Colloids Surf B Biointerfaces 2021 May 13;205:111850. Epub 2021 May 13.
LIMAV-Interdisciplinary Laboratory for Advanced Materials, BioMatLab, UFPI - Federal University of Piaui, Teresina, PI, 64049-550, Brazil; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, United States. Electronic address:
Currently, oxygen supply for in vitro cell culture is one of the major challenges in tissue engineering, especially in three-dimensional (3D) structures, such as polymeric hydrogels, because oxygen is an essential element for cells survival. In this context, oxygen levels must be maintained in articular cartilage to promote the differentiation, viability, and proliferation of chondrocytes due to the low level of oxygen presence in this region. Although some technologies employ oxygen-generating materials to add sufficient oxygen levels, the limitations and challenges of current technologies include the lack of controlled, sustained, and prolonged release of the oxygen. Read More