2,939 results match your criteria exploring integrated

Cyclic Plasma Halogenation of Amorphous Carbon for Defect-Free Area-Selective Atomic Layer Deposition of Titanium Oxide.

ACS Appl Mater Interfaces 2021 Jun 23. Epub 2021 Jun 23.

cMACS, KU Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium.

As critical dimensions in integrated circuits continue to shrink, the lithography-based alignment of adjacent patterned layers becomes more challenging. Area-selective atomic layer deposition (ALD) allows circumventing the alignment issue by exploiting the chemical contrast of the exposed surfaces. In this work, we investigate the selective deposition of TiO by plasma halogenation of amorphous carbon (a-C:H) acting as a growth-inhibiting layer. Read More

View Article and Full-Text PDF

Novel loci and potential mechanisms of major depressive disorder, bipolar disorder, and schizophrenia.

Sci China Life Sci 2021 Jun 16. Epub 2021 Jun 16.

Center for Bioinformatics and Computational Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.

Different psychiatric disorders share genetic relationships and pleiotropic loci to certain extent. We integrated and analyzed datasets related to major depressive disorder (MDD), bipolar disorder (BIP), and schizophrenia (SCZ) from the Psychiatric Genomics Consortium using multitrait analysis of genome-wide association analysis (MTAG). MTAG significantly increased the effective sample size from 99,773 to 119,754 for MDD, from 909,061 to 1,450,972 for BIP, and from 856,677 to 940,613 for SCZ. Read More

View Article and Full-Text PDF

Efficient Direct Band-Gap Transition in Germanium by Three-Dimensional Strain.

ACS Appl Mater Interfaces 2021 Jun 22. Epub 2021 Jun 22.

Department of Physics and Astronomy, KU Leuven, Celestijnenlaan 200D, 3001 Leuven, Belgium.

Complementary to the development of highly three-dimensional (3D) integrated circuits in the continuation of Moore's law, there has been a growing interest in new 3D deformation strategies to improve the device performance. To continue this search for new 3D deformation techniques, it is essential to explore beforehand, using computational predictive methods, which strain tensor leads to the desired properties. In this work, we study germanium (Ge) under an isotropic 3D strain on the basis of first-principles methods. Read More

View Article and Full-Text PDF

A novel strategy for exploring food originated anti-adipogenesis substances and mechanism by structural similarity evaluation, ADME prediction, network pharmacology and experimental validation.

Food Funct 2021 Jun 22. Epub 2021 Jun 22.

Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine, Formula-Pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China.

Screening potential functional substances based on active compounds is still a challenge faced by researchers since hundreds and thousands of possible compounds exist in natural products (food, herb, etc.). In this study, an integrated strategy by a combination of structural similarity evaluation, ADME (absorption, distribution, metabolism, excretion) prediction, network pharmacology and experimental validation (SANE strategy) was proposed and applied to explore anti-adipogenesis substances. Read More

View Article and Full-Text PDF

Independent living of individuals with intellectual disability: a combined study of the opinions of parents, educational staff, and individuals with intellectual disability in Greece.

Int J Dev Disabil 2018 Nov 21;66(2):153-159. Epub 2018 Nov 21.

Department of Educational and Social Policy, University of Macedonia, Thessaloniki, Greece.

The study of independent living (IL) of individuals with disabilities during the last decades has been in the focus of scientific field of educational and social sciences. The conceptual framework formed around the concept of IL led to practices that have been supporting the idea that IL may be a significant option for individuals with disabilities. Specifically, for individuals with intellectual disability (ID), the goal focuses on the development and implementation of integrated programs of IL in the community. Read More

View Article and Full-Text PDF
November 2018

Recent Progress in the Fabrication, Properties, and Devices of Heterostructures Based on 2D Materials.

Nanomicro Lett 2019 Feb 18;11(1):13. Epub 2019 Feb 18.

School of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, NSW, 2006, Australia.

With a large number of researches being conducted on two-dimensional (2D) materials, their unique properties in optics, electrics, mechanics, and magnetics have attracted increasing attention. Accordingly, the idea of combining distinct functional 2D materials into heterostructures naturally emerged that provides unprecedented platforms for exploring new physics that are not accessible in a single 2D material or 3D heterostructures. Along with the rapid development of controllable, scalable, and programmed synthesis techniques of high-quality 2D heterostructures, various heterostructure devices with extraordinary performance have been designed and fabricated, including tunneling transistors, photodetectors, and spintronic devices. Read More

View Article and Full-Text PDF
February 2019

Exploring the experiences of living with Lewy body dementia: An integrative review.

J Adv Nurs 2021 Jun 19. Epub 2021 Jun 19.

International Observatory on End of Life Care, Division of Health Research, Faculty of Health and Medicine, Health Innovation One, Lancaster University, Lancaster, UK.

Aim: Lewy body dementia is a common neurodegenerative dementia with unique challenges in managing day-to-day life. A more in-depth multifaceted picture of the Lewy body dementia lived experience will enable identification of best practice and future research direction. The review aim was to explore experiences of people living with Lewy body dementia and their family carers. Read More

View Article and Full-Text PDF

Exploring students' understanding of structured practical anatomy.

Mohammed A Akeel

J Taibah Univ Med Sci 2021 Jun 13;16(3):318-327. Epub 2021 Jan 13.

Department of Human Anatomy, Faculty of Medicine, Jazan University, Jazan, KSA.

Objectives: The shift from the traditional curriculum to an integrated organ and system-based one has fragmented anatomy courses. Thus, it has become necessary to implement a structured active learning process for the practical teaching of anatomy. We achieved this goal by using an innovative teaching strategy for practical sessions called structured practical anatomy (SPA). Read More

View Article and Full-Text PDF

Italian nursing students' attitudes towards care of the dying patient: A multi-center descriptive study.

Nurse Educ Today 2021 Jun 1;104:104991. Epub 2021 Jun 1.

Research Unit of Nursing Science, Campus Bio-Medico di Roma University, Via Alvaro del Portillo 21, Rome, Italy.. Electronic address:

Background: International literature reports that nursing students feel unprepared when facing patients and families within dying care. They consider their curricula inadequate in teaching end-of-life care and promoting the attitudes required to care for dying patients. Findings of recent studies exploring nursing students' attitudes towards care of the dying patient are often contradictory. Read More

View Article and Full-Text PDF

Self-categorization and autism: Exploring the relationship between autistic traits and group homogeneity.

J Exp Psychol Appl 2021 Jun 17. Epub 2021 Jun 17.

School of Psychology, The University of Queensland.

The Integrated Self-Categorization model of Autism (ISCA; Bertschy et al., 2019; Skorich & Haslam, 2021) argues that the theory of mind differences seen in autism arises from Enhanced Perceptual Functioning/Weak Central Coherence, via a dysfunctional self-categorization mechanism. The ISCA model also makes the novel prediction that phenomena that arise from self-categorization should also be affected in autistic people. Read More

View Article and Full-Text PDF

Survivors of childhood cancer in Latin America: Role of foundations and peer groups in the lack of transition processes to adult long-term follow-up.

Cancer Rep (Hoboken) 2021 Jun 16:e1474. Epub 2021 Jun 16.

University of California, San Francisco, California, USA.

Background: Over the last decade, the population of childhood cancer survivors has rapidly increased in Latin America, opening a long chapter of challenges for healthcare providers in these countries to provide follow-up and adult care.

Aim: In the process of exploring childhood cancer parent and patient engagement in resource-limited settings, we highlight the challenges faced by Latin American survivors from El Salvador, Mexico, and Peru as they transitioned from receiving cancer treatment to life as a cancer survivors.

Methods And Results: Focus group discussions and interviews were performed as part of a larger qualitative study involving 10 low and middle-income countries in four continents regarding patient and caregiver engagement in childhood cancer treatment. Read More

View Article and Full-Text PDF

The Landscape of Microbial Composition and Associated Factors in Pancreatic Ductal Adenocarcinoma Using RNA-Seq Data.

Front Oncol 2021 31;11:651350. Epub 2021 May 31.

Department of General Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China.

Recent research studies on interrogation of the tumor microbiome (including bacteria, viruses, and fungi) have yielded important insights into the role of microbes in carcinogenesis, therapeutic responses, and resistance. Once thought to be a sterile organ, a number of studies have showed the presence of microbes within this organ in PDAC status. A microbiome-pancreas axis for PDAC (pancreatic ductal adenocarcinoma) carcinogenesis is proposed. Read More

View Article and Full-Text PDF

The potential impacts of community drug checking within the overdose crisis: qualitative study exploring the perspective of prospective service users.

BMC Public Health 2021 Jun 16;21(1):1156. Epub 2021 Jun 16.

Canadian Institute for Substance Use Research, University of Victoria, PO Box 1700, STN CSC, Victoria, BC, Canada.

Background: As drug checking becomes more integrated within public health responses to the overdose crisis, and potentially more institutionalized, there is value in critically questioning the impacts of drug checking as a harm reduction response.

Methods: As part of a pilot project to implement community drug checking in Victoria, BC, Canada, in-depth interviews (N = 27) were held with people who use or have used substances, family or friends of people who use substances, and/or people who make or distribute substances. Critical harm reduction and social justice perspectives and a socioecological model guided our analysis to understand the potential role of drug checking within the overdose crisis, from the perspective of prospective service users. Read More

View Article and Full-Text PDF

Hybrid power generation for increasing water and energy securities during drought: Exploring local and regional effects in a semi-arid basin.

J Environ Manage 2021 Jun 12;294:112989. Epub 2021 Jun 12.

Division of Impacts, Adaptation and Vulnerabilities - DIIAV, Brazilian Institute for Space Research - INPE, São José Dos Campos, SP, Brazil.

Reservoirs of hydropower plants (HPP) can amend water, energy, and food security in semi-arid regions. However, during severe droughts, the priority of energy demand leads to critical conditions of water availability. To reduce water use for energy, one possible measure is the adoption of solar power, an abundant energy source in semi-arid regions. Read More

View Article and Full-Text PDF

Negative Magnetoresistance in the GeSn Strip.

ACS Appl Mater Interfaces 2021 Jun 15. Epub 2021 Jun 15.

State Key Laboratory on Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, P. R. China.

Discovery of topological materials associated with an exotic phenomenon has attracted increasing attention in modern condensed matter physics. A typical example is the chiral anomaly proposed in the Dirac or Weyl semimetals. In addition to the well-known topological semimetals, such as TaAs and NaBi, recently, group IV GeSn alloys were also proposed to be Dirac semimetals in theory, demonstrating potential applications compatible with current Si-based technology. Read More

View Article and Full-Text PDF

Metabolic alterations mediated by STAT3 promotes drug persistence in CML.

Leukemia 2021 Jun 12. Epub 2021 Jun 12.

Department of Medicine, Division of Hematology/Oncology, O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA.

Leukemic stem cells (LSCs) can acquire non-mutational resistance following drug treatment leading to therapeutic failure and relapse. However, oncogene-independent mechanisms of drug persistence in LSCs are incompletely understood, which is the primary focus of this study. We integrated proteomics, transcriptomics, and metabolomics to determine the contribution of STAT3 in promoting metabolic changes in tyrosine kinase inhibitor (TKI) persistent chronic myeloid leukemia (CML) cells. Read More

View Article and Full-Text PDF

Novel archetype in psoriasis management bridging molecular dynamics in exploring novel therapies.

Eur J Pharmacol 2021 Jun 9;907:174254. Epub 2021 Jun 9.

University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, 492010, India. Electronic address:

Psoriasis is an autoimmune chronic inflammatory condition of skin affecting 125 million populaces around the globe. It is implicated as a result of multifaceted phenomena involving various cell and subcell activities with the aid of numerous cellular and molecular components including signaling aisle and regulatory proteins owing to the development of such hyperproliferative dermatological conditions. This involves a deeply complex and conflicting pathology owing to genetic and immunological deviations resulting from the unusual presentation of different signaling pathways and regulatory proteins. Read More

View Article and Full-Text PDF

Understanding general practitioners' views and experiences of using clinical prediction rules in the management of respiratory infections: a qualitative study.

BJGP Open 2021 Jun 11. Epub 2021 Jun 11.

Primary Care Research Centre, School of Primary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

Background: Respiratory tract infections (RTIs) account for 60% of antibiotic prescribing in primary care. Several clinical prediction rules (CPRs) have been developed to help reduce unnecessary prescribing for RTIs, but there are a lack of studies exploring whether or how these CPRs are being used in UK general practice.

Aim: To explore UK GPs' views and experiences with regards to RTI CPRs and to identify barriers and facilitators to their use in practice. Read More

View Article and Full-Text PDF

TTSurv: Exploring the Multi-Gene Prognosis in Thousands of Tumors.

Front Oncol 2021 25;11:691310. Epub 2021 May 25.

Department of Gynecology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

Thoracic malignancies are a common type of cancer and area major global health problem. These complex diseases, including lung cancer, esophageal cancer, and breast cancer, etc. have attracted considerable attention from researchers. Read More

View Article and Full-Text PDF

Schema modes and their associations with emotion regulation, mindfulness, and self-compassion among patients with personality disorders.

Borderline Personal Disord Emot Dysregul 2021 Jun 10;8(1):19. Epub 2021 Jun 10.

Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary.

Background: The current study's goal was to examine the multivariate patterns of associations between schema modes and emotion regulation mechanisms in personality disorders. Schema modes are either integrated or dissociative states of mind, including intense emotional states, efforts to regulate emotions, or self-reflective evaluative thought processes. Exploring the multivariate patterns of a shared relationship between schema modes and emotion regulation strategies may lead to a better understanding of their associations and a deeper understanding of the latent personality profiles that organize their associations in a mixed personality disorder sample. Read More

View Article and Full-Text PDF

Exploring collective identity of a group of teaching-oriented academics amid research discourse: a Chinese case.

High Educ (Dordr) 2021 Jun 4:1-18. Epub 2021 Jun 4.

College of Education, University of Canterbury, Christchurch, New Zealand.

This article explores how a group of teaching-oriented academics-College English (CE) teachers in China-negotiate their collective identity at the workplace amid research discourse. Drawing on an integrated theoretical framework focusing on the interrelationship between discourse, practice, and social networks, the study reveals the field of research where CE teachers lived imbued by multiple, dynamic discourses and power relations, i.e. Read More

View Article and Full-Text PDF

Exploring care of hospital inpatients with substance involvement.

Soc Sci Med 2021 May 24;281:114071. Epub 2021 May 24.

St. Joseph's Care Group, Canada. Electronic address:

Introduction: This article presents demographic and care factors related to persons who are substance-involved and require inpatient administration of intravenous antibiotics.

Purpose: This study was conducted to explore healthcare responses to support substance-involved inpatients, through exploration of documented client outcomes, healthcare provider accounts, and representation of clients through documentation.

Method(s): A patient-oriented research team undertook this multiple methods, exploratory study. Read More

View Article and Full-Text PDF

Exploring the synergistic mechanism of Gegen Qinlian Decoction on the Wnt signaling pathway using an integrated strategy of network pharmacology and RNA-seq.

J Ethnopharmacol 2021 Jun 4:114283. Epub 2021 Jun 4.

School of Chinese Materia Medica, Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang District, Beijing, 100029, China. Electronic address:

Ethnopharmacological Relevance: Gegen Qinlian Decoction (GQD) (including: Puerariae lobatae (Willd.) Ohwi, radix; (short for Gengen) Glycyrrhiza uralensis Fisch., root and rhizome (short for Gancao), honeyed; Coptis chinensis Franch. Read More

View Article and Full-Text PDF

Osteosarcopenia in Very Old Age Adults After Hip Fracture: A Real-World Therapeutic Standpoint.

Front Med (Lausanne) 2021 20;8:612506. Epub 2021 May 20.

Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Policlinico San Martino, Genoa, Italy.

Loss of bone and muscle mass and strength (i. e., osteosarcopenia) is a highly prevalent clinical condition in older adults, associated with an increased risk of fragility fractures and unfavorable clinical outcomes. Read More

View Article and Full-Text PDF

Exploring the Challenges of Social-Emotional Learning Integration in Secondary Schools: A Phenomenological Research in Vietnam.

Psychol Res Behav Manag 2021 28;14:621-635. Epub 2021 May 28.

Early Childhood Department, Thai Nguyen University of Education, Thai Nguyen, Vietnam.

Introduction: With the advantage of the restructured education in Vietnam, the social-emotional learning (SEL) framework has been gradually piloting applied into the educational curriculum. However, the SEL integration is only effective in primary school.

Methods: This study applied qualitative phenomenological research, which used in-depth interviews with students and core teachers who have experienced SEL from previous studies to explore and explain the SEL integration is not successful at the secondary level. Read More

View Article and Full-Text PDF

Autonomy and developing physicians: Reimagining supervision using self-determination theory.

Med Educ 2021 Jun 5. Epub 2021 Jun 5.

Program in Professionalism and Values, Mayo Clinic, Rochester, MN, USA.

In this article, we address the question, 'What is the role of autonomy in physician development?' Medical education is a developmental process, and autonomy plays a motivational role in physician development. Calls for increased supervision of residents have raised concerns that the resulting decreased autonomy might interfere with resident development, leading the authors to explore the relationship between supervision and autonomy. The medical education literature posits a simple inverse relationship between supervision and autonomy. Read More

View Article and Full-Text PDF

Clinical insight, cognitive insight and metacognition in psychosis: Evidence of mediation.

J Psychiatr Res 2021 May 23;140:1-6. Epub 2021 May 23.

Mental-Health Clinic, No1 Named After N.A. Alexeev, Zagorodnoye Shosse 2, Moscow, Russia. Electronic address:

Objective: Schizophrenia is increasingly understood as an interactive network of disturbances in different elements of self-awareness. In this study we have examined the relationship between disturbances in two forms of awareness: cognitive insight and clinical insight by exploring whether their relationship is mediated by a third form of larger awareness: metacognition.

Methods: Participants were 41 outpatients with schizophrenia and 37 outpatients with early episode psychosis gathered in Moscow, Russia. Read More

View Article and Full-Text PDF

Factors influencing physical activity engagement following coronary artery bypass graft surgery: A mixed methods systematic review.

Heart Lung 2021 Jun 1;50(5):589-598. Epub 2021 Jun 1.

Centre for Health, Activity and Rehabilitation Research, School of Physiotherapy, Division of Health Sciences, University of Otago, Dunedin, New Zealand. Electronic address:

Background: Engagement in physical activity during the initial months following coronary artery bypass graft (CABG) surgery is important in order to improve health, quality of life and functional outcomes. There are, however, many potential barriers to physical activity engagement during the recovery period. No review studies have focused on barriers and facilitators to engagement in physical activity during the early stages of recovery following CABG surgery. Read More

View Article and Full-Text PDF

Custom Hardware Architectures for Deep Learning on Portable Devices: A Review.

IEEE Trans Neural Netw Learn Syst 2021 Jun 4;PP. Epub 2021 Jun 4.

The staggering innovations and emergence of numerous deep learning (DL) applications have forced researchers to reconsider hardware architecture to accommodate fast and efficient application-specific computations. Applications, such as object detection, image recognition, speech translation, as well as music synthesis and image generation, can be performed with high accuracy at the expense of substantial computational resources using DL. Furthermore, the desire to adopt Industry 4. Read More

View Article and Full-Text PDF

An insight into lung cancer: a comprehensive review exploring ALK TKI and mechanisms of resistance.

Bosn J Basic Med Sci 2021 May 15. Epub 2021 May 15.

Department of Medical Sciences, Pneumology, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj Napoca, Romania.

Implementation of precision medicine in lung cancer has benefited from intense research in the past years, developing subsequently an improved quality of life and increased overall survival of the patients. Targeted therapy has become one of the most important therapeutic innovations for the non-small cell lung cancer (NSCLC) category with anaplastic lymphoma kinase (ALK) gene rearrangement. The aim of this review is to provide a through overview of the main molecules of ALK tyrosine kinase inhibitors (TKI) with their general and particular mechanisms of resistance, the main methods of ALK gene detection, each with advantages and limits and the future perspectives currently under research which try to overcome the mechanisms of resistance. Read More

View Article and Full-Text PDF