6,698 results match your criteria expanding knowledge

Microphase separation of stimuli-responsive interpenetrating network microgels investigated by scattering methods.

J Colloid Interface Sci 2021 Apr 5;597:297-305. Epub 2021 Apr 5.

Semenov Federal Research Center for Chemical Physics, Moscow 119991, Russia; Faculty of Physics, Lomonosov Moscow State University, Moscow 119991, Russia. Electronic address:

Polymer stimuli-responsive microgels find their use in various applications. The knowledge of its internal structure is of importance for further improvement and expanding the scope. Interpenetrating network (IPN) microgels may possess a remarkable feature of strongly non-uniform inner architecture, even microphase separation, in conditions of a selective solvent. Read More

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Gene Expression in Breast Tissue.

Sammy Al-Benna

Eur J Breast Health 2021 Apr 31;17(2):112-115. Epub 2021 Mar 31.

Division of Plastic and Reconstructive Surgery, Stellenbosch University and Tygerberg Academic Hospital, Cape Town, South Africa.

Objective: Binding to angiotensin-converting enzyme 2 (ACE2) receptor is a critical step for severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2) to mediate its entry into target cells. ACE2 is expressed in many human tissues, including the lungs. However, no research has demonstrated that SARS-CoV-2 can infect human breast tissue. Read More

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Generation of macrophages with altered viral sensitivity from genome-edited rhesus macaque iPSCs to model human disease.

Mol Ther Methods Clin Dev 2021 Jun 17;21:262-273. Epub 2021 Mar 17.

Shin Kaneko Laboratory, Department of Cell Growth and Development, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.

Because of their close biological similarity to humans, non-human primate (NHP) models are very useful for the development of induced pluripotent stem cell (iPSC)-based cell and regenerative organ transplantation therapies. However, knowledge on the establishment, differentiation, and genetic modification of NHP-iPSCs, especially rhesus macaque iPSCs, is limited. We succeeded in establishing iPSCs from the peripheral blood of rhesus macaques (Rh-iPSCs) by combining the Yamanaka reprograming factors and two inhibitors (GSK-3 inhibitor [CHIR 99021] and MEK1/2 inhibitor [PD0325901]) and differentiated the cells into functional macrophages through hematopoietic progenitor cells. Read More

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Love Island, Social Media, and Sousveillance: New Pathways of Challenging Realism in Reality TV.

Xavier L'Hoiry

Front Sociol 2019 2;4:59. Epub 2019 Aug 2.

Department of Sociological Studies, University of Sheffield, Sheffield, United Kingdom.

This paper explores the changing nature of audience participation and active viewership in the context of Reality TV. Thanks to the ongoing rise of social media, fans of popular entertainment programmes continue to be engaged in new and innovative ways across a number of platforms as part of an ever-expanding interactive economy. 2018 has pushed the boundaries of this participatory culture by exploiting new forms of digital media in order to encourage multi-platform consumption of content by the show's fans. Read More

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Co-producing Randomized Controlled Trials: How Do We Work Together?

Front Sociol 2019 29;4:21. Epub 2019 Mar 29.

Population Health Research Institute, St George's, University of London, London, United Kingdom.

In the light of the declaration "Nothing about us without us" (Charlton, 2000), interest in co-production, and coproduced research is expanding. Good work has been done establishing principles for co-production (Hickey et al., 2018) and for good quality involvement (Involve, 2013; 4Pi, 2015) and describing how this works in practice in mental health research (Gillard et al. Read More

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Psychologists in Long-Term Care (PLTC) Guidelines for Psychological and Behavioral Health Services in Long-Term Care Settings.

Prof Psychol Res Pr 2021 Feb 2;52(1):34-45. Epub 2020 Apr 2.

Palo Alto VA Health Care System, Palo Alto, California.

To address concerns about limited training of psychologists working in long-term care (LTC) facilities, the Psychologists in Long-Term Care (PLTC) organization published Standards for Psychological Services in Long-Term Care Facilities (Lichtenberg et al., 1998). The expanding evidence base for knowledge and skills, the increasing diversity of LTC residents, and the complexity of presenting problems have compounded the guidance psychologists need when providing services in this setting. Read More

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February 2021

An overview on breast cancer genetics and recent innovations: Literature survey.

Breast Dis 2021 Apr 7. Epub 2021 Apr 7.

Cell and Molecular Biology Division, Department of Botany, University of Calicut, Kerala, India.

Breast cancer is one of the leading cancers nowadays. The genetical mechanism behind breast cancer development is an intricate one. In this review, the genetical background of breast cancer, particularly BRCA 1 and BRCA 2 had been included. Read More

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Pharmacy students' perspectives on involvement in workplace-based preventative health and wellness events.

Curr Pharm Teach Learn 2021 Jun 2;13(6):699-704. Epub 2021 Feb 2.

The University of British Columbia, Faculty of Pharmaceutical Sciences, Vancouver Campus, 2405 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada. Electronic address:

Introduction: Canadian pharmacy students have varied exposure within their academic curricula and limited opportunities for hands-on preventative health experiences prior to practicums. We aimed to explore pharmacy student perceptions of readiness to engage in patient education and assessment activities in health promotion events.

Methods: Under licensed pharmacist supervision, volunteer pharmacy students delivered health promotion events to University of British Columbia staff and faculty between 2017 and 2020. Read More

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Formation mechanism of chloropicrin from amines and free amino acids during chlorination: A combined computational and experimental study.

J Hazard Mater 2021 Apr 6;416:125819. Epub 2021 Apr 6.

Beijing Key Laboratory of Environmental and Viral Oncology, College of Life Science & Bioengineering, Beijing University of Technology, Beijing 100124, China.

Chloropicrin as one of the most frequently detected N-DBPs has drawn great attention due to its high toxicity. However, our understanding of its formation mechanism is still very limited. A combined computational and experimental approach was used in this study to reveal chloropicrin formation mechanism during chlorination. Read More

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"What did you do this weekend?" Relationships between weekend activities, recovery experiences, and changes in work-related well-being.

Appl Psychol Health Well Being 2021 Apr 17. Epub 2021 Apr 17.

Univ. Grenoble Alpes, SENS, Grenoble, France.

Recovery refers to the process of replenishing resources that occurs when employees distance themselves from their work, leading to improvements in work-related well-being indicators (WRWB), such as burnout and vigor. Research has shown that weekend activities are related to changes in WRWB and that recovery experiences could mediate these relationships. This study aimed to examine the indirect relationships of recovery activities on changes in burnout and vigor, through weekend recovery experiences. Read More

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Beyond Baby Siblings-Expanding the Definition of "High-Risk Infants" in Autism Research.

Curr Psychiatry Rep 2021 Apr 16;23(6):34. Epub 2021 Apr 16.

UCLA Semel Institute for Neuroscience and Human Behavior, 760 Westwood Plaza, Los Angeles, CA, 90095, USA.

Purpose Of Review: Much of our understanding of early development in children with autism spectrum disorder (ASD) comes from studies of children with a family history of autism. We reviewed the current literature on neurodevelopmental profiles and autism prevalence from other high-risk infant groups to expose gaps and inform next steps. We focused on infants with early medical risk (e. Read More

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The Year 2020 in Review: Noteworthy Literature for Thoracic Transplant Anesthesiologists.

Semin Cardiothorac Vasc Anesth 2021 Apr 14:10892532211007636. Epub 2021 Apr 14.

University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.

The year 2020 was a monumental year in medicine, and this review focuses on selected articles for cardiothoracic anesthesiologists and perioperative physicians involved in the care of heart and lung transplant patients. In the field of lung transplantation, significant strides were made in our knowledge of risk stratification during the preoperative assessment of potential recipients, perioperative transfusion medicine, and the administration of coagulation factor concentrates. In addition, variations in perioperative management and outcomes between institutions were studied across an assortment of metrics regarding lung transplantation, including case volumes and anesthetic practices. Read More

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Designing an App to Overcome Language Barriers in the Delivery of Emergency Medical Services: Participatory Development Process.

JMIR Mhealth Uhealth 2021 Apr 14;9(4):e21586. Epub 2021 Apr 14.

Department of General Practice, University Medical Center Göttingen, Göttingen, Germany.

Background: In emergencies, language barriers may have dangerous consequences for the patients. There have been some technical approaches to overcome language barriers in medical care but not yet in the prehospital emergency care setting. The use of digital technologies in health care is expanding rapidly. Read More

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Thermodynamic Stability of G-Quadruplexes: Impact of Sequence and Environment.

Chembiochem 2021 Apr 12. Epub 2021 Apr 12.

Universität Greifswald Mathematisch-Naturwissenschaftliche Fakultät: Universitat Greifswald Mathematisch-Naturwissenschaftliche Fakultat, Institut für Biochemie, Felix-Hausdorff-Str. 4, 17489, Greifswald, GERMANY.

G-quadruplexes have attracted growing interest in recent years due to their occurrence in vivo and their possible biological functions. In addition to being promising targets for drug design, these four-stranded nucleic acid structures have also been recognized as versatile tools for various technological applications. Whereas a large number of studies have yielded insight into their remarkable structural diversity, our current knowledge on G-quadruplex stabilities as a function of sequence and environmental factors only gradually emerges with an expanding collection of thermodynamic data. Read More

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An equivalence analysis of provider education in youth mental health care.

Health Serv Res 2021 Apr 12. Epub 2021 Apr 12.

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Objective: To test for equivalence between providers with and without advanced degrees in multiple domains related to delivery of evidence-based treatment.

Data Source: Provider and client data from an effectiveness trial of Alternatives for Families: A Cognitive Behavioral Therapy (AF-CBT) in a major metropolitan area in the United States.

Study Design: We tested for equivalence between providers (N = 182) with and without advanced degrees in treatment-related knowledge, practices, and attitudes; job demands and stress; and training engagement and trainer-rated competence in AF-CBT. Read More

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How does "A Bit of Everything American" state feel about COVID-19? A quantitative Twitter analysis of the pandemic in Ohio.

Cantay Caliskan

J Comput Soc Sci 2021 Apr 5:1-27. Epub 2021 Apr 5.

Department of Data Analytics, Denison University, 100 W. College Street, Granville, OH 43023 USA.

COVID-19 has proven itself to be one of the most important events of the last two centuries. This defining moment in our lives has created wide-ranging discussions in many segments of our societies, both politically and socially. Over time, the pandemic has been associated with many social and political topics, as well as sentiments and emotions. Read More

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Perception and Belief on Cannabinoids: A Comparative Study of Rheumatology Patients and Primary Care Physicians on the Use of Cannabinoids for Pain Management.

Cureus 2021 Mar 7;13(3):e13756. Epub 2021 Mar 7.

Medicine, College of Life Sciences, Leicester Medical School, University of Leicester, Leicester, GBR.

Introduction With the recent increase in popularity of cannabinoids in the management of chronic pain, the inquisitiveness among our patients and health care professionals are probably now at its peak. Many treating health care professionals in their clinical practice come across patients who either use cannabinoids or are interested in their efficacy and side effects. As there is paucity of data and research about their use in rheumatology, patient's self-reported responses and experience of primary care physicians (General Practitioners [GPs]) can guide in expanding our knowledge. Read More

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Chlorpyrifos pesticide promotes oxidative stress and increases inflammatory states in BV-2 microglial cells: A role in neuroinflammation.

Chemosphere 2021 Mar 29;278:130417. Epub 2021 Mar 29.

Department of Morphology, Federal University of Santa Maria, Santa Maria, RS, Brazil. Electronic address:

The exposure to environmental stressors, such as organophosphate (OP) pesticides, has been associated with the development of neurodegenerative diseases. Chlorpyrifos (CPF) is the worldwide most used OP pesticide and one of the most hazardous pesticides as it can cross the blood-brain barrier. Since studies evaluating the effects of CPF on brain immune cells are scarce, this research investigated the oxidative and inflammatory responses of CPF exposure in murine microglial cells. Read More

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Tackling Diversity in Prostate Cancer Clinical Trials: A Report From the Diversity Working Group of the IRONMAN Registry.

JCO Glob Oncol 2021 Apr;7:495-505

Moffitt Cancer Center, Tampa, FL.

Prostate cancer disproportionately affects racial and ethnic minority populations. Reasons for disparate outcomes among minority patients are multifaceted and complex, involving factors at the patient, provider, and system levels. Although advancements in our understanding of disease biology have led to novel therapeutics for men with advanced prostate cancer, including the introduction of biomarker-driven therapeutics, pivotal translational studies and clinical trials are underrepresented by minority populations. Read More

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The History of Gene Hunting in Hereditary Spinocerebellar Degeneration: Lessons From the Past and Future Perspectives.

Front Genet 2021 23;12:638730. Epub 2021 Mar 23.

Institut du Cerveau, INSERM U1127, CNRS UMR7225, Sorbonne Université, Paris, France.

Hereditary spinocerebellar degeneration (SCD) encompasses an expanding list of rare diseases with a broad clinical and genetic heterogeneity, complicating their diagnosis and management in daily clinical practice. Correct diagnosis is a pillar for precision medicine, a branch of medicine that promises to flourish with the progressive improvements in studying the human genome. Discovering the genes causing novel Mendelian phenotypes contributes to precision medicine by diagnosing subsets of patients with previously undiagnosed conditions, guiding the management of these patients and their families, and enabling the discovery of more causes of Mendelian diseases. Read More

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eHealth for patients with rare diseases: the eHealth Working Group of the European Reference Network on Rare Multisystemic Vascular Diseases (VASCERN).

Orphanet J Rare Dis 2021 Apr 8;16(1):164. Epub 2021 Apr 8.

Cardiovascular-Genetic Center, IRCCS Policlinico San Donato, Via Morandi 30, 20097, San Donato Milanese, MI, Italy.

Background: The European Reference Network on Rare Multisystemic Vascular Diseases (VASCERN) was launched in 2017 and involves, to date, 35 highly specialised multidisciplinary expert centres (from the 30 full Healthcare Provider members) coming from 11 countries and more than 70 patient organizations from 16 countries. The eHealth Working Group (WG) of VASCERN was set up to develop practical, patient-centred solutions and strategies for effective use of eHealth tools to answer the needs of patients with multisystemic vascular rare diseases.

The Ehealth Wg: Following the identified patients' needs and following the guiding principles of collaboration and patient-centredness, the eHealth WG was created with the following aims: to develop a mobile app to help patients find expert centres and patient organizations, and to develop resources (Pills of Knowledge, PoK) for training and education via digital platforms (eLearning). Read More

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Clinicopathological and prognostic significance of circRNAs in lung cancer: A systematic review and meta-analysis.

Medicine (Baltimore) 2021 Apr;100(14):e25415

Department of Breast Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

Background: Circular RNAs (circRNAs) regulate multiple pathways during lung cancer pathogenesis. Apart from functional significance, many circRNAs have been shown to be associated with clinicopathological characteristics and predict lung cancer prognosis. Our aim is to summarize the expanding knowledge of clinical roles of circRNAs in lung cancer. Read More

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Towards improving community pharmacy-based mental health services in Nigeria.

J Pharm Policy Pract 2021 Apr 7;14(1):34. Epub 2021 Apr 7.

Department of Public Health, Mount Kenya University Rwanda, Kigali, Rwanda.

In Nigeria, there is a prevalence of aversive life circumstances that frequently assail the mental health and well-being of the citizens, mitigating the impact of which necessitates the institution of psychotherapy and other mental health care methods. These responsibilities, however, appear to be much more for pharmacists in low-resource settings where they are the most accessible healthcare professional. Some of these responsibilities include patient confidentiality as well as counseling patients on medication use, lifestyle as well as other personal matters that may arise in relation to their health. Read More

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Data silos are undermining drug development and failing rare disease patients.

Orphanet J Rare Dis 2021 Apr 7;16(1):161. Epub 2021 Apr 7.

Department of Medicine, Orphan Disease Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Data silos are proliferating while research and development activity explode following genetic and immunological advances for many clinically described disorders with previously unknown etiologies. The latter event has inspired optimism in the patient, clinical, and research communities that disease-specific treatments are on the way. However, we fear the tendency of various stakeholders to balkanize databases in proprietary formats, driven by current economic and academic incentives, will inevitably fragment the expanding knowledge base and undermine current and future research efforts to develop much-needed treatments. Read More

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Outcomes assessment pitfalls: challenges to quantifying knowledge gain in a sex education game.

Gates Open Res 2020 16;4:73. Epub 2021 Feb 16.

Department of Obstetrics and Gynecology, David Geffen School of Medicine, Los Angeles, CA, 90095, USA.

The use of videogames as a public health tool is rapidly expanding. Accurate assessment of the efficacy of such games is complicated by many factors. We describe challenges associated with measuring the impact of playing a videogame with information about human sexual anatomy and reproduction and discuss motivations for, and solutions to, these challenges. Read More

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February 2021

Pupillary light reflex as a diagnostic aid from computational viewpoint: A systematic literature review.

J Biomed Inform 2021 Apr 4;117:103757. Epub 2021 Apr 4.

Institute of Informatics, Federal University of Goias, Goiania, Goias, Brazil. Electronic address:

This work presents a detailed and complete review of publications on pupillary light reflex (PLR) used to aid diagnoses. These are computational techniques used in the evaluation of pupillometry, as well as their application in computer-aided diagnoses (CAD) of pathologies or physiological conditions that can be studied by observing the movements of miosis and mydriasis of the human pupil. A careful survey was carried out of all studies published over the last 10 years which investigated, electronic devices, recording protocols, image treatment, computational algorithms and the pathologies related to PLR. Read More

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gen. et sp. nov. and sp. nov. (Diatrypaceae) from China.

Biodivers Data J 2021 26;9:e63864. Epub 2021 Mar 26.

Engineering Research Centre of the Utilization for Characteristic Bio-Pharmaceutical Resources in Southwest, Ministry of Education, Guizhou University, Guiyang, Guizhou Province 550025, China Engineering Research Centre of the Utilization for Characteristic Bio-Pharmaceutical Resources in Southwest, Ministry of Education, Guizhou University Guiyang, Guizhou Province 550025 China.

Background: In this study, we introduce a novel genus, , of the family Diatrypaceae comprising three species viz. sp. nov. Read More

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Emerging concepts in the science of vaccine adjuvants.

Nat Rev Drug Discov 2021 Apr 6. Epub 2021 Apr 6.

GSK Vaccines, Rockville, MD, USA.

Adjuvants are vaccine components that enhance the magnitude, breadth and durability of the immune response. Following its introduction in the 1920s, alum remained the only adjuvant licensed for human use for the next 70 years. Since the 1990s, a further five adjuvants have been included in licensed vaccines, but the molecular mechanisms by which these adjuvants work remain only partially understood. Read More

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BEExact: a Metataxonomic Database Tool for High-Resolution Inference of Bee-Associated Microbial Communities.

mSystems 2021 Apr 6;6(2). Epub 2021 Apr 6.

Department of Microbiology & Immunology, The University of Western Ontario, London, Ontario, Canada

High-throughput 16S rRNA gene sequencing technologies have robust potential to improve our understanding of bee (Hymenoptera: Apoidea)-associated microbial communities and their impact on hive health and disease. Despite recent computation algorithms now permitting exact inferencing of high-resolution exact amplicon sequence variants (ASVs), the taxonomic classification of these ASVs remains a challenge due to inadequate reference databases. To address this, we assemble a comprehensive data set of all publicly available bee-associated 16S rRNA gene sequences, systematically annotate poorly resolved identities via inclusion of 618 placeholder labels for uncultivated microbial dark matter, and correct for phylogenetic inconsistencies using a complementary set of distance-based and maximum likelihood correction strategies. Read More

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First report of causing cankers and dieback in sweet cherry in Chile.

Plant Dis 2021 Apr 6. Epub 2021 Apr 6.

Instituto de Investigaciones Agropecuarias, Producción Vegetal, Av. Vicente Méndez 515, Chillán, Ñuble, Chile;

Sweet cherry () is one the most important fruit crops in Chile. Its production has significantly grown in recent years, reaching 228,448 tons exported in 2019/2020, to 47 countries. One of the main threats for this expanding crop are fungal pathogens, especially those that cause wood diseases. Read More

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