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HDL infusion protects from acute graft-versus-host disease in experimental allogeneic hematopoietic cell transplantation.

Am J Transplant 2022 Jan 17. Epub 2022 Jan 17.

Univ. Bourgogne Franche-Comté, INSERM, EFS BFC, UMR1098 RIGHT Interactions Greffon-Hôte-Tumeur/Ingénierie Cellulaire et Génique, LabEX LipSTIC, FHU INCREASE, F-25000, Besançon, France.

Acute graft-versus-host disease (aGVHD) is a major limitation of the therapeutic potential of allogeneic hematopoietic cell transplantation. Lipopolysaccharides (LPS) derived from intestinal Gram-negative bacteria are well-known aGVHD triggers and amplifiers. Here, we explored the LPS metabolism in aGVHD mouse models using an innovative quantification method. Read More

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January 2022

Could COVID expand the future of addiction research? Long-term implications in the pandemic era.

Addiction 2022 Jan 17. Epub 2022 Jan 17.

National Addiction Centre, Addictions Department, Institute of Psychiatry, Psychology & Neuroscience.

Background/aims: The COVID-19 pandemic has significantly impacted face-to-face research. This has propelled ideas and plans for more remote styles of research and provided new perspectives on conducting research. This paper aimed to identify challenges specific to conducting remote forms of experimental addiction research, although some of these challenges apply to all types of addiction research. Read More

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January 2022

Nutrient timing and metabolic regulation symposium review from "Novel dietary approaches to appetite regulation, health and performance (2021)".

J Physiol 2022 Jan 17. Epub 2022 Jan 17.

Centre for Nutrition Exercise and Metabolism, Department for Health, University of Bath, Bath, BA2 7AY, United Kingdom.

Daily (circadian) rhythms coordinate our physiology and behaviour with regular environmental changes. Molecular clocks in peripheral tissues (e.g. Read More

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January 2022

Temperature Optimization Within 2 Uniquely Designed Courier Lockboxes During Extreme Summer Temperatures.

Am J Clin Pathol 2022 Jan 17. Epub 2022 Jan 17.

Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA.

Objectives: To determine optimal temperature profiles for 2 uniquely designed courier lockboxes (steel vs polymer) by standardizing daily ice (-20ºC) and cold (4-8ºC) pack placement.

Methods: Paired courier lockboxes were placed outside in direct sunlight. Ambient outdoor and lockbox temperatures were monitored during 2 4-day cycles, and temperature mean and range were determined daily (time frame, 4:00-10:00 pm). Read More

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January 2022

Morphology and energy transfer study between conjugated polymers thin films: experimental and theoretical approaches.

J Phys Condens Matter 2022 Jan 17. Epub 2022 Jan 17.

Departamento de Fisica, Federal University of Paraná Department of Physics, Caixa Postal 19081, Curitiba, Paraná, 81531-980, BRAZIL.

In this paper, the effect of a silafluorene derivative copolymer, the poly[2,7-(9,9-dioctyl-dibenzosilole)-alt-4,7-bis(thiophene-2-yl)benzo-2,1,3-thiadiazole] (PSiF-DBT) sensitized by a simpler homopolymer, the poly[2-methoxy-5-(3',7'-dimethyloctyloxy)-1,4-phenylenevinylene] (MDMO-PPV) were investigated in a bi layer and ternary blend configuration. The energy transfer between the polymers prior to electron transfer to the acceptors can be an efficient alternative to photocurrent improvement in photovoltaic devices. The interactions between the two donor polymer films were evaluated optically and morphologically with several experimental techniques and correlated to the photovoltaic performance. Read More

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January 2022

The ultra high sensitivity blood counter: a compact, MRI-compatible, radioactivity counter for pharmacokinetic studies in µL volumes.

Biomed Phys Eng Express 2022 Jan 17. Epub 2022 Jan 17.

Sherbrooke Molecular Imaging Centre of CRCHUS and Department of Nuclear Medicine and Radiobiology, Universite de Sherbrooke, 3001 12 Ave Nord, Sherbrooke, Quebec, J1K 2R1, CANADA.

Quantification of physiological parameters in preclinical pharmacokinetic studies based on nuclear imaging requires the monitoring of arterial radioactivity over time, known as the arterial input function (AIF). Continuous derivation of the AIF in rodent models is very challenging because of the limited blood volume available for sampling. To address this challenge, an Ultra High Sensitivity Blood Counter (UHS-BC) was developed. Read More

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January 2022

Pulsed low dose-rate radiotherapy: radiobiology and dosimetry.

Phys Med Biol 2022 Jan 17. Epub 2022 Jan 17.

Department of Radiation Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA, philadelphia, Pennsylvania, 19111, UNITED STATES.

Pulsed low dose-rate radiotherapy (PLDR) relies on two radiobiological findings, the hyper-radiosensitivity of tumor cells at small doses and the reduced normal tissue toxicity at low dose rates. This is achieved by delivering the daily radiation dose of 2 Gy in 10 sub-fractions (pulses) with a 3-minute time interval, resulting in an effective low dose rate of 0.067 Gy/minute. Read More

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January 2022

La2Pd2In: superconductivity and lattice properties at ambient and elevated pressures.

J Phys Condens Matter 2022 Jan 17. Epub 2022 Jan 17.

Department of Condensed Matter Physics, Charles University Faculty of Mathematics and Physics, Ke Karlovu 5, Prague, 121 16, CZECH REPUBLIC.

Lattice and electronic properties of La2Pd2In were studied at ambient and elevated pressures so as to determine features related to a specific atomic coordination without any influence of magnetism. We describe temperature dependences of lattice parameters, heat capacity and electrical resistivity of single-crystalline La2Pd2In (s.g. Read More

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January 2022

A deep convolutional neural network for estimating hemodynamic response function with reduction of motion artifacts in fNIRS.

J Neural Eng 2022 Jan 17. Epub 2022 Jan 17.

Research Center for Bioconvergence Analysis, Korea Basic Science Institute, 162 Yeongudanji-ro, Cheongwon-gu, Ochang-eup, Cheongju, 28119, Korea (the Republic of).

Objective: Functional near-infrared spectroscopy (fNIRS) is a neuroimaging technique for monitoring hemoglobin concentration changes in a non-invasive manner. However, subject movements are often significant sources of artifacts. While several methods have been developed for suppressing this confounding noise, the conventional techniques have limitations on optimal selections of model parameters across participants or brain regions. Read More

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January 2022

Intestinal changes and immune responses during Clostridium perfringens-induced necrotic enteritis in broiler chickens.

Poult Sci 2021 Dec 7;101(3):101652. Epub 2021 Dec 7.

Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA. Electronic address:

Clostridium perfringens-induced necrotic enteritis (NE) is an economically important disease of broiler chickens. The present study evaluated the effect of C. perfringens on the intestinal histomorphometry, enteric microbial colonization, and host immune responses using 3 experimental NE reproduction methods. Read More

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December 2021

Long-term stability of outcomes of endoscopic surgery for rhinogenic contact point headache (Sluder''s neuralgia).

Am J Otolaryngol 2022 Jan 12;43(2):103368. Epub 2022 Jan 12.

Department of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia," ENT Section, University of Catania, Catania, Italy.

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January 2022

OCT retinal nerve fiber layer thickness differentiates acute optic neuritis from MOG antibody-associated disease and Multiple Sclerosis: RNFL thickening in acute optic neuritis from MOGAD vs MS.

Mult Scler Relat Disord 2022 Jan 11;58:103525. Epub 2022 Jan 11.

Departments of Neurology, Mayo Clinic, Rochester, MN; Departments of Laboratory Medicine and Pathology; Center for MS and Autoimmune Neurology, Mayo Clinic, Rochester, MN.

Background: Optic neuritis (ON) is the most common manifestation of myelin oligodendrocyte glycoprotein antibody associated disorder (MOGAD) and multiple sclerosis (MS). Acute ON in MOGAD is thought to be associated with more severe optic disk edema than in other demyelinating diseases, but this has not been quantitatively confirmed. The goal of this study was to determine whether optical coherence tomography (OCT) can distinguish acute ON in MOGAD from MS, and establish the sensitivity of OCT as a confirmatory biomarker of ON in these entities. Read More

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January 2022

Protective effects of melatonin on changes occurring in the experimental autoimmune encephalomyelitis model of multiple sclerosis.

Mult Scler Relat Disord 2022 Jan 11;58:103520. Epub 2022 Jan 11.

Maimonides Institute for Research in Biomedicine of Cordoba, (IMIBC), Cordoba, Spain; Department of Biochemistry and Molecular Biology, Faculty of Medicine and Nursing, University of Cordoba, Av. Menendez Pidal, Cordoba 14004, Spain; Cooperative Research Thematic Excellent Network on Brain Stimulation (REDESTIM), Spain. Electronic address:

Background: Melatonin has been related to the pathophysiology of multiple sclerosis (MS), and its anti-inflammatory and immunomodulatory properties have been proved in numerous neurodegenerative diseases. This study aimed to find out whether a melatonin supplement in MS is able to act as a benefit to its clinical status, i.e. Read More

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January 2022

Design and analysis of a structured questionnaire to assess the probability of elimination of Rhipicephalus microplus from farms in a subtropical area.

Prev Vet Med 2022 Jan 8;200:105576. Epub 2022 Jan 8.

University of Prince Edwards Island, 550 University Ave, Charlottetown, PE C1A4P3, Canada. Electronic address:

In areas in which R. microplus may be eliminated from farms, it is essential to evaluate the infestation situation and the biosecurity measures available when deciding whether or not to undertake an elimination effort. Multiple questionnaires have been developed to evaluate the cattle tick situation on farms, however, the validity of those questionnaires has not been evaluated. Read More

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January 2022

Does smoking have an impact on the immunological response to COVID-19 vaccines? Evidence from the VASCO study and need for further studies.

Public Health 2022 Jan 13;203:97-99. Epub 2022 Jan 13.

Center of Excellence for the Acceleration of HArm Reduction (CoEHAR), University of Catania, Catania, Italy; Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

Objectives: The aim of this study was to investigate the possible impact of smoking on the humoral response to the BNT162b2 mRNA COVID-19 vaccine (also known as the BioNTech-Pfizer COVID-19 vaccine).

Study Design: A longitudinal sero-epidemiological study was conducted in sample of Italian healthcare workers (HCWs).

Methods: HCWs who were administered two doses of the BNT162b2 mRNA vaccine, 21 days apart, between December 2020 and January 2021, were invited to undergo multiple serology tests to identify SARS-CoV-2 S-RBD-specific immunoglobulin G (IgG) antibodies. Read More

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January 2022

Symmetric positive definite manifold learning and its application in fault diagnosis.

Neural Netw 2021 Dec 29;147:163-174. Epub 2021 Dec 29.

School of Electrical Engineering and Information, Northeast Petroleum University, Daqing 163318, China. Electronic address:

Locally linear embedding (LLE) is an effective tool to extract the significant features from a dataset. However, most of the relevant existing algorithms assume that the original dataset resides on a Euclidean space, unfortunately nearly all the original data space is non-Euclidean. In addition, the original LLE does not use the discriminant information of the dataset, which will degrade its performance in feature extraction. Read More

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December 2021

The surface coating of iron oxide nanoparticles drives their intracellular trafficking and degradation in endolysosomes differently depending on the cell type.

Biomaterials 2022 Jan 6;281:121365. Epub 2022 Jan 6.

Department of Immunology and Oncology and Nanobiomedicine Initiative, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, 28049, Madrid, Spain. Electronic address:

Magnetic nanoparticles (MNPs) are potential theranostic tools that are biodegraded through different endocytic pathways. However, little is known about the endolysosomal network through which MNPs transit and the influence of the surface coating in this process. Here, we studied the intracellular transit of two MNPs with identical iron oxide core size but with two distinct coatings: 3-aminopropyl-trietoxysilane (APS) and dimercaptosuccinic acid (DMSA). Read More

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January 2022

AT-rich interactive domain 1A (ARID1A) cannot be considered a morphological marker for prostate cancer progression: A pilot study.

Acta Histochem 2022 Jan 14;124(2):151847. Epub 2022 Jan 14.

Department of Biomedical Sciences and Public Health, Section of Pathological Anatomy, Università Politecnica delle Marche, School of Medicine, United Hospitals, Ancona, Italy.

Prostate cancer (PCa) is one of the most common cancers worldwide but it presents many subtypes and patient heterogeneity. It is necessary to discriminate localised not aggressive PCa and metastatic cancer in order to better define the personalised treatment. The identification of an appropriate biomarker to combine with Gleason grading system, that is one of the most important prognostic factors in prostate cancer outcome, remains a major clinical issue. Read More

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January 2022

Experimental and numerical analysis of electroactive characteristics of scleral tissue.

Acta Biomater 2022 Jan 13. Epub 2022 Jan 13.

Mechanical and Industrial Engineering Department, University of Illinois at Chicago, Chicago, IL USA. Electronic address:

The sclera provides mechanical support to retina and protects internal contents of the eye against external injuries. The scleral extracellular matrix is mainly composed of collagen fibers and proteoglycans (PGs). At physiological pH, collagen molecules are neutral but PGs contain negatively charged glycosaminoglycan chains. Read More

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January 2022

Synapsin III gene silencing redeems alpha-synuclein transgenic mice from Parkinson's disease-like phenotype.

Mol Ther 2022 Jan 13. Epub 2022 Jan 13.

Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123, Brescia, Italy;. Electronic address:

Fibrillary aggregated α-synuclein (α-syn) deposition in Lewy bodies (LB) characterizes Parkinson's Disease (PD) and is believed to trigger dopaminergic synaptic failure and a retrograde terminal-to-cell body neuronal degeneration. We described that the neuronal phosphoprotein synapsin III (Syn III) cooperates with α-syn to regulate dopamine (DA) release and can be found in the insoluble α-syn fibrils composing LB. Moreover, we showed that α-syn aggregates deposition, and the associated onset of synaptic deficits and neuronal degeneration occurring following adeno-associated viral vectors (AAV)-mediated overexpression of human α-syn in the nigrostriatal system, are hindered in Syn III knock out (ko) mice. Read More

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January 2022

The antitumoral activity of TLR7 ligands is corrupted by the microenvironment of pancreatic tumors.

Mol Ther 2022 Jan 13. Epub 2022 Jan 13.

Université Fédérale Toulouse Midi-Pyrénées, Université Toulouse III, Paul Sabatier, INSERM, CRCT, Toulouse, France. Electronic address:

Toll like receptors (TLR) are key players in the innate immune system. Recent studies have suggested that they may impact the growth of pancreatic cancer, a disease with no cure. Among them, Toll like receptor-7 (TLR7) shows promise for therapy but may also promotes tumor growth. Read More

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January 2022

Bio-templated synthesis of porous silica nano adsorbents to wastewater treatment inspired by a circular economy.

Sci Total Environ 2022 Jan 14:152929. Epub 2022 Jan 14.

College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science & Technology, Xi'an 710021, Shaanxi, China; National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science & Technology, Xi'an 710021, China.

Water is an indispensable substance in human life activities. However, due to industrial discharge problems, water resources are polluted, so there is an urgent need for material and technology for wastewater treatment. This paper presents an innovative synthesis of porous silica microspheres (PSM) from a biomass template material (fish skin collagen) to treat protein from wastewater. Read More

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January 2022

A novel method for in situ stabilization of calcium arsenic residues via yukonite formation.

Sci Total Environ 2022 Jan 14:153090. Epub 2022 Jan 14.

Key Laboratory of Pollution Ecology and Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China. Electronic address:

Stabilizing the hazardous calcium arsenic residues (CAR) and monitoring the subsequent fate of arsenic (As) are critical to reduce its risk to the environment. In this work, a novel in situ method has been proposed to stabilize CAR by adding Fe solution and subsequent formation of the secondary mineral (yukonite). The experiments were conducted at pH 6-9 with different Fe/As molar ratios (0. Read More

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January 2022

A Novel Low-Shrinkage Resin for 3D Printing.

J Dent 2022 Jan 13:103957. Epub 2022 Jan 13.

Glidewell Dental, Irvine, CA, USA.

Objective: To evaluate the shrinkage, accuracy, and mechanical properties of a newly developed photo-polymerizable resin material for 3D printing dental applications and compare it with three commercially available resins.

Methods: An experimental novel proprietary resin material for 3D printing was formulated. This new resin, Die and Model Tan (SprintRay), Formlabs Grey (FormLabs), and LCD Grey (Roxel 3D) were evaluated and tested for volumetric shrinkage, accuracy, and flexural and tensile properties. Read More

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January 2022

Harnessing oxidative stress for anti-glioma therapy.

Neurochem Int 2022 Jan 14:105281. Epub 2022 Jan 14.

Department of Experimental and Clinical Neuropathology,Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland.

Glioma cells use intermediate levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS) for growth and invasion, and suppressing these reactive molecules thus may compromise processes that are vital for glioma survival. Increased oxidative stress has been identified in glioma cells, in particular in glioma stem-like cells. Studies have shown that these cells harbor potent antioxidant defenses, although endogenous protection against nitrosative stress remains understudied. Read More

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January 2022

Improving diagnostic accuracy in pregnancy with individualised, gestational age-specific reference intervals.

Clin Chim Acta 2022 Jan 13. Epub 2022 Jan 13.

Women's Centre, John Radcliffe Hospital, Oxford, OX3 9DU; Nuffield Department of Women's & Reproductive Health, University of Oxford, Women's Centre, John Radcliffe Hospital, Oxford, OX39DU.

Background And Aims: Investigations in pregnancy should be interpreted using pregnancy-specific reference intervals (RIs). However, because of the progressive nature of pregnancy, even pregnancy-specific RIs may not be equally representative at different gestations. We proposed that gestational age-specific RIs may increase diagnostic accuracy over those with fixed limits. Read More

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January 2022

4-nitrobenzoylcoumarin potentiates the antiparasitic, anti-inflammatory and cardioprotective effects of benznidazole in a murine model of acute Trypanosoma cruzi infection.

Acta Trop 2022 Jan 14:106314. Epub 2022 Jan 14.

Departamento de Patologia e Parasitologia, Universidade Federal de Alfenas, 37130-001 Alfenas, MG, Brazil.

The anti-inflammatory and cardioprotective potential of coumarin metabolites in infectious myocarditis remains overlooked. Thus, the impact of the synthetic 4-nitrobenzoylcoumarin (4NB) alone and combined with benznidazole (Bz) in a murine model of Trypanosoma cruzi-induced acute myocarditis was investigated. Swiss mice infected with T. Read More

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January 2022

Novel Insights into the 1969 Whole-Eye Transplant: Medical Ethics and Evolving Safety Mechanisms: The 1969 Whole-Eye Transplant and Medical Ethics.

Am J Ophthalmol 2022 Jan 13. Epub 2022 Jan 13.

Truhlsen Eye Institute, Department of Ophthalmology, University of Nebraska Medical Center, Omaha, NE. Electronic address:

Purpose: The controversial whole-eye transplant (WET) of 1969 performed by Texas Medical Center (TMC) eye surgeon Conard Moore, MD is examined to determine whether he performed a WET or a different operation. New materials are reviewed to evaluate the conflicting historical WET reports: Moore claimed that he performed the world's first WET, then retracted his claim amid criticism. Medical and ethical factors are explored. Read More

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January 2022

TFEB signaling attenuates NLRP3-driven inflammatory responses in severe asthma.

Allergy 2022 Jan 17. Epub 2022 Jan 17.

Cellular Immunology Laboratory, Center for Basic Research, Biomedical Research Foundation of the Academy of Athens (BRFAA), Athens, 115 27, Greece.

Background: NLRP3-driven inflammatory responses by circulating and lung-resident monocytes are critical drivers of asthma pathogenesis. Autophagy restrains NLRP3-induced monocyte activation in asthma models. Yet, the effects of autophagy and its master regulator, transcription factor EB (TFEB), on monocyte responses in human asthma remain unexplored. Read More

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January 2022