91 results match your criteria expense disc

Targeting tumor resistance mechanisms.

Fac Rev 2021 26;10. Epub 2021 Jan 26.

Laboratory of Molecular Cancer Biology, Molecular Physiology Research Unit (URPhyM), Namur Research Institute for Life Sciences (NARILIS), Faculty of Medicine, University of Namur, Namur, Belgium.

Cancer develops resistance to treatments through many mechanisms. Single-cell analyses reveal the intratumor heterogeneity and dynamic relationships between cancer cell subpopulations. These analyses also highlight that various mechanisms of resistance may coexist in a given tumor. Read More

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January 2021

Is fusion the most suitable treatment option for recurrent lumbar disc herniation? A systematic review.

Neurol Res 2020 Dec 30;42(12):1034-1042. Epub 2020 Jun 30.

Department of Neurosurgery, Royal Victoria Hospital, Belfast Health and Social Care Trust , Belfast, UK.

Objective: Recurrent lumbar disc herniation (rLDH) is a common issue after primary discectomy and can cause severe pain, morbidity, and reoperation. The purpose of this systematic review was to evaluate the surgical management of recurrent lumbar disc herniation.

Methods: A systematic literature search was conducted using Pubmed and Embase databases on 18August, 2019. Read More

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December 2020

Medicaid payer status and other factors associated with hospital length of stay in patients undergoing primary lumbar spine surgery.

Clin Neurol Neurosurg 2020 01 24;188:105570. Epub 2019 Oct 24.

Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA. Electronic address:

Objective: The Medicaid patient population and health care costs for spine surgeries among these patients have increased since 2010. Hospital length of stay (LOS) contributes appreciably to hospital costs for patients undergoing primary lumbar spine surgery (PLSS). The aim of this study was to identify independent risk factors for increased LOS in patients undergoing PLSS. Read More

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January 2020

Stepwise Local Anesthesia for Percutaneous Endoscopic Interlaminar Discectomy: Technique Strategy and Clinical Outcomes.

World Neurosurg 2020 Feb 18;134:e346-e352. Epub 2019 Oct 18.

Spine Lab, Department of Orthopedic Surgery, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. Electronic address:

Background: Due to suboptimal pain control under conventional local anesthesia, percutaneous endoscopic interlaminar discectomy is typically performed under general anesthesia. The purpose of this study was to develop a stepwise approach of local anesthesia for endoscopic interlaminar discectomy and evaluate its efficacy.

Methods: A stepwise local anesthesia was developed, which mainly includes 3 steps: conventional local anesthesia from skin to laminae, epidural injection, and nerve root block. Read More

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February 2020

Minimally Invasive Versus Open Transforaminal Lumbar Interbody Fusion for Single-Level Degenerative Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

World Neurosurg 2020 Jan 30;133:358-365.e4. Epub 2019 Aug 30.

DePuy Synthes, Raynham, Massachusetts, USA.

Objective: We compared the safety and effectiveness of minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) to open TLIF (O-TLIF) for lumbar degenerative disease.

Methods: We systematically searched Medline, Embase, and the Cochrane Central Register of Controlled Trials for randomized trials of MI-TLIF versus O-TLIF. The perioperative outcomes included the procedure time, fluoroscopy time, blood loss, complications, and hospital stay. Read More

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January 2020

An Unusual Case of Transdural Herniation of a Lumbar Intervertebral Disc: Diagnostic and Surgical Challenges.

World Neurosurg 2019 Aug 20;128:385-389. Epub 2019 May 20.

Spine Unit, Indian Spinal Injuries Centre, New Delhi, India.

Background: Intradural lumbar disc herniation is rare, with an incidence of 0.3%-1%, but has been well reported in the literature. Transdural migration of the disc penetrating both ventral and dorsal dura is extremely rare, and there is a dearth of literature in the pathophysiology and surgical management of transdural herniation. Read More

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Expression of Mammalian BM88/CEND1 in Drosophila Affects Nervous System Development by Interfering with Precursor Cell Formation.

Neurosci Bull 2019 Dec 11;35(6):979-995. Epub 2019 May 11.

"Alexander Fleming" Biomedical Sciences Research Centre, 16672, Athens, Greece.

We used Drosophila melanogaster as an experimental model to express mouse and pig BM88/CEND1 (cell cycle exit and neuronal differentiation 1) in order to investigate its potential functional effects on Drosophila neurogenesis. BM88/CEND1 is a neuron-specific protein whose function is implicated in triggering cells to exit from the cell cycle and differentiate towards a neuronal phenotype. Transgenic flies expressing either mouse or pig BM88/CEND1 in the nervous system had severe neuronal phenotypes with variable expressivity at various stages of embryonic development. Read More

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December 2019

Inverse resource allocation between vision and olfaction across the genus Drosophila.

Nat Commun 2019 03 11;10(1):1162. Epub 2019 Mar 11.

Max Planck Institute for Chemical Ecology, Department of Evolutionary Neuroethology, Hans-Knöll-Straße 8, D-07745, Jena, Germany.

Divergent populations across different environments are exposed to critical sensory information related to locating a host or mate, as well as avoiding predators and pathogens. These sensory signals generate evolutionary changes in neuroanatomy and behavior; however, few studies have investigated patterns of neural architecture that occur between sensory systems, or that occur within large groups of closely-related organisms. Here we examine 62 species within the genus Drosophila and describe an inverse resource allocation between vision and olfaction, which we consistently observe at the periphery, within the brain, as well as during larval development. Read More

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Influence of Preparation Technology on Microstructural and Magnetic Properties of Fe₂MnSi and Fe₂MnAl Heusler Alloys.

Materials (Basel) 2019 Feb 28;12(5). Epub 2019 Feb 28.

Department of Physics, VŠB-Technical University of Ostrava, 17 listopadu 15/2172, 708 33 Ostrava-Poruba, Czech Republic.

Microstructural and magnetic properties of the X₂YZ, namely Fe₂MnSi and Fe₂MnAl, Heusler alloys have been studied from the viewpoint of technology for their production and for the Z element effect. First, arc melting was applied to produce button-type ingots from which samples in a form of 500 µm thick discs were cut. Second, planar flow casting technology yielded samples in a ribbon-form 2 mm wide and 20 μm thick. Read More

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February 2019

Postoperative direct health care costs of lumbar discectomy are reduced with the use of a novel annular closure device in high-risk patients.

Spine J 2019 07 15;19(7):1170-1179. Epub 2019 Feb 15.

Department of Neurological Surgery, University of California, Davis, CA, USA.

Background Context: Lumbar discectomy is largely successful surgical procedure; however, reherniation rates in patients with large annular defects are as high as 27%. The expense associated with a revision surgery places significant burden on the healthcare system.

Purpose: To compare the direct health care costs through 5 years follow-up of conventional discectomy (Control) with those of discectomy supplemented by an adjunctive annular closure device (ACD) in high-risk patients with large annular defects. Read More

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A Cost-utility Analysis of Percutaneous Endoscopic Lumbar Discectomy for L5-S1 Lumbar Disc Herniation: Transforaminal versus Interlaminar.

Spine (Phila Pa 1976) 2019 Apr;44(8):563-570

Orthopedic Department, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Study Design: A cost-utility analysis (CUA).

Objective: The aim of this study was to evaluate the cost-effectiveness of percutaneous endoscopic transforaminal discectomy (PETD) and percutaneous endoscopic interlaminar discectomy (PEID) techniques for the treatment of L5-S1 lumbar disc herniation (LDH).

Summary Of Background Data: The annual cost of treatment for lumbar disc herniation is staggering. Read More

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Fusion Techniques Are Related to a Lower Risk of Reoperation in Lumbar Disc Herniation: A 5-Year Observation Study of a Nationwide Cohort in Taiwan.

World Neurosurg 2018 Sep 23;117:e660-e668. Epub 2018 Jun 23.

Department of Neurosurgery, Chang Gung Memorial Hospital, Chiayi, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Objective: Lumbar disc herniation (LDH) is a common spinal problem, with reoperation rates of 6%-24%. Although different surgical techniques are used for treatment, there is still debate regarding whether fusion techniques can reduce the reoperation rate in patients with LDH.

Methods: This retrospective study used a 5-year nationwide database to analyze reoperation rates in Taiwan. Read More

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September 2018

Effect of Body Mass Index on Perioperative Outcomes in Minimally Invasive Oblique Lateral Lumbar Interbody Fusion versus Open Fusions: A Multivariant Analysis.

Cureus 2018 Mar 8;10(3):e2288. Epub 2018 Mar 8.

Fairview Health Services, Fairview Ridges Hospital.

Background Obesity is an increasing public health concern associated with increased perioperative complications and expense in lumbar spine fusions. While open and mini-open fusions such as transforaminal lumbar interbody fusion (TLIF) and minimally invasive TLIF (MIS-TLIF) are more challenging in obese patients, new MIS procedures like oblique lateral lumbar interbody fusion (OLLIF) may improve perioperative outcomes in obese patients relative to TLIF and MIS-TLIF. Purpose The purpose of this study is to determine the effects of obesity on perioperative outcomes in OLLIF, MIS-TLIF, and TLIF. Read More

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A dual-mode hemispherical sparse array for 3D passive acoustic mapping and skull localization within a clinical MRI guided focused ultrasound device.

Phys Med Biol 2018 03 15;63(6):065008. Epub 2018 Mar 15.

Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, United States of America.

Previous work has demonstrated that passive acoustic imaging may be used alongside MRI for monitoring of focused ultrasound therapy. However, past implementations have generally made use of either linear arrays originally designed for diagnostic imaging or custom narrowband arrays specific to in-house therapeutic transducer designs, neither of which is fully compatible with clinical MR-guided focused ultrasound (MRgFUS) devices. Here we have designed an array which is suitable for use within an FDA-approved MR-guided transcranial focused ultrasound device, within the bore of a 3 Tesla clinical MRI scanner. Read More

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Increased accuracy of starch granule type quantification using mixture distributions.

Plant Methods 2017 6;13:107. Epub 2017 Dec 6.

CSIRO Agriculture and Food, 1600 Clunies Ross Street, Canberra, 2601 Australia.

Background: The proportion of granule types in wheat starch is an important characteristic that can affect its functionality. It is widely accepted that granule types are either large, disc-shaped A-type granules or small, spherical B-type granules. Additionally, there are some reports of the tiny C-type granules. Read More

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December 2017

STITCHLESS Percutaneous Endoscopic Cervical Discectomy: Are We Moving Towards Day Care Discectomy Procedure?

Indian J Orthop 2017 Nov-Dec;51(6):653-657

Department of Spine Surgery, Shree Vithalrao Joshi Charities Trust's B.K.L. Walawalkar Hospital and Rural Medical College, Dervan, Ratnagiri, Maharashtra, India.

Background: STITCHLESS percutaneous endoscopic cervical discectomy s[PECD] is safe, precise, targeted, and a complete endoscopic procedure to treat soft cervical disc herniation with unilateral radiculopathy. It allows direct visualization of herniated fragment and its removal, inspection of decompressed nerve root in an awake and aware patient. It reduces the risk related to general anesthesia and to the neurological structures. Read More

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December 2017

Current practice and usual care of major cervical disorders in Korea: A cross-sectional study of Korean health insurance review and assessment service national patient sample data.

Medicine (Baltimore) 2017 Nov;96(46):e8751

aJaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul bDepartment of Korean Rehabilitation Medicine, College of Korean Medicine, Dae-Jeon University, Daejeon cALS & MND Center at Wonkwang University Korean Medicine Hospital in Gwangju, Gwangju dDepartment of Cardiovascular and Neurological Diseases (Stroke Center), College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.

Neck pain is a highly common condition and is the 4th major cause of years lived with disability. Previous literature has focused on the effect of specific treatments, and observations of actual practice are lacking to date. This study examined Korean health insurance review and assessment service (HIRA) claims data to the aim of assessing prevalence and comparing current medical practice and costs of cervical disorders in Korea. Read More

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November 2017

Surgical Site Infections and Antimicrobial Resistance Pattern.

J Nepal Health Res Counc 2017 Sep 8;15(2):120-123. Epub 2017 Sep 8.

Department of Microbiology, Tri- Chandra College, Kathmandu, Nepal.

Background: Post-operative surgical site infections (SSIs) are among the leading cause of morbidity and increased medical expense. The aim of this study is to isolate identify and study antimicrobial susceptibility pattern of microorganism from surgical wound of admitted patients.

Methods: This retrospective study was carried at the Microbiology Laboratory of Bharatpur hospital, Nepal, from May 2015 to October 2015. Read More

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September 2017

A Detailed Comparative Analysis of Anterior Versus Posterior Approach to Lenke 5C Curves.

Spine (Phila Pa 1976) 2018 03;43(5):E285-E291

Rady Children's Hospital and Health Center, San Diego, CA.

Study Design: Prospective cohort study.

Objective: To prospectively compare radiographic, perioperative, and functional outcomes between anterior spinal instrumentation and fusion (ASIF) and posterior spinal instrumentation and fusion (PSIF) in Lenke 5C curves.

Summary Of Background Data: Historically, ASIF has been the treatment of choice for treatment of thoracolumbar adolescent idiopathic scoliosis. Read More

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Distal Fusion Level Selection in Scheuermann's Kyphosis: A Comparison of Lordotic Disc Segment Versus the Sagittal Stable Vertebrae.

Global Spine J 2017 May 7;7(3):254-259. Epub 2017 Apr 7.

Columbia University Medical Center, New York, NY, USA.

Study Design: Retrospective study.

Objective: To compare 2 methods of selecting the lowest instrumented vertebra (LIV) on the rates of revision surgery for distal junctional kyphosis (DJK) following treatment for Scheuermann's kyphosis (SK).

Methods: A retrospective review of patients who have undergone surgical treatment for SK was performed. Read More

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ISSLS PRIZE IN BIOENGINEERING SCIENCE 2017: Automation of reading of radiological features from magnetic resonance images (MRIs) of the lumbar spine without human intervention is comparable with an expert radiologist.

Eur Spine J 2017 05 6;26(5):1374-1383. Epub 2017 Feb 6.

Spinal Studies, RJAH Orthopaedic Hospital Foundation Trust and ISTM (Keele University), Oswestry, UK.

Study Design: Investigation of the automation of radiological features from magnetic resonance images (MRIs) of the lumbar spine.

Objective: To automate the process of grading lumbar intervertebral discs and vertebral bodies from MRIs. MR imaging is the most common imaging technique used in investigating low back pain (LBP). Read More

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[The perspective fluoroplastic porous carrier for conservation and transfer of samples of blood plasma: application of "dry drop" technique with the purpose of detection of individual fatty acids.]

Klin Lab Diagn 2017 ;62(9):526-536

The Russian cardiologic R&D production complex of Minzdrav of Russia, 121552, Moscow, Russia.

It is proposed for preserving samples of biological fluids (blood plasma first of all) and mailing them to analytical laboratory to significantly modify a well-known technique of "dried blood spot" (DBS) at the expense of application of home-made fluoroplastic filtering material type MFFK-G as a porous carrier of fluid biological sample. The synthetic material contains no chemically active molecular fragments and it has four times greater water capacity than filter and chromatographic paper. Thus, fluoroplastic porous disc of mass of 15 mg is suitable to carrying of 70-100 mkl (instead of 15-20 mkl) of fluid. Read More

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January 2017

Optimizing the Adverse Event and HRQOL Profiles in the Management of Primary Spine Tumors.

Spine (Phila Pa 1976) 2016 Oct;41 Suppl 20:S212-S217

Department of Neurosurgery, University of California-San Francisco Medical Center, San Francisco, CA.

Study Design: Systematic literature review.

Objective: To investigate if evidence-based principles of oncologic resection for primary spinal tumors are correlated with an acceptable morbidity and mortality profile and satisfactory health-related quality of life (HRQOL) measures.

Summary Of Background Data: Respecting oncologic principles for primary spinal tumor surgery is correlated with lower recurrence rates. Read More

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October 2016

A Multiscale Computational Model Combining a Single Crystal Plasticity Constitutive Model with the Generalized Method of Cells (GMC) for Metallic Polycrystals.

Materials (Basel) 2016 May 4;9(5). Epub 2016 May 4.

NASA Glenn Research Center, Cleveland, OH 44135, USA.

A multiscale computational model is developed for determining the elasto-plastic behavior of polycrystal metals by employing a single crystal plasticity constitutive model that can capture the microstructural scale stress field on a finite element analysis (FEA) framework. The generalized method of cells (GMC) micromechanics model is used for homogenizing the local field quantities. At first, the stand-alone GMC is applied for studying simple material microstructures such as a repeating unit cell (RUC) containing single grain or two grains under uniaxial loading conditions. Read More

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Barrierless growth of precursor-free, ultrafast laser-fragmented noble metal nanoparticles by colloidal atom clusters - A kinetic in situ study.

J Colloid Interface Sci 2016 Feb 22;463:299-307. Epub 2015 Oct 22.

Technical Chemistry I and Center for Nanointegration Duisburg-Essen (CENIDE), University of Duisburg-Essen, Universitaetsstr. 7, 45141 Essen, Germany. Electronic address:

Unintended post-synthesis growth of noble metal colloids caused by excess amounts of reactants or highly reactive atom clusters represents a fundamental problem in colloidal chemistry, affecting product stability or purity. Hence, quantified kinetics could allow defining nanoparticle size determination in dependence of the time. Here, we investigate in situ the growth kinetics of ps pulsed laser-fragmented platinum nanoparticles in presence of naked atom clusters in water without any influence of reducing agents or surfactants. Read More

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February 2016

Treatment of Contained Herniated Lumbar Discs With Ozone and Corticosteroid: A Pilot Clinical Study.

Can Assoc Radiol J 2015 Nov 17;66(4):377-84. Epub 2015 Jun 17.

ActiveO, Salt Lake City, Utah, USA.

Purpose: The primary objective of this pilot study was to compare pain and function scores from patients before and after an ozone injection in combination with steroids and bupivacaine to treat herniated discs. A secondary objective was to correct some of the methodological weaknesses of some previously published ozone studies.

Methods: Fifty patients were enrolled; 1-3 mL of 2 wt% ozone in 98 wt% oxygen was delivered into the nucleus pulposus, and 7-9 mL into the adjacent paravertebral tissues. Read More

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November 2015

Ras/MEK/MAPK-mediated regulation of heparin sulphate proteoglycans promotes retinal fate in the Drosophila eye-antennal disc.

Dev Biol 2015 Jun 4;402(1):109-18. Epub 2015 Apr 4.

Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6. Electronic address:

Generating cellular heterogeneity is crucial to the development of complex organs. Organ-fate selector genes and signalling pathways generate cellular diversity by subdividing and patterning naïve tissues to assign them regional identities. The Drosophila eye-antennal imaginal disc is a well-characterised system in which to study regional specification; it is first divided into antennal and eye fates and subsequently retinal differentiation occurs within only the eye field. Read More

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[Financial expenses incurred by herniated disk in health professionals].

Cir Cir 2013 Sep-Oct;81(5):400-4

Background: Long-term sick leave by illeness is cause of financial expences and worker's loss of productivity.

Objective: To evaluate the financial expense incurred by spinal disk herniation in health professionals.

Methods: 3000 health professionals of the Instituto Mexicano del Seguro Social work in Tecate, Tijuana and Rosarito, cities of Baja California, Mexico. Read More

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Etiology of lumbar lordosis and its pathophysiology: a review of the evolution of lumbar lordosis, and the mechanics and biology of lumbar degeneration.

Neurosurg Focus 2014 May;36(5):E1

Mechatronic Systems Engineering, Simon Fraser University, Surrey, British Columbia, Canada;

The goal of this review is to discuss the mechanisms of postural degeneration, particularly the loss of lumbar lordosis commonly observed in the elderly in the context of evolution, mechanical, and biological studies of the human spine and to synthesize recent research findings to clinical management of postural malalignment. Lumbar lordosis is unique to the human spine and is necessary to facilitate our upright posture. However, decreased lumbar lordosis and increased thoracic kyphosis are hallmarks of an aging human spinal column. Read More

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Demographic and clinical characteristics of patients with restless legs syndrome in spine clinic.

J Korean Neurosurg Soc 2014 Feb 28;55(2):83-8. Epub 2014 Feb 28.

Department of Neurosurgery, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon, Korea.

Objective: The restless legs syndrome (RLS) is a common disorder affecting up to 5% to 15% of the general population, in which the incidence increases with age, and includes paresthesia in the legs. The purpose of this study is to investigate the incidence of RLS in spine center and to review clinical manifestations of this syndrome and its current treatments.

Methods: Over a period of a year, retrospective medical record review and lumbar magnetic resonance images were performed on 32 patients with RLS in spine clinic who were diagnosed by National Institutes of Health criteria. Read More

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February 2014