12,449 results match your criteria expression notch

Logic and lineage impacts on functional transcription factor deployment for T-cell fate commitment.

Biophys J 2021 Apr 7. Epub 2021 Apr 7.

Division of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125 USA. Electronic address:

Transcription factors are the major agents that read the regulatory sequence information in the genome to initiate changes in expression of specific genes, both in development and in physiological activation responses. Their actions depend on site-specific DNA binding and are largely guided by their individual DNA target sequence specificities. However, their action is far more conditional in a real developmental context than would be expected for simple reading of local genomic DNA sequence, which is common to all cells in the organism. Read More

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Curcumin and cancer biology: Focusing regulatory effects in different signalling pathways.

Phytother Res 2021 Apr 9. Epub 2021 Apr 9.

Poona college of pharmacy, Bharati Vidyapeeth (Deemed to be University), Pune, India.

Cancer is the second-leading cause of death worldwide. Till date, many such effective treatments are available, for example chemotherapy, surgery, and radiation therapy, but there are severe associated side effects, such as increased infection risk, constipation, hair loss, anaemia, among others. Thus, the need for effective therapeutic strategies and screening methodology arises. Read More

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Extracellular vesicle-derived microRNA-18b ameliorates preeclampsia by enhancing trophoblast proliferation and migration via Notch2/TIM3/mTORC1 axis.

J Cell Mol Med 2021 Apr 9. Epub 2021 Apr 9.

Department of Obstetrics and Gynecology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China.

Preeclampsia (PE), a common disorder of pregnancy, is characterized by insufficient trophoblast migration and inadequate vascular remodelling, such that promotion of trophoblast proliferation might ameliorate PE. In the current study, we sought to study the underlying mechanism of extracellular vesicle (EV)-derived microRNA-18 (miR-18b) in PE. Human umbilical cord mesenchymal stem cells (HUCMSCs) isolated from placental tissues were verified through osteogenic, adipogenic and chondrogenic differentiation assays. Read More

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Age-associated expression of p21and p53 during human wound healing.

Aging Cell 2021 Apr 9:e13354. Epub 2021 Apr 9.

Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.

In mice, cellular senescence and senescence-associated secretory phenotype (SASP) positively contribute to cutaneous wound healing. In this proof-of-concept study, we investigated the expressions of p16, p21, and other senescence-associated biomarkers during human wound healing in 24 healthy subjects using a double-biopsy experimental design. The first punch biopsy created the wound and established the baseline. Read More

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Using lncRNA Sequencing to Reveal a Putative lncRNA-mRNA Correlation Network and the Potential Role of PCBP1-AS1 in the Pathogenesis of Cervical Cancer.

Front Oncol 2021 23;11:634732. Epub 2021 Mar 23.

Department of Gynaecology and Obstetrics, Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China.

Background/aims: Long non-coding RNAs (lncRNAs) play important roles in many diseases and participate in posttranscriptional regulatory networks in tumors. However, the functions of major lncRNAs in cervical cancer are unclear. Therefore, the aim of this study was to construct a lncRNA-mRNA coexpression functional network and analyze lncRNAs that might contribute to the pathogenesis of cervical cancer. Read More

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FZD2 promotes TGF-β-induced epithelial-to-mesenchymal transition in breast cancer via activating notch signaling pathway.

Cancer Cell Int 2021 Apr 8;21(1):199. Epub 2021 Apr 8.

Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, No. 305 East Zhongshan Road, Nanjing, 210002, China.

Background: Breast cancer (BC) is one of the commonest female cancers, which is characterized with high incidence. Although treatments have been improved, the prognosis of BC patients in advanced stages remains unsatisfactory. Thus, exploration of the molecular mechanisms underneath BC progression is necessary to find novel therapeutic methods. Read More

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Research progress on the molecular mechanisms of hepatic metastasis in lung cancer: a narrative review.

Ann Palliat Med 2021 Mar 24. Epub 2021 Mar 24.

Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, China.

The liver is one of the most common sites of metastatic spread of lung cancer, and the process of metastasis is regulated by many factors. A number of genes, including multiple tumor suppressor 1 (mts1), p120 catenin, and CT45A1, increase the possibility of hepatic metastasis in lung cancer, whereas Tip30/ CC3, CUL5, and SOCS3 expression in lung tumors inhibit tumor metastasis. microRNAs (miRNAs), such as miRNA-126, miRNA-338, and miRNA-218, can affect the metastasis of lung cancer cells to the liver. Read More

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Delta-like 4 is required for pulmonary vascular arborization and alveolarization in the developing lung.

JCI Insight 2021 Apr 8;6(7). Epub 2021 Apr 8.

Division of Neonatology, Department of Pediatrics, Children's Mercy Hospital, Kansas City, Missouri, USA.

The molecular mechanisms by which endothelial cells (ECs) regulate pulmonary vascularization and contribute to alveolar epithelial cell development during lung morphogenesis remain unknown. We tested the hypothesis that delta-like 4 (DLL4), an EC Notch ligand, is critical for alveolarization by combining lung mapping and functional studies in human tissue and DLL4-haploinsufficient mice (Dll4+/lacz). DLL4 expressed in a PECAM-restricted manner in capillaries, arteries, and the alveolar septum from the canalicular to alveolar stage in mice and humans. Read More

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Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain.

Nat Commun 2021 04 7;12(1):2083. Epub 2021 Apr 7.

Mathematical Neuroscience Unit, Institute for Frontier Science Initiative, Kanazawa University, Kanazawa, Ishikawa, Japan.

While Delta non-autonomously activates Notch in neighboring cells, it autonomously inactivates Notch through cis-inhibition, the molecular mechanism and biological roles of which remain elusive. The wave of differentiation in the Drosophila brain, the 'proneural wave', is an excellent model for studying Notch signaling in vivo. Here, we show that strong nonlinearity in cis-inhibition reproduces the second peak of Notch activity behind the proneural wave in silico. Read More

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Quinomycin A reduces cyst progression in polycystic kidney disease.

FASEB J 2021 May;35(5):e21533

Departments of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA.

Polycystic kidney disease (PKD) is a genetic disorder characterized by aberrant renal epithelial cell proliferation and formation and progressive growth of numerous fluid-filled cysts within the kidneys. Previously, we showed that there is elevated Notch signaling compared to normal renal epithelial cells and that Notch signaling contributes to the proliferation of cystic cells. Quinomycin A, a bis-intercalator peptide, has previously been shown to target the Notch signaling pathway and inhibit tumor growth in cancer. Read More

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Chemotherapy-elicited exosomal miR-378a-3p and miR-378d promote breast cancer stemness and chemoresistance via the activation of EZH2/STAT3 signaling.

J Exp Clin Cancer Res 2021 Apr 6;40(1):120. Epub 2021 Apr 6.

Third Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.

Background: Not all breast cancer (BC) patients who receive neoadjuvant chemotherapy achieve a pathologic complete response (pCR), but the reasons for this are unknown. Previous studies have shown that exosomes produced in the tumor microenvironment in response to chemotherapy promote a chemotherapy-resistant phenotype in tumors. However, the role of BC chemotherapy-elicited exosomes in regulating chemoresistance is poorly understood. Read More

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Vascular endothelial growth factor-mediated peritoneal neoangiogenesis in peritoneal dialysis.

Perit Dial Int 2021 Apr 7:8968608211004683. Epub 2021 Apr 7.

Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Peritoneal dialysis (PD) is an important renal replacement therapy for patients with end-stage renal diseases, which is limited by peritoneal neoangiogenesis leading to ultrafiltration failure (UFF). Vascular endothelial growth factor (VEGF) and its receptors are key angiogenic factors involved in almost every step of peritoneal neoangiogenesis. Impaired mesothelial cells are the major sources of VEGF in the peritoneum. Read More

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The FBXW7-NOTCH interactome: A ubiquitin proteasomal system-induced crosstalk modulating oncogenic transformation in human tissues.

Cancer Rep (Hoboken) 2021 Apr 6:e1369. Epub 2021 Apr 6.

Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida, Uttar Pradesh, 201310, India.

Background: Ubiquitin ligases or E3 ligases are well programmed to regulate molecular interactions that operate at a post-translational level. Skp, Cullin, F-box containing complex (or SCF complex) is a multidomain E3 ligase known to mediate the degradation of a wide range of proteins through the proteasomal pathway. The three-dimensional domain architecture of SCF family proteins suggests that it operates through a novel and adaptable "super-enzymatic" process that might respond to targeted therapeutic modalities in cancer. Read More

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Transcriptomic profiling as biological markers of depression- a pilot study in unipolar and bipolar women.

World J Biol Psychiatry 2021 Apr 6:1-31. Epub 2021 Apr 6.

Department of Psychiatric Genetics, Poznan University of Medical Sciences, Poland.

Objectives: A significant challenge in psychiatry is the differential diagnosis of depressive episodes in the course of mood disorders. Gene expression profiling may provide an opportunity for such distinguishment.

Methods: We studied differentially expressed genes in women with a depressive episode in the course of unipolar depression (UD) (n = 24) and bipolar disorder types I (BDI) (n = 13) and II (BDII) (n = 19), and healthy controls (n = 15). Read More

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Upregulation of miR-150-5p alleviates LPS-induced inflammatory response and apoptosis of RAW264.7 macrophages by targeting Notch1.

Open Life Sci 2020 28;15(1):544-552. Epub 2020 Jul 28.

Department of Burn and Plastic Surgery, Linyi People's Hospital, No. 27, Jiefang Rd, Linyi City, 276000, Shandong Province, China.

Circulating miR-150-5p has been identified as a prognostic marker in patients with critical illness and sepsis. Herein, we aimed to further explore the role and underlying mechanism of miR-150-5p in sepsis. Quantitative real-time-PCR assay was performed to detect the expression of miR-150-5p upon stimulation with lipopolysaccharide (LPS) in RAW264. Read More

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Long non-coding RNA TUG1 knockdown hinders the tumorigenesis of multiple myeloma by regulating the microRNA-34a-5p/NOTCH1 signaling pathway.

Open Life Sci 2020 9;15(1):284-295. Epub 2020 Jun 9.

Department of Hematology, Ji'ning No. 1 People's Hospital, Ji'ning, Shandong, China.

Multiple myeloma (MM) is a serious health issue in hematological malignancies. Long non-coding RNA taurine-upregulated gene 1 (TUG1) has been reported to be highly expressed in the plasma of MM patients. However, the functions of TUG1 in MM tumorigenesis along with related molecular basis are still undefined. Read More

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Treatment of collagen-induced arthritis rat model by using Notch signalling inhibitor.

J Orthop Translat 2021 May 17;28:100-107. Epub 2021 Mar 17.

Center for Translational Medicine Research and Development, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China.

Background: The Notch signalling pathway has been reported to play a key role in rheumatoid arthritis (RA) development. Thus, inhibition of the activation of this signalling pathway may be a promising approach to the treatment of RA. In this study, the Notch signalling inhibitor LY411575, which can inhibit both Notch1 and Notch3, was used for the treatment of collagen-induced arthritis (CIA) rats. Read More

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Gamma-Secretase Inhibitor (DAPT), a potential therapeutic target drug, caused neurotoxicity in planarian regeneration by inhibiting Notch signaling pathway.

Sci Total Environ 2021 Mar 26;781:146735. Epub 2021 Mar 26.

College of Life Science, Henan Normal University, Xinxiang 453007, Henan, China. Electronic address:

DAPT (N-[N-(3, 5-difluorophenacetyl)-l-alanyl]-s-phenylglycinet-butyl ester) is a γ-secretase inhibitor that indirectly blocks the activity of Notch pathway. It is a potential therapeutic target drug for many diseases, such as cancer, neurological, cardiovascular, and cerebrovascular diseases. However, the pharmacological action and specific mechanisms of DAPT are not clear. Read More

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Notch Signaling Regulation in HCC: From Hepatitis Virus to Non-Coding RNAs.

Cells 2021 Mar 1;10(3). Epub 2021 Mar 1.

Division of Internal Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.

The Notch family includes evolutionary conserved genes that encode for single-pass transmembrane receptors involved in stem cell maintenance, development and cell fate determination of many cell lineages. Upon activation by different ligands, and depending on the cell type, Notch signaling plays pleomorphic roles in hepatocellular carcinoma (HCC) affecting neoplastic growth, invasion capability and stem like properties. A specific knowledge of the deregulated expression of each Notch receptor and ligand, coupled with resultant phenotypic changes, is still lacking in HCC. Read More

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Theasaponin E Inhibits Platinum-Resistant Ovarian Cancer Cells through Activating Apoptosis and Suppressing Angiogenesis.

Molecules 2021 Mar 17;26(6). Epub 2021 Mar 17.

College of Science, Technology and Mathematics, Alderson Broaddus University, Philippi, WV 26416, USA.

Novel therapeutic strategies for ovarian cancer treatment are in critical need due to the chemoresistance and adverse side effects of platinum-based chemotherapy. Theasaponin E (TSE1) is an oleanane-type saponin from seeds. Its apoptosis-inducing, cell cycle arresting and antiangiogenesis activities against platinum-resistant ovarian cancer cells were elucidated in vitro and using the chicken chorioallantoic membrane (CAM) assay. Read More

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Selenite Inhibits Notch Signaling in Cells and Mice.

Int J Mol Sci 2021 Mar 3;22(5). Epub 2021 Mar 3.

Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA.

Selenium is an essential micronutrient with a wide range of biological effects in mammals. The inorganic form of selenium, selenite, is supplemented to relieve individuals with selenium deficiency and to alleviate associated symptoms. Additionally, physiological and supranutritional selenite have shown selectively higher affinity and toxicity towards cancer cells, highlighting their potential to serve as chemotherapeutic agents or adjuvants. Read More

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Retinal Genomic Fabric Remodeling after Optic Nerve Injury.

Genes (Basel) 2021 Mar 11;12(3). Epub 2021 Mar 11.

Laboratório de Neurogênese, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.

Glaucoma is a multifactorial neurodegenerative disease, characterized by degeneration of the retinal ganglion cells (RGCs). There has been little progress in developing efficient strategies for neuroprotection in glaucoma. We profiled the retina transcriptome of Lister Hooded rats at 2 weeks after optic nerve crush (ONC) and analyzed the data from the genomic fabric paradigm (GFP) to bring additional insights into the molecular mechanisms of the retinal remodeling after induction of RGC degeneration. Read More

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An experimental model of anti-PD-1 resistance exhibits activation of TGFß and Notch pathways and is sensitive to local mRNA immunotherapy.

Oncoimmunology 2021 Mar 16;10(1):1881268. Epub 2021 Mar 16.

Sanofi Research and Development, Cambridge, MA, USA.

Immune checkpoint blockade elicits durable anti-cancer responses in the clinic, however a large proportion of patients do not benefit from treatment. Several mechanisms of innate and acquired resistance to checkpoint blockade have been defined and include mutations of MHC I and IFNγ signaling pathways. However, such mutations occur in a low frequency of patients and additional mechanisms have yet to be elucidated. Read More

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Growth hormone induces mitotic catastrophe of glomerular podocytes and contributes to proteinuria.

Cell Death Dis 2021 Apr 1;12(4):342. Epub 2021 Apr 1.

Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, 500046, India.

Glomerular podocytes are integral members of the glomerular filtration barrier in the kidney and are crucial for glomerular permselectivity. These highly differentiated cells are vulnerable to an array of noxious stimuli that prevail in several glomerular diseases. Elevated circulating growth hormone (GH) levels are associated with podocyte injury and proteinuria in diabetes. Read More

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Genomic variants within chromosome 14q32.32 regulate bone mass through MARK3 signaling in osteoblasts.

J Clin Invest 2021 Apr;131(7)

Department of Orthopaedic Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

Bone mineral density (BMD) is a highly heritable predictor of osteoporotic fracture. GWAS have identified hundreds of loci influencing BMD, but few have been functionally analyzed. In this study, we show that SNPs within a BMD locus on chromosome 14q32. Read More

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Systematic Evaluation for the Influences of the SOX17/Notch Receptor Family Members on Reversing Enzalutamide Resistance in Castration-Resistant Prostate Cancer Cells.

Front Oncol 2021 10;11:607291. Epub 2021 Mar 10.

Department of Urology, First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

The treatment of castration-resistant prostate cancer (CRPC) remains challenging due to the failure of androgen deprivation therapy (ADT); hence the search for other molecular therapeutic targets besides androgen receptor signaling is ongoing. This study systematically investigated the expression of SOX17 and Notch receptors in CRPC tissues and cells , showing that consistent clinical CRPC, SOX17/Notch1, and Notch4 were responsible for enzalutamide resistance in CRPC cells. The secretase inhibitors, BMS-708163, GSI-IX, PF-3084014, and RO4929097 abrogated the enzalutamide resistance by inhibiting Notch1 or/and Notch4 , with GSI-IX and RO4929097 being more effective than BMS-708163 and PF-3084014 in reliving bone metastasis . Read More

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Neuritin promotes angiogenesis through inhibition of DLL4/Notch signaling pathway.

Acta Biochim Biophys Sin (Shanghai) 2021 Mar 31. Epub 2021 Mar 31.

Department of Biochemistry and Molecular Biology, Department of Basic Medical Sciences, School of Medicine, Shihezi University, Shihezi 832000, China.

Neuritin is a member of the neurotrophic factor family, which plays an important role in the promotion and development of the nervous system. Neuritin is also involved in angiogenesis. Neuritin was recently found to be a negative regulatory factor of the Notch 1 signaling pathway. Read More

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Drug Development in Neuroendocrine Tumors: What Is on the Horizon?

Curr Treat Options Oncol 2021 Mar 30;22(5):43. Epub 2021 Mar 30.

Gastrointestinal and Endocrine Tumor Unit, Medical Oncology Department, Vall Hebron Institute of Oncology (VHIO), Vall d'Hebron University Hospital, Pg Vall d'Hebron, 119-129 08035, Barcelona, Spain.

Opinion Statement: Neuroendocrine neoplasms (NENs) constitute a heterogenous group of malignancies. Translational research into NEN cell biology is the cornerstone for drug development strategies in this field. Somatostatin receptor type 2 (SSTR2) expression is the hallmark of well-differentiated neuroendocrine tumors (NETs). Read More

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GALNT2 promotes cell proliferation, migration, and invasion by activating the Notch/Hes1-PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma.

Life Sci 2021 Mar 27;276:119439. Epub 2021 Mar 27.

Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. Electronic address:

Aims: Our study aimed to investigate the function of GALNT2 in lung adenocarcinoma (LUAD).

Main Methods: We used network tools and tissue microarray immunohistochemistry to measure the expression levels of GALNT2 in LUAD. Kaplan-Meier curves and Cox regression methods were used in survival analysis. Read More

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LncRNA DLEU2 is activated by STAT1 and induces gastric cancer development via targeting miR-23b-3p/NOTCH2 axis and Notch signaling pathway.

Life Sci 2021 Mar 27:119419. Epub 2021 Mar 27.

Department of Gastroenterology, The Second Hospital of Shandong University, Jinan, 250033, Shandong, China. Electronic address:

Introduction: Gastric cancer (GC) has severely affected the health of patients and caused high mortality around the world. Long non-coding RNAs (lncRNAs) have been validated to play significant roles in biological process of multiple cancers.

Methods: Quantitative real-time PCR (RT-qPCR) and western blot analysis were conducted to evaluate the expression levels and protein levels of related genes in GC cells. Read More

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