623,036 results match your criteria expression associated

Lymphocyte soluble factors from pregnant cows modulate mRNA transcript abundances encoding for proteins associated with trophoblast growth and development.

Anim Reprod Sci 2021 Mar 27;228:106747. Epub 2021 Mar 27.

Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA; School of Veterinary Medicine, Utah State University, Logan, UT, USA. Electronic address:

This study was conducted to determine whether T cell populations are responsible for modulating placental development during gestation in cattle. It was hypothesized that CD4+CD25+ and γ/δ+ T cells modulate gene expression, based on mRNA transcript abundances, and promote proliferation and survival of trophoblast cells. Peripheral blood was collected from cows at 160 to 180 days of gestation and non-pregnant cows, T cell populations CD8+, CD4+, CD4+CD25+, CD24+CD25-, and γ/δ+ T cells were isolated, cultured for 48 h, and supernatant was collected. Read More

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Intramammary infection caused by Staphylococcus aureus increases IgA antibodies to iron-regulated surface determinant-A, -B, and -H in bovine milk.

Vet Immunol Immunopathol 2021 Mar 31;235:110235. Epub 2021 Mar 31.

Dairy Hygiene Research Division, National Institute of Animal Health, National Agriculture and Food Research Organization, 4 Hitsujigaoka, Toyohira, Sapporo, Hokkaido, 062-0045, Japan. Electronic address:

The aim of this study was to identify virulence factors that have high immunogenicity. An in vivo-expressed Staphylococcus aureus antigen was identified by probing bacteriophage expression libraries of S. aureus with antibodies in bovine mastitis milk. Read More

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Co-expression network analysis identifies novel molecular pathways associated with cadmium and pyriproxyfen testicular toxicity in Gammarus fossarum.

Aquat Toxicol 2021 Mar 26;235:105816. Epub 2021 Mar 26.

INRAE, UR RiverLy, Ecotoxicology Team. Centre de Lyon-Grenoble Auvergne Rhône-Alpes, 5 rue de la Doua CS 20244, 69625 Villeurbanne, France. Electronic address:

Omics approaches are continuously providing new clues on the mechanisms of action of contaminants in species of environmental relevance, contributing to the emergence of molecular ecotoxicology. Co-expression network approaches represent a suitable methodological framework for studying the rich content of omics datasets. This study aimed to find evidence of key pathways and proteins related to the testicular toxicity in the sentinel crustacean species Gammarus fossarum exposed to endocrine disruptors using a weighted protein co-expression network analysis. Read More

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The ecotoxicological contaminant tris(4-chlorophenyl)methanol (TCPMOH) impacts embryonic development in zebrafish (Danio rerio).

Aquat Toxicol 2021 Mar 26;235:105815. Epub 2021 Mar 26.

San Diego State University School of Public Health, 5500 Campanile Dr., Hardy Tower 119, San Diego, CA, 92182, USA. Electronic address:

Tris(4-chlorophenyl)methanol (TCPMOH) is a water contaminant with unknown etiology, but is believed to be a byproduct of DDT manufacturing. It is highly persistent in the environment, and bioaccumulates in marine species. TCPMOH has also been measured in human breast milk, which poses a risk for developing infants. Read More

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The responses of Salmonella enterica serovar Typhimurium to vanillin in apple juice through global transcriptomics.

Int J Food Microbiol 2021 Mar 31;347:109189. Epub 2021 Mar 31.

School of Food Science and Engineering, South China University of Technology, Guangzhou City, Guangdong Province 510640, China. Electronic address:

Salmonella enterica serovar Typhimurium can survive some extreme environment in food processing, and vanillin generally recognized as safe is bactericidal to pathogens. Thus, we need to explore the responses of S. Typhimurium to vanillin in order to apply this antimicrobial agent in food processing. Read More

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The effects of antibiotics on the efficacy of immune checkpoint inhibitors in patients with non-small-cell lung cancer differ based on PD-L1 expression.

Eur J Cancer 2021 Apr 7;149:73-81. Epub 2021 Apr 7.

Department of Allergy and Respiratory Medicine, Okayama University Hospital, Japan.

Background: Immune checkpoint inhibitors (ICIs) are essential for treatment of various malignancies, including non-small-cell lung cancer (NSCLC). Recently, several studies have shown that the gut microbiome plays an important role in ICI treatment of solid cancers, and antibiotic (ATB) use had a negative impact on the outcomes of ICI treatment via dysbiosis in the gut. However, whether this is applicable to NSCLC remains unclear. Read More

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The effect of environmental diesel exhaust pollution on SARS-CoV-2 infection: The mechanism of pulmonary ground glass opacity.

Environ Toxicol Pharmacol 2021 Apr 7:103657. Epub 2021 Apr 7.

Gazi University, Faculty of Medicine, Department of General Surgery, Ankara, Turkey.

Diesel exhaust particles (DEP) are the major components of atmospheric particulate matter (PM) and chronic exposure is recognized to enhance respiratory system complications. Although the spread of SARS-CoV-2 was found to be associated with the PMs, the mechanism by which exposure to DEP increases the risk of SARS-CoV-2 infection is still under discussion. However, diesel fine PM (dPMs) elevate the probability of SARS-CoV-2 infection, as it coincides with the increase in the number of ACE2 receptors. Read More

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Inhibition of the CDK5/caspase-3 pathway by p5-TAT protects hippocampal neurogenesis and alleviates radiation-induced cognitive dysfunction.

Neuroscience 2021 Apr 7. Epub 2021 Apr 7.

Department of Radiotherapy and Oncology, the Second Affiliated Hospital of Soochow University, Suzhou City, China; Institute of Radiotherapy and Oncology, Soochow University; Suzhou Key Laboratory for Radiation Oncology. Electronic address:

Radiation-induced cognitive dysfunction is a common complication associated with cranial radiation therapy. Inhibition of hippocampal neurogenesis and proliferation plays a critical role in this complication. Relieving hippocampal apoptosis may significantly protect hippocampal neurogenesis and proliferation. Read More

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Anti-inflammatory activity of the Tongmai Yangxin Pill in the treatment of Coronary Heart Disease is associated with Estrogen Receptor and NF-κB signaling pathway.

J Ethnopharmacol 2021 Apr 7:114106. Epub 2021 Apr 7.

School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. Electronic address:

Ethnopharmacological Relevance: The Tongmai Yangxin Pill (TMYX) is a patented traditional Chinese medicine originating from two classic prescriptions, Zhigancao Decoction and Shenmai Yin, which composed of 11 Chinese medicinal herbs: Rehmannia glutinosa (Gaertn.) DC., Spatholobus suberectus Dunn, Ophiopogon japonicus (Thunb. Read More

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A genome-wide association study, supported by a new chromosome-level genome assembly, suggests sox2 as a main driver of the undifferentiatiated ZZ/ZW sex determination of turbot (Scophthalmus maximus).

Genomics 2021 Apr 7. Epub 2021 Apr 7.

Departament of Zoology, Genetics and Physical Anthropology, Faculty of Biology, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain. Electronic address:

Background: Understanding sex determination (SD) across taxa is a major challenge for evolutionary biology. The new genomic tools are paving the way to identify genomic features underlying SD in fish, a group frequently showing limited sex chromosome differentiation and high SD evolutionary turnover. Turbot (Scophthalmus maximus) is a commercially important flatfish with an undifferentiated ZW/ZZ SD system and remarkable sexual dimorphism. Read More

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Cannabinoid 2 Receptors Regulate Dopamine 2 Receptor Expression by a Beta-Arrestin 2 and GRK5-Dependent Mechanism in Neuronal Cells.

Neurosci Lett 2021 Apr 7:135883. Epub 2021 Apr 7.

Department of Biomedical Sciences, Copper Medical School of Rowan University, United States. Electronic address:

We have previously reported that the repeated exposure to cannabinoids upregulates and enhances the activity of serotonin 2A (5-HT) and dopamine 2 (D) receptors and facilitates the formation of D-5-HT receptor heterodimers in the rat prefrontal cortex and two neuronal cell lines. Because the repeated exposure to cannabinoids has been associated with adverse neuropsychiatric disorders, this study investigated the mechanisms that underly the cannabinoid-mediated regulation of D receptor expression in a neuronal cell model, CLU213 cells. We initially tested the effects of repeated exposure (72 hours) to a non-selective cannabinoid agonist (1 nM CP55940), a selective CB receptor agonist (15 nM ACEA), or a selective CB receptor drug (1 nM GP1a) on the expression of postsynaptic D (DL) receptors in CLU213 cells. Read More

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Fasudil enhances the phagocytosis of myelin debris and the expression of neurotrophic factors in cuprizone-induced demyelinating mice.

Neurosci Lett 2021 Apr 7:135880. Epub 2021 Apr 7.

Department of Neurology, Bethune Hospital Affiliated to Shanxi Medical University, Taiyuan, 030032, China; The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Research Center of Neurobiology, Shanxi University of Chinese Medicine, Taiyuan, 030024, China; Institute of Brain Science, Shanxi Key Laboratory of Inflammatory Neurodegenerative Diseases, Medical School of Shanxi Datong University, Datong, 037009, China. Electronic address:

Multiple sclerosis (MS) is mainly associated with the neuroinflammation and demyelination in the central nervous system (CNS), in which the failure of remyelination results in persistent neurological dysfunction. Fasudil, a typical Rho kinase inhibitor, has been exhibited beneficial effects on several models of neurodegenerative disorders. In this study, we showed that Fasudil promoted the uptake of myelin debris by microglia via cell experiments and through a cuprizone (CPZ)-induced demyelinating model. Read More

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Olive oil-derived nitro-fatty acids: protection of mitochondrial function in non-alcoholic fatty liver disease.

J Nutr Biochem 2021 Apr 7:108646. Epub 2021 Apr 7.

Departamento de Bioquímica and Centro de Investigaciones Biomédicas (CENIBIO), Facultad de Medicina, Universidad de la República, Montevideo, Uruguay. Electronic address:

Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive liver fat deposition in the absence of significant alcohol intake. Since extra virgin olive oil (EVOO) reduces fat accumulation, we analyzed the involvement of nitro-fatty acids (NO-FA) on the beneficial effects of EVOO consumption on NAFLD. Nitro-fatty acids formation was observed during digestion in mice supplemented with EVOO and nitrite. Read More

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A novel role of claudin-5 in prevention of mitochondrial fission against ischemic/hypoxic stress in cardiomyocytes.

Can J Cardiol 2021 Apr 7. Epub 2021 Apr 7.

Division of Cardiology, Department of Medicine, School of Medicine, University of California Irvine, Irvine, CA 92697, USA. Electronic address:

Background: Downregulation of claudin-5 in the heart is associated with the end-stage heart failure. However, the underlying mechanism of claudin-5 is unclear. Here we investigated the molecular actions of claudin-5 in perspective of mitochondria in cardiomyocytes to better understand the role of claudin-5 in cardioprotection during ischemia. Read More

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Reduced cardiac response to the adrenergic system is a key limiting factor for physical capacity in old age.

Exp Gerontol 2021 Apr 7:111339. Epub 2021 Apr 7.

Faculty of Biological Sciences, University of Leeds, LS2 9JT, UK.

Ageing is associated with a progressive reduction in physical capacity reducing quality of life. One key physiological limitation of physical capacity that deteriorates in a progressive age-dependent manner is cardiac reserve. Peak cardiac output falls progressively with advancing age such that in extreme old age there is limited ability to enhance cardiac output beyond basal function as is required to support the increased metabolic needs of physical activity. Read More

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Hydrogen-saturated saline mediated neuroprotection through autophagy via PI3K/AKT/mTOR pathway in early and medium stages of rotenone-induced Parkinson's disease rats.

Brain Res Bull 2021 Apr 7. Epub 2021 Apr 7.

Life science research center, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, China. Electronic address:

Some cardiovascular symptoms in the early stage of Parkinson's disease (PD) were related to degeneration of the rostral ventrolateral medulla (RVLM) catecholaminergic neurons. To date, little is known about the effects of hydrogen water on early stage of PD. Here, protective actions of hydrogen-saturated saline (HS) on rotenone-induced PD rats, as well as its underlying mechanisms were investigated. Read More

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GILT in tumor cells improves T cell-mediated anti-tumor immune surveillance.

Immunol Lett 2021 Apr 7. Epub 2021 Apr 7.

Department of Biochemistry and Molecular Biology, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China; Key Laboratory of Immune Microenvironment and Disease, Ministry of Education, Key Laboratory of Cellular and Molecular Immunology in Tianjin, Excellent Talent Project, Tianjin Medical University, Tianjin, China. Electronic address:

The lysosomal thiol reductase GILT catalyzes the reduction of disulfide bonds of protein antigens, facilitating antigen-presenting cells (APCs) to present antigen to T cells. However, whether GILT expression in tumor cells can be associated with improved T cell-mediated anti-tumor responses remains unknown. Here, we identify that GILT is able to facilitate anti-tumor immune surveillance via promoting MHC class I mediated-antigen presentation in colon carcinoma. Read More

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Effect of sub-lethal doses of nisin on Staphylococcus aureus toxin production and biofilm formation.

Toxicon 2021 Apr 7. Epub 2021 Apr 7.

Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address:

Staphylococcus aureus is one of the commonest food-borne pathogens that can cause gastroenteritis owing to having several enterotoxins. Also, biofilm formation can complicate infections caused by this microorganism. Nisin is a safe food bio preservative which is usually used as an agent to prevent pathogen growth; however, it is important to identify the exact impact of nisin on the growth of S. Read More

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Genome-wide association study of serum metabolites in the African American Study of Kidney Disease and Hypertension.

Kidney Int 2021 Apr 7. Epub 2021 Apr 7.

Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore MD, USA; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore MD, USA; Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore MD, USA.

The genome-wide association study (GWAS) is a powerful means to study genetic determinants of disease traits and generate insights into disease pathophysiology. To date, few GWAS of circulating metabolite levels have been performed in African Americans with chronic kidney disease. Hypothesizing that novel genetic-metabolite associations may be identified in a unique population of African Americans with a lower glomerular filtration rate (GFR), we conducted a GWAS of 652 serum metabolites in 619 participants (mean measured glomerular filtration rate 45 mL/min/1. Read More

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Isorhynchophylline ameliorates paraquat-induced acute kidney injury by attenuating oxidative stress and mitochondrial damage via regulating toll-interacting expression.

Toxicol Appl Pharmacol 2021 Apr 7:115521. Epub 2021 Apr 7.

Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China. Electronic address:

Isorhynchophylline (IRN) is an alkaloid with anti-inflammatory and anti-oxidative activities in cardiovascular and brain diseases, but its role in paraquat (PQ)-induced acute kidney injury (AKI) is yet unknown. The model of PQ-induced AKI in rats was established by intraperitoneal injection of PQ (25 mg/kg). We found that the tail vein injection of IRN (4 mg/kg) significantly increased the survival rate of PQ-intoxicated rats. Read More

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The daily gene transcription cycle in mouse retina.

Exp Eye Res 2021 Apr 7:108565. Epub 2021 Apr 7.

Aier School of Ophthalmology, Central South University, Changsha, China; Aier Eye Institute, Changsha, China; CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China. Electronic address:

Many physiological retinal processes, such as outer segment disk shedding and visual sensitivity, exhibit a daily rhythm. However, the detailed transcriptome dynamics and related biological processes of the retina are not fully understood. Retinal tissues were collected from C57BL/6J male mice housed in a 12h light/12h dark (LD) cycle for 4 weeks, at Zeitgeber time (ZT) 0, 4, 8, 12, 16, and 20. Read More

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Glucocorticoids suppressed osteoblast differentiation by decreasing Sema3A expression via the PIK3/Akt pathway.

Exp Cell Res 2021 Apr 7:112595. Epub 2021 Apr 7.

Department of Operative Dentistry and Endodontics, Guanghua School and Hospital of Stomatology & Institute of Stomatological Research, Sun Yat-sen University, 510055,Guangzhou, China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China. Electronic address:

Glucocorticoids(GCs) are extensively used to treat inflammatory and autoimmune diseases. Excessive prolonged exposure to glucocorticoids is associated with an increased risk of osteoporosis. The inhibition of osteoblast differentiation by GCs is suggested as a major cause for GCs-induced osteoporosis (GIO). Read More

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miR-1253, a novel tumor suppressor gene in colon cancer, is associated with poor patients prognosis.

Clin Exp Med 2021 Apr 10. Epub 2021 Apr 10.

Department of 3rd General Surgery, The Fourth Affiliated Hospital of China Medical University, Chongshan East Road in Huanggu District, Shenyang, Liaoning, 11032, China.

MiR-1253 has been reported to play vital roles in a variety of cancers. However, its function in the progression and prognosis of colon cancer remains unclear. Here, the clinical significance and biological function of miR-1253 in the development of colon cancer was investigated. Read More

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Diacylglycerol kinase α inhibition cooperates with PD-1-targeted therapies to restore the T cell activation program.

Cancer Immunol Immunother 2021 Apr 10. Epub 2021 Apr 10.

Immunology and Oncology, Centro Nacional de Biotecnología-CSIC, Madrid, Spain.

Background: Antibody-based therapies blocking the programmed cell death-1/ligand-1 (PD-1/PD-L1) axis have provided unprecedent clinical success in cancer treatment. Acquired resistance, however, frequently occurs, commonly associated with the upregulation of additional inhibitory molecules. Diacylglycerol kinase (DGK) α limits the extent of Ras activation in response to antigen recognition, and its upregulation facilitates hypofunctional, exhausted T cell states. Read More

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Pepper E3 ligase CaAIRE1 promotes ABA sensitivity and drought tolerance by degradation of protein phosphatase CaAITP1.

J Exp Bot 2021 Apr 10. Epub 2021 Apr 10.

Department of Life Science (BK21 program), Chung-Ang University, Seoul, Korea.

Plants have developed defense mechanisms to survive in extreme environmental conditions. Abscisic acid (ABA) is a key phytohormone associated with plant adaptation to environmental stress. In this study, we isolated and functionally characterized pepper RING-type E3 ligase CaAIRE1 (Capsicum annuum  ABA Induced RING-type E3 ligase 1) containing the C3HC4-type RING domain. Read More

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Upregulation of ZHX2 predicts poor prognosis and is correlated with immune infiltration in gastric cancer.

FEBS Open Bio 2021 Apr 10. Epub 2021 Apr 10.

Department of Gastrointestinal Surgery, Laboratory Research Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, PR China.

The transcriptional repressor Zinc-finger and homeoboxes 2 (ZHX2) is reported to regulate tumor progression in several human cancers, but little is known about its role in gastric cancer (GC). In this study, we examined the expression of ZHX2 and its relationship with clinicopathological characteristics and prognosis of GC patients, and examined the effect of ZHX2 overexpression in GC cell lines. We used UALCAN and Tumor Immune Estimation Resource (TIMER) to examine ZHX2 mRNA expression, and used Kaplan-Meier plotter to determine whether ZHX2 expression was related to GC prognosis. Read More

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Screening and identification of autophagy-related biomarkers for oral squamous cell carcinoma (OSCC) via integrated bioinformatics analysis.

J Cell Mol Med 2021 Apr 9. Epub 2021 Apr 9.

Department of Oral & Maxillofacial Surgery, NanFang Hospital, Southern Medical University, Guangzhou, China.

Increasing evidences have showed that autophagy played a significant role in oral squamous cell carcinoma (OSCC). Purpose of our study was to explore the prognostic value of autophagy-related genes (ATGs) and screen autophagy-related biomarkers for OSCC. RNA-seq and clinical data were downloaded from The Cancer Genome Atlas (TCGA) database following extracting ATG expression profiles. Read More

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Long non-coding RNA MFAT1 promotes skeletal muscle fibrosis by modulating the miR-135a-5p-Tgfbr2/Smad4 axis as a ceRNA.

J Cell Mol Med 2021 Apr 9. Epub 2021 Apr 9.

Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China.

Fibrosis after skeletal muscle injury is common in sports and can cause irreversible damage to the biomechanical properties of skeletal muscle. Long non-coding RNAs (lncRNAs) have been validated to act as important modulators in the fibrosis of various organs. Here, we reported a novel lncRNA (the skeletal muscle fibrosis-associated transcript 1, lnc-MFAT1), which was highly expressed in skeletal muscle fibrosis. Read More

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Fluid Shear Stress Promotes Embryonic Stem Cell Pluripotency via Interplay between β-catenin and Vinculin in Bioreactor Culture.

Stem Cells 2021 Apr 9. Epub 2021 Apr 9.

Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

The expansion of pluripotent stem cells (PSCs) as aggregates in stirred suspension bioreactors is garnering attention as an alternative to adherent culture. However, the hydrodynamic environment in the bioreactor can modulate PSC behavior, pluripotency and differentiation potential in ways that need to be well understood. In this study, we investigated how murine embryonic stem cells (mESCs) sense fluid shear stress and modulate a non-canonical Wnt signaling response to promote pluripotency. Read More

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Curcumin and cancer biology: Focusing regulatory effects in different signalling pathways.

Phytother Res 2021 Apr 9. Epub 2021 Apr 9.

Poona college of pharmacy, Bharati Vidyapeeth (Deemed to be University), Pune, India.

Cancer is the second-leading cause of death worldwide. Till date, many such effective treatments are available, for example chemotherapy, surgery, and radiation therapy, but there are severe associated side effects, such as increased infection risk, constipation, hair loss, anaemia, among others. Thus, the need for effective therapeutic strategies and screening methodology arises. Read More

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