627 results match your criteria experimental dentifrices


Effect of dentifrice slurry abrasivity and erosive challenge on simulated non-carious cervical lesions development in vitro.

J Oral Sci 2021 ;63(2):191-194

Department of Cariology, Operative Dentistry, and Dental Public Health, School of Dentistry, Indiana University, Oral Health Research Institute.

Purpose: To investigate the effect of slurry abrasive levels and acidic challenges on the development of non-carious cervical lesions.

Methods: Ninety-six extracted upper premolars were affixed in pairs to acrylic blocks and had their root surfaces covered by acrylic resin except for 2 mm from the cemento-enamel junction. The specimens were distributed into six groups (n = 8 pairs) based on two experimental factors: (1) slurry abrasivity level [low/medium/high] and (2) citric acid challenge [yes/no]. Read More

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Investigation of oral malodor prevention by dentifrices as measured by VSC reduction.

J Breath Res 2021 Mar 25. Epub 2021 Mar 25.

Procter and Gamble Co, 8700 Mason-Montgomery Road, Mason, Ohio, 45040, UNITED STATES.

The oral malodor reduction efficacy of dentifrices containing stannous fluoride (SnF2) or zinc plus arginine (Zn/Arg) was evaluated using a halimeter to measure volatile sulfur compounds (VSCs) in two randomized, controlled, single-blind, cross-over pilot clinical trials. Study 1 (N=16) had five 1100 ppm F dentifrices and five treatment periods: Negative Control (NC): 0.243% sodium fluoride (NaF); SnF2 A: 0. Read More

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Efficacy of an Experimental Occlusion Technology Toothpaste in the Relief of Dentinal Hypersensitivity: An 8-week Randomised Controlled Trial.

Oral Health Prev Dent 2021 Jan;19(1):195-202

Purpose: A novel anhydrous toothpaste formulation has been developed containing the anti-dentinal hypersensitivity (DH) ingredient stannous fluoride (SnF2).

Materials And Methods: This randomised, controlled, examiner-blind, parallel-group, stratified (by baseline Schiff sensitivity score) study compared efficacy of an experimental 'Test' toothpaste (n = 67) containing 0.454% SnF2, 0. Read More

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January 2021

In vitro efficacy of commercial and experimental proteolytic enzyme-based whitening dentifrices on enamel whitening and superficial roughness.

J Esthet Restor Dent 2020 Dec 5. Epub 2020 Dec 5.

Graduate Program in Dentistry, School of Dentistry, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.

Objective: To evaluate the whiteness index (W ) and surface roughness (Ra) of bovine enamel after simulated tooth brushing with different commercial and experimental whitening dentifrices.

Materials And Methods: Cylindrical enamel bovine specimens were acid etched, stained, and divided in nine groups (n = 8): Colgate® Optic White®, Crest® Baking Soda and Peroxide, Arm and Hammer® Advanced White™ Extreme Whitening, Rembrandt® Deeply White® + Peroxide, Close up® White Attraction Natural Glow, Hinode Prowhite, and experimental dentifrice containing papain (PP), bromelain (PB), or papain and bromelain (PPB). Ra and W were obtained initially and after 600, 1200, and 3,600 cycles of simulated tooth brushing. Read More

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December 2020

Nanoencapsulated fluoride as a remineralization option for dental erosion: an study.

Acta Odontol Scand 2020 Nov 27:1-6. Epub 2020 Nov 27.

Clinical and Social Dentistry Department, Federal University of Paraíba, João Pessoa, Brazil.

Objective: To compare the performance of different dentifrices indicated for dental erosion and a new dentifrice with controlled fluoride release system (NanoF) in terms of surface microhardness remineralization in enamel erosion lesions.

Materials And Methods: 72 human enamel specimens were divided into 6 groups ( = 12): PC (100% NaF - positive control); NC (Placebo - negative control); 50%nF (50% NanoF + 50% free NaF), 100%nF (100% NanoF); PN (Sensodyne ProNamel™) and AG (Colgate Sensitive Pro-Relief™). A surface microhardness analysis was performed before (SH) and after (SH) the erosion lesion formation. Read More

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November 2020

Development of an Experimental Dentifrice with Hydroxyapatite Nanoparticles and High Fluoride Concentration to Manage Root Dentin Demineralization.

Int J Nanomedicine 2020 5;15:7469-7479. Epub 2020 Oct 5.

Department of Restorative Dentistry, Federal University of Piaui, Teresina, Piauí, Brazil.

Background: High-fluoride dentifrice is used to manage root caries, but there is no evidence whether its association with nanohydroxyapatite could provide an additional protection for root caries. Therefore, this study aimed to develop and evaluate the effect of an experimental dentifrice with high fluoride (F) concentration and nanohydroxyapatite (nano-HA) on root dentin demineralization.

Materials And Methods: After formulation of dentifrices, root dentin specimens were randomly assigned to six groups (n = 10) using different dentifrice treatments: placebo; nano-HA without F; 1,100 µg F/g; 1,100 µg F/g + nano-HA; 5,000 µg F/g; and 5,000 µg F/g + nano-HA. Read More

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December 2020

Remineralization of enamel subsurface lesions using toothpaste containing tricalcium phosphate and fluoride: an in vitro µCT analysis.

BMC Oral Health 2020 10 27;20(1):292. Epub 2020 Oct 27.

Department of Operative Dentistry, Cariology and Pulp Biology, Tokyo Dental College, 2-9-18, Kanda-Misakicho, Chiyoda-ku, Tokyo, 101-0061, Japan.

Background: This study aimed to compare the efficacies of experimental toothpastes containing functionalized tricalcium phosphate (fTCP) with and without fluoride for in vitro enamel remineralization under pH-cycling conditions.

Methods: To create artificial white spot lesions, 36 bovine enamel specimens were immersed in a demineralization solution for 10 days. During pH-cycling for 12 days, the specimens were divided into four groups based on the experimental toothpaste type used: (a) fTCP-free, fluoride-free (fTCP - F -); (b) fTCP-containing, fluoride-free (fTCP + F -); (c) fTCP-free, fluoride-containing (fTCP - F +); and (d) fTCP-containing, fluoride-containing (fTCP + F +). Read More

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October 2020

Dose-Response Effect of Fluoride Dentifrices on De-/Remineralization of Root Dentine in situ.

Caries Res 2020 19;54(5-6):502-508. Epub 2020 Oct 19.

Department of Restorative Dentistry, Federal University of Piaui, Teresina, Brazil,

The present study aimed to evaluate the effect of fluoride (F) dentifrice with different F concentrations on root dentine de-/remineralization. Ten healthy volunteers took part in this randomized, double-blinded, cross-over, and split-mouth in situ experimental study. During 4 phases of 7 days, they wore a palatal appliance containing 4 bovine dentine blocks (2 sound and 2 with caries) of 4 × 4 × 2 mm. Read More

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October 2020

Antimicrobial activity of effervescent denture tablets on multispecies biofilms.

Gerodontology 2021 Mar 30;38(1):87-94. Epub 2020 Sep 30.

Department of Dental Materials and Prosthodontics, Dental School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.

Purpose: To investigate the impact of peroxide-based solutions in reducing viability and metabolic activity of multispecies biofilms on denture base acrylic resin surfaces and for removing them from these surfaces.

Background: Denture cleansers are effective in reducing monospecies biofilm; however, studies evaluating their action on multispecies biofilms are scarce.

Materials And Methods: Sixty-nine denture base acrylic resin specimens (Ø 15 × 3 mm) were sterilised then contaminated with Candida albicans, Staphylococcus aureus and Pseudomonas aeruginosa to form multispecies biofilms. Read More

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Effects of toothpaste containing surface pre-reacted glass-ionomer (S-PRG) filler on crystallinity and acid resistance of hydroxyapatite.

Am J Dent 2020 Aug;33(4):183-186

Department of Conservative Dentistry, Institute of Biomedical Sciences, Tokushima University Graduate School, Kuramoto, Tokushima, Japan.

Purpose: To examine the acid resistance of experimental toothpaste containing different wt% of surface pre-reacted glass-ionomer (S-PRG) filler.

Methods: Hydroxyapatite (HAP) pellets were treated with toothpaste containing 0, 1, 5, 10, 20, or 30 wt% S-PRG filler for 5 minutes. A demineralization and remineralization cycle was repeated for 7 days. Read More

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Efficacy of a Stannous-containing Dentifrice for Protecting Against Combined Erosive and Abrasive Tooth Wear In Situ.

Oral Health Prev Dent 2020 Jun 8;18(1):619-624. Epub 2020 Jun 8.

Purpose: The in-situ efficacy of an experimental stannous (Sn)-containing sodium fluoride (NaF) dentifrice against erosion and erosive tooth wear was compared with a conventional NaF dentifrice.

Materials And Methods: This was a randomised, controlled, double-blind, parallel-group clinical trial. Mandibular appliances containing four enamel specimens (2 per side [L/R] of the appliance) were worn by 60 generally healthy adult subjects. Read More

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Remote psychophysical evaluation of olfactory and gustatory functions in early-stage coronavirus disease 2019 patients: the Bologna experience of 300 cases.

J Laryngol Otol 2020 Jul 28;134(7):571-576. Epub 2020 Jul 28.

Maxillofacial Surgery Operative Unit, University Hospital of Sassari, Italy.

Background: An objective evaluation of coronavirus disease 2019 in the first days of infection is almost impossible, as affected individuals are generally in home quarantine, and there is limited accessibility for the operator who should perform the test. To overcome this limitation, a recently validated psychophysical self-administered test was used, which can be performed remotely in the assessment of early-stage coronavirus disease 2019 patients.

Methods: Olfactory and gustatory functions were objectively assessed in 300 patients in the first 7 days from coronavirus disease 2019 symptom onset. Read More

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Oral biofilm uptake of mineral ions released from experimental toothpaste containing surface pre-reacted glass-ionomer (S-PRG) filler.

Arch Oral Biol 2020 Sep 27;117:104777. Epub 2020 May 27.

Department of Preventive Dentistry and Dental Public Health, School of Dentistry, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya 464-8650, Japan.

Objective: To clarify the fluoride/mineral kinetics in an oral biofilm following concurrent application of fluoride and other mineral ions released from experimental toothpaste containing S-PRG filler using depth-specific analysis.

Study Design: Twenty subjects wore in situ plaque-generating devices, comprised of a pair of enamel slabs, and a biofilm was allowed to form. The devices were removed after three days, immersed in the toothpaste filtrate containing Al, B, Sr and F ions for 1 min, and then reinserted at the same location. Read More

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September 2020

Effect of nanohydroxyapatite associated with photobiomodulation in the control of dentin hypersensitivity: A randomized, double-blind, placebo-controlled clinical trial.

Am J Dent 2020 Jun;33(3):138-144

School of Dentistry, Federal University of Para, Belem, PA, Brazil,

Purpose: To evaluate the effect of nanohydroxyapatite ( nHAP) associated with photobiomodulation (PBM) in the control of dentin hypersensitivity (DH). (C-Shape It).

Methods: 32 subjects with 83 hypersensitive teeth were randomized into four groups (N =8) : GPlacebo - simulated PBM (without light emission) followed by the application of nHAP-free toothpaste; GLaser - PBM followed by the application of nHAP-free toothpaste; GnHAP - simulated PBM followed by the application of nHAP; GLasernHAP - PBM followed by the application of nHAP. Read More

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In vitro effect of children's toothpaste on brushing abrasion of eroded primary enamel.

Eur Arch Paediatr Dent 2021 Apr 18;22(2):157-162. Epub 2020 May 18.

Departament of Academic Master's Degree in Dental Sciences, Christus University Center-Unichristus, Fortaleza, CE, Brazil.

Purpose: Emerging data have suggested that acid erosion has become an increasing clinical problem in pediatric dentistry. This study aimed to investigate the abrasive effects of two commercial toothpastes on primary enamel eroded by orange juice using an in vitro model.

Methods: Thirty enamel slabs were obtained from primary teeth and then randomly assigned to three groups (n = 8) comprising two different toothpastes: G1-control-distilled water; G2-Dentifrice A (containing no fluoride); and G3-Dentifrice B (1. Read More

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In situ efficacy of an experimental toothpaste on enamel rehardening and prevention of demineralisation: a randomised, controlled trial.

BMC Oral Health 2020 04 17;20(1):118. Epub 2020 Apr 17.

Department of Cariology, Operative Dentistry and Dental Public Health and Oral Health Research Institute, Indiana University School of Dentistry, 415 Lansing Street, Indianapolis, IN, 46202, USA.

Background: A novel sodium fluoride toothpaste containing lactate ion and polyvinylmethylether-maleic anhydride has been developed to promote enamel remineralisation and resistance to demineralisation. In this in situ study, we compared this toothpaste ('Test') with a stannous fluoride-zinc citrate (SnF-Zn) toothpaste ('Reference') (both 1100-1150 ppm fluoride) and a fluoride-free toothpaste ('Placebo') using an enamel dental erosion-rehardening model.

Methods: In each phase of this randomised, investigator-blind, crossover study, participants wore palatal appliances holding bovine enamel specimens with erosive lesions. Read More

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Gingivitis efficacy of a 0.454% w/w stannous fluoride dentifrice: a 24-week randomized controlled trial.

BMC Oral Health 2020 03 26;20(1):89. Epub 2020 Mar 26.

Salus Research, Inc., Fort Wayne, IN, USA.

Background: Plaque-induced gingivitis can be prevented and treated with regular effective oral hygiene, principally via mechanical cleaning with regular toothbrushing. To complement the mechanical plaque removal, antimicrobial ingredients can be incorporated into dentifrices to inhibit the growth of plaque. This study aimed to evaluate and compare gingivitis and the proportion of subjects moving between gingivitis severity (< 10, > 10 < 30, > 30% bleeding sites), and plaque reduction, following twice daily use of an experimental non-aqueous 0. Read More

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HMU Fluorinze Mouthwash Enhances Enamel Remineralization: An In Vitro Study.

Open Access Maced J Med Sci 2019 Dec 20;7(24):4319-4323. Epub 2019 Dec 20.

Department of Human and Animal Physiology, Faculty of Biology, Hanoi National University of Education, Hanoi, Vietnam.

Background: Fluoride therapy has long been used extensively to prevent dental caries. Fluoride appears in a variety of dental care products such as mouth rinses, dentifrices, gels, etc. HMU Fluorinze is the first mouthwash containing fluoride in Vietnam. Read More

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December 2019

Effectiveness of Thymoquinone and Fluoridated Bioactive Glass/Nano-Oxide Contained Dentifrices on Abrasion and Dentine Tubules Occlusion: An Ex Vivo Study.

Eur J Dent 2020 Feb 13;14(1):45-54. Epub 2020 Mar 13.

Department of Restorative Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Objectives:  Dentin hypersensitivity (DH) is mainly due to the loss and replenishment of minerals from tooth structure, where the lost minerals can be rehabilitated with a biomimetic approach. The objectives were to determine the relative dentin abrasivity (RDA) of experimental (EXT) dentifrices and to determine the efficacy to occlude dentinal tubules.

Materials And Methods:  Experimental dentifrices contained nano-fluoridated bioactive glass (n-FBG: 1. Read More

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February 2020

Re- and demineralization characteristics of dentin depending on fluoride application and baseline characteristics in situ.

J Dent 2020 03 26;94:103305. Epub 2020 Feb 26.

Department of Restorative, Preventive and Pediatric Dentistry, School of Dental Medicine, University of Bern, 3010 Bern, Switzerland.

Objectives: The aim of this double-blinded, randomized, cross-over in situ study was to evaluate the re- and demineralization characteristics of sound dentin as well as highly and lowly demineralized dentin after the application of different fluoride concentrations.

Methods: In each of four experimental legs of four weeks 20 participants wore intraoral mandibular appliances containing two (highly demineralized [E]) bovine enamel and four (lowly and highly demineralized [D,D]) bovine dentin specimens (n = 480). Each specimen included one sound (ST) and one demineralized lesion area (DT). Read More

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Comparative Fluoride Release and Antimicrobial Analysis of Commercial and Experimental Bioactive Glass/Nano-Oxide-Based Dentifrices.

Eur J Dent 2020 Feb 4;14(1):38-44. Epub 2020 Feb 4.

Department of Restorative Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Objectives:  The objectives were to measure fluoride release and assess the antimicrobial behavior of fluoride-doped nano bioactive glass (F-nBG) and nano zinc oxide (ZnO)-enriched novel dentifrices.

Materials And Methods:  Experimental dentifrices were synthesized by incorporating ZnO nanoparticles and F-nBG (1.5 wt% and 4 wt%) as active ingredients. Read More

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February 2020

Hydrazone Based Dual - Responsive Colorimetric and Ratiometric Chemosensor for the Detection of Cu/F Ions: DNA Tracking, Practical Performance in Environmental Samples and Tooth Paste.

J Fluoresc 2020 Mar 29;30(2):275-289. Epub 2020 Jan 29.

Department of Inorganic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu, 625 021, India.

Colorimetric sensors have attracted wide scope of attentions due to its fascinating advantages, like handy, equipment-free and naked eye detections. In this investigation, a new and novel hydrazone based dual-responsive ratiometric/colorimetric chemosensor have been developed for highly selective and sensitive detection of Cu and F ions in dimethyl sulfoxide (DMSO) solvent. The probe showed highly selective sensing towards Cu and F ions by exhibiting a color change from pale yellow to yellowish green and pale yellow to yellowish brown respectively. Read More

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Development of New Experimental Dentifrice of Peruvian (Tocosh) Fermented by Water Stress: Antibacterial and Cytotoxic Activity.

J Contemp Dent Pract 2019 Oct 1;20(10):1206-1211. Epub 2019 Oct 1.

Academic Department of Medicine and Buccomaxillofacial Surgery, Faculty of Stomatology, Universidad Peruana Cayetano Heredia, Lima, Peru.

Aim: "Tocosh" is a potato that has undergone a process of hydraulic oxidation that enhances its antimicrobial properties so that this natural resource can be used in medical sciences. The aim of this study was to develop and evaluate the antibacterial and cytotoxic activity of a new experimental tooth based on "Tocosh" on the cell lines 3T3 and DU145.

Materials And Methods: To evaluate the cytotoxicity, cell cultures 3T3 and DU145 were used. Read More

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October 2019

Influence of pure fluorides and stannous ions on the initial bacterial colonization in situ.

Sci Rep 2019 12 6;9(1):18499. Epub 2019 Dec 6.

Clinic of Operative Dentistry, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, D-01307, Dresden, Germany.

The present clinical-experimental study aims to examine the effect of pure experimental fluoride solutions and stannous chloride on the initial oral bioadhesion under in situ conditions. After 1 min of pellicle formation on bovine enamel slabs, 12 subjects rinsed with 8 ml of the fluoride test solutions (NaF, NaPOF, AmF, SnF,) with 500 ppm fluoride concentration each for 1 min. Additionally, rinsing without a solution (control) and rinsing with 1563 ppm SnCl solution took place for 1 min. Read More

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December 2019

Influence of cigarette smoke combined with different toothpastes on enamel erosion.

Braz Oral Res 2019 2;33:e114. Epub 2019 Dec 2.

Universidade Estadual de Campinas - Unicamp, Piracicaba Dental School, Department of Restorative Dentistry, Piracicaba, SP, Brazil.

This in vitro study aimed to evaluate the effect of different toothpastes on dental enamel subjected to an erosive cycle with and without exposure to cigarette smoke. Bovine enamel specimens were randomly allocated into 12 groups (n = 12). For the in vitro simulation of smoking, half the groups underwent an exposure cycle of 20 cigarettes per day for 5 days. Read More

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December 2019

Comparative evaluation of combined remineralization agents on demineralized tooth surface.

Niger J Clin Pract 2019 Nov;22(11):1546-1552

Department of Pediatric Dentistry, Faculty of Dentistry, Harran University, Sanliurfa, Turkey.

Objectives: The aim of this in vitro study was to evaluate the effects of casein phosphopeptides (CPP)-ACPF, NovaMin+ fluoride-containing toothpaste and Xylitol+ fluoride containing cream on demineralized areas on the enamel surface.

Materials And Methods: A total of 100 enamel slab samples was prepared to investigate in the laboratory experiments. For this purpose, a total of 50 freshly extracted third molar teeth which completed root formation split into two portions in the mesiodistal direction. Read More

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November 2019

Dentin Tubule Occlusion Potential of Novel Dentifrices Having Fluoride Containing Bioactive Glass and Zinc Oxide Nanoparticles.

Med Princ Pract 2020 5;29(4):338-346. Epub 2019 Nov 5.

Center of Excellence in Nanotechnology, King Fahd University of Petroleum and Minerals, Dhahran, Saudi Arabia.

Objective: To compare the in vitro potential of dentin tubule occlusion of two novel experimental dentifrices consisting of fluoride containing bioactive glass (BG) with zinc oxide nanoparticles.

Materials And Methods: Forty-eight dentin discs (n = 48) were divided into 6 groups (n = 8), based on their brushing dentifrices: Group 1 = artificial saliva (AS; control); Group 2 = fluoride dentifrice (Colgate Palmolive©, UK); Group 3 = experimental nonactive agent dentifrice; Group 4 = experimental dentifrice with 1.5% BG; Group 5 = experimental dentifrice with 4% BG; and Group 6 = BioMinF© dentifrice. Read More

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November 2019

In vitro evaluation of the effectiveness of alkaline peroxide solutions in reducing the viability of specific biofilms.

Am J Dent 2019 Aug;32(4):201-207

Department of Dental Materials and Prosthesis, School of Dentistry of Ribeirão Preto, USP - University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Purpose: To evaluate in vitro the effectiveness of eight different cleansers containing alkaline peroxide against yeast [Candida albicans (Ca) and Candida glabrata (Cg) ], Gram-negative bacteria [Escherichia coli (Ec) and Pseudomonas aeruginosa (Pa) ], and Gram-positive bacteria [ Bacillus subtilis (Bs), Enterococcus faecalis (Ef), Staphylococcus aureus (Sa), and Streptococcus mutans (Sm) ].

Methods: Denture base acrylic resin specimens (Lucitone 550; 1264 denture base acrylic resin specimens) were obtained from a circular metal matrix (15 x 3 mm) and sterilized with microwave irradiation (650 W, 6 minutes). The specimens were contaminated with 10⁶ CFU/mL suspension of yeasts and 10⁸ CFU/mL suspensions of Gram-positive and -negative bacteria. Read More

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Effects of Active Oxygen Toothpaste in Supragingival Biofilm Reduction: A Randomized Controlled Clinical Trial.

Int J Dent 2019 1;2019:3938214. Epub 2019 Jul 1.

Graduate Program in Dentistry, Universidade Positivo, Rua Professor Pedro Viriato Parigot de Souza, 5300, Cidade Industrial, Curitiba, PR, Brazil.

Gingivitis is still considered a major risk factor for the occurrence and progression of periodontal disease. The aim of the present study was to compare the long-term (1, 12, and 18 weeks) antiplaque and antigingivitis efficacies of two commercially available toothpastes, Colgate Total (CT) and BlueM (BM), against attached supragingival dental plaque and gingival inflammation in an experimental gingivitis model. A parallel double-blinded randomized clinical trial including 39 dental students who refrained from all plaque control methods (manual or chemical) for 7 days was conducted. Read More

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Development and Formulation of the Experimental Dentifrice Based on (Tumbo) with and without Fluoride Anion: Antibacterial Activity on Seven Antimicrobial Strains.

Int J Dent 2019 13;2019:9056590. Epub 2019 Jun 13.

Stomatology School, Universidad Privada San Juan Bautista, Lima, Peru.

Objectives: To develop and formulate a new experimental dentifrice with and without fluoride based on the peel and the fruit of the (tumbo) and also to evaluate its antimicrobial activity against seven bacterial strains.

Methods: The sample was calculated using the mean comparison formula, obtaining wells ( = 12) for each of the strains evaluated: , , , , , , and . The antibacterial activity of the dentifrice was evaluated by the direct contact technique. Read More

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