Bioelectrochemistry 2021 Jul 13;142:107886. Epub 2021 Jul 13.
Department of Biomedical Engineering and Mechanics, Virginia Tech, 325 Stanger Street, Blacksburg, VA 24061, USA; Department of Mechanical Engineering, Virginia Tech, Goodwin Hall, 635 Prices Fork Road, Blacksburg, VA 24061, USA; Institute for Critical Technology and Applied Sciences, Virginia Tech, Kelly Hall, Blacksburg, VA 24061, USA. Electronic address:
Expansion of cytotoxic T lymphocytes (CTLs) is a crucial step in almost all cancer immunotherapeutic methods. Current techniques for expansion of tumor-reactive CTLs present major limitations. This study introduces a novel method to effectively produce and expand tumor-activated CTLs using high-voltage pulsed electric fields. Read More