2,032 results match your criteria exosomes promote


Cancer Extracellular Vesicles, Tumoroid Models, and Tumor Microenvironment.

Semin Cancer Biol 2022 Jan 12. Epub 2022 Jan 12.

Division of Molecular and Cellular Biology, Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

Cancer extracellular vesicles (EVs), or exosomes, promote tumor progression through enhancing tumor growth, initiating epithelial-to-mesenchymal transition, remodeling the tumor microenvironment, and preparing metastatic niches. Three-dimensionally (3D) cultured tumoroids / spheroids aim to reproduce some aspects of tumor behavior in vitro and show increased cancer stem cell properties. These properties are transferred to their EVs that promote tumor growth. Read More

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January 2022

Inflammatory osteoclasts-derived exosomes promote bone formation by selectively transferring lncRNA LIOCE into osteoblasts to interact with and stabilize Osterix.

FASEB J 2022 Feb;36(2):e22115

Medical College, Guizhou University, Guiyang, China.

Bone loss is a hallmark of inflammatory bone diseases caused by aberrantly activated osteoclasts (OCLs). Studies have shown that OCLs exhibit various phenotypes and functions due to variations in the source(s) of precursor cells, cytokine expressions, and microenvironment-dependent factors. During these conditions, inflammatory osteoclasts (iOCLs) lose their immune-suppressive effect relative to OCLs under physiological conditions. Read More

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February 2022

Potential Application of Exosomes in Vaccine Development and Delivery.

Pharm Res 2022 Jan 13. Epub 2022 Jan 13.

Department of Pharmaceutical Sciences, University of Texas at El Paso School of Pharmacy, 1101 N. Campbell St, El Paso, TX, 79902, USA.

Exosomes are cell-derived components composed of proteins, lipid, genetic information, cytokines, and growth factors. They play a vital role in immune modulation, cell-cell communication, and response to inflammation. Immune modulation has downstream effects on the regeneration of damaged tissue, promoting survival and repair of damaged resident cells, and promoting the tumor microenvironment via growth factors, antigens, and signaling molecules. Read More

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January 2022

Hypoxic Breast Cancer Cell-Derived Exosomal SNHG1 Promotes Breast Cancer Growth and Angiogenesis via Regulating miR-216b-5p/JAK2 Axis.

Cancer Manag Res 2022 7;14:123-133. Epub 2022 Jan 7.

Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, People's Republic of China.

Background: Hypoxia is an important process that involved in the tumor microenvironment. In addition, hypoxic tumor cell-derived exosomes could promote tumor growth and angiogenesis. Thus, we aimed to investigate whether exosomes could regulate tumor development and progression under hypoxia in breast cancer. Read More

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January 2022

Hepatocyte TGF-β Signaling Inhibiting WAT Browning to Promote NAFLD and Obesity Is Associated With Let-7b-5p.

Hepatol Commun 2022 Jan 11. Epub 2022 Jan 11.

Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Transforming growth factor beta (TGF-β) signaling in hepatocytes promotes steatosis and body weight gain. However, processes that TGF-β signaling in hepatocytes promote pathological body weight gain in nonalcoholic fatty liver disease (NAFLD) are incompletely understood. Obesity and NAFLD were induced by 16 weeks of feeding a high-fat diet (HFD) in hepatocyte-specific TGF-β receptor II-deficient (Tgfbr2 ) and Tgfbr2 mice. Read More

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January 2022

N6‑methyladenosine upregulates miR‑181d‑5p in exosomes derived from cancer‑associated fibroblasts to inhibit 5‑FU sensitivity by targeting NCALD in colorectal cancer.

Int J Oncol 2022 Feb 11;60(2). Epub 2022 Jan 11.

Division of Gastrointestinal Surgery, Department of General Surgery, Shanghai Eighth People Hospital, Jiangsu University, Shanghai 200232, P.R. China.

Resistance to 5‑Fluorouracil (5‑FU) is a frequent occurrence in patients with colorectal cancer (CRC). MicroRNAs (miRNAs) from cancer‑associated fibroblasts (CAFs)‑secreted exosomes have been associated with 5‑FU sensitivity. The potential molecular mechanism of CAFs‑exosomal miRNAs in CRC remains unclear. Read More

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February 2022

Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression.

Gut 2022 Jan 10. Epub 2022 Jan 10.

i3S Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal

Objective: Intratumor heterogeneity drives cancer progression and therapy resistance. However, it has yet to be determined whether and how subpopulations of cancer cells interact and how this interaction affects the tumour.

Design: We have studied the spontaneous flow of extracellular vesicles (EVs) between subpopulations of cancer cells: cancer stem cells (CSC) and non-stem cancer cells (NSCC). Read More

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January 2022

Update of application of olfactory ensheathing cells and stem cells/exosomes in the treatment of retinal disorders.

Stem Cell Res Ther 2022 Jan 10;13(1):11. Epub 2022 Jan 10.

Department of Ophthalmology, The Second Affiliated Hospital of Fujian Medical University, Engineering Research Center of Assistive Technology for Visual Impairment, Fujian Province University, Quanzhou, 362000, Fujian Province, China.

Age-related macular degeneration, diabetic retinopathy, retinitis pigmentosa and other retinal disorders are the main causes of visual impairment worldwide. In the past, these retinal diseases, especially dry age-related macular degeneration, proliferative diabetic retinopathy and retinitis pigmentosa, were treated with traditional surgery and drugs. However, the effect was moderate. Read More

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January 2022

LncRNA TP73-AS1 promotes nasopharyngeal carcinoma progression through targeting miR-342-3p and M2 polarization via exosomes.

Cancer Cell Int 2022 Jan 10;22(1):16. Epub 2022 Jan 10.

Department of Otolaryngology Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University, No. 246 Xue Fu Road, Harbin, 150086, China.

Background: Nasopharyngeal carcinoma (NPC) is a deadly cancer, mainly presenting in southeast and east Asia. Long noncoding RNAs (lncRNAs) play essential roles in cancer progression. Exosomes are critical for intercellular communication. Read More

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January 2022

Exogenous and Endogenous Dendritic Cell-Derived Exosomes: Lessons Learned for Immunotherapy and Disease Pathogenesis.

Cells 2021 Dec 30;11(1). Epub 2021 Dec 30.

Department of Periodontics, Augusta University, Augusta, GA 30912, USA.

Immune therapeutic exosomes, derived exogenously from dendritic cells (DCs), the 'directors' of the immune response, are receiving favorable safety and tolerance profiles in phase I and II clinical trials for a growing number of inflammatory and neoplastic diseases. DC-derived exosomes (EXO), the focus of this review, can be custom tailored with immunoregulatory or immunostimulatory molecules for specific immune cell targeting. Moreover, the relative stability, small size and rapid uptake of EXO by recipient immune cells offer intriguing options for therapeutic purposes. Read More

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December 2021

Understanding the Role and Clinical Applications of Exosomes in Gynecologic Malignancies: A Review of the Current Literature.

Cancers (Basel) 2021 Dec 29;14(1). Epub 2021 Dec 29.

Sylvester Comprehensive Cancer Center, Division of Gynecologic Oncology, University of Miami, Miami, FL 33136, USA.

Background: Gynecologic malignancies are those which arise in the female reproductive organs of the ovaries, cervix, and uterus. They carry a great deal of morbidity and mortality for patients, largely due to challenges in diagnosis and treatment of these cancers. Although advances in technology and understanding of these diseases have greatly improved diagnosis, treatment, and ultimately survival for patients with gynecologic malignancies over the last few decades, there is still room for improvements in diagnosis and treatment, for which exosomes may be the key. Read More

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December 2021

Tumor cell-derived exosomes deliver TIE2 protein to macrophages to promote angiogenesis in cervical cancer.

Cancer Lett 2022 Jan 7;529:168-179. Epub 2022 Jan 7.

Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, Hubei, 430022, PR China. Electronic address:

Tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 2 (TIE2)-expressing macrophages (TEMs) are an angiogenesis-promoting subset of tumor-associated macrophages that have been demonstrated to be increased in solid tumors and associated with the progression of cervical cancer. However, the induction mechanism of TEMs remains unclear. Here, based on multicolor immunofluorescence of 58 cervical cancer tissues and the GEPIA database, we found that TEMs were increased in TIE2-high cervical cancer and related to shorter survival. Read More

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January 2022

Stem Cell Mimicking Nanoencapsulation for Targeting Arthritis.

Int J Nanomedicine 2021 31;16:8485-8507. Epub 2021 Dec 31.

Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon, 21999, South Korea.

Mesenchymal stem cells (MSCs) are considered a promising regenerative therapy due to their ability to migrate toward damaged tissues. The homing ability of MSCs is unique compared with that of non-migrating cells and MSCs are considered promising therapeutic vectors for targeting major cells in many pathophysiological sites. MSCs have many advantages in the treatment of malignant diseases, particularly rheumatoid arthritis (RA). Read More

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January 2022

MiR-192-5p-Modified Tumor-Associated Macrophages-Derived Exosome Suppressed Endometrial Cancer Progression Through Targeting IRAK1/NF-κB Signaling.

Reprod Sci 2022 Jan 9. Epub 2022 Jan 9.

Department of Obstetrics and Gynecology, Inner Mongolia People's Hospital, 20 Zhaowuda Road, Saihan District, Hohhot City, Inner Mongolia, China.

Tumor-associated macrophages (TAMs) are a major regulator in the development of endometrial cancer (EC). It was indicated that TAMs could crosstalk with cancer cells via transferring exosomes which carrying microRNAs (miRNAs). Firstly, we found that TAMs could promote the epithelial-mesenchymal transition (EMT) of EC cells and inhibit its apoptosis. Read More

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January 2022

Serum Exosomal mir-340-5p Promotes Angiogenesis in Brain Microvascular Endothelial Cells During Oxygen-Glucose Deprivation.

Neurochem Res 2022 Jan 7. Epub 2022 Jan 7.

Department of Interventional Radiology, Northern Jiangsu People's Hospital, Clinical Medical Hospital of Yangzhou University, Yangzhou, 225001, China.

Ischemic stroke (IS) is a cerebrovascular disease with high morbidity, recurrence, and mortality. The purpose of the present study was to investigate the role and mechanism of human serum exosomes on angiogenesis after IS. The middle cerebral artery occlusion (MCAO) in vivo model and oxygen-glucose deprivation (OGD) in vitro model were established. Read More

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January 2022

Intrinsic Tendon Regeneration After Application of Purified Exosome Product: An In Vivo Study.

Orthop J Sports Med 2021 Dec 17;9(12):23259671211062929. Epub 2021 Dec 17.

Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Background: Tendons are primarily acellular, limiting their intrinsic regenerative capabilities. This limited regenerative potential contributes to delayed healing, rupture, and adhesion formation after tendon injury.

Purpose: To determine if a tendon's intrinsic regenerative potential could be improved after the application of a purified exosome product (PEP) when loaded onto a collagen scaffold. Read More

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December 2021

Trimethylamine-N-oxide-stimulated hepatocyte-derived exosomes promote inflammation and endothelial dysfunction through nuclear factor-kappa B signaling.

Ann Transl Med 2021 Nov;9(22):1670

Department of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Background: Trimethylamine-N-oxide (TMAO) has been proven to be a new proatherogenic compound for promoting inflammation and endothelial dysfunction. Hepatocyte-derived exosomes (Exos), including those derived from hepatocytes, play a pivotal role in the regulation of inflammation and endothelial function. As TMAO is produced in the liver, hepatocytes may be the potential target of TMAO. Read More

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November 2021

Milk exosomes-mediated miR-31-5p delivery accelerates diabetic wound healing through promoting angiogenesis.

Drug Deliv 2022 Dec;29(1):214-228

Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

The refractory diabetic wound has remained a worldwide challenge as one of the major health problems. The impaired angiogenesis phase during diabetic wound healing partly contributes to the pathological process. MicroRNA (miRNA) is an essential regulator of gene expression in crucial biological processes and is a promising nucleic acid drug in therapeutic fields of the diabetic wound. Read More

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December 2022

[Effects of activated CD4 T cell-derived exosomes on cardiac remodeling after myocardial infarction].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Nov;33(11):1332-1336

Department of Emergency, Xuanwu Hospital of Capital Medical University, Beijing 100053, China. Corresponding author: Wang Jing, Email:

Objective: To explore the role of activated CD4 T cells in cardiac remodeling after myocardial infarction (MI).

Methods: (1) Experiment in vitro: naive CD4 T cells were isolated in mouse spleen, and then stimulated with plate-bound anti-CD3 and anti-CD28 for 48 hours. Exosomes isolated from the supernatant of activated CD4 T cells were incubated with cardiac fibroblasts (CFs) for 48 hours, and then the ability of CFs proliferation, migration and differentiation were detected by cell counting kit-8 (CCK-8) assay, Transwell assay, and immunofluorescence assay. Read More

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November 2021

Induction of mA methylation in adipocyte exosomal LncRNAs mediates myeloma drug resistance.

J Exp Clin Cancer Res 2022 Jan 3;41(1). Epub 2022 Jan 3.

Houston Methodist Cancer Center, Research Institute Houston Methodist Hospital, Houston, TX, 77030, USA.

Background: Therapeutic resistance occurs in most patients with multiple myeloma (MM). One of the key mechanisms for MM drug resistance comes from the interaction between MM cells and adipocytes that inhibits drug-induced apoptosis in MM cells; MM cells reprogram adipocytes to morph into different characterizations, including exosomes, which are important for tumor-stroma cellular communication. However, the mechanism by which exosomes mediate the cellular machinery of the vicious cycle between MM cells and adipocytes remains unclear. Read More

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January 2022

Treatment of inflammatory bone loss in periodontitis by stem cell-derived exosomes.

Acta Biomater 2022 Jan 1. Epub 2022 Jan 1.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China; State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Chengdu 610041, China. Electronic address:

Periodontitis is the primary cause of tooth loss, but there is no effective treatment to repair inflammatory bone loss in periodontitis. Exosomes emerge as essential paracrine factors of mesenchymal stem cells (MSCs) that mediated tissue regeneration. Here, we investigated the potential of exosomes secreted by periodontal ligament stem cells (PDLSCs) as therapeutics for the bone defect in periodontitis. Read More

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January 2022

Osteoblast/Osteoclast and Immune Cocktail Therapy of an Exosome/Drug Delivery Multifunctional Hydrogel Accelerates Fracture Repair.

ACS Nano 2022 Jan 3. Epub 2022 Jan 3.

Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China.

The osteoblast/osteoclast and M1/M2 macrophage ratios play critical roles in delayed fracture healing. Robust osteoblast differentiation and M2 macrophage polarization can substantiality promote fracture repair; however, the combined effect of these strategies has not been previously studied. In this study, we constructed a cocktail therapy to simultaneously regulate the osteoblast/osteoclast and M1/M2 macrophage balance. Read More

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January 2022

Exosomes derived from hepatitis B virus-infected hepatocytes promote liver fibrosis via miR-222/TFRC axis.

Cell Biol Toxicol 2022 Jan 3. Epub 2022 Jan 3.

Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, No. 650 New Songjiang Road, Shanghai, 201620, China.

Exosomal miRNAs activates hepatic stellate cell (HSC) and promote fibrosis. miR-222 was found to be increased in hepatitis B virus (HBV)-infected hepatocytes, and ferroptosis was reported to ameliorate liver fibrosis (LF). Although miR-222 and ferroptosis have been implicated in LF, the association between miR-222 and ferroptosis and how they coordinate to regulate LF are still not explicit. Read More

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January 2022

MiR-221-3p targets HIPK2 to promote diabetic wound healing.

Microvasc Res 2021 Dec 30;140:104306. Epub 2021 Dec 30.

Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, Anhui Province 230022, People's Republic of China. Electronic address:

Diabetic foot ulcer is a severe complication of diabetes and is prone to being a chronic non-healing wound. We previously demonstrated that endothelial progenitor cell-derived exosomes, which contain miR-221-3p, alleviate diabetic ulcers. Here, to explore the mechanisms underlying this wound healing, we investigated the potential angiogenic effects of miR-221-3p in vitro using cultured human umbilical vein endothelial cells (HUVECs) and in vivo using a streptozotocin-induced mouse model of diabetes. Read More

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December 2021

Extracellular Vesicles Induce an Aggressive Phenotype in Luminal Breast Cancer Cells PKM2 Phosphorylation.

Front Oncol 2021 13;11:785450. Epub 2021 Dec 13.

Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea.

Background: Aerobic glycolysis is a hallmark of glucose metabolism in cancer. Previous studies have suggested that cancer cell-derived extracellular vesicles (EVs) can modulate glucose metabolism in adjacent cells and promote disease progression. We hypothesized that EVs originating from cancer cells can modulate glucose metabolism in recipient cancer cells to induce cell proliferation and an aggressive cancer phenotype. Read More

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December 2021

[Repair of osteoarthritis in animal model with exosomes derived from BMSCs transfected by the siRNA -Piezo1 through CT navigation].

Zhongguo Gu Shang 2021 Dec;34(12):1171-8

Department of Orthopaedics, the Jinhua Hospital Affiliated to Zhejiang University, Jinhua 321000, Zhejiang, China.

Objective: To investigate the effect of the exosomes from bone marrow mesenchymal stem cells (BMSCs) transfected with silence plasmid of Piezol small interference RNA (siRNA)on osteoarthritis (OA) animal model.

Methods: Twenty male SD rats with specific pathogen free (SPF) were selected, ranging in age from 5.46 to 6. Read More

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December 2021

Integration of exosomal miR-106a and mesothelial cells facilitates gastric cancer peritoneal dissemination.

Cell Signal 2021 Dec 25;91:110230. Epub 2021 Dec 25.

Department of Gastroenterology, First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, Shaanxi, Xi'an 710061, China.

Background: Metastatic organotropism is considered the end stage of malignancy with the mechanism still have some mysteries that have not been disclosed. Although the role of miR-106a is well studied, its involvement in the formation of peritoneal metastasis transported by exosomes is less discussed.

Methods: Gastric cancer (GC)-derived exosomes were identified by transmission electron microscopy and the integration with peritoneal mesothelial cells (PMC) was confirmed by PKH-26 staining. Read More

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December 2021

Exosomal circRNAs: a new communication method in cancer.

Am J Transl Res 2021 15;13(11):12913-12928. Epub 2021 Nov 15.

Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University Nanjing 210029, Jiangsu, China.

Exosomes are extracellular vesicles with unique membrane markers and components that participate in cellular communication. The contents of exosomes, including growth factors, microRNAs, long noncoding RNAs, and circular RNAs (circRNAs), have been recognized as prognostic biomarkers and promote cancer progression through cancer cell growth, metastasis, angiogenesis, and cancer development. One of the components of exosomes, circRNAs, are covalently closed and prevented from degrading, which results in their continually accumulating in exosomes. Read More

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November 2021

Gingival mesenchymal stem cell-derived exosomes are immunosuppressive in preventing collagen-induced arthritis.

J Cell Mol Med 2021 Dec 24. Epub 2021 Dec 24.

Department of Tissue Engineering, School of Intelligent Medicine, China Medical University, Shenyang, China.

Due to the unsatisfied effects of clinical drugs used in rheumatoid arthritis (RA), investigators shifted their focus on the biotherapy. Although human gingival mesenchymal stem cells (GMSC) have the potential to be used in treating RA, GMSC-based therapy has some inevitable side effects such as immunogenicity and tumorigenicity. As one of the most important paracrine mediators, GMSC-derived exosomes (GMSC-Exo) exhibit therapeutic effects via immunomodulation in a variety of disease models, bypassing potential shortcomings of the direct use of MSCs. Read More

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December 2021

Human MSC-Derived Exosomes Reduce Cellular Senescence in Renal Epithelial Cells.

Int J Mol Sci 2021 Dec 17;22(24). Epub 2021 Dec 17.

Biochemistry and Tumor Biology Lab, Department of Gynecology and Obstetrics, Hannover Medical School, 30625 Hannover, Germany.

Cellular senescence of renal tubular cells is associated with chronic diseases and age-related kidney disorders. Therapies to antagonize senescence are, therefore, explored as novel approaches in nephropathy. Exosomes derived from human mesenchymal stroma-/stem-like cells (MSC) entail the transfer of multiple bioactive molecules, exhibiting profound regenerative potential in various tissues, including therapeutic effects in kidney diseases. Read More

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December 2021