701,052 results match your criteria experience


Complications of intrathecal drug delivery therapy (ITDD): A retrospective study of 231 implantations between 1999 and 2014.

Clin Neurol Neurosurg 2021 Apr 2;205:106630. Epub 2021 Apr 2.

Department of Rehabilitation Medicine, Region Östergötland & Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.

Objective: Determination of types and frequencies of complications related to ITDD therapy, and assessment of possible risk factors for such complications.

Methods: Retrospective study (1999-2014) including all ITDD-implantations at one regional center in Sweden. Descriptors comprised: sex; age; medical condition; body weight index; preoperative ASA-grade; presence of indwelling urinary catheters, feeding tubes, and/or daily urinary or anal incontinence; primary or re-implantation; type of pump and catheter; drug delivered; weekday of surgery; surgical procedure time; surgeon; experience of surgeon; surgical theater; and type of antibiotic prophylaxis. Read More

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Real-world experience with botulinum toxin A for the treatment of hemifacial spasm: A study of 1138 injections.

Clin Neurol Neurosurg 2021 Apr 2;205:106632. Epub 2021 Apr 2.

Section of Neurology, Institute for Neurosciences, St. Luke's Medical Center, Quezon City, Philippines; Movement Disorders Service and Section of Neurology, Institute for Neurosciences, St. Luke's Medical Center, Quezon City, Philippines; Department of Neurosciences, College of Medicine - Philippine General Hospital, University of the Philippines Manila, Philippines; Movement Disorders Service and Section of Neurology, Institute for Neurosciences, St. Luke's Medical Center, Global City, Philippines. Electronic address:

Background: Hemifacial spasm (HFS) is a chronic, potentially disabling disorder that often requires long-term management with botulinum toxin (BoNT). In a country where healthcare costs limit compliance to medical follow-up and treatment, the study aims to provide a real-world experience on the use of BoNT for HFS among Filipinos.

Methods: We retrospectively collected data from 162 HFS patients who received 1138 botulinum toxin (BoNT) injections from 2006 to 2019 in our movement disorders center in the Philippines. Read More

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Effect of chronic binge-like ethanol consumption on subsequent cocaine reinforcement in rhesus monkeys.

Drug Alcohol Depend 2021 Apr 10;223:108707. Epub 2021 Apr 10.

Department of Physiology & Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, 27157, United States. Electronic address:

Background: Although most individuals with cocaine use disorder also abuse alcohol, little is known about the behavioral and pharmacological mechanisms that promote co-abuse. For example, it is unclear whether prior experience with alcohol renders individuals more sensitive to cocaine when it is subsequently experienced.

Methods: This study examined the effects of chronic ethanol consumption on subsequent cocaine reinforcement in rhesus monkeys. Read More

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Combining immunotherapy with an epidrug in squamous cell carcinomas of different locations: rationale and design of the PEVO basket trial.

ESMO Open 2021 Apr 14;6(3):100106. Epub 2021 Apr 14.

Department of Drug Development and Innovation (D3i), Institut Curie, Paris, France; Inserm U900 Research Unit, Saint Cloud, France; Paris-Saclay University, Paris, France. Electronic address:

Squamous cell carcinomas (SCCs) are among the most frequent solid tumors in humans. SCCs, related or not to the human papillomavirus, share common molecular features. Immunotherapies, and specifically immune checkpoint inhibitors, have been shown to improve overall survival in multiple cancer types, including SCCs. Read More

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Nurse educators' perceptions of factors related to the competence of graduating nursing students.

Nurse Educ Today 2021 Apr 8;101:104884. Epub 2021 Apr 8.

Turku University Hospital, Department of Nursing Science, University of Turku, 20014, Finland. Electronic address:

Background: Clinical practice, clinical nursing teaching, curricula, working experience and previous healthcare degrees are factors related to the competence of graduating nursing students from the points of view of nursing students and clinical mentors. However, nurse educators' perceptions of these factors are lacking in previous studies, despite assessing student performance and competence is a core competence and one of the main duties of nurse educators.

Objectives: The aim of this study was to describe nurse educators' perceptions of factors related to graduating nursing students' competence. Read More

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Nursing applicants' reasoning skills and factors related to them: A cross-sectional study.

Nurse Educ Today 2021 Apr 9;101:104890. Epub 2021 Apr 9.

Department of Nursing Science, Hospital District of Satakunta, 20014 University of Turku, Finland. Electronic address:

Background: The assessment of reasoning skills is recommended in undergraduate nursing student selection. Reasoning skills are crucial for sound decision-making, improving patient safety and are necessary from the very beginning of studies. Nursing applicants' reasoning skills based on the reasoning process have not been previously measured. Read More

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#MentalHealthArt: How Instagram artists promote mental health awareness online.

Public Health 2021 Apr 14;194:67-74. Epub 2021 Apr 14.

Department of Psychology, Bowling Green State University, Bowling Green, OH, 43403, USA. Electronic address:

Objectives: Instagram artwork about mental illness was examined to learn how artists promote awareness about mental health and mental illness.

Study Design: Mixed methods predictive and descriptive analyses were conducted on a public dataset of artwork posts from Instagram.

Methods: One thousand art images were classified by media (painting, drawing, collage, photograph, digital art, printmaking, sculpture, jewelry, or other) and style (representational, nonrepresentational, and functional). Read More

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Analysis of volatiles organic compounds in Venice lagoon water reveals COVID 19 lockdown impact on microplastics and mass tourism related pollutants.

Authors:
Teresa Cecchi

Sci Total Environ 2021 Apr 7;783:146951. Epub 2021 Apr 7.

ITT MONTANI, Via Montani 7, 63900 Fermo, FM, Italy.. Electronic address:

The Lagoon of Venice is a continuously evolving ecosystem that rapidly responds to anthropic stressors. The UNESCO World Heritage site "Venice and its Lagoon", is one of the top tourist destinations in the world. Mass tourism increases marine litter, water traffic emissions, solid waste, and sewage release. Read More

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Reflecting on educational preparedness and professional development for early-career nurse faculty: A phenomenological study.

Nurse Educ Pract 2021 Apr 2;53:103052. Epub 2021 Apr 2.

Northcentral University, 11355 N. Torrey Pines Road, La Jolla, CA, United States. Electronic address:

Bedside nurses are assuming the faculty role without the necessary skill set to meet their role's rigorous expectations. The researchers sought to explore the lived experiences of early-career nursing faculty and what it feels to be unprepared to teach. A qualitative research design using semi-structured interviews served as the primary data collection method. Read More

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Psychotic symptoms in drug resistant epilepsy patients after cortical stimulation.

Epilepsy Res 2021 Apr 2;173:106630. Epub 2021 Apr 2.

Epilepsy Program, Neurology Department, Hospital Clinic of Barcelona, Barcelona, 08036, Spain; Clinical Institute of Neurosciences, Hospital Clinic of Barcelona, Barcelona, 08036, Spain; Biomedical Research Institute August Pi i Sunyer (IDIBAPS), Hospital Clinic of Barcelona, Barcelona, 08036, Spain.

Purpose: The use of invasive EEG (iEEG) recordings before epilepsy surgery has increased as more complex focal epilepsies are evaluated. Psychotic symptoms (PS) during iEEG have been scarcely reviewed. We aim to report our series of patients with psychotic symptoms (PS) brought about by cortical stimulation (CS) and to identify triggers. Read More

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Beach litter deep dives - A method for improved understanding of sources of and behaviour behind littering.

Mar Pollut Bull 2021 Apr 14;167:112346. Epub 2021 Apr 14.

SALT Lofoten AS, Flow coworking, Strandgata 9, 9008 Tromsø, Troms, Norway. Electronic address:

Information from established beach litter protocols is insufficient to implement targeted, preventive management measures. Complementary methodologies, named "Beach litter Deep Dives", have been developed to get a better understanding of the sources of and behaviour behind littering. The methods are adaptive and determined by the context and aim of the deep dive. Read More

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Systematic Review and Meta-analysis: The Science of Early-Life Precursors and Interventions for Attention-Deficit/Hyperactivity Disorder.

J Am Acad Child Adolesc Psychiatry 2021 Apr 14. Epub 2021 Apr 14.

Faculdade de Medicina FMUSP, Universidade de São Paulo, Brazil.

Objective: To evaluate which early neurocognitive and behavioural precursors are associated with the development of attention-deficit/hyperactivity disorder (ADHD) and whether these are currently targeted in early interventions.

Method: We conducted two systematic reviews and meta-analyses of empirical studies to examine (1) early-life (0-5 years) neurocognitive and behavioural precursors associated with familial likelihood for ADHD, an early ADHD diagnosis/elevated ADHD symptoms, and/or the presence of later-childhood ADHD, and (2) interventions delivered to children aged 0-5 years targeting the identified precursors or measuring these as outcomes. Standardised mean differences (Hedge's g) and pre-post-treatment change scores (SMD) were computed. Read More

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Factors associated with independent nurse prescribers' antibiotic prescribing practice: A mixed methods study using the Reasoned Action Approach.

J Hosp Infect 2021 Apr 14. Epub 2021 Apr 14.

Glasgow Caledonian University, Cowcaddens Road, Glasgow. G4 0BA.

Background: Numbers of nurse prescribers is increasing, yet little evidence exists about their antibiotic prescribing behaviour.

Aim: This paper presents the findings of a study which measured nurse independent prescribers' (NIPs) intention to manage patients, presenting with an Upper Respiratory Tract Infection (URTI) for the first time, without prescribing an antibiotic and to examine the determinants of this behaviour.

Methods: This was a mixed method study using the Reasoned Action Approach (RAA). Read More

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Local and Regional Recurrences of Clinically Localized Renal Cell Carcinoma after Nephrectomy: A 15 Year Institutional Experience with Prognostic Features and Oncologic Outcomes.

Urology 2021 Apr 14. Epub 2021 Apr 14.

Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address:

Objective: To evaluate outcomes for patients with local recurrence (LR) of clinically localized renal cell carcinoma (RCC) without concurrent systemic metastasis from our institution, an event that occurs rarely (1-3%) after surgery. LR may be a harbinger of poor outcomes, and the best management of these patients is unclear.

Materials/methods: We retrospectively reviewed patients surgically treated for clinically localized RCC (cT1-2N0M0) with subsequent LR (in the partial or radical nephrectomy bed) and/or regional recurrence (RR; in the abdomen distant from the direct site of surgery) without concurrent metastasis from our institutional database (2004-2018). Read More

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Exploring providers' experience of stigma following the introduction of more liberal abortion care in the Republic of Ireland.

Contraception 2021 Apr 14. Epub 2021 Apr 14.

UCD Perinatal Research Centre, University College Dublin, National Maternity Hospital, Holles St, Dublin 2, Ireland.

Objective: To explore if abortion care providers in the Republic of Ireland experience abortion-related stigma.

Study Design: The survey was distributed to abortion care providers working in community and hospital units nationwide. We measured stigma using the 35-item version of the Abortion Providers Stigma Scale (APSS). Read More

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Neonates with Right Aortic Arch Requiring Arch Reconstruction: A Single-Institution Experience.

Ann Thorac Surg 2021 Apr 14. Epub 2021 Apr 14.

Boston Children's Hospital, Harvard Medical School, Department of Cardiac Surgery, Boston, MA. Electronic address:

Background: Reconstruction of a right aortic arch (RAA) is rarely required in the newborn period and has rarely been reported.

Methods: All patients who underwent a RAA repair in the neonatal period from a single institution were retrospectively reviewed. The primary outcome measures included survival, complications, and reintervention. Read More

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Predictors of Venous Thromboembolism in Patients with COVID-19 in an Underserved Urban Population: A Single Tertiary Center Experience.

Clin Respir J 2021 Apr 17. Epub 2021 Apr 17.

Department of Medicine, Einstein Medical Center, Philadelphia.

Introduction: Venous thromboembolism (VTE) is reported in up to 27% of patients with COVID-19 due to SARS-CoV-2 infection. Dysregulated systemic inflammation and various patient traits are presumed to underlie this anomaly. Optimal VTE prophylaxis in COVID-19 patients has not been established due to a lack of validated models for predicting VTE in this population. Read More

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Pregnancies in women with moderate and severe pulmonary hypertension remain challenging: A single-center experience in East China.

Int J Gynaecol Obstet 2021 Apr 17. Epub 2021 Apr 17.

Department of Obstetrics and Gynecology, Affiliated Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objective: To determine the outcomes in women with pulmonary hypertension (PH) and determine the factors related to adverse outcomes.

Methods: Data from 684 women with PH admitted to the Affiliated Renji Hospital from January 2001 to December 2020 were collected. Outcomes were compared based on the causes and severity of PH. Read More

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[Combination of tumors of different histogenesis in pediatric neurosurgery].

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(2):80-90

Almazov National Medical Research Center, St. Petersburg, Russia.

Multiple gliomas are determined by synchronous two or more tumors located in different brain regions. It is important to distinguish multiple primary tumors and metastatic brain lesion. In the first case, tumor spread can`t be explained by dissemination along the cerebrospinal fluid pathways, commissural fibers or local metastases. Read More

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January 2021

[Hemangioblastomas of the filum terminale and cauda equina].

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(2):60-66

Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

Hemangioblastoma of the filum terminale and cauda equina is a rare tumor of nervous system. There are only few case reports in the literature. In this manuscript, the authors analyze the diagnosis and treatment of patients with this disease. Read More

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January 2021

[Stereotactic irradiation in the complex treatment of patients with intracranial pilocytic astrocytoma].

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(2):34-46

Burdenko Neurosurgical Center, Moscow, Russia.

Complex management of patients with intracranial pilocytic astrocytoma (PA) consists of surgical treatment, drug therapy (mainly in young children) and radiotherapy. For many years, radiotherapy (RT) has been a standard for residual tumors, recurrence or continued growth of PA. Currently, stereotactic radiosurgery and radiotherapy are preferred for PA, because these procedures are characterized by high conformity and selectivity, precise irradiation of tumor with minimal damage to surrounding intact tissues. Read More

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January 2021

Semiparametric analysis of clustered interval-censored survival data using soft Bayesian Additive Regression Trees (SBART).

Biometrics 2021 Apr 17. Epub 2021 Apr 17.

Brigham & Women's Hospital.

Popular parametric and semiparametric hazards regression models for clustered survival data are inappropriate and inadequate when the unknown effects of different covariates and clustering are complex. This calls for a flexible modeling framework to yield efficient survival prediction. Moreover, for some survival studies involving time to occurrence of some asymptomatic events, survival times are typically interval censored between consecutive clinical inspections. Read More

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Correction to: A decade of service development: audit of service users' experience of a rural Psychiatry of Later Life (POLL) service.

Ir J Med Sci 2021 Apr 17. Epub 2021 Apr 17.

Consultant Psychiatrist of Later Life, St Brendan's CNU, Ballinasloe Co, CreaghGalway, Ireland.

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Augmented reality in anesthesia, pain medicine and critical care: a narrative review.

J Clin Monit Comput 2021 Apr 17. Epub 2021 Apr 17.

Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, USA.

Augmented reality (AR) is the integration of computer-generated information with the user's environment in real time. AR is used in many industries, including healthcare, where it has gained significant popularity. Recent strides in hardware and software engineering have reduced the cost of AR, while significantly improving the experience for users and developers. Read More

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Management and endovascular therapy of ureteroarterial fistulas: experience from a single center and review of the literature.

CVIR Endovasc 2021 Apr 17;4(1):36. Epub 2021 Apr 17.

Department of Radiology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Background: Ureteroarterial fistula (UAF) is a rare but potentially life threatening disease. The aim of this study was to evaluate the outcome of endovascular therapy for UAF treatment.

Methods: This retrospective case series evaluates a single center experience of percutaneous stent graft (SG) angioplasty and/or coil embolization for UAF. Read More

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Targeted therapy for pediatric low-grade glioma.

Childs Nerv Syst 2021 Apr 17. Epub 2021 Apr 17.

Pediatric Hematology and Oncology, Hospital Sant Joan de Déu, Barcelona, Spain.

Purpose: Pediatric low-grade gliomas are the most frequent brain tumors in children. The standard approach for symptomatic unresectable tumors is chemotherapy. Recently, key molecular alterations/pathways have been identified and targeted drugs developed and tested in clinical trials. Read More

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The effect of acute low-load resistance exercise with the addition of blood flow occlusion on muscle function in boys and men.

Eur J Appl Physiol 2021 Apr 17. Epub 2021 Apr 17.

Department of Kinesiology, Faculty of Applied Health Sciences, Brock University, 1812 Sir Isaac Brock Way, St. Catharines, ON, L2S 3A1, Canada.

Purpose: In adults, low-load resistance training with blood flow occlusion (BFO) mimics strength increases that occur from high-load training, without the need to experience high mechanical stress. In view of child-adult differences in exercise responses, this study examined whether BFO during exercise elicits differential changes in maximal voluntary contraction (MVC) and electromyographical (EMG) activity in children and adults.

Methods: Sixteen men (24. Read More

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Microscale Thermophoresis and additional effects measured in NanoTemper Monolith instruments.

Eur Biophys J 2021 Apr 17. Epub 2021 Apr 17.

ProteinTechnology, Vienna Biocenter Core Facilities GmbH, Dr. Bohr-Gasse 3, 1030, Vienna, Austria.

NanoTemper Monolith instruments have gained enormous popularity for measuring molecular interactions both in academia and industry. The underlying technology has been extensively reviewed along with its assumptions, limitations, and applications (Scheuermann et al., Anal Biochem 496:79-93, 2016). Read More

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Burnout among healthcare professionals during COVID-19 pandemic: a cross-sectional study.

Int Arch Occup Environ Health 2021 Apr 17. Epub 2021 Apr 17.

Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: To describe the prevalence of burnout among healthcare professionals dealing with COVID-19 patients and the associated factors.

Methods: In this cross-sectional survey, healthcare workers at six university-affiliated hospitals, who had been taking care of COVID-19 patients were studied. Age, gender, marital status, having children, hospital, job category, experience, and work load, as well as the level of burnout in each subscale were measured. Read More

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Conscious awareness modulates processing speed in the redundant signal effect.

Exp Brain Res 2021 Apr 17. Epub 2021 Apr 17.

School of Psychology, University of Aberdeen, Aberdeen, UK.

Evidence for the influence of unaware signals on behaviour has been reported in both patient groups and healthy observers using the Redundant Signal Effect (RSE). The RSE refers to faster manual reaction times to the onset of multiple simultaneously presented target than those to a single stimulus. These findings are robust and apply to unimodal and multi-modal sensory inputs. Read More

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