779,348 results match your criteria expressed genes


Homeostatic control of nuclear-encoded mitochondrial gene expression by the histone variant H2A.Z is essential for neuronal survival.

Cell Rep 2021 Sep;36(11):109704

Department of Biology, University of Toronto Mississauga, Mississauga, ON L5L 1C6, Canada; Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada. Electronic address:

Histone variants are crucial regulators of chromatin structure and gene transcription, yet their functions within the brain remain largely unexplored. Here, we show that the H2A histone variant H2A.Z is essential for neuronal survival. Read More

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September 2021

RORα is critical for mTORC1 activity in T cell-mediated colitis.

Cell Rep 2021 Sep;36(11):109682

Institute for Immunology, Tsinghua University, Beijing 100084, China; Shanghai Immune Therapy Institute, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai 200127, China. Electronic address:

Inflammatory bowel disease (IBD) is multi-factorial chronic intestinal inflammation driven by pathogenic T cells, among which a large portion of patients are resistant to current anti-inflammatory regimes. The mechanisms underlying colitis pathogenicity and drug resistance are not fully understood. Here, we demonstrate that RORα is highly expressed in active UC patients, particularly in those non-responsive to anti-TNF treatment. Read More

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September 2021

Strigolactone biosynthesis catalyzed by cytochrome P450 and sulfotransferase in sorghum.

New Phytol 2021 Sep 15. Epub 2021 Sep 15.

Department of Biological Production Science, United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Tokyo, 183-8509, Japan.

・Root parasitic plants such as Striga, Orobanche, and Phelipanche spp., cause serious damage to crop production worldwide. Deletion of the Low Germination Stimulant 1 (LGS1) gene gives a Striga-resistance trait in sorghum (Sorghum bicolor). Read More

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September 2021

Cellular resolution anatomical and molecular atlases for prenatal human brains.

J Comp Neurol 2021 Sep 15. Epub 2021 Sep 15.

Allen Institute for Brain Science, Seattle, WA, 98109.

Increasing interest in studies of prenatal human brain development, particularly using new single-cell genomics and anatomical technologies to create cell atlases, creates a strong need for accurate and detailed anatomical reference atlases. In this study, we present two cellular-resolution digital anatomical atlases for prenatal human brain at post-conceptional weeks (PCW) 15 and 21. Both atlases were annotated on sequential Nissl-stained sections covering brain-wide structures on the basis of combined analysis of cytoarchitecture, acetylcholinesterase staining and an extensive marker gene expression dataset. Read More

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September 2021

IGFBP-2 as a biomarker in NAFLD improves hepatic steatosis:an integrated bioinformatics and experimental study.

Endocr Connect 2021 Sep 1. Epub 2021 Sep 1.

Q Wang, Department of Toxicology, Sun Yat-Sen University, Guangzhou, 510275, China.

Background And Aims: Non-alcoholic fatty liver disease (NAFLD) has become a common chronic liver disease in the world. Simple steatosis is the early phase of NAFLD. However, the molecular mechanisms underlying the development of steatosis have not yet been fully elucidated. Read More

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September 2021

Infection of Glia by Human Pegivirus Suppresses Peroxisomal and Antiviral Signaling Pathways.

J Virol 2021 Sep 15:JVI0107421. Epub 2021 Sep 15.

Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada.

Human pegivirus (HPgV) infects peripheral leukocytes but was recently shown to be a neurotropic virus associated with leukoencephalitis in humans. In the present study, we investigated the neural cell tropism of HPgV as well as its effects on host immune responses. HPgV wild type (WT) as well as a mutant virus with a deletion in the HPgV gene (ΔNS2) were able to productively infect human astrocytes and microglia but not neurons or an oligodendrocyte-derived cell line. Read More

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September 2021

Riboflavin transporter SLC52A1, a target of p53, suppresses cellular senescence by activating mitochondrial complex II.

Mol Biol Cell 2021 Sep 15:mbcE21050262. Epub 2021 Sep 15.

Biosignal Research Center, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan.

Cellular senescence is a state of permanent proliferative arrest induced by a variety of stresses, such as DNA damage. The transcriptional activity of p53 has been known to be essential for senescence induction. It remains unknown, however, whether among the downstream genes of p53, there is a gene that has anti-senescence function. Read More

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September 2021

Gene expression profiles in the brain of phenylketonuria mouse model reversed by the low phenylalanine diet therapy.

Metab Brain Dis 2021 Sep 15. Epub 2021 Sep 15.

Department of Pediatric Endocrinology and Genetic Metabolism, Shanghai Institute for Pediatric Research, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Kongjiang Road 1665#, Shanghai, 200092, China.

To gain insight into the potential protective mechanisms of low phenylalanine diet (LPD) in phenylketonuria (PKU), gene expression profiles were studied in the cerebral cortex and hippocampus of a PKU mouse model (BTBR-Pah). PKU mice were fed with low Phe diet (LPD-PKU group) and normal diet (PKU group). Wild-type mice were treated with normal diet (WT group) as control. Read More

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September 2021

Impact of the menstrual cycle on commercial prognostic gene signatures in oestrogen receptor-positive primary breast cancer.

Breast Cancer Res Treat 2021 Sep 15. Epub 2021 Sep 15.

Ralph Lauren Centre for Breast Cancer Research, Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, UK.

Purpose: Changes occur in the expression of oestrogen-regulated and proliferation-associated genes in oestrogen receptor (ER)-positive breast tumours during the menstrual cycle. We investigated if Oncotype® DX recurrence score (RS), Prosigna® (ROR) and EndoPredict® (EP/EPclin) prognostic tests, which include some of these genes, vary according to the time in the menstrual cycle when they are measured.

Methods: Pairs of test scores were derived from 30 ER-positive/human epidermal growth factor receptor-2-negative tumours sampled at two different points of the menstrual cycle. Read More

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September 2021

Master regulator NtrC controls the utilization of alternative nitrogen sources in Pseudomonas stutzeri A1501.

World J Microbiol Biotechnol 2021 Sep 15;37(10):177. Epub 2021 Sep 15.

Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing, China.

Pseudomonas stutzeri A1501 is a model strain used to study associative nitrogen fixation, and it possesses the nitrogen regulatory NtrC protein in the core genome. Nitrogen sources represent one of the important factors affecting the efficiency of biological nitrogen fixation in the natural environment. However, the regulation of NtrC during nitrogen metabolism in P. Read More

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September 2021

Megestrol acetate is a specific inducer of CYP3A4 mediated by human pregnane X receptor.

Cancer Chemother Pharmacol 2021 Sep 15. Epub 2021 Sep 15.

Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine and Simmons Cancer Institute, Springfield, IL, 62794-9626, USA.

Purpose: Megestrol acetate is a synthetic progestogen used to treat some cancers and cancer-associated cachexia, but its potential interactions with other drugs are not well known. This study aims to determine the regulation of drug metabolizing enzymes by megestrol acetate.

Methods: Primary human hepatocytes were treated and analyzed by PCR array to identify genes involved in drug metabolism that are impacted by megestrol acetate. Read More

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September 2021

Genome-wide high-resolution mapping of DNA methylation reveals epigenetic variation in the offspring of sexual and asexual propagation in Robinia pseudoacacia.

Plant Cell Rep 2021 Sep 15. Epub 2021 Sep 15.

National Engineering Laboratory for Tree Breeding, College of Biological Science and Technology, Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, Engineering Technology Research Center of Black Locust of National Forestry and Grassland Administration, Beijing Forestry University, Beijing, 100083, People's Republic of China.

Key Message: We detected the genome-wide pattern of DNA methylation and its association with gene expression in sexual and asexual progenies of mature Robinia pseudoacacia trees. DNA methylation plays an important role in plant reproduction and development. Although some studies on sexual reproduction have been carried out in model plants, little is known about the dynamic changes in DNA methylation and their effect on gene expression in sexual and asexual progeny of woody plants. Read More

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September 2021

Circular RNA Hsa_circ_0006766 targets microRNA miR-4739 to regulate osteogenic differentiation of human bone marrow mesenchymal stem cells.

Bioengineered 2021 Dec;12(1):5679-5687

The Clinical laboratory, The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.

Circular RNAs (circRNAs) are emerging as important regulators in bone metabolism, which is mediated by microRNA (miRNA) sponges. However, it is not clear how circRNA regulates osteogenic differentiation of human bone marrow mesenchymal stem cells (hBM-MSCs).Therefore, based on the previous circRNA chip results, hsa_circ_0006766, which is differentially expressed in the osteogenic differentiation of hBM-MSCs, was screened out, and bioinformatics analysis was performed to predict potential target miRNAs. Read More

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December 2021

Black Mulberry Extract Elicits Hepatoprotective Effects in Nonalcoholic Fatty Liver Disease Models by Inhibition of Histone Acetylation.

J Med Food 2021 Sep;24(9):978-986

Research Group of Healthcare, Korea Food Research Institute, Wanju-gun, Jeollabuk-do, Korea.

Epigenetic regulation by histone acetyltransferase (HAT) is associated with various biological processes and the progression of diseases, including nonalcoholic fatty liver disease (NAFLD). The objective of this study was to investigate whether the hypolipidemic properties of black mulberry ( Roxb.) fruit extract (BME) contribute toward protection against NAFLD by HAT inhibition. Read More

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September 2021

Temporal Transcriptomics of Gut Escherichia coli in Caenorhabditis elegans Models of Aging.

Microbiol Spectr 2021 Sep 15:e0049821. Epub 2021 Sep 15.

Juniata Collegegrid.258264.f, Huntingdon, Pennsylvania, USA.

Host-bacterial interactions over the course of aging are understudied due to complexities of the human microbiome and challenges of collecting samples that span a lifetime. To investigate the role of host-microbial interactions in aging, we performed transcriptomics using wild-type Caenorhabditis elegans () and three long-lived mutants (, , and ) fed Escherichia coli OP50 and sampled at days 5, 7.5, and 10 of adulthood. Read More

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September 2021

Diverse Host Immune Responses of Different Geographical Populations of the Coconut Rhinoceros Beetle to Oryctes Rhinoceros Nudivirus (OrNV) Infection.

Microbiol Spectr 2021 Sep 15:e0068621. Epub 2021 Sep 15.

School of Biological Sciences, The University of Queenslandgrid.1003.2, Brisbane, Queensland, Australia.

Incursions of the coconut rhinoceros beetle (CRB), Oryctes rhinoceros, into different islands in the South Pacific have been detected in recent years. It has been suggested that this range expansion is related to an haplotype reported to show reduced susceptibility to the well-established classical biocontrol agent, Oryctes rhinoceros nudivirus (OrNV). Our understanding of the genetic characteristics which distinguish the population of that has recently established in Solomon Islands from other well-established populations across the region is very limited. Read More

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September 2021

Insights into the Lignocellulose-Degrading Enzyme System of var. Based on Genome and Transcriptome Analysis.

Microbiol Spectr 2021 Sep 15:e0108821. Epub 2021 Sep 15.

Laboratory of Genetics and Biotechnology, EMBRAPA Agroenergy, Brasília, Brazil.

Humicola grisea var. is a thermophilic ascomycete and important enzyme producer that has an efficient enzymatic system with a broad spectrum of thermostable carbohydrate-active (CAZy) enzymes. These enzymes can be employed in lignocellulose biomass deconstruction and other industrial applications. Read More

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September 2021

Immunophenotyping and transcriptional profiling of human plasmablasts in dengue.

J Virol 2021 Sep 15:JVI0061021. Epub 2021 Sep 15.

ICGEB-Emory Vaccine Center, International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India.

Plasmablasts represent a specialized class of antibody secreting effector B cell population that transiently appear in blood circulation following infection or vaccination. The expansion of these cells generally tends to be massive in patients with systemic infections leading to viral hemorrhagic fevers such as dengue or ebola. To gain a detailed understanding of the human plasmablast responses beyond antibody expression, here we performed immunophenotyping and RNA seq analysis of the plasmablasts from dengue febrile children in India. Read More

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September 2021

APOBEC3B potently restricts HIV-2 but not HIV-1 in a Vif-dependent manner.

J Virol 2021 Sep 15:JVI0117021. Epub 2021 Sep 15.

Centro de investigação interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz, Quinta da Granja, 2829-511 Caparica, Portugal.

Vif is a lentiviral accessory protein that counteracts the antiviral activity of cellular APOBEC3 cytidine deaminases in infected cells. The exact contribution of each member of the A3 family for the restriction of HIV-2 is still unclear. Thus, the aim of this work was to identify the A3s with anti-HIV-2 activity and compare their restriction potential for HIV-2 and HIV-1. Read More

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September 2021

Beyond the Biosynthetic Gene Cluster Paradigm: Genome-Wide Coexpression Networks Connect Clustered and Unclustered Transcription Factors to Secondary Metabolic Pathways.

Microbiol Spectr 2021 Sep 15:e0089821. Epub 2021 Sep 15.

Chair of Applied and Molecular Microbiology, Institute of Biotechnology, Technische Universität Berlin, Berlin, Germany.

Fungal secondary metabolites are widely used as therapeutics and are vital components of drug discovery programs. A major challenge hindering discovery of novel secondary metabolites is that the underlying pathways involved in their biosynthesis are transcriptionally silent under typical laboratory growth conditions, making it difficult to identify the transcriptional networks that they are embedded in. Furthermore, while the genes participating in secondary metabolic pathways are typically found in contiguous clusters on the genome, known as biosynthetic gene clusters (BGCs), this is not always the case, especially for global and pathway-specific regulators of pathways' activities. Read More

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September 2021

Ablation of USP21 in skeletal muscle promotes oxidative fibre phenotype, inhibiting obesity and type 2 diabetes.

J Cachexia Sarcopenia Muscle 2021 Sep 15. Epub 2021 Sep 15.

College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University-Seoul, Goyang-si, Gyeonggi-Do, South Korea.

Background: Skeletal muscle as a metabolic consumer determines systemic energy homeostasis by regulating myofibre type conversion and muscle mass control. Perturbation of the skeletal muscle metabolism elevates the risk of a variety of diseases including metabolic disorders. However, the regulatory pathways and molecules are not completely understood. Read More

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September 2021

Identification of metabolism-associated molecular subtype in ovarian cancer.

J Cell Mol Med 2021 Sep 15. Epub 2021 Sep 15.

Institutes of Biomedical Sciences, Fudan University, Shanghai, China.

Ovarian cancer (OC) is the most lethal gynaecological cancer with genomic complexity and extensive heterogeneity. This study aimed to characterize the molecular features of OC based on the gene expression profile of 2752 previously characterized metabolism-relevant genes and provide new strategies to improve the clinical status of patients with OC. Finally, three molecular subtypes (C1, C2 and C3) were identified. Read More

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September 2021

Genetic and phenotypic heterogeneity in KIAA0753-related ciliopathies.

Am J Med Genet A 2021 Sep 15. Epub 2021 Sep 15.

Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Primary ciliopathies are heterogenous disorders resulting from perturbations in primary cilia form and/or function. Primary cilia are cellular organelles which mediate key signaling pathways during development, such as the sonic hedgehog (SHH) pathway which is required for neuroepithelium and central nervous system development. Joubert syndrome is a primary ciliopathy characterized by cerebellar/brain stem malformation, hypotonia, and developmental delays. Read More

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September 2021

A novel prognostic signature based on four glycolysis-related genes predicts survival and clinical risk of hepatocellular carcinoma.

J Clin Lab Anal 2021 Sep 15:e24005. Epub 2021 Sep 15.

Medical College of Shantou University, Shantou, China.

Background: Hepatocellular carcinoma (HCC) is the most common cancer with limited cure and poor survival. In our study, a bioinformatic analysis was conducted to investigate the role of glycolysis in the pathogenesis and progression of HCC.

Methods: Single-sample gene set enrichment analysis (ssGESA) was used to calculate enrichment scores for each sample in TCGA-LIHC and GEO14520 according to the glycolysis gene set. Read More

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September 2021

Insights Into the Gene Regulation in Jasmonate-Induced Whole-Plant Senescence of Tobacco Under Non-Starvation Condition.

Plant Cell Physiol 2021 Sep 15. Epub 2021 Sep 15.

Tobacco Research Institute, Chinese Academy of Agricultural Sciences, Qingdao 266101, China.

Jasmonate (JA)-induced plant senescence was mainly studied with the dark/starvation-promoted system using detached leaves, yet the induction of whole-plant senescence by JA remains largely unclear. This work reports the finding of a JA-induced whole-plant senescence of tobacco under light/non-starvation condition and the investigation of underlying regulations. MeJA (methyl jasmonate) treatment induces the whole-plant senescence of tobacco in a light-intensity-dependent manner, which is suppressed by silencing of NtCOI1 that encodes the receptor protein of JA-Ile (the bioactive derivative of JA). Read More

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September 2021

Oncogene-specific inhibition in the treatment of advanced pediatric thyroid cancer.

J Clin Invest 2021 Sep;131(18)

Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Papillary thyroid cancer (PTC) is the most common form of differentiated thyroid cancer in the pediatric population and represents the second most common malignancy in adolescent females. Historically, PTC has been classified on the basis of histology, however, accumulating data indicate that molecular subtyping based on somatic oncogenic alterations along with gene expression profiling can better predict clinical behavior and may provide opportunities to incorporate oncogene-specific inhibitory therapy to improve the response to radioactive iodine (RAI). In this issue of the JCI, Y. Read More

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September 2021

Molecular biomarkers as tool for early warning by chlorpyrifos exposure on Alpine chironomids.

Environ Pollut 2021 Aug 26;290:118061. Epub 2021 Aug 26.

Department of Invertebrate Zoology and Hydrobiology, MUSE-Museo delle Scienze, Corso del Lavoro e della Scienza 3, I-38122, Trento, Italy.

Pesticides used in agriculture can be transported at a medium-high distance due to the drift effect, reaching even remote areas as mountain regions, glaciers, and snow cover. With the melting process, pesticides enter freshwater glacier ecosystems, becoming a threat to wildlife fauna, mainly dominated by Diptera Chironomidae. Chlorpyrifos (CPF), as one of the most commonly used pesticides in alpine vineyards and apple orchards, is frequently detected in icemelt waters. Read More

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Desulfonation and defluorination of 6:2 fluorotelomer sulfonic acid (6:2 FTSA) by Rhodococcus jostii RHA1: Carbon and sulfur sources, enzymes, and pathways.

J Hazard Mater 2021 Aug 28;423(Pt A):127052. Epub 2021 Aug 28.

Zachry Department of Civil and Environmental Engineering, Texas A&M University, 3136 TAMU, College Station, TX 77843, USA. Electronic address:

6:2 fluorotelomer sulfonic acid (6:2 FTSA) is one per- and poly-fluoroalkyl substances commonly detected in the environment. While biotransformation of 6:2 FTSA has been reported, factors affecting desulfonation and defluorination of 6:2 FTSA remain poorly understood. This study elucidated the effects of carbon and sulfur sources on the gene expression of Rhodococcus jostii RHA1 which is responsible for the 6:2 FTSA biotransformation. Read More

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Transcriptome-wide m6A methylation profile reveals regulatory networks in roots of barley under cadmium stress.

J Hazard Mater 2021 Sep 5;423(Pt A):127140. Epub 2021 Sep 5.

Department of Agronomy, Key Laboratory of Crop Germplasm Resource of Zhejiang Province, Zhejiang University, Hangzhou 310058, China.

Cadmium (Cd) pollutants restrict crop yield and food security in long-term agricultural activities. Crops have evolved adaptive strategies under Cd condition, however, the transcriptional regulatory mechanism of Cd-tolerant genes remains to be largely illustrated. In this study, barley roots were exposed to 5 µM CdCl for physiological response and transcriptome-wide m6A methylation profile. Read More

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September 2021

A novel form of bivalent chromatin associates with rapid induction of camalexin biosynthesis genes in response to a pathogen signal in Arabidopsis.

Elife 2021 Sep 15;10. Epub 2021 Sep 15.

Department of Plant Biology, Carnegie Institution for Science, Stanford, United States.

Temporal dynamics of gene expression underpin responses to internal and environmental stimuli. In eukaryotes, regulation of gene induction includes changing chromatin states at target genes and recruiting the transcriptional machinery that includes transcription factors. As one of the most potent defense compounds in , camalexin can be rapidly induced by bacterial and fungal infections. Read More

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September 2021