428 results match your criteria explorative growth


Young people's Perception of Group Climate in Juvenile Justice Centers in an Australian State, a Pilot Study.

Int J Offender Ther Comp Criminol 2021 Jun 11:306624X211022664. Epub 2021 Jun 11.

Department of Justice and Community Safety, Melbourne, VIC, Australia.

There is ample evidence to demonstrate that a positive group climate in juvenile justice centers contributes to improvements in motivation for positive behavior and reducing incidents and even recidivism. Being provided opportunities for growth and development and being actively supported by well-trained staff creates a positive atmosphere and minimal repression. Such a pedagogical group climate is strongly related to fulfilling the basic psychological needs of the young people and is promoted by relational security. Read More

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Effects of physical exercise on natural killer cell activity during (neo)adjuvant chemotherapy: A randomized pilot study.

Physiol Rep 2021 Jun;9(11):e14919

Department of Physiology, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.

Natural killer (NK) cells are a population of innate immune cells known to play a pivotal role against tumor spread. In multiple murine models, it was shown that physical exercise had the potential to increase NK cell antitumor activity through their mobilization and tissue redistribution in an interleukin (IL)-6 and epinephrine-dependent manner. The translation of this finding to patients is unclear. Read More

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Predicting outcome in acute myocardial infarction: an analysis investigating 175 circulating biomarkers.

Eur Heart J Acute Cardiovasc Care 2021 Jun 7. Epub 2021 Jun 7.

Department of Medical Sciences, Uppsala University, Uppsala 751 85, Sweden.

Aims : There is a paucity of studies comprehensively comparing the prognostic value of larger arrays of biomarkers indicative of different pathobiological axes in acute myocardial infarction (MI).

Methods And Results : In this explorative investigation, we simultaneously analysed 175 circulating biomarkers reflecting different inflammatory traits, coagulation activity, endothelial dysfunction, atherogenesis, myocardial dysfunction and damage, apoptosis, kidney function, glucose-, and lipid metabolism. Measurements were performed in samples from 1099 MI patients (SWEDEHEART registry) applying two newer multimarker panels [Proximity Extension Assay (Olink Bioscience), Multiple Reaction Monitoring mass spectrometry]. Read More

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Prenatal Exposure to Butyl Paraben Is Associated With Fat Percentage in 7-Year-Old Boys.

J Clin Endocrinol Metab 2021 Jun;106(7):e2633-e2638

Department of Clinical Pharmacology, Pharmacy and Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark.

Context: Parabens are used as preservatives in consumer products but are suspected of having endocrine-disrupting properties. A recent study reported an association between in utero exposure to butyl paraben and overweight in childhood, with a stronger trend in girls.

Objective: We therefore studied the association between parabens in maternal urine in third trimester and fat percentage in children aged 7 years. Read More

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Prenatal exposure to bisphenol A and autistic- and ADHD-related symptoms in children aged 2 and5 years from the Odense Child Cohort.

Environ Health 2021 Mar 12;20(1):24. Epub 2021 Mar 12.

Department of Clinical Pharmacology, Pharmacy and Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark.

Background: Bisphenol A (BPA) is a non-persistent chemical with endocrine disrupting abilities used in a variety of consumer products. Fetal exposure to BPA is of concern due to the elevated sensitivity, which particularly relates to the developing brain. Several epidemiological studies have investigated the association between prenatal BPA exposure and neurodevelopment, but the results have been inconclusive. Read More

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The Strategy of Successful Exclusive Breastfeeding of Policewomen in Regional Police Department, East Nusa Tenggara.

J Nutr Sci Vitaminol (Tokyo) 2020 ;66(Supplement):S107-S110

Public Health Faculty, University of Nusa Cendana.

Exclusive breastfeeding is an effort to obtain optimal growth, as breast milk contains essential nutrients required for the growth and development of infants as well as antibodies for the immune system. This study aimed to explore the strategies of successful exclusive breastfeeding among policewomen in East Nusa Tenggara Regional Police. This was a qualitative study with an explorative design consisting of 10 female police as informants. Read More

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January 2020

Cerebrospinal fluid proteome shows disrupted neuronal development in multiple sclerosis.

Sci Rep 2021 Feb 18;11(1):4087. Epub 2021 Feb 18.

Department of Clinical Medicine, University of Bergen, Bergen, Norway.

Despite intensive research, the aetiology of multiple sclerosis (MS) remains unknown. Cerebrospinal fluid proteomics has the potential to reveal mechanisms of MS pathogenesis, but analyses must account for disease heterogeneity. We previously reported explorative multivariate analysis by hierarchical clustering of proteomics data of MS patients and controls, which resulted in two groups of individuals. Read More

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February 2021

Personality and pace-of-life: Ecological lessons learnt from free-ranging lemon sharks.

J Anim Ecol 2021 02;90(2):314-316

Behavioural Ecology, Department of Biology, Ludwig Maximilians University of Munich, Planegg-Martinsried, Germany.

In Focus: Dhellemmes, F., Finger J.S. Read More

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February 2021

Effects of the Prenatal Administration of Tetanus Toxoid on the Sociability and Explorative Behaviors of Rat Offspring: A Preliminary Study.

Clin Psychopharmacol Neurosci 2021 Feb;19(1):84-92

Department of Radiation Oncolgy, Kartal Education and Research Hospital, Turkey.

Objective: Autism spectrum disorder (ASD) is a severely disabling psychiatric disease characterized by impairments in communication and social skills. Although efforts have been made to explore the etiology of ASD, its pathophysiology remains unclear. This issue is rendered more challenging by confounding data about the effects of vaccination on disease etiology. Read More

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February 2021

Latent class growth analyses reveal overrepresentation of dysfunctional fear conditioning trajectories in patients with anxiety-related disorders compared to controls.

J Anxiety Disord 2021 03 18;78:102361. Epub 2021 Jan 18.

Department of Clinical Psychology, Utrecht University, Utrecht, The Netherlands; Altrecht Academic Anxiety Center, Utrecht, The Netherlands; Department of Psychiatry, University Medical Center Groningen and University of Groningen, GGZ Drenthe, Department of Specialist Training, The Netherlands. Electronic address:

Recent meta-analyses indicated differences in fear acquisition and extinction between patients with anxiety-related disorders and comparison subjects. However, these effects are small and may hold for only a subsample of patients. To investigate individual trajectories in fear acquisition and extinction across patients with anxiety-related disorders (N = 104; before treatment) and comparison subjects (N = 93), data from a previous study (Duits et al. Read More

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A centric view of JAK/STAT5 in intestinal homeostasis, infection, and inflammation.

Cytokine 2021 Mar 19;139:155392. Epub 2021 Jan 19.

Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH, USA. Electronic address:

Cytokines, growth factors or hormones take action through the JAK/STAT5 signaling pathway, which plays a critical role in regulating the intestinal response to infection and inflammation. However, the way in which STAT5 regulates intestinal epithelial compartment is largely ignored due to the lack of genetic tools for proper exploration and because the two STAT5 transcription factors (STAT5A and STAT5B) have some redundant but also distinct functions. In this review article, by focusing on STAT5 functions in the intestinal undifferentiated and differentiated epithelia, we discuss major advances of the growth factor/cytokine-JAK/STAT5 research in view of intestinal mucosal inflammation and immunity. Read More

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What a weight loss programme should contain if people with obesity were asked - a qualitative analysis within the DO:IT study.

BMC Public Health 2021 01 6;21(1):28. Epub 2021 Jan 6.

Department of Public Health, University of Southern Denmark, JB Winsløwsvej 9A, 5000, Odense C, Denmark.

Background: Currently 1.9 billion adults worldwide are estimated to be overweight or obese. In Denmark the municipalities hold the responsibility to deliver weight loss programmes to overweight and obese citizens. Read More

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January 2021

The Putative Role of 1,25(OH)D in the Association of Milk Consumption and Parkinson's Disease.

Neurosignals 2020 12;28(1):14-24

Institute of Medical Genetics and Applied Genomics, NGS Competence Centre Tübingen (NCCT), Eberhard-Karls-University of Tübingen, Tübingen, Germany.

The consumption of dairy products, particularly of low fat milk, has been shown to be associated with the occurrence of Parkinson's disease. This association does not necessarily reflect a pathophysiological role of milk intake in the development of Parkinson's disease. Nevertheless, the present review discusses a potential mechanism possibly mediating an effect of milk consumption on Parkinson's disease. Read More

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December 2020

The Putative Role of 1,25(OH)D in the Association of Milk Consumption and Parkinson's Disease.

Neurosignals 2020 12;28(1):14-24

Institute of Medical Genetics and Applied Genomics, NGS Competence Centre Tübingen (NCCT), Eberhard-Karls-University of Tübingen, Tübingen, Germany.

The consumption of dairy products, particularly of low fat milk, has been shown to be associated with the occurrence of Parkinson's disease. This association does not necessarily reflect a pathophysiological role of milk intake in the development of Parkinson's disease. Nevertheless, the present review discusses a potential mechanism possibly mediating an effect of milk consumption on Parkinson's disease. Read More

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December 2020

Optical coherence tomography angiography measured area of retinal neovascularization is predictive of treatment response and progression of disease in patients with proliferative diabetic retinopathy.

Int J Retina Vitreous 2020 Nov 4;6(1):49. Epub 2020 Nov 4.

Department of Ophthalmology, Odense University Hospital, Kloevervaenget 5, indgang 132, 5000, Odense C, Denmark.

Background: The purpose of this study was to evaluate the area of retinal neovascularization in patients with treatment-naïve proliferative diabetic retinopathy (PDR) as measured by optical coherence tomography angiography (OCT-A) as a marker of subsequent treatment response after panretinal photocoagulation (PRP), and to examine if this area correlated with area of retinal neovascularization as measured by fluorescein angiography (FA).

Methods: En face OCT-A scans (4.5 × 4. Read More

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November 2020

The mediating role of insomnia severity in internet-based cognitive behavioral therapy for chronic stress: Secondary analysis of a randomized controlled trial.

Behav Res Ther 2021 01 27;136:103782. Epub 2020 Nov 27.

Department of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, Stockholm, Sweden; Osher Center for Integrative Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

The aim of this study was to investigate insomnia symptom severity as a putative mediator of treatment response in therapist-guided internet-based cognitive behavioral therapy (ICBT) for chronic stress, using data from a randomized controlled trial. Participants (N = 100) were randomized to 12 weeks of ICBT or to a waitlist control condition (WLC). Insomnia severity was assessed weekly with the Insomnia Severity Index (ISI), as were the stress-related outcomes the Perceived Stress Scale (PSS) and the Shirom-Melamed Burnout Questionnaire (SMBQ). Read More

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January 2021

Effect of contact incubation on stress, behavior and body composition in the precocial Red jungle fowl.

Horm Behav 2021 Feb 26;128:104892. Epub 2020 Nov 26.

AVIAN Behavioural Physiology and Genomics Group, IFM Biology, Linköping University, Linköping, Sweden.

Birds use contact incubation to warm their eggs above ambient temperature required for embryonic development. In contrast, birds in the industry as well as many birds in breeding programs and scientific studies are incubated in conventional incubators that warm eggs via circulating warm air. This means that contact incubated eggs have different thermal properties than eggs incubated in a conventional incubator. Read More

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February 2021

Indigenous village chicken production: a tool for poverty alleviation, the empowerment of women, and rural development.

Trop Anim Health Prod 2020 Nov 13;53(1). Epub 2020 Nov 13.

Department of Biology, College of Natural and Computational Science, Kotebe Metropolitan University, Addis Ababa, Ethiopia.

Indigenous village chickens (IVCs) greatly contribute to food security and rural development. Consequently, IVCs cover incidental expenses, economically empower women, and support the livelihood of disadvantaged groups. Interestingly, ritual practices of traditional communities across the Global South utilise IVCs. Read More

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November 2020

Exploration of Barriers to the Uptake of Nutritional Services Among Adolescent Girls from the Rural Communities of Tigray Region, Northern Ethiopia: A Qualitative Study.

Adolesc Health Med Ther 2020 22;11:157-171. Epub 2020 Oct 22.

Department of Nutrition and Dietetics, School of Public Health, College of Health Sciences, Mekelle University, Mekelle, Ethiopia.

Background: Adolescence is a time of tremendous physical growth and mental development, with high nutrient requirements. Ethiopia is among the countries with a high prevalence of nutritional deficiencies among the women of reproductive age group, whilst adolescent girls from rural areas suffered disproportionately. However, there is a dearth of evidence regarding the barriers that hinder adolescent girls to utilize the available nutritional services. Read More

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October 2020

Occurrence of Fibrotic Tumor Vessels in Grade I Meningiomas Is Strongly Associated with Vessel Density, Expression of VEGF, PlGF, IGFBP-3 and Tumor Recurrence.

Cancers (Basel) 2020 Oct 21;12(10). Epub 2020 Oct 21.

Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.

Angiogenesis is a key feature during oncogenesis and remains a potential target of antiangiogenic therapy. While commonly described in high-grade lesions, vascularization and its correlation with prognosis in grade I meningiomas is largely unexplored. In the histological classification, not only the number but also the composition of blood vessels seems to be important. Read More

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October 2020

Growth trajectories of the human fetal brain in healthy and complicated pregnancies and associations with neurodevelopmental outcome in the early life course.

Early Hum Dev 2020 12 12;151:105224. Epub 2020 Oct 12.

Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Center, 3000, CA, Rotterdam, the Netherlands; Department of Pediatrics, Division of Neonatology, Sophia Children's Hospital, 3000, CA, Rotterdam, the Netherlands. Electronic address:

Background: There is a need for non-invasive prenatal markers of the brain to assess fetuses at risk for poor postnatal neurodevelopmental outcome. Periconceptional maternal conditions and pregnancy complications impact prenatal brain development.

Aims: To investigate associations between growth trajectories of fetal brain structures and neurodevelopmental outcome in children in the early life course. Read More

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December 2020

Prognostic impact of serum levels of EGFR and EGFR ligands in early-stage breast cancer.

Sci Rep 2020 10 6;10(1):16558. Epub 2020 Oct 6.

Department of Biochemistry and Immunology, Lillebaelt Hospital, University Hospital of Southern Denmark, Vejle, Denmark.

Epidermal growth factor receptor (EGFR) and its ligands are involved in cancer pathogenesis. The emerging role of treatments co-targeting the EGFR system in breast cancer has increased the need to identify companion biomarkers. The aim of this study is to investigate whether pretreatment serum levels of EGFR and EGFR ligands in early-stage breast cancer patients might provide prognostic information as a stepping stone for further investigation. Read More

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October 2020

Personality-driven life history trade-offs differ in two subpopulations of free-ranging predators.

J Anim Ecol 2021 01 27;90(1):260-272. Epub 2020 Jul 27.

Leibniz-Institute of Freshwater Ecology and Inland Fisheries, Berlin, Germany.

Consistent individual differences in behaviour (i.e. personality) can be explained in an evolutionary context if they are favoured by life history trade-offs as conceptualized in the pace-of-life syndrome (POLS) hypothesis. Read More

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January 2021

Effects of a Multidisciplinary Residential Nutritional Rehabilitation Program in Head and Neck Cancer Survivors-Results from the NUTRI-HAB Randomized Controlled Trial.

Nutrients 2020 Jul 17;12(7). Epub 2020 Jul 17.

REHPA, The Danish Knowledge Centre for Rehabilitation and Palliative Care, Odense University Hospital, and Department of Clinical Research, University of Southern Denmark, Vestergade 17, 5800 Nyborg, Denmark.

Head and neck cancer survivors frequently experience nutritional challenges, and proper rehabilitation should be offered. The trial objective was to test the effect of a multidisciplinary residential nutritional rehabilitation programme addressing physical, psychological, and social aspects of eating problems after treatment. In a randomized controlled trial, 71 head and neck cancer survivors recruited through a nationwide survey were randomized to the program or a wait-list control group. Read More

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Ganglioneuroma of Glossopharyngeal Nerve in a Patient with Glossopharyngeal Neuralgia: A Case Report.

NMC Case Rep J 2020 Jul 24;7(3):117-120. Epub 2020 Jun 24.

National Institute of Neurosciences and Hospital, Dhaka, Bangladesh.

Ganglioneuroma is a rare tumor. Such tumor arising from cranial nerve is further rare. So far our knowledge, in the literature there is no report of ganglioneuroma involving glossopharyngeal nerve. Read More

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Pathophysiology of Intracranial Aneurysms: COX-2 Expression, Iron Deposition in Aneurysm Wall, and Correlation With Magnetic Resonance Imaging.

Stroke 2020 08 10;51(8):2505-2513. Epub 2020 Jul 10.

Department of Neurosurgery (J.R., B.C., D.P., P.D., M.D.O., Y.Z., R.J., U.S., K.H.W.), University Hospital Essen, Germany.

Background And Purpose: The pathophysiology of development, growth, and rupture of intracranial aneurysms (IAs) is only partly understood. Cyclooxygenase 2 (COX-2) converts arachidonic acid to prostaglandin H, which, in turn, is isomerized to prostaglandin E. In the human body, COX-2 plays an essential role in inflammatory pathways. Read More

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ERGO2: A Prospective, Randomized Trial of Calorie-Restricted Ketogenic Diet and Fasting in Addition to Reirradiation for Malignant Glioma.

Int J Radiat Oncol Biol Phys 2020 11 30;108(4):987-995. Epub 2020 Jun 30.

Dr Senckenberg Institute of Neurooncology, University Hospital Frankfurt, Goethe University, Frankfurt, Germany; Interdisciplinary Division of Neuro-Oncology, University Hospital Tübingen, Tübingen, Germany.

Purpose: ERGO2 is the first randomized clinical trial on a calorically restricted ketogenic diet (KD) and intermittent fasting (KD-IF) in addition to reirradiation for recurrent malignant gliomas.

Methods And Materials: Fifty patients were randomized 1:1 to reirradiation combined with either a calorically unrestricted diet or KD-IF. The KD-IF schedule included 3 days of KD (21-23 kcal/kg/d), followed by 3 days of fasting and again 3 days of KD. Read More

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November 2020

Acute Neurofilament Light Chain Plasma Levels Correlate With Stroke Severity and Clinical Outcome in Ischemic Stroke Patients.

Front Neurol 2020 11;11:448. Epub 2020 Jun 11.

Department of Neurology, Odense University Hospital, Odense, Denmark.

Ischemic stroke causes increased blood-brain barrier permeability and release of markers of axonal damage and inflammation. To investigate diagnostic and prognostic roles of neurofilament light chain (NF-L), we assessed levels of NF-L, S100B, interleukin-6 (IL-6), E-selectin, vascular endothelial growth factor-A (VEGF-A), vascular cell adhesion molecule-1 (VCAM-1), and intercellular adhesion molecule-1 (ICAM-1) in patients with acute ischemic stroke or transient ischemic attack (TIA) and healthy controls. We studied neurofilament (NF) expression in 2 cases of human postmortem ischemic stroke, representing infarcts aged 3- to >7-days. Read More

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Trait-based approaches reveal fungal adaptations to nutrient-limiting conditions.

Environ Microbiol 2020 08 8;22(8):3548-3560. Epub 2020 Jul 8.

Institute of Biology, Freie Universität Berlin, Berlin, Altensteinstr. 6, 14195, Germany.

The dependency of microbial activity on nutrient availability in soil is only partly understood, but highly relevant for nutrient cycling dynamics. In order to achieve more insight on microbial adaptations to nutrient limiting conditions, precise physiological knowledge is needed. Therefore, we developed an experimental system assessing traits of 16 saprobic fungal isolates in nitrogen (N) limited conditions. Read More

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Blood Pressure and Angiogenic Markers in Pregnancy: Contributors to Pregnancy-Induced Hypertension and Offspring Cardiovascular Risk.

Hypertension 2020 09 8;76(3):901-909. Epub 2020 Jun 8.

Department of Obstetrics and Gynecology, Odense University Hospital, Odense, Denmark (A. Birukov, J.S.J., L.B.A.).

Pregnancy-induced hypertension is a severe pregnancy complication, increasing risk of long-term cardiovascular disease in mothers and offspring. We hypothesized that maternal blood pressure in pregnancy associated with offspring blood pressure; that the associations were sex-specific; and that maternal circulating placental angiogenic markers (PlGF [placental growth factor] and sFlt-1 [soluble fms-like tyrosine kinase-1]) mediated this relationship. We analyzed data from 2434 women and 2217 children from the Odense Child Cohort, a prospective Danish cohort study. Read More

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September 2020