Stroke 2020 08 10;51(8):2505-2513. Epub 2020 Jul 10.
Department of Neurosurgery (J.R., B.C., D.P., P.D., M.D.O., Y.Z., R.J., U.S., K.H.W.), University Hospital Essen, Germany.
Background And Purpose: The pathophysiology of development, growth, and rupture of intracranial aneurysms (IAs) is only partly understood. Cyclooxygenase 2 (COX-2) converts arachidonic acid to prostaglandin H, which, in turn, is isomerized to prostaglandin E. In the human body, COX-2 plays an essential role in inflammatory pathways. Read More