717,149 results match your criteria experience cases

Efficacy of a pediatric headache infusion center: A single-center experience.

Headache 2021 Jul 29. Epub 2021 Jul 29.

Division of Child Neurology, Dayton Children's Hospital, Dayton, OH, USA.

Objective: To evaluate the efficacy of a pediatric headache infusion center (HIC) in alleviating the symptoms and preventing future visits to the emergency department (ED).

Background: Headache is a common reason for visits to the pediatric ED. ED visits are associated with inordinate costs of care and are conceived by parents to be avoidable if adequate alternatives are available. Read More

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A template for physical resilience research in older adults: Methods of the PRIME-KNEE study.

J Am Geriatr Soc 2021 Jul 29. Epub 2021 Jul 29.

Duke University School of Medicine, Durham, North Carolina, USA.

Background: Older adults with similar health conditions often experience widely divergent outcomes following health stressors. Variable recovery after a health stressor may be due in part to differences in biological mechanisms at the molecular, cellular, or system level, that are elicited in response to stressors. We describe the PRIME-KNEE study as an example of ongoing research to validate provocative clinical tests and biomarkers that predict resilience to specific health stressors. Read More

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Cold-Injection Molded Gentamicin-Impregnated Polymethyl Methacrylate Implants for Cranioplasty.

Oper Neurosurg (Hagerstown) 2021 Jul 29. Epub 2021 Jul 29.

Department of Clinical Neuroscience, Salmaniya Medical Complex, Ministry of Health, Manama, Kingdom of Bahrain.

Background: Cranioplasty can be carried out using either fresh, frozen autologous bone or synthetic substitutes. Ordering artificial 3 dimensional (3D) implants is challenging and time consuming depending on geographical location. In this article, we share our experience using a streamlined process of producing 3D computer-assisted design (CAD) implants using commercially available 3D printers and silicone molds that can be easily replicated with consistent results and are associated with good outcomes. Read More

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Adverse Events Associated With Electromyogram Endotracheal Tubes in Thyroid and Parathyroid Surgery.

J Patient Saf 2021 Jul 29. Epub 2021 Jul 29.

From the Department of Otolaryngology-Head and Neck Surgery, Drexel University College of Medicine, Philadelphia, PA Department of Otolaryngology-Head and Neck Surgery, University of Miami Miller School of Medicine, Miami, FL Division of Otolaryngology-Head and Neck Surgery, George Washington University School of Medicine and Health Sciences, Washington, DC.

Objective: Thyroid and parathyroid surgeries are frequently performed with the aid of electromyogram endotracheal tubes. However, the most common adverse events have not been reported comprehensively. This study aimed to summarize the device adverse events, patient complications, and subsequent interventions related to electromyogram endotracheal tubes. Read More

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Oncologists' Perceptions of Tumor Genomic Profiling and the Communication of Test Results and Risks.

Public Health Genomics 2021 Jul 29:1-6. Epub 2021 Jul 29.

College of Public Health, Cancer Prevention and Control Program, Fox Chase Cancer Center, Temple University, Philadelphia, Pennsylvania, USA.

Tumor genomic profiling (TGP) identifies genetic targets for precision cancer treatments. The complexity of TGP can expose gaps in oncologists' skills, complicating test interpretation and patient communication. Research on oncologists' use and perceptions of TGP could inform practice patterns and training needs. Read More

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Merozoites of Theileria orientalis buffeli reduce the parasitaemia of T. orientalis ikeda following tick challenge.

Vet Parasitol 2021 Jul 24;298:109532. Epub 2021 Jul 24.

Tick Fever Centre, Wacol, QLD, 4076, Australia.

Theileria orientalis is a tick-borne protozoal parasite causing anaemia and death in susceptible cattle. This investigation aimed to confirm whether immunisation with the "benign" buffeli genotype of T. orientalis could reduce the parasitaemia of the virulent ikeda genotype. Read More

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"Does that mean I can't use my phone to pay when I'm in the Maccas drive thru?": Younger drivers' uncertainty and attitude toward smartphone law and punishment.

Accid Anal Prev 2021 Jul 26;160:106314. Epub 2021 Jul 26.

Monash University Accident Research Centre, Monash University, Australia.

This study employed a mixed methods approach (a survey [n = 2,774] and focus groups [n = 16]) to understand the perceptions of younger drivers (18-25) on current smartphone laws in the Australian state of Victoria. First, by analysing quantitative data gathered from an online survey regarding smartphone laws, perceptions of punishment when breaking the law, and attitudes to both the law and fines, this study found younger drivers were less likely to understand the law around phone use while driving, even after direct or indirect experience with police. Additionally, the severity and impact of fines were perceived as more impactful and severe among younger drivers, women, and those on lower incomes, and the most common types of illegal use younger drivers engaged with were navigation, music applications, and hands-free calling, mostly facilitated through Bluetooth with their device placed out of sight. Read More

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The effect of dispatch of national medical teams to Wuhan on its control and prevention of COVID-19.

X Fan Y Gu B Guan

Public Health 2021 Apr 27;198:1-5. Epub 2021 Apr 27.

Institute of Social Development, Chinese Academy of Macroeconomic Research, Beijing, 100038, China.

Objectives: As a unique prevention and control measure, the dispatch of national medical teams to Wuhan has played a key role in protecting Wuhan against COVID-19. This study aimed to quantitatively evaluate the effect of this key measure in reducing infections and fatalities.

Study Design: A scenario analysis is used in this study, where the forming of scenarios is on the basis of the stages of medical to Wuhan. Read More

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Behavioral and mental health problems in adolescents with ADHD: Exploring the role of family resilience.

J Affect Disord 2021 Jul 22;294:450-458. Epub 2021 Jul 22.

Department of Family, Youth, and Community Sciences, University of Florida, Gainesville, FL, United States.

Background: Family resilience and its role in behavioral and mental health problems has not been well documented among U.S. adolescents, especially those with ADHD. Read More

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A systematic review and meta-analysis of the association between expressive suppression and positive affect.

Clin Psychol Rev 2021 Jul 14;88:102068. Epub 2021 Jul 14.

Georgia State University, Department of Psychology, 140 Decatur St SE, 1172 Urban Life, Atlanta, GA, United States of America. Electronic address:

People differ in their self-reported propensities to experience positive affect (PA). Even those prone to internalizing symptoms show varied proclivities to PA; social anxiety (SA), for instance, unlike other types of anxiety, shows a strong negative association with PA that cannot be explained by diminished reward sensitivity. Heightened reliance on suppression of emotional displays (expressive suppression; ES) may be an alternate contributor to attenuated PA among people with elevated SA, relative to people with other types of anxiety. Read More

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Neurosurgical outcomes, protocols and resource management during lockdown: An early institutional experience from one of world's largest COVID 19 hotspots.

World Neurosurg 2021 Jul 26. Epub 2021 Jul 26.

Department of Neuroanaesthesiology; INHS Asvini, Colaba, Mumbai, India 400005. Electronic address:

Background: As the COVID-19 pandemic completes one year, it is prudent to reflect back upon the challenges faced and the management strategies employed to tackle this overwhelming healthcare crisis. We undertook this study to validate our institutional protocols which were formulated to cater to the change in volume and pattern of neurosurgical cases during the raging pandemic.

Methods: All admitted patients scheduled to undergo major neurosurgical intervention during the lockdown period (15 March 2020 to 15 September 2020) were included in the study. Read More

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Clin Res Hepatol Gastroenterol 2021 Jul 26:101761. Epub 2021 Jul 26.

Service d'hépato-gastroentérologie, Hôpital Haut-Lévêque, CHU Bordeaux, pessac & INSERM U1053, Université de Bordeaux, Bordeaux.

Liver elastography offers the possibility of a quick, non-invasive, and painless evaluation of the liver with immediate results at bedside. Transient elastography is the most validated technology, and many others such as point shear wave elastography, 2D-shear wave elastography, or magnetic resonance elastography have been developed. To ensure the best evaluation, several conditions of examination must be respected for liver stiffness measurement. Read More

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Does mobile payment change consumers' perception during payment process? -an ERP study.

Neurosci Lett 2021 Jul 26:136138. Epub 2021 Jul 26.

School of Business Administration, Guizhou University of Finance and Economics, Guiyang, P.R. China.

Innovative payment methods have been getting worldwide attention. Exploring the mechanisms behind consumers' purchase behaviors modulated by different payment methods was critical but challenging. In this paper, we proposed a 2 (payment methods: cash payment vs mobile payment) × 2 (price levels of products: high vs low) Event-Related Potentials (ERPs) experiment to study the difference of cash payment and mobile payment on consumers' purchase intention of products in different price level from a neuroscience perspective. Read More

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Phenothiazines alter plasma membrane properties and sensitize cancer cells to injury by inhibiting annexin-mediated repair.

J Biol Chem 2021 Jul 26:101012. Epub 2021 Jul 26.

Membrane Integrity, Danish Cancer Society Research Center, Strandboulevarden 49, DK-2100 Copenhagen, Denmark; Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark. Electronic address:

Repair of damaged plasma membrane in eukaryotic cells is largely dependent on the binding of annexin repair proteins to phospholipids. Changing the biophysical properties of the plasma membrane may provide means to compromise annexin-mediated repair and sensitize cells to injury. Since, cancer cells experience heightened membrane stress, and are more dependent on efficient plasma membrane repair, inhibiting repair may provide approaches to sensitize cancer cells to plasma membrane damage and cell death. Read More

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Endofistula Laser Ablation of Fistula-in-Ano: A New Minimally Invasive Technique for the Treatment of Fistula-in-Ano.

Ann Coloproctol 2021 Jul 29. Epub 2021 Jul 29.

Department of Surgery, Zoram Medical College, Falkawn, India.

Purpose: Many techniques are used to treat fistula-in-ano (FIA). The major problems associated with conventional surgical techniques are postoperative complications like sepsis, incontinence, etc. Therefore, several sphincter-saving techniques have been developed in recent years including laser diodes. Read More

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A qualitative analysis of vertical leadership development amongst NHS health-care workers in low to middle income country settings.

Leadersh Health Serv (Bradf Engl) 2021 Jul;ahead-of-print(ahead-of-print)

Head of Faculty, Global Health Partnerships Directorate, Health Education England, Manchester, UK.

Purpose: The improving global health (IGH) programme is a leadership development programme that aims to develop leadership skills and behaviours alongside quality improvement methodology in National Health Service (NHS) employees in a global health setting. Through collaboration, experiential learning and mentorship, the programme aims to produce both vertical and horizontal leadership development in its participants. This paper aims to describe the programme and its impact, in terms of leadership development, in a sample of participants. Read More

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Acute lymphoblastic leukemia in infants: a quarter century of nationwide efforts in Japan.

Pediatr Int 2021 Jul 29. Epub 2021 Jul 29.

Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Japan.

Acute lymphoblastic leukemia (ALL) with KMT2A gene rearrangement (KMT2A-r) in infants is a biologically and clinically unique disease and one of the most difficult-to-cure forms of pediatric leukemia. Continuing nationwide efforts by conducting multicenter clinical trials have been carried out in Japan since the mid-1990s by introducing allogeneic hematopoietic stem cell transplantation (HSCT) in first remission, which led to a modest improvement in outcome of infants with KMT2A-r ALL. Because of the emerging evidence that HSCT does not benefit every infant with KMT2A-r ALL, the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) trial MLL-10 introduced risk stratification using age and presence of CNS leukemia and introduced intensive chemotherapy including high-dose cytarabine in early consolidation; indication of HSCT was restricted to the patients with high-risk features. Read More

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Thromboprophylaxis after kidney transplantation in children: Ten-year experience of a single Brazilian center.

Pediatr Transplant 2021 Jul 29:e14101. Epub 2021 Jul 29.

Division of Pediatric Hematology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

Background: Kidney transplantation is the gold standard treatment for children with end-stage chronic kidney disease. Graft thrombosis is an important cause of graft failure, with high morbidity, mortality, and impact on quality of life and to the health system. The role of thromboprophylaxis in this setting is still uncertain. Read More

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Multi-Disciplinary Clinic Models: A Paradigm of Care for Management of Non-Alcoholic Fatty Liver Disease (NAFLD).

Hepatology 2021 Jul 29. Epub 2021 Jul 29.

Division of Gastroenterology and Hepatology, Weill Cornell Medicine, New York, NY, USA.

The complex nature and comorbidities of patients with non-alcoholic fatty liver disease (NAFLD) highlights the need for a multidisciplinary care model. These multidisciplinary patient-centered models deliver personalized specialty care and improve efficiency and efficacy of therapy. In this paper, we review current models of multidisciplinary care teams and introduce a framework for building a comprehensive NAFLD program based on real-world experience within our institution. Read More

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Barriers and potential solutions in the recruitment and retention of older patients in clinical trials-lessons learned from six large multicentre randomized controlled trials.

Age Ageing 2021 Jul 29. Epub 2021 Jul 29.

Department of Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Berlin, Germany.

Background: older people remain underrepresented in clinical trials, and evidence generated in younger populations cannot always be generalized to older patients.

Objective: to identify key barriers and to discuss solutions to specific issues affecting recruitment and retention of older participants in clinical trials based on experience gained from six current European randomised controlled trials (RCTs) focusing on older people.

Methods: a multidisciplinary group of experts including representatives of the six RCTs held two networking conferences and compiled lists of potential barriers and solutions. Read More

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Food insecurity and mental health of women during COVID-19: Evidence from a developing country.

PLoS One 2021 29;16(7):e0255392. Epub 2021 Jul 29.

Centre for Development Economics and Sustainability, Department of Economics, Monash University, Melbourne, Australia.

Background: This study examines the association between food insecurity and mental health of women during the COVID-19 pandemic in a resource poor setting.

Materials And Methods: Data were collected at two time-points (wave 1 and 2) from 2402 women, one per household, participating in a larger study during extended COVID-19 lockdown in the rural areas of the southwest region of Bangladesh. The primary outcome of the analyses is the association between food insecurity, measured using the Food Insecurity Experience Scale (FIES), and stress level, measured using the Perceived Stress Scale (PSS), for women during the lockdown. Read More

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Experiences of people with opioid use disorder during the COVID-19 pandemic: A qualitative study.

PLoS One 2021 29;16(7):e0255396. Epub 2021 Jul 29.

Department of Emergency Medicine, St Paul's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.

Aim: To capture pandemic experiences of people with opioid use disorder (OUD) to better inform the programs that serve them.

Design: We designed, conducted, and analyzed semi-structured qualitative interviews using grounded theory. We conducted interviews until theme saturation was reached and we iteratively developed a codebook of emerging themes. Read More

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Predicting pain among female survivors of recent interpersonal violence: A proof-of-concept machine-learning approach.

PLoS One 2021 29;16(7):e0255277. Epub 2021 Jul 29.

Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.

Interpersonal violence (IPV) is highly prevalent in the United States and is a major public health problem. The emergence and/or worsening of chronic pain are known sequelae of IPV; however, not all those who experience IPV develop chronic pain. To mitigate its development, it is critical to identify the factors that are associated with increased risk of pain after IPV. Read More

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Lack of neophobic responses to color in a jumping spider that uses color cues when foraging (Habronattus pyrrithrix).

PLoS One 2021 29;16(7):e0254865. Epub 2021 Jul 29.

Entomology and Nematology Department, University of Florida, Gainesville, FL, United States of America.

Chemically defended prey often advertise their toxins with bright and conspicuous colors. To understand why such colors are effective at reducing predation, we need to understand the psychology of key predators. In bird predators, there is evidence that individuals avoid novelty-including prey of novel colors (with which they have had no prior experience). Read More

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Streamlining brain tumor surgery care during the COVID-19 pandemic: A case-control study.

PLoS One 2021 29;16(7):e0254958. Epub 2021 Jul 29.

Pacific Neuroscience Institute, Providence Saint John's Health Center, Santa Monica, California, United States of America.

Background: The COVID-19 pandemic forced a reconsideration of surgical patient management in the setting of scarce resources and risk of viral transmission. Herein we assess the impact of implementing a protocol of more rigorous patient education, recovery room assessment for non-ICU admission, earlier mobilization and post-discharge communication for patients undergoing brain tumor surgery.

Methods: A case-control retrospective review was undertaken at a community hospital with a dedicated neurosurgery and otolaryngology team using minimally invasive surgical techniques, total intravenous anesthesia (TIVA) and early post-operative imaging protocols. Read More

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1.5 vs 3 Tesla Magnetic Resonance Imaging: A Review of Favorite Clinical Applications for Both Field Strengths-Part 1.

Invest Radiol 2021 Jul 26. Epub 2021 Jul 26.

From the Section of Experimental Radiology, Department of Radiology, Diagnostic, and Interventional Radiology, University of Tübingen, Tübingen Clinic for Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn Department of Radiology, Diagnostic, and Interventional Radiology, University of Tübingen, Tübingen, Germany.

Abstract: Whole-body magnetic resonance imaging (MRI) systems with a field strength of 3 T have been offered by all leading manufacturers for approximately 2 decades and are increasingly used in clinical diagnostics despite higher costs. Technologically, MRI systems operating at 3 T have reached a high standard in recent years, as well as the 1.5-T devices that have been in use for a longer time. Read More

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First-in-man Implantation of a Cardiac Microcurrent Device for Chronic Systolic Heart Failure.

ASAIO J 2021 Jul 27. Epub 2021 Jul 27.

From the Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany Department of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany BerlinHeals GmbH, Berlin, Germany.

Current therapies significantly improve survival and clinical endpoints in patients suffering from chronic heart failure with reduced ejection fraction (HFrEF), but most are not sufficient to reverse adverse remodeling and improve myocardial contractility. Herein, we report the first-in-man experience with a novel fully implantable device for cardiac electrical microcurrent (C-MIC) application. A 79-year-old man suffering from HFrEF (dilated cardiomyopathy, NYHA class III, left ventricular ejection fraction 30%) successfully underwent implantation of the C-MIC device through left anterolateral thoracotomy. Read More

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An Extracorporeal Membrane Oxygenation First Strategy in COVID-19 Acute Respiratory Distress Syndrome.

ASAIO J 2021 Jul 28. Epub 2021 Jul 28.

MD Candidate 2022 Howard University Medical School Washington DC 20059 Medical Director, Adult ECMO Program, Methodist Hospital, 7700 Medical Drive, San Antonio, TX 78229 Clin. Professor Cardiovascular Surgery, Division of Cardiac Surgery, George Washington University, Washington DC 20037 Nurse Practitioner, Adult ECMO Program, Methodist Hospital, 7700 Floyd Curl Drive, San Antonio, TX 78229.

COVID-19 can be associated with acute respiratory distress syndrome (ARDS) which increases the likelihood of morbidity and mortality. Ventilator-induced lung injury (VLI) is a known complication of mechanical ventilation (MV) and can further compound lung injury and recovery. Escalation to extracorporeal membrane oxygenation (ECMO) can be required in patients who deteriorate on MV. Read More

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Longitudinal Experience With and Impressions of COVID-19-Related Clinical Research Changes.

JCO Oncol Pract 2021 Jul 29:OP2100169. Epub 2021 Jul 29.

Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX.

Purpose: The COVID-19 pandemic has led to profound changes in clinical research, including remote consent, telehealth, off-site procedures, shipment of therapy, and remote study monitoring. We assessed longitudinal perceptions of these adjustments among clinical research professionals.

Methods: We distributed an anonymous survey assessing experiences, perceptions, and recommendations regarding COVID-19-related clinical research adjustments to cancer clinical research office personnel in May 2020 and again in November 2020. Read More

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The challenge of prostate biopsy guidance in the era of mpMRI detected lesion: ultrasound-guided versus in-bore biopsy.

Br J Radiol 2021 Jul 29:20210363. Epub 2021 Jul 29.

Department of Urology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.

The current recommendation in patients with a clinical suspicion for prostate cancer is to perform systematic biopsies extended with targeted biopsies, depending on mpMRI results. Following a positive mpMRI [i.e. Read More

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