346,967 results match your criteria experiment


Antilithiatic activity of a non-pharmacopoeial Unani formulation in chemically induced urolithiasis in rats.

J Complement Integr Med 2021 May 10. Epub 2021 May 10.

Department of Ilmul Advia (Unani Pharmacology), National Institute of Unani Medicine, Bangalore, India.

Objectives: ( L.), ( C.B. Read More

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Automatic magnetic projection for one-step separation of mixed plastics using ring magnets.

Sci Total Environ 2021 Apr 21;786:147217. Epub 2021 Apr 21.

State Key Lab of Fluid Power Transmission and Control, School of Mechanical Engineering, Zhejiang University, Hangzhou, China; Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province, School of Mechanical Engineering, Zhejiang University, Hangzhou, China; Jiangsu Jianghuai Magnetic Industry Co., Ltd., Xuyi 211700, China. Electronic address:

Magnetic projection, a novel separation method proposed recently, can separate multiple mixed materials in an efficient and low-cost way. Although promising, existing magnetic projection method cannot achieve the automatic feeding of mixed materials, which limits its applications. To address this challenge, ring magnets were used to replace conventional square magnets in this research. Read More

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Aquatic microbial community is partially functionally redundant: Insights from an in situ reciprocal transplant experiment.

Sci Total Environ 2021 Apr 30;786:147433. Epub 2021 Apr 30.

Biodiversity Research Center, Academia Sinica, Taipei 11529, Taiwan; Bioinformatics Program, Institute of Information Science, Taiwan International Graduate Program, Academia Sinica, Taipei 11529, Taiwan. Electronic address:

Microbial communities are considered to be functionally redundant, but few studies have tested this hypothesis empirically. In this study, we performed an in situ reciprocal transplant experiment on the surface and bottom waters of two lakes (Tsuei-Feng (T) and Yuan-Yang (Y)) with disparate trophic states and tracked changes in their microbial community composition and functions for 6 weeks using high-throughput sequencing and functional approaches. T lake's surface (Ts) and bottom (Tb) water active bacterial community (16S rRNA gene-transcript) was dominated by Actinobacteria, Bacteroidia, and Cyanobacteria, whereas Y lake's surface (Ys) and bottom (Yb) water had Gammaproteobacteria, Alphaproteobacteria, and Bacteroidia as the dominant classes. Read More

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Agronomic performance of polyethylene and biodegradable plastic film mulches in a maize cropping system in a humid continental climate.

Sci Total Environ 2021 Apr 30;786:147460. Epub 2021 Apr 30.

College of Land and Environment, Shenyang Agricultural University, Shenyang 110086, China.

Plastic polyethylene mulch has been widely used in crop production, but also causes environmental pollution if plastic residues accumulate in soil. Biodegradable plastic mulches (BDM) are a potential solution to problems caused by polyethylene mulches, as BDMs are designed be tilled into the soil after the growing season and then biodegrade. However, the agronomic performance of BDMs still needs to be tested for comparison to polyethylene mulch. Read More

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Effective utilisation of influence maximization technique for the identification of significant nodes in breast cancer gene networks.

Comput Biol Med 2021 Apr 18;133:104378. Epub 2021 Apr 18.

School of Computer Science and Engineering, Vellore Institute of Technology, Vellore, India. Electronic address:

Background: Identifying the most important genes in a cancer gene network is a crucial step in understanding the disease's functional characteristics and finding an effective drug.

Method: In this study, a popular influence maximization technique was applied on a large breast cancer gene network to identify the most influential genes computationally. The novel approach involved incorporating gene expression data and protein to protein interaction network to create a customized pruned and weighted gene network. Read More

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Organics removal and microbial interaction attributes of zeolite and ceramsite assisted bioretention system in copper-contaminated stormwater treatment.

J Environ Manage 2021 May 7;292:112654. Epub 2021 May 7.

College of Environment, Hohai University, 210098, PR China.

Bioretention has been increasingly used recently to treat heavy metals contaminated stormwater. However, less is known about how metal accumulation influences microbial performance and organics removal mechanisms in different layers of the bioretention system. Two lab-scale bioretention columns (i. Read More

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How unintentional cues can bias threat assessments during shoot/don't-shoot simulations.

Appl Ergon 2021 May 7;95:103451. Epub 2021 May 7.

Naval Medical Research Unit Dayton, United States.

Objective: Identify whether contextual information may unintentionally alter decision-making during lethal force training.

Background: Lethal force decisions inherently involve a threat assessment, where an individual learns to identify a threat and use force commensurate to the situation. This decision is ultimately subject to numerous cognitive influences, particularly during training where artificial factors may bias decision-making. Read More

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How should external human-machine interfaces behave? Examining the effects of colour, position, message, activation distance, vehicle yielding, and visual distraction among 1,434 participants.

Appl Ergon 2021 May 7;95:103450. Epub 2021 May 7.

Faculty of Mechanical, Maritime and Materials Engineering, Delft University of Technology, Delft, the Netherlands.

External human-machine interfaces (eHMIs) may be useful for communicating the intention of an automated vehicle (AV) to a pedestrian, but it is unclear which eHMI design is most effective. In a crowdsourced experiment, we examined the effects of (1) colour (red, green, cyan), (2) position (roof, bumper, windshield), (3) message (WALK, DON'T WALK, WILL STOP, WON'T STOP, light bar), (4) activation distance (35 or 50 m from the pedestrian), and (5) the presence of visual distraction in the environment, on pedestrians' perceived safety of crossing the road in front of yielding and non-yielding AVs. Participants (N = 1434) had to press a key when they felt safe to cross while watching a random 40 out of 276 videos of an approaching AV with eHMI. Read More

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Children's understanding of economic demand: A dissociation between inference and choice.

Cognition 2021 May 7;214:104747. Epub 2021 May 7.

Department of Psychological & Brain Sciences, Boston University, USA; Center for Systems Neuroscience, Boston University, USA. Electronic address:

Adults infer that resources that become scarce over time are in higher demand, and use this "demand inference" to guide their own economic decisions. However, it is unclear when children begin to understand and use economic demand. In six experiments, we investigated the development of demand inference and demand-based economic decisions in 4- to 10-year-old children and adults in the United States. Read More

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"Light cannabis" consumption in a sample of young adults: Preliminary pharmacokinetic data and psychomotor impairment evaluation.

Forensic Sci Int 2021 May 2;323:110822. Epub 2021 May 2.

Department of Medical and Surgical Sciences, Unit of Legal Medicine, University of Bologna, Via Irnerio 49, 40126 Bologna, Italy.

Introduction: In 2019, the Italian Supreme Court established that hemp cannot be commercialized for human use, when the "psychotropic effect" of the product or its "offensiveness" can be demonstrated. The aim of the present study is to assess Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) blood concentrations after smoking cannabis with a low percentage of Δ9-THC, also referred as "light cannabis", and its effects on young adults' vigilance, cognitive and motor skills.

Materials And Methods: Eighteen young adults consumed three light cannabis cigarettes containing 400 mg of inflorescences each, with a percentage of 0. Read More

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Object affordances from the perspective of an avatar.

Conscious Cogn 2021 May 7;92:103133. Epub 2021 May 7.

Work and Cognitive Psychology, RWTH Aachen University, Germany.

Humans often interact with avatars in video gaming, workplace, or health applications, for instance. The present research studied object affordances from an avatar's perspective. In two experiments, participants responded to objects with a left/right keypress, indicating whether the objects were upright or inverted. Read More

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Discovery of novel tripeptide propylene oxide proteasome inhibitors for the treatment of multiple myeloma.

Bioorg Med Chem 2021 May 1;40:116182. Epub 2021 May 1.

College of Life Science, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing 210037, PR China; Jiangsu Chia Tai Fenghai Pharmaceutical Co. Ltd., No. 9 Weidi Road, Nanjing 210046, PR China. Electronic address:

The ubiquitin proteasome pathway (UPP) plays a critical role in the maintenance of cell homeostasis and the development of diseases, such as cancer and neurodegenerative disease. A series of novel tripeptide propylene oxide compounds as proteasome inhibitors were designed, synthesized and biologically investigated in this manuscript. The enzymatic activities of final compounds against 20S human proteasome were investigated and structure-activity relationship (SAR) was summarized. Read More

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Cu-Fe embedded cross-linked 3D hydrogel for enhanced reductive removal of Cr(VI): Characterization, performance, and mechanisms.

Chemosphere 2021 May 3;280:130663. Epub 2021 May 3.

School of Environment and Architecture, University of Shanghai for Science and Technology, Shanghai, 200093, China. Electronic address:

Porous hydrogel, as a high-efficiency adsorbent for heavy metals, suffers the drawbacks of the use of expensive and toxic reagents during the process of preparation, further limiting its application ranges. Besides, the heavy metals couldn't be transformed into nontoxic species, which leads to the environmental pollution risk. Herein, a three-dimensionally (3D) structured Cu-Fe embedded cross-linked cellulose hydrogel (nFeCu-CH) was innovatively fabricated by a novel self-assembly and in-situ reduction method, which exhibited exceptionally enhanced adsorption-reduction property towards Cr(VI) wastewater. Read More

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Comparison of the effects of large-grained and nano-sized biochar, ferrihydrite, and complexes thereof on Cd and As in a contaminated soil-plant system.

Chemosphere 2021 Apr 30;280:130731. Epub 2021 Apr 30.

College of Natural Resources and Environment, South China Agricultural University, Guangzhou, 510642, China; College of Resource and Environmental Engineering, Jiangxi University of Science and Technology, Ganzhou, Jiangxi, 341000, China.

Cd and As are difficult to co-remediate in co-contaminated soils. In this study, remediation materials comprising large-grained and nano-sized biochar (BC), ferrihydrite (FH), and complexes thereof were added to Cd- and As-contaminated soil. The uptake of Cd and As by pak choi (Brassica chinensis L. Read More

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Successful application of municipal domestic wastewater as a co-substrate in 2,4,6-trichlorophenol degradation.

Chemosphere 2021 May 4;280:130707. Epub 2021 May 4.

National Engineering Laboratory for Advanced Municipal Wastewater Treatment and Reuse Technology, Beijing University of Technology, Beijing, 100124, PR China. Electronic address:

Wastewater containing 2,4,6-trichlorophenol (2,4,6-TCP) is highly toxic and causes harmful effects on aquatic ecosystems and human health. In this study, wastewater containing high levels of 2,4,6-TCP was successfully co-metabolized by introducing municipal domestic wastewater (MDW) as the co-catabolic carbon source. The concentration of degraded 2,4,6-TCP increased from 0 to 208. Read More

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Circulating extracellular vesicles are endowed with enhanced procoagulant activity in SARS-CoV-2 infection.

EBioMedicine 2021 May 7;67:103369. Epub 2021 May 7.

Laboratory for Cardiovascular Theranostics, Istituto Cardiocentro Ticino, Ente Ospedaliero Cantonale Lugano, Switzerland; Faculty of Biomedical Sciences, Università della Svizzera italiana, Lugano, Switzerland; Institute of Life Science, Scuola Superiore Sant'Anna, Pisa, Italy. Electronic address:

Background: Coronavirus-2 (SARS-CoV-2) infection causes an acute respiratory syndrome accompanied by multi-organ damage that implicates a prothrombotic state leading to widespread microvascular clots. The causes of such coagulation abnormalities are unknown. The receptor tissue factor, also known as CD142, is often associated with cell-released extracellular vesicles (EV). Read More

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Synthesis of starch-based super absorbent polymer with high agglomeration and wettability for applying in road dust suppression.

Int J Biol Macromol 2021 May 7. Epub 2021 May 7.

School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China.

Dust pollution is an important factor restricting social development and affecting human health, especially in some developing countries. Herein, mechanical activation-assisted solid phase reaction (MASPR) and conventional liquid phase (LP) method were employed to synthesize different superabsorbent polymers (SAPs), defined as SAP-MA and SAP-LP, respectively. The rheological properties, crystal structure, changes of functional groups, and dust suppression performance of the SAPs prepared by these two methods were compared, and the dust suppression mechanism of SAPs was discussed via the adsorption experiment between dust suppressant and dust particles. Read More

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Current and next-year cranberry yields predicted from local features and carryover effects.

PLoS One 2021 10;16(5):e0250575. Epub 2021 May 10.

Département des Sols et de Génie Agroalimentaire, Université Laval, Québec, Québec, Canada.

Wisconsin and Quebec are the world leading cranberry-producing regions. Cranberries are grown in acidic, naturally low-fertility sandy beds. Cranberry fertilization is guided by general soil and tissue nutrient tests in addition to yield target and vegetative biomass. Read More

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Detection of Emotional Sensitivity Using fNIRS based Dynamic Functional Connectivity.

IEEE Trans Neural Syst Rehabil Eng 2021 May 10;PP. Epub 2021 May 10.

In this study, we proposed an analytical framework to identify dynamic task-based functional connectivity (FC) features as new biomarkers of emotional sensitivity in nursing students, by using a combination of unsupervised and supervised machine learning techniques. The dynamic FC was measured by functional Near-Infrared Spectroscopy (fNIRS), and computed using a sliding window correlation (SWC) analysis. A k-means clustering technique was applied to derive four recurring connectivity states. Read More

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PthAW1, a transcription activator-like effector of Xanthomonas citri subsp. citri, promotes host specific immune responses.

Mol Plant Microbe Interact 2021 May 10. Epub 2021 May 10.

University of Florida, Citrus Research and Education Center/Department of Microbiology and Cell Science, 700 Experiment Station Road, Lake Alfred, Florida, United States, 33850;

Citrus canker disease caused by Xanthomonas citri subsp. citri (Xcc) is one of the most destructive diseases in citrus. XccA causes canker disease in most commercial citrus varieties, whereas XccAW, which is genetically similar to XccA, infects only lime and alemow. Read More

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Protein mapping of peanut extract with capillary electrophoresis.

Electrophoresis 2021 May 10. Epub 2021 May 10.

Kantisto BV, Baarn, the Netherlands.

Protein separation can be achieved with different modes of capillary electrophoresis, such as with capillary gel electroporesis (CGE) or with capillary zone electrophoresis (CZE). CZE protein mapping of peanut extract was approached in four different ways, combining neutral-coated or multilayer-coated capillaries with pHs well over or under the isoelectric point range of the proteins of interest. At acidic pHs, the mobility ranges of the major peanut allergens Ara h1, Ara h2, Ara h3 and Ara h6 were identified. Read More

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Long-term continuous cropping affects ecoenzymatic stoichiometry of microbial nutrient acquisition: A case study from a Chinese Mollisol.

J Sci Food Agric 2021 May 10. Epub 2021 May 10.

Key Laboratory of Mollisols Agroecology, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Harbin, 150081.

Background: Soil- and plant-produced extracellular enzymes drive nutrient cycling in soils and are thought to be regulated supply and demand for carbon (C) and nutrients within the soil. Thus, agriculture management decisions that alter the balance of plant and supplemental nutrients should directly alter extracellular enzyme activities (EEAs), and EEA stoichiometry in predictable ways. We used a 12-year experiment varying three major continuous grain crops (wheat, soybean, and maize) each crossed with mineral fertilizer (WCF, SCF, and MCF, respectively) or not fertilized (WC, SC, and MC, respectively, as controls). Read More

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Pathfinders in oncology from the time the causal relation between tobacco use and lung cancer was established to publication of the first Cancer Staging Manual by the American Joint Committee on Cancer.

Authors:
Steven I Hajdu

Cancer 2021 May 10. Epub 2021 May 10.

Pathology Consultants, Westlake Village, California.

During the period from 1962 to 1977, several antigens, notably carcinoembryonic antigen and prostate-specific antigen, were discovered and entered clinical use. Ultrasonography, positron emission tomography scanning, and magnetic resonance imaging were introduced, and adjuvant radiation and chemotherapy after limited surgery became routine procedures. Radioimmunoassay and immunohistochemistry techniques were standardized. Read More

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α-Acetylcholine Receptor Signaling Reduces Neuroinflammation After Subarachnoid Hemorrhage in Mice.

Neurotherapeutics 2021 May 10. Epub 2021 May 10.

The Vivian L Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center At Houston, Houston, TX, USA.

Aneurysmal subarachnoid hemorrhage (aSAH) causes a robust inflammatory response which leads worse brain injury and poor outcomes. We investigated if stimulation of nicotinic acetylcholine α receptors (α-AChR) (receptors shown to have anti-inflammatory effects) would reduce inflammation and improve outcomes. To investigate the level of peripheral inflammation after aSAH, inflammatory markers were measured in plasma samples collected in a cohort of aSAH patients. Read More

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Rapid noninvasive screening of cerebral ischemia and cerebral infarction based on tear Raman spectroscopy combined with multiple machine learning algorithms.

Lasers Med Sci 2021 May 10. Epub 2021 May 10.

College of Information Science and Engineering, Xinjiang University, Urumqi, 830046, China.

Researchers have established a classification model based on tear Raman spectroscopy combined with machine learning classification algorithms, which realizes rapid noninvasive classification of cerebral infarction and cerebral ischemia, which is of great significance for clinical medical diagnosis. Through spectral data analysis, it is found that there are differences in the content of tyrosine, phenylalanine, and carotenoids in the tears of patients with cerebral ischemia and patients with cerebral infarction. We try to establish a classification model for rapid noninvasive screening of cerebral infarction and cerebral ischemia through these differences. Read More

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Neglecting polydispersity degrades propensity measurements in supercooled liquids.

Eur Phys J E Soft Matter 2021 May 10;44(5):65. Epub 2021 May 10.

Department of Physics, Emory University, Atlanta, GA, 30322, USA.

We conduct molecular dynamics simulations of a bidisperse Kob-Andersen (KA) glass former, modified to add in additional polydispersity. The original KA system is known to exhibit dynamical heterogeneity. Prior work defined propensity, the mean motion of a particle averaged over simulations reconstructing the initial positions of all particles but with randomized velocities. Read More

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Enabling LIFDI-MS measurements of highly air sensitive organometallic compounds: a combined MS/glovebox technique.

Dalton Trans 2021 May 10. Epub 2021 May 10.

Department of Chemistry, Technical University of Munich, Lichtenbergstraße 4, D-85748 Garching, Germany. and Catalysis Research Center, Technical University of Munich, Ernst-Otto-Fischer-Straße 1, D-85748 Garching, Germany.

A new setup combining a ThermoFisher Exactive Plus Orbitrap Mass Spectrometer with a liquid injection field desorption ionization (LIFDI) source directly connected to an inert atmosphere glovebox is presented. The described setup allows for the analysis of very air- and moisture sensitive samples. Furthermore, the soft nature of LIFDI ionization gives access to the molecular ions of fragile molecules. Read More

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A Versatile Kit Based on Digital Microfluidics Droplet Actuation for Science Education.

J Vis Exp 2021 Apr 26(170). Epub 2021 Apr 26.

Electrical Engineering, National Tsing Hua University;

This paper describes an educational kit based on digital microfluidics. A protocol for luminol-based chemiluminescence experiment is reported as a specific example. It also has fluorescent imaging capability and closed humidified enclosure based on an ultrasonic atomizer to prevent evaporation. Read More

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Detecting Connected Consciousness During Propofol-Induced Anesthesia Using EEG Based Brain Decoding.

Int J Neural Syst 2021 May 7:2150021. Epub 2021 May 7.

School of Life Science and Technology, Xidian University, Xi'an, P. R. China.

Connected consciousness refers to the state when external stimuli can enter into the stream of our consciousness experience. Emerging evidence suggests that although patients may not respond behaviorally to external stimuli during anesthesia, they may be aware of their surroundings. In this work, we investigated whether EEG based brain decoding could be used for detecting connected consciousness in the absence of behavioral responses during propofol infusion. Read More

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Prospective inference of bioprocess cell viability through chemometric modeling of fluorescence multiway data.

Biotechnol Prog 2021 May 10. Epub 2021 May 10.

Laboratorio de Desarrollo Analítico y Quimiometría (LADAQ), Cátedra de Química Analítica I, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Ciudad Universitaria, Santa Fe, Argentina.

In this investigation, the fermentation step of a standard mammalian cell-based industrial bioprocess for the production of a therapeutic protein was studied, with particular emphasis on the evolution of cell viability. This parameter constitutes one of the critical variables for bioprocess monitoring, since it can affect downstream operations and the quality of the final product. In addition, when the cells experiment an unpredictable drop in viability, the assessment of this variable through classic off-line methods may not provide information sufficiently in advance to take corrective actions. Read More

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