845,023 results match your criteria expression genes


Regulation of the expression of the nickel uptake system in Vibrio cholerae by iron and heme via ferric uptake regulator (Fur).

J Inorg Biochem 2022 Jan 5;228:111713. Epub 2022 Jan 5.

Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo 060-8628, Japan; Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan. Electronic address:

Fur (ferric uptake regulator) is a transcription factor that regulates expression of downstream genes containing a specific Fe-binding sequence called the Fur box. In Vibrio cholerae, a Fur box is located upstream of the nik operon, which is responsible for nickel uptake, suggesting that its expression is regulated by Fur. However, there are no reports that Ni induces expression of Fur box genes. Read More

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January 2022

Signaling pathways modulated by miRNAs in breast cancer angiogenesis and new therapeutics.

Pathol Res Pract 2022 Jan 10;230:153764. Epub 2022 Jan 10.

Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

MicroRNAs (miRNAs) act as oncogenes or tumor suppressors by suppressing the expression of target genes, some of which are engaged in angiogenic signaling pathways directly or indirectly. Tumor development and metastasis are dependent on angiogenesis, and it is the main reason for the poor prognosis of cancer patients. New blood vessels are formed from pre-existing vessels when angiogenesis occurs. Read More

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January 2022

Commonly expressed key transcriptomic profiles of sepsis in the human circulation and brain via integrated analysis.

Int Immunopharmacol 2022 Jan 12;104:108518. Epub 2022 Jan 12.

Department of Anesthesiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province 410013, PR China. Electronic address:

Background: Sepsis is the leading cause of death in intensive care units and is characterized by multiple organ failure, including dysfuction of the immune system and brain. This study aims to determine the differential effect of sepsis on specific circulating immune cell subsets compared with brain transcriptome and identify the genes co-expressed by them, so as to identify key genes and regulatory factors involved in the pathogenesis of sepsis induced brain injury and identify novel therapeutic targets.

Methods: The GSE133822 and GSE135838 datasets were obtained from the Gene Expression Omnibus (GEO) database and utilized for bioinformatics analyses. Read More

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January 2022

Treatment of preadipocytes with fish oil, mixed oil, or soybean oil-based lipid emulsions have differential effects on the regulation of lipogenic and lipolytic genes in mature 3T3-L1 adipocytes.

Prostaglandins Leukot Essent Fatty Acids 2022 Jan 6;177:102396. Epub 2022 Jan 6.

Department of Biochemistry, Memorial University, St. John's, NL, Canada. Electronic address:

The key adipose tissue characteristics are established during early development, where lipids play an essential role. Lipid emulsions used in total parenteral nutrition have different omega-(n) 6 to n-3 fatty acid ratios. A lower n-6:n-3 fatty acid decreases lipid accumulation; however, the effects of lipid emulsions with different n-6 to n-3 fatty acid ratios on the programming of preadipocytes to affect lipid accumulation in mature adipocytes is not known. Read More

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January 2022

Cannibalism rate and mLeptin expression are influenced by photoperiod and diets in Piracanjuba, Brycon orbignyanus (Valenciennes, 1850) larvae.

Res Vet Sci 2022 Jan 8;143:142-147. Epub 2022 Jan 8.

Universidade Federal de Lavras, Campus Universitário, Caixa Postal 3037, CEP 37200-000 Minas Gerais, Brazil. Electronic address:

Piracanjuba (Brycon orbignyanus) is a species with great productive potential, and during its larval phase, it presents intense cannibal activity. The photoperiod and diet are primary feed behaviour and cannibalism modulators to fishes. This experiment aimed to verify the effect of different photoperiods and diets in Piracanjuba larviculture. Read More

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January 2022

Bioinformatics based discovery of new keratinases in protease family M36.

N Biotechnol 2022 Jan 12. Epub 2022 Jan 12.

Section for Protein Chemistry and Enzyme Technology, Department of Biotechnology and Biomedicine, DTU Bioengineering, Building 221, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark. Electronic address:

Keratinases are proteases that can catalyze the degradation of insoluble keratinous biomass. Keratinases in protease family M36 (MEROPS database) are endo-acting proteases. In total, 687 proteases are classified in family M36. Read More

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January 2022

Dysregulation of Mitochondrial Complexes and Dynamics by Chronic Cigarette Smoke Exposure in MitoQC Reporter Mice.

Mitochondrion 2022 Jan 12. Epub 2022 Jan 12.

Department of Environmental Medicine, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY, USA. Electronic address:

Cigarette smoke (CS) is known to cause impaired mitophagy and mitochondrial dysregulation in the pathogenesis of chronic obstructive pulmonary disease (COPD)/emphysema. Mitochondrial complexes and dynamics are affected by acute CS exposure in lung epithelium and mouse lung. We hypothesize that chronic CS exposure (4 months) will induce lung mitochondrial dysregulation and abnormal mitophagy. Read More

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January 2022

Polycomb repressive complex 1 initiates and maintains tailless repression in Drosophila embryo.

Authors:
Gwo-Jen Liaw

Biochim Biophys Acta Gene Regul Mech 2022 Jan 12:194786. Epub 2022 Jan 12.

Department of Life Sciences and Institute of Genomic Sciences, National Yang Ming Chiao Tung University, Yangming Campus, No. 155, Sec. 2, Linong St., Taipei 112, Taiwan. Electronic address:

Maternally-deposited morphogens specify the fates of embryonic cells via hierarchically regulating the expression of zygotic genes that encode various classes of developmental regulators. Once the cell fates are determined, Polycomb-group proteins frequently maintain the repressed state of the genes. This study investigates how Polycomb-group proteins repress the expression of tailless, which encodes a developmental regulator in Drosophila embryo. Read More

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January 2022

Lycopene attenuates oxidative stress, inflammation, and apoptosis by modulating Nrf2/NF-κB balance in sulfamethoxazole-induced neurotoxicity in grass carp (Ctenopharyngodon Idella).

Fish Shellfish Immunol 2022 Jan 12. Epub 2022 Jan 12.

College of Wildlife and Protected Area, Northeast Forestry University, Harbin, 150040, Heilongjiang, PR China. Electronic address:

All drugs that can penetrate the blood-brain barrier (BBB) may lead to mental state changes, including the widely used anti-infective drug sulfamethoxazole (SMZ). Herein, we investigated whether lycopene (LYC) could ameliorate SMZ-induced brain injury and the postulated mechanisms involved. A total of 120 grass carps were exposed under SMZ (0. Read More

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January 2022

Grouper USP12 exerts antiviral activity against nodavirus infection.

Fish Shellfish Immunol 2022 Jan 12. Epub 2022 Jan 12.

University Joint Laboratory of Guangdong Province, Hong Kong and Macao Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural University, Guangzhou, 510642, China. Electronic address:

The ubiquitin-specific proteases (USPs) have attracted particular attention due to their multiple functions in different biological processes. USP12, a member of the USP family, has been demonstrated to exert critical roles in diverse cellular processes, including cell death, cancer and antiviral immunity. Here, we cloned a USP12 homolog from orange spotted grouper (Epinephelus coioides, E. Read More

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January 2022

Overexpression of OsMYBR22/OsRVE1 transcription factor simultaneously enhances chloroplast-dependent metabolites in rice grains.

Metab Eng 2022 Jan 12. Epub 2022 Jan 12.

Department of Genetics and Biotechnology, College of Life Sciences, Kyung Hee University, Yongin, 17104, Republic of Korea. Electronic address:

The OsMYBR22 (same to OsRVE1), an R1type-MYB transcription factor belonging to the rice CCA1-like family, was upregulated under blue light condition, which enhanced the chlorophyll and carotenoid accumulation. The overexpression of OsMYBR22 in rice (Oryza sativa, L) led to everlasting green seeds and leaves of a darker green. Transgene expression patterns showed more concordance with chlorophyll than carotenoid profiles. Read More

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January 2022

Identification of ribosomal protein L24 (RPL24) from the oriental river prawn, Macrobrachium nipponense, and its roles in ovarian development.

Comp Biochem Physiol A Mol Integr Physiol 2022 Jan 12:111154. Epub 2022 Jan 12.

Engineering Lab of Henan Province for Aquatic Animal Disease Control, Engineering Technology Research Center of Henan Province for Aquatic Animal Cultivation, College of Fisheries, Henan Normal University, Xinxiang 453007, PR China.

Ribosomal proteins exhibit various extraribosomal functions in addition to their roles in protein synthesis. In this study, complementary DNA (cDNA) of ribosomal protein L24 in Macrobrachium nipponense (MnRPL24) was isolated, and its role in ovarian development was investigated using quantitative real-time PCR (qPCR), immunohistochemistry (IHC), RNA interference (RNAi) and histological observations. The complete cDNA of MnRPL24 is 564 base pairs (bps) and contains a 486 bp open reading frame (ORF) encoding 162 amino acids (aas). Read More

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January 2022

Tanshinone IIA and its derivative activate thermogenesis in adipocytes and induce "beiging" of white adipose tissue.

Mol Cell Endocrinol 2022 Jan 12:111557. Epub 2022 Jan 12.

Department of Biochemistry, Molecular Cancer Research Center, School of Medicine, Sun yat-sen University, Shenzhen, 518107, Guangdong Province, China. Electronic address:

Tanshinone IIA (TAN2A) is a major active ingredient of Salvia miltiorrhiza used in traditional Chinese medicine and tanshinone 20 (TAN20) is a derivative of TAN2A. In this study, we examined the effects of TAN2A and TAN20 on adipogenesis, lipid metabolism, and thermogenesis. Our experiments showed that both TAN2A and TAN20 increased mitochondria content in adipose tissue, enhanced energy expenditure, reduced body weight, and improved insulin sensitivity and metabolic homeostasis in obese and diabetic mouse models. Read More

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January 2022

In vitro anti-Helicobacter pylori activity of Syzygium aromaticum and the preliminary mechanism of action.

J Ethnopharmacol 2022 Jan 12:114995. Epub 2022 Jan 12.

School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen, 518107, China. Electronic address:

Ethnopharmacological Relevance: The dried flower bud of Syzygium aromaticum (L.) Merr. & L. Read More

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January 2022

Paternal acrylamide exposure induces transgenerational effects on sperm parameters and learning capability in mice.

Food Chem Toxicol 2022 Jan 12:112817. Epub 2022 Jan 12.

Medical College of Soochow University, Suzhou, China; Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, China. Electronic address:

Acrylamide (AA) has been shown to have neurological and reproductive toxicities, but little is known about transgenerational effects of AA. In this study, male C57BL/6 mice were exposed to AA (0.01, 1, 10 μg/mL) and its metabolite glycidamide (GA, 10 μg/mL) in drinking water, which were then mated with unexposed female mice to produce F1 and F2 generations. Read More

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January 2022

Transcriptomic changes in the hypothalamus of ovariectomized mice: Data from RNA-seq analysis.

Ann Anat 2022 Jan 12:151886. Epub 2022 Jan 12.

Department of Anatomy and Histoembryology, School of Basic Medical Science, Peking University, Beijing 100191, China. Electronic address:

Background: Menopausal symptoms can affect the physical and mental health of females and are often related to abnormal function of the hypothalamus. In this study, we evaluated changes in the hypothalamus transcriptome in ovariectomized mice to identify key mRNAs, and systematically elucidated the possible molecular mechanisms underlying the menopausal syndrome to provide a theoretical basis for clinical diagnosis and treatment.

Methods: Forty-six adult female C57BL/6J mice were randomly divided into SHAM and OVX groups, 23 mice per group. Read More

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January 2022

Expression profiling of S100-proteins in healthy and irreversibly inflamed human dental pulps.

J Endod 2022 Jan 12. Epub 2022 Jan 12.

Department of Periodontology, Operative and Preventive Dentistry, University Hospital, Faculty of Medicine, University of Bonn, Welschnonnenstr. 17, 53111 Bonn, Germany.

Aim: Several S100 proteins have been shown to play an important role in the innate immune response to infection and in regenerative processes. However, they have scarcely been investigated during inflammation of the dental pulp. Therefore, in this study we performed gene expression profiling of S100 proteins in healthy and inflamed human dental pulps. Read More

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January 2022

Hyperammonemia-induced changes in the cerebral transcriptome and proteome.

Anal Biochem 2022 Jan 12:114548. Epub 2022 Jan 12.

Clinic for Gastroenterology, Hepatology and Infectious Diseases, Germany. Electronic address:

Molecular alterations underlying cerebral impairment in hyperammonemic disorders such as in hepatic encephalopathy (HE) are only poorly understood. Using transcriptomics and proteomics on brains of mice with systemic hyperammonemia resulting from knockout of hepatic glutamine synthetase (LGS-KO) we identified up to 214 genes and 34 proteins whose expressions were altered in brains of LGS-KO mice in a brain region-specific way. Differentially expressed genes were enriched for those related to oxidative stress, cell proliferation, heme metabolism and others. Read More

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January 2022

Time-restricted feeding during the inactive phase abolishes the daily rhythm in mitochondrial respiration in rat skeletal muscle.

FASEB J 2022 Feb;36(2):e22133

Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology, Endocrinology, and Metabolism, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Shift-workers show an increased incidence of type 2 diabetes mellitus (T2DM). A possible mechanism is the disruption of the circadian timing of glucose homeostasis. Skeletal muscle mitochondrial function is modulated by the molecular clock. Read More

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February 2022

Mitigation of portal fibrosis and cholestatic liver disease in ANKS6-deficient livers by macrophage depletion.

FASEB J 2022 Feb;36(2):e22157

Division of Nephrology, Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Congenital hepatic fibrosis (CHF) is a developmental liver disease that is caused by mutations in genes that encode ciliary proteins and is characterized by bile duct dysplasia and portal fibrosis. Recent work has demonstrated that mutations in ANKS6 can cause CHF due to its role in bile duct development. Here, we report a novel ANKS6 mutation, which was identified in an infant presenting with neonatal jaundice due to underlying biliary abnormalities and liver fibrosis. Read More

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February 2022

MAP Kinases 3 and 6 control Salicylic Acid signaling by upregulating NLR receptors during Pattern- and Effector-Triggered Immunity.

J Exp Bot 2022 Jan 15. Epub 2022 Jan 15.

Institute of Plant Sciences Paris Saclay (IPS2), CNRS, INRAE, UEVE, Université Paris-Saclay, Orsay, France.

Arabidopsis thaliana Mitogen-Activated Protein Kinases 3 and 6 (MPK3/6) are transiently activated during PAMP-Triggered Immunity (PTI) and durably during Effector-Triggered Immunity (ETI). However the functional differences between these two kinds of activation kinetics and how they coordinate the two layers of plant immunity remain poorly understood. Here, by suppressor analyses, we demonstrate that ETI-mediating Nucleotide-binding domain Leucine-rich repeat Receptors (NLRs) and the NLR signaling components NDR1 and EDS1 can promote the SA sector of defense downstream of MPK3 activity. Read More

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January 2022

Short-term tetrabromobisphenol A exposure promotes fibrosis of human uterine fibroid cells in a 3D culture system through TGF-beta signaling.

FASEB J 2022 Feb;36(2):e22101

Mechanistic Toxicology Branch (MTB), Division of the National Toxicology Program (DNTP), National Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle Park, North Carolina, USA.

Tetrabromobisphenol A (TBBPA), a derivative of BPA, is a ubiquitous environmental contaminant with weak estrogenic properties. In women, uterine fibroids are highly prevalent estrogen-responsive tumors often with excessive accumulation of extracellular matrix (ECM) and may be the target of environmental estrogens. We have found that BPA has profibrotic effects in vitro, in addition to previous reports of the in vivo fibrotic effects of BPA in mouse uterus. Read More

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February 2022

NAP1L2 drives mesenchymal stem cell senescence and suppresses osteogenic differentiation.

Aging Cell 2022 Jan 15:e13551. Epub 2022 Jan 15.

The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Key Laboratory of Cellular Homeostasis and Human Diseases, Department of Physiology and Pathophysiology, School of Basic Medical Science, Tianjin Medical University, Tianjin, China.

Senescence of bone marrow mesenchymal stem cells (BMSCs) impairs stemness and osteogenic differentiation, but the key regulators for senescence and the related osteogenesis are not well defined. Herein, we screened the gene expression profiles of human BMSCs from young and old donors and identified that elevation of the nucleosome assembly protein 1-like 2 (NAP1L2) expression was correlated with BMSC senescence and impaired osteogenesis. Elevated NAP1L2 expression was observed in replicative cell senescence and induced cell senescence in vitro, and in age-related senescent human and mouse BMSCs in vivo, concomitant with significantly augmented chromatin accessibility detected by ATAC-seq. Read More

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January 2022

The genome of low-chill Chinese plum 'Sanyueli' (Prunus salicina Lindl.) provides insights into the regulation of the chilling requirement of flower buds.

Mol Ecol Resour 2022 Jan 15. Epub 2022 Jan 15.

Fruit Research Institute, Fujian Academy of Agricultural Sciences, Fuzhou, Fujian, 350013, China.

Chinese plum (Prunus salicina Lindl.) is a stone fruit that belongs to the Prunus genus and plays an important role in the global production of plum. In this study, we report the genome sequence of the Chinese plum 'Sanyueli', which is known to have a low-chill requirement for flower bud break. Read More

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January 2022

CLAVATA modulates auxin homeostasis and transport to regulate stem cell identity and plant shape in a moss.

New Phytol 2022 Jan 15. Epub 2022 Jan 15.

School of Biological Sciences, University of Bristol, 24 Tyndall Avenue, Bristol, BS8 1TQ, UK.

The CLAVATA pathway is a key regulator of stem cell function in the multicellular shoot tips of Arabidopsis, where it acts via the WUSCHEL transcription factor to modulate hormone homeostasis. Broad scale evolutionary comparisons have shown that CLAVATA is a conserved regulator of land plant stem cell function, but CLAVATA acts independently of WUSCHEL-like (WOX) proteins in bryophytes. The relationship between CLAVATA, hormone homeostasis and the evolution of land plant stem cell functions is unknown. Read More

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January 2022

Hippocampal Cannabinoid 1 Receptors Are Modulated Following Cocaine Self-administration in Male Rats.

Mol Neurobiol 2022 Jan 15. Epub 2022 Jan 15.

Laboratoire de Neurosciences Cognitives Et Adaptatives (LNCA), Centre de La Recherche Nationale Scientifique, Université de Strasbourg, 12 rue Goethe, 67000, Strasbourg, France.

Cocaine addiction is a complex pathology inducing long-term neuroplastic changes that, in turn, contribute to maladaptive behaviors. This behavioral dysregulation is associated with transcriptional reprogramming in brain reward circuitry, although the mechanisms underlying this modulation remain poorly understood. The endogenous cannabinoid system may play a role in this process in that cannabinoid mechanisms modulate drug reward and contribute to cocaine-induced neural adaptations. Read More

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January 2022

RNA-seq analysis of phagocytic cells from murine epididymal white adipose tissue shows immunosenescence and age-related phosphorus metabolism.

Authors:
Martin Nwadiugwu

Hum Cell 2022 Jan 15. Epub 2022 Jan 15.

Leonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA.

The underlying state of alterations in adipose tissue is hypothesized to be as a result of age-related changes. Young and aged mice have been documented to show distinct gene expression and distinct macrophage-specific adipose tissue regulation. However, more biological understanding is required to know the processes associated with these conditions in relation to the aging process. Read More

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January 2022

An integrated in silico analysis highlighted angiogenesis regulating miRNA-mRNA network in PCOS pathophysiology.

J Assist Reprod Genet 2022 Jan 15. Epub 2022 Jan 15.

Department of Molecular Endocrinology, Indian Council of Medical Research-National Institute for Research in Reproductive Health, J.M. Street, Parel, Mumbai, 400012, India.

Background: Polycystic ovary syndrome (PCOS) is a heterogeneous endocrinopathy and a leading cause of anovulatory infertility. Angiogenesis is vital for ovarian folliculogenesis. The expression of angiogenesis-associated genes/proteins is altered in the ovary of PCOS women. Read More

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January 2022

Age Effects Aggressive Behavior: RNA-Seq Analysis in Cattle with Implications for Studying Neoteny Under Domestication.

Behav Genet 2022 Jan 15. Epub 2022 Jan 15.

Universidad Complutense de Madrid, Avenida Puerta de Hierro, s/n, 28040, Madrid, Spain.

The reactive type of aggression is regulated mostly by the brain's prefrontal cortex; however, the molecular changes underlying aggressiveness in adults have not been fully characterized. We used an RNA-seq approach to investigate differential gene expression in the prefrontal cortex of bovines from the aggressive Lidia breed at different ages: young three-year old and adult four-year-old bulls. A total of 50 up and 193 down-regulated genes in the adult group were identified. Read More

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January 2022

Knockdown of circ_0007290 alleviates oxygen-glucose deprivation-induced neuronal injury by regulating miR-496/PDCD4 axis.

Metab Brain Dis 2022 Jan 15. Epub 2022 Jan 15.

Department of Anesthesia and Pain, Gaomi People's Hospital, 77 Zhenfu Street, Gaomi City, Shandong Province , 261500, China.

Circular RNAs (circRNAs) are highly enriched in the brain and involved in many types of central nervous system pathologies. Herein, this study aimed to investigate the role and mechanism of circ_0007290 in ischemic stroke. The oxygen-glucose deprivation (OGD) model was established with the HCN-2 cells in vitro. Read More

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January 2022