Neurosci Lett 2021 Apr 7;753:135882. Epub 2021 Apr 7.
Graduate School of Wannan Medical College, Wuhu, 241002, Anhui, China; Department of Pathology, School of Basic Medical Sciences, Wannan Medical College, Wuhu, 241002, Anhui, China. Electronic address:
Traumatic brain injury (TBI) is a substantial clinical and social problem worldwide, causing high morbidity and mortality along with significant economic and medical costs. Forkhead box O transcription factors (FOXOs) have been found to play a critical role in the regulation of cell functions, such as nutrient metabolism, programmed cell death, and tumor suppression. In the central nervous system, FOXOs are reported to be pivotal regulators of learning and memory, neurite outgrowth, and axonal degeneration. Read More