure (HF) may further increase fibrosis within the SAN pacemaker complex, leading to impaired automaticity and conduction of electrical activity to the atria. However, unlike the role of cardiac fibroblasts in pathological fibrotic remodeling and tissue repair, nothing is known about fibroblasts that maintain the inherently fibrotic SAN environment. Read More

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Common gene expression in Medicago truncatula roots in response to Pseudomonas fluorescens colonization, mycorrhiza development and nodulation.

New Phytol 2004 Mar 8;161(3):855-863. Epub 2004 Jan 8.

UMR INRA 1088/CNRS 5184/U. Bourgogne Plante-Microbe-Environnement, INRA-CMSE, BP 86510, F-21065 Dijon cedex, France.

•  Beneficial rhizosphere microorganisms may share similar molecular steps during root colonization. To test this hypothesis, we compared Medicago truncatula Gaertn. gene expression in roots colonized, or not colonized, by Glomus mosseae BEG12, Pseudomonas fluorescens C7R12 or Sinorhizobium meliloti 2011. Read More

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The impact of ectomycorrhiza formation on monosaccharide transporter gene expression in poplar roots.

New Phytol 2004 Oct;164(1):147-155

Eberhard-Karls-Universität, Physiologische Ökologie der Pflanzen, Auf der Morgenstelle 1, D-72076 Tübingen, Germany.

•  By using degenerate primers, five putative poplar monosaccharide transporter genes were isolated from ectomycorrhizas by RT-PCR. The expression profiles of the three most strongly expressed ones are presented in detail. •  Two transporter genes (PttMST1. Read More

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October 2004

Targeted proteomics to identify cadmium-induced protein modifications in Glomus mosseae-inoculated pea roots.

New Phytol 2003 Mar;157(3):555-567

UMR 1088 BBCE-IPM, INRA-CMSE, BP 86510, 21065 Dijon Cedex, France.

•   Arbuscular mycorrhiza (AM) can increase plant tolerance to heavy metals. A targeted proteomic approach was used to determine the putative identity of some of the proteins induced/modulated by cadmium (Cd) and to analyse the impact of the mycorrhizal process. •   The effect of Cd (100 mg Cd kg  substrate) applied either at planting or 15 d later on two pea (Pisum sativum) genotypes, differing in sensitivity to Cd inoculated or not with the AM fungus Glomus mosseae, was studied at three levels: plant biomass production, development of G. Read More

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Gene expression profiling of α-gustducin-expressing taste cells in mouse fungiform and circumvallate papillae.

Biochem Biophys Res Commun 2021 Apr 16;557:206-212. Epub 2021 Apr 16.

Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka-city, Fukuoka, 812-8582, Japan; Research and Development Center for Five-Sense Devices Taste and Odor Sensing, Kyushu University, 744, Nishi-ku, Fukuoka-city, Fukuoka, 819-0395, Japan. Electronic address:

Taste buds are complex sensory organs embedded in the epithelium of fungiform papillae (FP) and circumvallate papillae (CV). The sweet, bitter, and umami tastes are sensed by type II taste cells that express taste receptors (Tas1rs and Tas2rs) coupled with the taste G-protein α-gustducin. Recent studies revealed that the taste response profiles of α-gustducin-expressing cells are different between FP and CV, but which genes could generate such distinctive cell characteristics are still largely unknown. Read More

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Correlations between tumor mutation burden and immune infiltrates and their prognostic value in pancreatic cancer by bioinformatic analysis.

Life Sci 2021 Apr 16:119505. Epub 2021 Apr 16.

Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. Electronic address:

Purpose: We aimed to investigate the patterns and prognostic roles of tumor mutation burden and immune microenvironment in pancreatic cancer.

Methods: The somatic mutation data, transcriptome profiles and clinical information were downloaded from the Cancer Genome Atlas database. Gene expression difference, Gene ontology, KEGG, gene set enrichment analyses and "CIBERSORT" algorithm were performed to screen differentially expressed genes, enriched functions or pathways and immune infiltrates differences between high and low TMB groups. Read More

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Quantitative proteome comparison of human hearts with those of model organisms.

PLoS Biol 2021 Apr 19;19(4):e3001144. Epub 2021 Apr 19.

Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Delineating human cardiac pathologies and their basic molecular mechanisms relies on research conducted in model organisms. Yet translating findings from preclinical models to humans present a significant challenge, in part due to differences in cardiac protein expression between humans and model organisms. Proteins immediately determine cellular function, yet their large-scale investigation in hearts has lagged behind those of genes and transcripts. Read More

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Exploring the Sexual Dimorphism of Crustacean Neuropeptide Expression Using as a Model Organism.

J Proteome Res 2021 Apr 19. Epub 2021 Apr 19.

Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States.

The impact of numerous diseases has been linked to differences in sex between organisms, including various neurological diseases. As neuropeptides are known to be key players in the nervous system, studying the variation of neuropeptidomic profiles between males and females in a crustacean model organism is of interest. By using high-resolution mass spectrometry with two complementary ionization sources in conjunction with quantitative chemical labeling (isotopic reductive dimethylation), differences were observed in five key neural tissues and hemolymph. Read More

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The transcriptome landscapes of citrus leaf in different developmental stages.

Plant Mol Biol 2021 Apr 19. Epub 2021 Apr 19.

Citrus Research & Education Center, Department of Microbiology and Cell Science, Institute of Food and Agricultural Sciences (IFAS), University of Florida, Lake Alfred, FL, 33850, USA.

Key Message: The temporal expression profiles of citrus leaves explain the sink-source transition of immature leaves to mature leaves and provide knowledge regarding the differential responses of mature and immature leaves to biotic stress such as citrus canker and Asian citrus psyllid (Diaphorina citri). Citrus is an important fruit crop worldwide. Different developmental stages of citrus leaves are associated with distinct features, such as differences in susceptibilities to pathogens and insects, as well as photosynthetic capacity. Read More

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Transcriptome Analysis in Yeast Reveals the Externality of Position Effects.

Mol Biol Evol 2021 Apr 19. Epub 2021 Apr 19.

Department of Biology and Medical Genetics, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.

The activity of a gene newly integrated into a chromosome depends on the genomic context of the integration site. This "position effect" has been widely reported, although the other side of the coin, i.e. Read More

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It's about time; divergent circadian clocks in livers of mice and naked mole-rats.

FASEB J 2021 May;35(5):e21590

BGES Department, Center for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH, USA.

Light is the key regulator of circadian clock, the time-keeping system synchronizing organism physiology and behavior with environmental day and night conditions. In its natural habitat, the strictly subterranean naked mole-rat (Heterocephalus glaber) has lived in a light-free environment for millennia. We questioned if this species retains a circadian clock and if the patterns of this clock and concomitant rhythms differed in liver tissue from mice and naked mole-rats. Read More

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Profiling children longitudinally: A three-year follow-up study of perceived and actual motor competence and physical fitness.

Scand J Med Sci Sports 2021 Apr;31 Suppl 1:35-46

AFIPS Research Group, Department of Teaching of Musical, Visual and Corporal Expression, University of Valencia, Valencia, Spain.

Longitudinal designs enhance our understanding of children's development and its influence on movement behaviors and health. This three-year follow-up study aimed to develop profiles according to perceived and actual motor competence (MC) (locomotion, object control, and overall) and physical fitness in boys and girls longitudinally including children's temporal migrations among clusters in terms of profiling trends. A secondary aim was to compare physical activity participation and weight status at each time point according to these profiles. Read More

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Transcriptome profiling of human pluripotent stem cell-derived cerebellar organoids reveals faster commitment under dynamic conditions.

Biotechnol Bioeng 2021 Apr 19. Epub 2021 Apr 19.

iBB - Institute for Bioengineering and Biosciences and Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Portugal.

Human induced pluripotent stem cells (iPSCs) have great potential for disease modeling. However, generating iPSC-derived models to study brain diseases remains a challenge. In particular, the ability to recapitulate cerebellar development in vitro is still limited. Read More

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Hyperactivity is a Core Endophenotype of Elevated Neuregulin-1 Signaling in Embryonic Glutamatergic Networks.

Schizophr Bull 2021 Apr 19. Epub 2021 Apr 19.

Department of Neurogenetics, Max-Planck-Institute of Experimental Medicine, Goettingen, Germany.

The neuregulin 1 (NRG1) ErbB4 module is at the core of an "at risk" signaling pathway in schizophrenia. Several human studies suggest hyperstimulation of NRG1-ErbB4 signaling as a plausible pathomechanism; however, little is known about the significance of stage-, brain area-, or neural cell type-specific NRG1-ErbB4 hyperactivity for disease-relevant brain endophenotypes. To address these spatiotemporal aspects, we generated transgenic mice for Cre recombinase-mediated overexpression of cystein-rich domain (CRD) NRG1, the most prominent NRG1 isoform in the brain. Read More

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Aggression expression among League of Legends and Fortnite players - a brief report.

Psychiatr Hung 2021 ;36(2):180-186

Department of Psychiatry and Psychotherapy, University of Pecs Medical School, PEcs, Hungary, E-mail:

Background And Aims: Our primary goal was to determine and compare the anger expression strategies used by players of the two most popular online games, League of Legends and Fortnite Battle Royale, as well as those used by non-gamers.

Methods: The study sample was comprised of 450 subjects, of whom 338 were males and 112 females. The sample was further divided into four groups: 1. Read More

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January 2021