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Prevalence and Distribution of Ankle Joint Equinus in 249 Consecutive Patients Attending a Foot and Ankle Specialty Clinic.

J Am Podiatr Med Assoc 2021 Mar;111(2)

Background: The definition of equinus varies from less than 0° to less than 25° of dorsiflexion with the foot at 90° to the leg. Despite its pervasive nature and broad association with many lower-extremity conditions, the prevalence of ankle equinus is unclear. Furthermore, there are few data to suggest whether equinus is predominantly a bilateral finding or isolated to the affected limb only. Read More

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Efficacy and Safety of a Hyaluronic Acid-Containing Gauze Pad in the Treatment of Chronic Venous or Mixed-Origin Leg Ulcers: A Prospective, Multicenter, Randomized Controlled Trial.

Wounds 2021 Apr 7. Epub 2021 Apr 7.

Department of Dermatology, Hospital Saint-Eloi, Montpellier, France.

Introduction: Hyaluronic acid (HA)-containing formulations routinely are utilized along with standard therapy to promote faster healing of chronic wounds; evidence to guide clinical decisions on the use of topical HA in the healing of vascular leg ulcers is limited.

Objective: This study compared the efficacy and safety of an HA-impregnated gauze pad with an identical gauze pad without HA in the treatment of chronic leg ulcers of vascular origin.

Materials And Methods: A prospective, multicenter, multinational, parallel-group, randomized, double-blind, clinical study was conducted between June 13, 2017, and December 31, 2018. Read More

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Prevalence and changes in depressive symptoms among postgraduate students: A systematic review and meta-analysis from 1980 to 2020.

Stress Health 2021 Mar 26. Epub 2021 Mar 26.

Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu, China.

Education actively helps us develop our well-being and health, but postgraduate students are at high risk of depression. The prevalence of depression symptoms varies from 6.2% to 84. Read More

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Autoantibodies to LG3 are Associated with Poor Long-term Survival after Liver Re-transplantation.

Clin Transplant 2021 Apr 19:e14318. Epub 2021 Apr 19.

Departmnt of Pathology, University of Pittsburgh, Pittsburgh.

Autoantibodies are detrimental to the survival of organ transplantation. We demonstrated that Angiotensin II Type I Receptor agonistic autoantibodies (AT1R-AA) were associated with poor outcomes after liver retransplantation. To examine the effect of other autoantibodies, we studied a retrospective cohort of 93 patients who received a second liver transplant. Read More

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The Impact of Coronavirus (COVID-19) Related Public-Health Measures on Training Behaviours of Individuals Previously Participating in Resistance Training: A Cross-Sectional Survey Study.

Sports Med 2021 Apr 19. Epub 2021 Apr 19.

Solent University, Southampton, UK.

Introduction: Understanding the impact of lockdown upon resistance training (RT), and how people adapted their RT behaviours, has implications for strategies to maintain engagement in similar positive health behaviours. Further, doing so will provide a baseline for investigation of the long-term effects of these public health measures upon behaviours and perceptions, and facilitate future follow-up study.

Objectives: To determine how the onset of coronavirus (COVID-19), and associated 'lockdown', affected RT behaviours, in addition to motivation, perceived effectiveness, enjoyment, and intent to continue, in those who regularly performed RT prior to the pandemic. Read More

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Evaluation of revised classification criteria for giant cell arteritis and its clinical phenotypes.

Rheumatology (Oxford) 2021 Apr 19. Epub 2021 Apr 19.

Rheumatology, Department of Clinical Sciences, Malmö,Lund University.

Background: Giant cell arteritis (GCA) is a systemic vasculitis of the elderly, viewed by many as a disease with multiple and overlapping clinical phenotypes. Retrospective studies have shown differences in clinical presentation between these phenotypes. To reflect the heterogeneity of GCA, and novel diagnostic methods, new classification criteria have been proposed. Read More

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Adverse Events Associated With the Addition of Aspirin to Direct Oral Anticoagulant Therapy Without a Clear Indication.

JAMA Intern Med 2021 Apr 19. Epub 2021 Apr 19.

Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor.

Importance: It is unclear how many patients treated with a direct oral anticoagulant (DOAC) are using concomitant acetylsalicylic acid (ASA, or aspirin) and how this affects clinical outcomes.

Objective: To evaluate the frequency and outcomes of prescription of concomitant ASA and DOAC therapy for patients with atrial fibrillation (AF) or venous thromboembolic disease (VTE).

Design, Setting, And Participants: This registry-based cohort study took place at 4 anticoagulation clinics in Michigan from January 2015 to December 2019. Read More

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Association between Pain, Pulmonary Function, and Respiratory Symptoms in People with HIV.

J Acquir Immune Defic Syndr 2021 Apr 5. Epub 2021 Apr 5.

Department of Medicine, University of Pittsburgh, Pittsburgh, PA Department of Medicine, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, WA Division of HIV, Infectious Diseases, and Global Medicine and Division of Pulmonary and Critical Care Medicine, Zuckerberg San Francisco General, University of California San Francisco, San Francisco, CA Department of Medicine, Veterans Affairs Pittsburgh Health Care System Department of Immunology, University of Pittsburgh, Pittsburgh, PA.

Background: People with HIV (PWH) experience chronic pain and respiratory symptoms, which are closely related in the general population. Pain may impact the impaired pulmonary function seen in PWH beyond its association with HIV alone. Our objective was to investigate the relationship of pain severity to pulmonary function, respiratory symptoms, and sleep disturbance in PWH. Read More

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Differences in end-of-life care and outcomes in palliative consultation-eligible patients with and without do-not-resuscitate orders - A propensity score matched study.

J Chin Med Assoc 2021 Apr 5. Epub 2021 Apr 5.

Department of Emergency Medicine, Taipei Veterans General Hospital, Taipei,ROC Taiwan; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC Department of Nursing, Taipei Veterans General Hospital, Taipei, Taiwan, ROC Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC Institute of Emergency and Critical Care Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC Department of Emergency Medicine, Taipei Veterans General Hospital; and National Defense Medical Center, Taipei, Taiwan, ROC.

Background: The primary objective of palliative care, not synonymous with end-of-life care, is to align care plans with patient goals, regardless of whether these goals include the pursuit of invasive, life-sustaining procedures or not. This study determines the differences in end-of-life (EOL) care, resource utilization, and outcome in palliative care consultation-eligible emergency department patients with and without do-not-resuscitate (DNR) orders.

Methods: This is a retrospective observational study. Read More

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Same family, divergent realities: How triangulation preserves parents' illusory harmony while adolescents navigate interparental conflicts.

J Fam Psychol 2021 Mar;35(2):128-137

Human Development and Family Studies and Edna Bennett Pierce Prevention Research Center.

Triangulation is a process in which a child is drawn into conflict between two parents, and is linked to adolescent psychological maladjustment. Although harmful, families may engage in triangulation due to its promotion of diverging realities in which youth become more attuned to interparental conflict (IPC), yet parents are distracted from tension within their interparental relationship. Although central to theoretical depictions of triangulation and carrying robust implications for family science and prevention, the phenomenon of diverging realities in triangulating families has received inadequate empirical evaluation. Read More

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With great power comes more job demands: The dynamic effects of experienced power on perceived job demands and their discordant effects on employee outcomes.

J Appl Psychol 2021 Apr 19. Epub 2021 Apr 19.

Department of Management, Warrington College of Business, University of Florida.

In this work, we consider the complex and discordant effects that psychological power has on powerholders. To do so, we integrate the situated focus theory of power, which identifies perceptions of job demands as a key outcome of power, with new insights from the challenge-hindrance framework, which acknowledges that job demands may both help and hurt employees. Our model delineates how power-induced job demands may simultaneously benefit (manifested as goal progress and meaningfulness) and harm (manifested as physical discomfort and anxiety) powerholders. Read More

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Frequency effects in action versus value learning.

J Exp Psychol Learn Mem Cogn 2021 Apr 19. Epub 2021 Apr 19.

Department of Psychological and Brain Sciences.

Recent work in reinforcement learning has demonstrated a choice preference for an option that has a lower probability of reward (A) when paired with an alternative option that has a higher probability of reward (C), if A has been experienced more frequently than C (the frequency effect). This finding is critical as it is inconsistent with widespread assumptions that expected value is based on average reward, and instead suggests that value is based on cumulative instances of reward. However, option frequency may also affect instrumental reinforcement of choosing A during training, which may then transfer to choice on AC trials. Read More

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Preoperative staging of advanced ovarian cancer: comparison between ultrasound, CT and WB-DWI/MRI (ISAAC).

Ultrasound Obstet Gynecol 2021 Apr 19. Epub 2021 Apr 19.

Gynecologic Oncology Center, Department of Obstetrics and Gynecology, First Faculty of Medicine, Charles University and General University Hospital in Prague.

Objectives: To evaluate transvaginal and transabdominal ultrasound for assessment of sites of disease and prediction of non-resectability compared with the first-line staging method (CT, computed tomography) and a novel technique (WB-DWI/MRI, whole-body magnetic resonance imaging with diffusion-weighted sequence) in patients with suspected ovarian cancer.

Methods: New patients planned for ovarian cancer surgery at a Gynecologic oncology centre were enrolled. They underwent preoperative staging and prediction of non-resectability with ultrasound, CT, and WB-DWI/MRI, following a single predefined evaluation. Read More

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Laparoscopic transhiatal esophagectomy in esophageal cancer patients with high-risk post-operative complications.

Dis Esophagus 2021 Apr 19. Epub 2021 Apr 19.

Department of Gastroenterology, Digestive Surgery Division, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

Surgical treatment of esophageal cancer is challenging, due to considerable morbidity, especially in high surgical risk patients. While transhiatal esophagectomy leads to good oncological outcomes and reduced postoperative complications, less invasive techniques might further improve outcomes. Our goal was to compare results of laparoscopic transhiatal esophagectomy (LTE) with open transhiatal esophagectomy (OTE) in esophageal cancer patients at high surgical risk. Read More

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Cognitive Load in Electromagnetic Navigational and Robotic Bronchoscopy for Pulmonary Nodules.

ATS Sch 2020 Dec 23;2(1):97-107. Epub 2020 Dec 23.

Division Pulmonary/Critical Care Medicine, Section of Interventional Pulmonology, Johns Hopkins University, Baltimore, Maryland.

Electromagnetic navigational bronchoscopy (ENB) and robotic-assisted bronchoscopy (RB) require a high degree of decision-making and psychomotor skill. Cognitive load theory is the overall effort expended by individuals in response to a task and is closely related to the usability of devices for medical procedures. High cognitive workload leads to poor surgical outcomes and represents a bottleneck for learning that affects performance. Read More

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December 2020

Treatment of head and neck carcinoma of unknown primary: Cracking a nut with a sledgehammer?

Laryngoscope Investig Otolaryngol 2021 Apr 26;6(2):211-218. Epub 2021 Mar 26.

Department of Otorhinolaryngology and Head and Neck Surgery Erasmus University Medical Center Rotterdam The Netherlands.

Objectives: To compare the impact on survival and late radiation toxicity of patients with squamous cell carcinoma of unknown primary who were treated with ipsilateral neck dissection and ipsilateral postoperative radiotherapy (PORT) and patients treated with ipsilateral neck dissection and PORT to both sides of the neck plus the pharyngeal axis.

Methods: Retrospective cohort study performed at the Erasmus University Medical Center in which 78 patients with squamous cell carcinoma of unknown primary were identified. Thirty-nine patients received PORT to both sides of the neck plus the pharyngeal axis (BILAX) and another 39 patients were irradiated on the ipsilateral neck (IPSI) only. Read More

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Lifelong impact of extreme stress on the human brain: Holocaust survivors study.

Neurobiol Stress 2021 May 20;14:100318. Epub 2021 Mar 20.

Central European Institute of Technology (CEITEC), Brain and Mind Research Program, Masaryk University, Brno, Czech Republic.

Background: We aimed to assess the lifelong impact of extreme stress on people who survived the Holocaust. We hypothesised that the impact of extreme trauma is detectable even after more than 70 years of an often complicated and stressful post-war life.

Methods: Psychological testing was performed on 44 Holocaust survivors (HS; median age 81. Read More

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Outcome Analysis of Intramedullary Nailing Augmented with Poller Screws for Treating Difficult Reduction Fractures of Femur and Tibia: a Retrospective Cohort Study.

Biomed Res Int 2021 2;2021:6615776. Epub 2021 Apr 2.

Department of Orthopedic Surgery, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, China.

Purpose: Poller screws may serve as an adjunctive reduction tool and aid fracture reduction while augmented with intramedullary (IM) nailing for treating diaphyseal or metaphyseal fractures of the femur and tibia. However, there is no consistent conclusion about whether the method of using IM nailing augmented with poller screws is more advantageous than using IM nailing alone.

Methods: A total of 96 patients who received IM nailing with or without supportive poller screw for treating long-bone fractures in lower limbs and who experienced difficulties in performing reduction or IM insertion during the surgical process were included in this retrospective cohort study (33 patients with poller screws in group A versus 63 patients without poller screws in group B). Read More

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Biomechanical Investigation Between Rigid and Semirigid Posterolateral Fixation During Daily Activities: Geometrically Parametric Poroelastic Finite Element Analyses.

Front Bioeng Biotechnol 2021 1;9:646079. Epub 2021 Apr 1.

Bone and Joint Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan.

While spinal fusion using rigid rods remains the gold standard treatment modality for various lumbar degenerative conditions, its adverse effects, including accelerated adjacent segment disease (ASD), are well known. In order to better understand the performance of semirigid constructs using polyetheretherketone (PEEK) in fixation surgeries, the objective of this study was to analyze the biomechanical performance of PEEK versus Ti rods using a geometrically patient-specific poroelastic finite element (FE) analyses. Ten subject-specific preoperative models were developed, and the validity of the models was evaluated with previous studies. Read More

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Serum Levels of Soluble Urokinase Plasminogen Activator Receptor Predict Tumor Response and Outcome to Immune Checkpoint Inhibitor Therapy.

Front Oncol 2021 1;11:646883. Epub 2021 Apr 1.

Clinic for Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Background: Immune checkpoint inhibitors (ICIs) have led to a paradigm shift in cancer therapy, improving outcomes in the treatment of various malignancies. However, not all patients benefit to the same extend from ICI. Reliable tools to predict treatment response and outcome are missing. Read More

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Safety and Tolerability of BRAF Inhibitor and BRAF Inhibitor-Based Combination Therapy in Chinese Patients With Advanced Melanoma: A Real World Study.

Front Oncol 2021 1;11:582676. Epub 2021 Apr 1.

Biotherapy Center, Sun Yat-sen University Cancer Center, Guangzhou, China.

The toxicity spectrum between Chinese and Caucasian patients with melanoma who were treated with BRAF inhibitors (BRAFi) may differ. The purpose of the present study was to assess the safety and tolerability of BRAFi and BRAFi-based combination therapies [MEK inhibitors (MEKi) or anti-programmed death-1 (PD-1) antibody] in Chinese patients with mutation-positive metastatic melanoma. We also investigated whether treatment-related adverse events (AEs) correlated with the prognosis. Read More

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The effects of mode of delivery, maternal age, birth weight, gender and family history on screening hearing results: A cross sectional study.

Ann Med Surg (Lond) 2021 Apr 26;64:102236. Epub 2021 Mar 26.

Department of General and Special Surgery, Faculty of Medicine, Hashemite University, Zarqa, Jordan.

Introduction: Congenital hearing impairment is one of the principal issues that make distress to families especially those with a family history of hearing problems. Early detection of hearing impairment can make a difference regarding cognitive, attention, learning, speech, and social and emotional development of babies. Otoacoustic test emission is a very common screening test that can be used to pick up early cases and relieve family stress. Read More

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Progression of Nonmotor Symptoms in Parkinson's Disease by Sex and Motor Laterality.

Parkinsons Dis 2021 1;2021:8898887. Epub 2021 Apr 1.

Department of Neurology, University of Louisville, Louisville, KY 40292, USA.

Nonmotor symptoms (NMS) in Parkinson's disease (PD) can start up to a decade before motor manifestations and strongly correlate with the quality of life. Understanding patterns of NMS can provide clues to the incipient site of PD pathology. Our goal was to systematically characterize the progression of NMS in PD ( = 489), compared to healthy controls, HC ( = 241), based on the sex of the subjects and laterality of motor symptom onset. Read More

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Risk of Stroke in Systemic Necrotizing Vasculitis: A Nationwide Study Using the National Claims Database.

Front Immunol 2021 31;12:629902. Epub 2021 Mar 31.

Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.

Objective: Evidences indicate that the risk of stroke is increased in autoimmune rheumatic diseases. This study aimed to investigate the incidence of stroke in patients with systemic necrotizing vasculitis (SNV) using the national health database.

Methods: Data were obtained from the Korean National Claims database between 2010 and 2018 to identify incident SNV [anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) and polyarteritis nodosa (PAN)] cases. Read More

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COVID-19: Are School Counseling Services Ready? Students' Psychological Symptoms, School Counselors' Views, and Solutions.

Front Psychol 2021 31;12:647740. Epub 2021 Mar 31.

Department of Guidance and Psychological Counseling, Hasan Kalyoncu University, Gaziantep, Turkey.

The purpose of the current study was to investigate the effects of COVID-19 on high school students' psychological symptoms and to understand how ready counselors and school counseling services are based on the data we have. Therefore, this research is designed under two different studies: (A) Study 1: Effects of COVID-19 pandemic on students' psychological symptoms and (B) Study 2: Views and expectations of students and school counselors about school counseling services. The first study was a quantitative study and included 549 high school students (398 female, 151 male). Read More

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Music Listening as a Strategy for Managing COVID-19 Stress in First-Year University Students.

Front Psychol 2021 1;12:647065. Epub 2021 Apr 1.

UQ Music, Dance & Health Research Group, The University of Queensland, St Lucia, QLD, Australia.

The COVID-19 pandemic brought rapid changes to travel, learning environments, work conditions, and social support, which caused stress for many University students. Research with young people has revealed music listening to be among their most effective strategies for coping with stress. As such, this survey of 402 first-year Australian University students (73. Read More

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Spiritual Well-Being and Mental Health During the COVID-19 Pandemic in Italy.

Front Psychiatry 2021 1;12:626944. Epub 2021 Apr 1.

Department of Education Sciences, School of Social Sciences, University of Genoa, Genova, Italy.

During the COVID-19 pandemic in Italy, people and families experienced a new and sudden situation that forced them to stay in their homes for a long period (February 25- May 26). In this context, many people found themselves in great difficulty, not only because of the fear of contagion or the economic problems deriving from the closure of production activities but also because the virus profoundly changed the way of life in society. The "Social distancing" concept became central in all personal relationships, including close family relationships. Read More

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Job demands, work engagement and job turnover intentions among registered nurses: Explained by work-family private life inference.

Work 2021 Apr 10. Epub 2021 Apr 10.

Department of Social and Behavioral Studies, Division of Psychology, Education and Sociology, University West, Trollhättan, Sweden.

Background: The job demands on nurses have increased. Conflict between work life and family life may lead to stress and lower work engagement. Consequently, nurses may choose a different career path or leave the profession. Read More

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Depression or anxiety symptoms associated with occupational role transitions in Brazilian adults with a traumatic spinal cord injury: A multivariate analysis.

Work 2021 Apr 10. Epub 2021 Apr 10.

Global Health and Tropical Medicine (GHTM) & WHO Collaborating Centre for Health Workforce Policy and Planning, Institute of Hygiene and Tropical Medicine, NOVA University of LisbonLisbonPortugal.

Background: Psychological morbidity is commonly experienced by people with a spinal cord injury (SCI), but whether it is associated with occupational role transitions in is unknown.

Objective: To analyze whether anxiety or depression symptoms are independently associated to increased likelihoods of role transitions in adults with SCI.

Methods: Cross-sectional study; multivariate analysis using a heteroscedastic Dirichlet regression. Read More

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Insomnia: Sex differences and age of onset in active duty Army soldiers.

Sleep Health 2021 Apr 15. Epub 2021 Apr 15.

Cpl. Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA; Department of Psychiatry, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA.

Background: The prevalence of insomnia symptoms, insomnia diagnostic status, and age of onset compared by sex is understudied within the military population.

Method: Data were examined from the All Army Study to Assess Risk and Resilience in Service members (N = 21,294; 18-61 years; 11.7% female and 87. Read More

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