J Biol Chem 2021 Jun 25;297(2):100916. Epub 2021 Jun 25.
School of Life Sciences, Tianjin University, Tianjin, PR China; Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, Tianjin, PR China; Department of Physiology, National University of Singapore, Singapore; Life Sciences Institute, National University of Singapore, Singapore. Electronic address:
The p75 neurotrophin receptor (p75) is a critical mediator of neuronal death and tissue remodeling and has been implicated in various neurodegenerative diseases and cancers. The death domain (DD) of p75 is an intracellular signaling hub and has been shown to interact with diverse adaptor proteins. In breast cancer cells, binding of the adaptor protein TRADD to p75 depends on nerve growth factor and promotes cell survival. Read More