906 results match your criteria expanded nanoparticle

Particle engineering principles and technologies for pharmaceutical biologics.

Adv Drug Deliv Rev 2021 Apr 9. Epub 2021 Apr 9.

Wuya College of Innovation, Shenyang Pharmaceutical University, Wenhua Road No. 103, 110016 Shenyang, China; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. Electronic address:

The global market of pharmaceutical biologics has expanded significantly during the last few decades and currently, pharmaceutical biologic products constitute anindispensable part of the modern medicines. Most pharmaceutical biologic products are injections either in solutions or lyophilized powders because of their low oral bioavailability. There are certain pharmaceutical biologic entities formulated into particulate delivery systems for the administration via non-invasive routes or to achieve prolonged pharmaceutical actions to reduce the frequency of injections. Read More

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Plasmonic optical trapping of nanoparticles using T-shaped copper nanoantennas.

Opt Express 2021 Mar;29(7):9826-9835

We demonstrate the optical trapping of single dielectric nanoparticles in a microfluidic chamber using a coupled T-shaped copper plasmonic nanoantenna for studying light-matter interaction. The nanoantenna is composed of two identical copper elements separated by a 50 nm gap and each element is designed with two nanoblocks. Our nanoantenna inherits three different advantages compared to previous plasmonic nanoantennas, which are usually made of gold. Read More

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Nanoplatforms for Targeted Stimuli-Responsive Drug Delivery: A Review of Platform Materials and Stimuli-Responsive Release and Targeting Mechanisms.

Nanomaterials (Basel) 2021 Mar 16;11(3). Epub 2021 Mar 16.

Materials Engineering Program, Mechanical Engineering Department, Auburn University, 101 Wilmore Drive, Auburn, AL 36830, USA.

To achieve the promise of stimuli-responsive drug delivery systems for the treatment of cancer, they should (1) avoid premature clearance; (2) accumulate in tumors and undergo endocytosis by cancer cells; and (3) exhibit appropriate stimuli-responsive release of the payload. It is challenging to address all of these requirements simultaneously. However, the numerous proof-of-concept studies addressing one or more of these requirements reported every year have dramatically expanded the toolbox available for the design of drug delivery systems. Read More

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Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS.

Mol Ther Nucleic Acids 2021 Jun 15;24:1-10. Epub 2021 Feb 15.

Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Syowa-ku, Nagoya, Aichi 466-8550, Japan.

Polyglutamine (polyQ) diseases are inherited neurodegenerative disorders caused by expansion of cytosine-adenine-guanine (CAG)-trinucleotide repeats in causative genes. These diseases include spinal and bulbar muscular atrophy (SBMA), Huntington's disease, dentatorubral-pallidoluysian atrophy, and spinocerebellar ataxias. Targeting expanded CAG repeats is a common therapeutic approach to polyQ diseases, but concomitant silencing of genes with normal CAG repeats may lead to toxicity. Read More

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Skeletal muscle regeneration via the chemical induction and expansion of myogenic stem cells in situ or in vitro.

Nat Biomed Eng 2021 Mar 18. Epub 2021 Mar 18.

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.

Muscle loss and impairment resulting from traumatic injury can be alleviated by therapies using muscle stem cells. However, collecting sufficient numbers of autologous myogenic stem cells and expanding them efficiently has been challenging. Here we show that myogenic stem cells (predominantly Pax7 cells)-which were selectively expanded from readily obtainable dermal fibroblasts or skeletal muscle stem cells using a specific cocktail of small molecules and transplanted into muscle injuries in adult, aged or dystrophic mice-led to functional muscle regeneration in the three animal models. Read More

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Spray-dried assembly of 3D N,P-Co-doped graphene microspheres embedded with core-shell CoP/MoP@C nanoparticles for enhanced lithium-ion storage.

Dalton Trans 2021 Apr 17;50(13):4555-4566. Epub 2021 Mar 17.

Shanghai Electrochemical Energy Devices Research Centre, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

The advancement of novel synthetic approaches for micro/nanostructural manipulation of transition metal phosphide (TMP) materials with precisely controlled engineering is crucial to realize their practical use in batteries. Here, we develop a novel spray-drying strategy to construct three-dimensional (3D) N,P co-doped graphene (G-NP) microspheres embedded with core-shell CoP@C and MoP@C nanoparticles (CoP@C⊂G-NP, MoP@⊂G-NP). This intentional design shows a close correlation between the microstructural G-NP and chemistry of the core-shell CoP@C/MoP@C nanoparticle system that contributes towards their anode performance in lithium-ion batteries (LIBs). Read More

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In-house validation of AF4-MALS-UV for polystyrene nanoplastic analysis.

Anal Bioanal Chem 2021 May 16;413(11):3027-3039. Epub 2021 Mar 16.

Environment and Health Department, Istituto Superiore di Sanità, 00161, Rome, Italy.

The suitability of asymmetric flow field-flow fractionation (AF4) coupled on-line to multi-angle light scattering (MALS) and UV diode array (UV-DAD) detectors was tested to simultaneously detect polystyrene nanoplastics (PS-NPs) and collect information about their size. A mixture of four sizes of PS-NPs at 20 nm, 60 nm, 100 nm and 200 nm was prepared by dilution with ultrapure deionized water and gentle mixing and was used as test sample for a polydisperse nanoplastic system. The AF4 method separated each single size of PS-NP mixture in a total time of 48 min by using 0. Read More

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PD-L1 siRNA Theranostics With a Dextran Nanoparticle Highlights the Importance of Nanoparticle Delivery for Effective Tumor PD-L1 Downregulation.

Front Oncol 2020 25;10:614365. Epub 2021 Feb 25.

Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Purpose: The inhibition of immune checkpoints such as programmed cell death ligand-1 (PD-L1/CD274) with antibodies is providing novel opportunities to expose cancer cells to the immune system. Antibody based checkpoint blockade can, however, result in serious autoimmune complications because normal tissues also express immune checkpoints. As sequence-specific gene-silencing agents, the availability of siRNA has significantly expanded the specificity and range of "druggable" targets making them promising agents for precision medicine in cancer. Read More

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February 2021

Comparison of Immobilization Methods for TiO₂-Embedded Expanded Polystyrene Balls and Growth Inhibition of .

J Nanosci Nanotechnol 2021 Jul;21(7):3960-3964

Department of Civil, Urban and Real Estate Development, Shinhan University, Uijeongbu, 11644, Republic of Korea.

Two immobilization methods (i.e., ice water-soaked using a digital temperature controller vs. Read More

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Insecticidal efficacy and mechanism of nanoparticles synthesized from chitosan and carboxymethyl chitosan against Solenopsis invicta (Hymenoptera: Formicidae).

Carbohydr Polym 2021 May 20;260:117839. Epub 2021 Feb 20.

Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, South China Agricultural University, Guangzhou, 510642, China. Electronic address:

The efficacy and mode of action of biodegradable chitosan (CS) and carboxymethyl chitosan (CMCS) organic polymer nanoparticles (NPs) on insects were studied. The prepared CS/CMCS-NPs were spherical with a particle size of 142.1 ± 2. Read More

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Nanoengineered CAR-T Biohybrids for Solid Tumor Immunotherapy with Microenvironment Photothermal-Remodeling Strategy.

Small 2021 Apr 12;17(14):e2007494. Epub 2021 Mar 12.

Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab for Biomaterials, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, 518055, China.

Chimeric antigen receptor T cell (CAR-T) therapy has shown remarkable clinical success in eradicating hematologic malignancies. However, hostile microenvironment in solid tumors severely prevents CAR-T cells migrating, infiltrating, and killing. Herein, a nanoengineered CAR-T strategy is reported for enhancing solid tumor therapy through bioorthogonal conjugation with a nano-photosensitizer (indocyanine green nanoparticles, INPs) as a microenvironment modulator. Read More

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Mutagenicity of silver nanoparticles evaluated using whole-genome sequencing in mouse lymphoma cells.

Nanotoxicology 2021 04 12;15(3):418-432. Epub 2021 Mar 12.

Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA.

The increasing medical and food applications of silver nanoparticles (AgNPs) raise concerns about their safety, including the potential health consequences of human exposure. Previous studies found that AgNPs were negative in the Ames test due to both their microbicidal activity and the inability of nanoparticles to penetrate bacterial cell walls. Thus, the mutagenicity of AgNPs is still not completely clear, though they do induce chromosome damage, as suggested by many previous genotoxicity studies. Read More

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Hydroxyapatite Nanoparticles Facilitate Osteoblast Differentiation and Bone Formation Within Sagittal Suture During Expansion in Rats.

Drug Des Devel Ther 2021 1;15:905-917. Epub 2021 Mar 1.

Department of Plastic Surgery, Peking University Third Hospital, Beijing, 100191, People's Republic of China.

Background: The potential of relapse of craniofacial disharmony after trans-sutural distraction osteogenesis is high due to the failure to produce a stable bone bridge in the suture gap. The aim of this study is to evaluate whether hydroxyapatite nanoparticles (nHAP) have the effect of promoting osteoblast differentiation of suture-derived stem cells (SuSCs) and bone formation in sagittal suture during expansion.

Methods: SuSCs were isolated from sagittal sutures and exposed to various concentrations of nHAP (0, 25, 50, and 100 μg mL) to determine the optimal concentration of nHAP in osteoblast differentiation via performing Western Blotting and RT-qPCR. Read More

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Highly dispersed and stabilized CoO/C anchored on porous biochar for bisphenol A degradation by sulfate radical advanced oxidation process.

Sci Total Environ 2021 Feb 20;777:145794. Epub 2021 Feb 20.

State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, PR China.

Cobalt oxide and porous carbon materials are desirable catalysts for peroxymonosulfate (PMS) advanced oxidation reaction in the degradation of organic pollutants. Herein, carbon-coated CoO (CoO/C) mounted biochar (BC) composites (CoO/C-BC) with a three-dimensional spongy-like network were constructed by driving a dual-precursors of zeolitic imidazolate framework (ZIF-67) and Eichhornia crassipes. Considering the unique structures and compositions, the CoO/C-BC composites enhanced the dispersion of CoO/C nanoparticles, minimized the Co leaching, mediated the size of CoO/C nanoparticles, and enhanced the overall catalytic activity. Read More

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February 2021

Nanoparticles in the Food Industry and Their Impact on Human Gut Microbiome and Diseases.

Int J Mol Sci 2021 Feb 16;22(4). Epub 2021 Feb 16.

Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering, Faculty of Medicine, McGill University, 3775 University Street, Montreal, QC H3A 2B4, Canada.

The use of inorganic nanoparticles (NPs) has expanded into various industries including food manufacturing, agriculture, cosmetics, and construction. This has allowed NPs access to the human gastrointestinal tract, yet little is known about how they may impact human health. As the gut microbiome continues to be increasingly implicated in various diseases of unknown etiology, researchers have begun studying the potentially toxic effects of these NPs on the gut microbiome. Read More

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February 2021

Tuning morphology, surface, and nanocrystallinity of rare earth vanadates by one-pot colloidal conversion of hydroxycarbonates.

Nanoscale 2021 Mar 25;13(9):4931-4945. Epub 2021 Feb 25.

Department of Inorganic Chemistry, Institute of Chemistry, University of Campinas (Unicamp), PO Box 6154, 13083-970 Campinas, SP, Brazil.

We show that particle size, morphology, nanocrystallinity, surface area, and defect density of (Y,Eu)VO structures can be tuned by one-pot colloidal conversion of rare earth hydroxycarbonates in water/ethylene glycol (EG) suspensions. Using small angle X-ray scattering, transmission electron microscopy and dynamic light scattering, we show how volume fractions of EG direct the amorphous to crystalline conversion at 1 atm/95 °C by controlling size and aggregation of hydroxycarbonate precursors. A template effect due to a Kirkendall-type conversion occurs for low EG contents, yielding solids with high densities of oxygen defects, as demonstrated by O uptakes in thermogravimetry and X-ray photoelectron spectroscopy profiles. Read More

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Comparative and Combined Vasotoxicity of Nanoparticles Containing Lead and Cadmium.

Dose Response 2021 Jan-Mar;19(1):1559325820982163. Epub 2021 Feb 11.

The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Yekaterinburg, Russia.

toxicological experiments were performed on an endothelial cell line exposed to different doses of spherical nanoparticles of cadmium and/or of lead sulfides with mean diameter 37 ± 5 nm and 24 ± 4 nm, respectively. Toxic effects were estimated by Luminescent Cell Viability Assay, endothelin-1 concentration and cell size determination. Some dose-response relationships were typically monotonic (well approximated with hyperbolic function) while others were bi- or even 3-phasic and could be described within the expanded hormesis paradigm. Read More

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February 2021

Synthesis of a thermoresponsive crosslinked MEOMA polymer coating on microclusters of iron oxide nanoparticles.

Sci Rep 2021 Feb 17;11(1):3947. Epub 2021 Feb 17.

ECsens Group, Department of Analytical Chemistry, Campus Fuentenueva, University of Granada, 18071, Granada, Spain.

Encapsulation of magnetic nanoparticles (MNPs) of iron (II, III) oxide (FeO) with a thermopolymeric shell of a crosslinked poly(2-(2-methoxyethoxy)ethyl methacrylate) P(MEOMA) is successfully developed. Magnetic aggregates of large size, around 150-200 nm are obtained during the functionalization of the iron oxide NPs with vinyl groups by using 3-butenoic acid in the presence of a water soluble azo-initiator and a surfactant, at 70 °C. These polymerizable groups provide a covalent attachment of the P(MEOMA) shell on the surface of the MNPs while a crosslinked network is achieved by including tetraethylene glycol dimethacrylate in the precipitation polymerization synthesis. Read More

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February 2021

Fluorescence In Situ Hybridization with Quantum Dot Labels in E. coli Cells.

Methods Mol Biol 2021 ;2246:141-155

Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

In this chapter we describe the use of fluorescent quantum dots (QDs) as labels for microbial mRNA transcripts using fluorescence in situ hybridization (FISH). Unlike organic dyes, which are the standard labels in modern FISH methods, QDs provide fluorescence signals that are much brighter and resistant to photobleaching, with an expanded spectral range for multiplexing. We describe the preparation of QDs with compact sizes necessary for accurate labeling, their application for analyzing lacZ transcripts in Escherichia coli cells using FISH, and an assessment of signal stability. Read More

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Revealing High-Temperature Reduction Dynamics of High-Entropy Alloy Nanoparticles Transmission Electron Microscopy.

Nano Lett 2021 Feb 11;21(4):1742-1748. Epub 2021 Feb 11.

Department of Mechanical and Industrial Engineering, University of Illinois at Chicago, Chicago, Illinois 60607, United States.

Understanding the behavior of high-entropy alloy (HEA) materials under hydrogen (H) environment is of utmost importance for their promising applications in structural materials, catalysis, and energy-related reactions. Herein, the reduction behavior of oxidized FeCoNiCuPt HEA nanoparticles (NPs) in atmospheric pressure H environment was investigated by gas-cell transmission electron microscopy (TEM). The reduction reaction front was maintained at the external surface of the oxide. Read More

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February 2021

Optical Force-Induced Chemistry at Solution Surfaces.

Annu Rev Phys Chem 2021 Feb 10. Epub 2021 Feb 10.

Department of Chemistry, Osaka City University, Osaka 558-8585, Japan; email:

When an intense 1,064-nm continuous-wave laser is tightly focused at solution surfaces, it exerts an optical force on molecules, polymers, and nanoparticles (NPs). Initially, molecules and NPs are gathered into a single assembly inside the focus, and the laser is scattered and propagated through the assembly. The expanded laser further traps them at the edge of the assembly, producing a single assembly much larger than the focus along the surface. Read More

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February 2021

An effective polymeric nanocarrier that allows for active targeting and selective drug delivery in cell coculture systems.

Nanoscale 2021 Feb;13(6):3500-3511

GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Avda. Ilustración 114, 18016 Granada, Spain. and Department of Medicinal & Organic Chemistry and Excellence Research Unit of "Chemistry applied to Biomedicine and the Environment", Faculty of Pharmacy, University of Granada, Campus de Cartuja s/n, 18071, Granada, Spain and Biosanitary Research Institute of Granada (ibs.GRANADA), University Hospitals of Granada-University of Granada, Granada, 18071, Spain.

In this manuscript, we report the development of a versatile, robust, and stable targeting nanocarrier for active delivery. This nanocarrier is based on bifunctionalized polymeric nanoparticles conjugated to a monoclonal antibody that allows for active targeting of either (i) a fluorophore for tracking or (ii) a drug for monitoring specific cell responses. This nanodevice can efficiently discriminate between cells in coculture based on the expression levels of cell surface receptors. Read More

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February 2021

Identification of novel 1,4-dioxane degraders and related genes from activated sludge by taxonomic and functional gene sequence analysis.

J Hazard Mater 2021 Jan 23;412:125157. Epub 2021 Jan 23.

Civil and Environmental Engineering, University of California, Los Angeles, CA 90095, USA.

This study used integrated omics technologies to investigate the potential novel pathways and enzymes for 1,4-dioxane degradation by a consortium enriched from activated sludge of a domestic wastewater treatment plant. An unclassified genus belonging to Xanthobacteraceae increased significantly after magnetic nanoparticle-mediated isolation for 1,4-dioxane degraders. Species with relatively higher abundance (> 0. Read More

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January 2021

Ultrasensitive detection of cyclin D1 by a self-enhanced ECL immunosensor based on BiS quantum dots.

Analyst 2021 Mar 4;146(6):2057-2064. Epub 2021 Feb 4.

National and Local Joint Engineering Research Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, P. R. China.

Bismuth sulfide quantum dots (BiS QDs), which have excellent optical and thermoelectric properties, represent a green and non-toxic semiconductor material that has been widely used in catalysis and photoelectric conversion devices. At present, research on this material has gradually expanded into the biological field. Herein, the biomineralization method mediated by bovine serum albumin (BSA) was utilized to synthesize BiS QDs with monodispersity, excellent colloidal stability, and good biocompatibility. Read More

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A Combination of Anti-PD-L1 Treatment and Therapeutic Vaccination Facilitates Improved Retroviral Clearance via Reactivation of Highly Exhausted T Cells.

mBio 2021 02 2;12(1). Epub 2021 Feb 2.

Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

PD-1-targeted therapies have shown modest antiviral effects in preclinical models of chronic viral infection. Thus, novel therapy protocols are necessary to enhance T cell immunity and viral control to overcome T cell dysfunction and immunosuppression. Here, we demonstrate that nanoparticle-based therapeutic vaccination improved PD-1-targeted therapy during chronic infection with Friend retrovirus (FV). Read More

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February 2021

Smart nano-micro platforms for ophthalmological applications: The state-of-the-art and future perspectives.

Biomaterials 2021 Mar 21;270:120682. Epub 2021 Jan 21.

Shenzhen Eye Hospital, School of Ophthalmology & Optometry Affiliated to Shenzhen University, Shenzhen, 518040, PR China; Department of Ophthalmology, Shenzhen People's Hospital (The Second Clinical Medical College,Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, 518020, PR China. Electronic address:

Smart nano-micro platforms have been extensively applied for diverse biomedical applications, mostly focusing on cancer therapy. In comparison with conventional nanotechnology, the smart nano-micro matrix can exhibit specific response to exogenous or endogenous triggers, and thus can achieve multiple functions e.g. Read More

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Nanofibrous ε-polycaprolactone scaffolds containing Ag-doped magnetite nanoparticles: Physicochemical characterization and biological testing for wound dressing applications and .

Bioact Mater 2021 Jul 9;6(7):2070-2088. Epub 2021 Jan 9.

Advanced Materials and Nanobiotechnology Laboratory, TardigradeNano LLC, Irvine, CA, 92604, USA.

Skin wounds can lead to numerous complications with dangerous health consequences. In this work, magnetite nanoparticles were doped with different concentrations of antimicrobial silver (Ag) ions and incorporated into the electrospun nanofibrous ε-polycaprolactone (PCL) scaffolds. Nanoparticles and scaffolds with various Ag contents were characterized using a range of physicochemical techniques. Read More

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Poly(aspartic acid)-based pH-responsive targeting co-delivery nanoparticles.

J Biomater Appl 2021 Jan 28:885328220988071. Epub 2021 Jan 28.

Large Apparatus Analysis and Test Centre, Shanxi Academy of Analytical Science, Taiyuan, China.

Encapsulation of therapeutic molecules into nanocarrier is an extensively explored strategy to treat cancer more effectively. In this study, pH-responsive targeting dual-agent delivery nanoparticles were prepared, into which hydrophilic doxorubicin hydrochloride (DOX) and hydrophobic curcumin (CUR) were entrapped. Tyrosine (Tyr) was grafted onto poly(aspartic acid) (PASP) to produce PASP-Tyr, the following reaction between hyaluronic acid (HA) and ethylenediamine (EDA) modified PASP-Tyr formed the nanocarrier HA-EDA-PASP-Tyr (HEPT), and the loading capacity was up to 50. Read More

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January 2021

A Superior Potassium-Ion Anode Material from Pitch-based Activated Carbon Fibers with Hierarchical Pore Structure Prepared by Metal Catalytic Activation.

ACS Appl Mater Interfaces 2021 Feb 27;13(5):6557-6565. Epub 2021 Jan 27.

Hunan Province Key Laboratory for Advanced Carbon Materials and Applied Technology, College of Materials Science and Engineering, Hunan University, Changsha, 410082, China.

The pitch-based activated carbon fibers with nickel sulfide nanoparticles (ACF/NiS) were designed by in situ polymerization of ethylene tar with the addition of nickel nitrate followed by melt spinning, stabilization, carbonization, steam activation, and vulcanization processes. The ACF/NiS with hierarchical pore structure and abundant active sites was used as an anode material to improve Coulombic efficiency and increase capacity of potassium-ion batteries (PIBs). The results showed the obtained ACF/NiS with excellent specific surface area of 1552 m g and high mesopore volume contribution of 38%, which delivered a high initial Coulombic efficiency of 84. Read More

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February 2021

Development of nanochitosan-based active packaging films containing free and nanoliposome caraway (. L) seed extract.

Food Sci Nutr 2021 Jan 18;9(1):553-563. Epub 2020 Nov 18.

Food Safety and Hygiene Division Department of Environmental Health School of Public Health Tehran University of Medical Sciences Tehran Iran.

The biocompatible active films were prepared based on nanochitosan (NCh) containing free and nanoliposome caraway seed extract (NLCE). The produced films were characterized by physico-mechanical, barrier, structural, color, antimicrobial, and antioxidant properties. The average particle size of NLCE was 78-122 nm, and the encapsulation efficiency (EE%) was obtained 49. Read More

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January 2021