1,630 results match your criteria exogenous melatonin


Melatonin Abates TMJOA Chronic Pain by MTR in Trigeminal Ganglion Neurons.

J Dent Res 2021 Jul 27:220345211026551. Epub 2021 Jul 27.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China.

Temporomandibular joint osteoarthritis (TMJOA) is one of the most common diseases causing chronic pain in the oral and maxillofacial region. So far, there are few ways to relieve the pain of TMJOA. Melatonin (MT) has a good analgesic effect in many diseases, including fibromyalgia, neuropathic pain, chronic headache, and burn pain, with very low acute toxicity and side effects. Read More

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Effects of exogenous melatonin on photosynthesis and physiological characteristics of chry-santhemum seedlings under high temperature stress.

Ying Yong Sheng Tai Xue Bao 2021 Jul;32(7):2496-2504

College of Horticultural Science and Engineering, Shandong Agricultural University/State Key Laboratory of Crop Biology, Tai'an 271018, Shandong, China.

We examined the effects of exogenous melatonin (MT) on the resistance of 'Jinba' to high temperature stress. Chrysanthemum leaves were sprayed with 200 μmol·LMT, and then subjected to high temperature stress at 40 ℃ (day)/ 35 ℃ (night). The ultrastructure of chloroplast and thylakoid of chrysanthemum leaves were observed, and the photosynthetic and physiological indices were measured. Read More

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Exogenous application of melatonin to plants, algae, and harvested products to sustain agricultural productivity and enhance nutritional and nutraceutical value: A meta-analysis.

Environ Res 2021 Jul 21:111746. Epub 2021 Jul 21.

Department of Agricultural Sciences, Biotechnology and Food Science, Cyprus University of Technology, Lemesos, 3603, Cyprus.

Melatonin is produced by plants, algae, and animals. Worldwide studies show diverse positive effects of exogenous melatonin on plants, edible plant products, and algae, but the potential of melatonin to enhance food and feed systems through these positive effects remains largely unexplored. Through a meta-analysis of about 25,000 observations, we show for the first time that exogenous application of melatonin significantly increases crop productivity and yields, and enhances the nutritional and nutraceutical value of edible plant products and algae by regulating diverse biological functions. Read More

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Melatonin and Its Homologs Induce Immune Responses Receptors trP47363-trP13076 in .

Front Plant Sci 2021 30;12:691835. Epub 2021 Jun 30.

Key Laboratory of Monitoring and Management of Crop Diseases and Pest Insects, Department of Plant Pathology, College of Plant Protection, Ministry of Education, Nanjing Agricultural University, Nanjing, China.

Melatonin (N-acetyl-5-methoxytryptamine), a naturally occurring small molecule, can protect plants against abiotic stress after exogenous treatmenting with it. It is not known if melatonin homologs, such as 5-methoxytryptamine and 5-methoxyindole, that are easy and more cost-effective to synthesize can stimulate the plant immune system in the same manner as melatonin. In the present study, we assessed the biological activity of the melatonin homologs, 5-methoxytryptamin and 5-methoxyindole. Read More

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Exogenous melatonin-mediated regulation of K /Na transport, H -ATPase activity and enzymatic antioxidative defence operate through endogenous hydrogen sulphide signalling in NaCl-stressed tomato seedling roots.

Plant Biol (Stuttg) 2021 Jul 15. Epub 2021 Jul 15.

Department of Biology, Faculty of Science and Humanities, Quwayiyah, Shaqra University, Shaqra, Saudi Arabia.

Melatonin (Mel) and hydrogen sulphide (H S) have emerged as potential regulators of plant metabolism during abiotic stress. Presence of excess NaCl in the soil is one of the main causes of reduced crop productivity worldwide. The present investigation examines the role of exogenous Mel and endogenous H S in tomato seedlings grown under NaCl stress. Read More

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Melatonin Improves Cotton Salt Tolerance by Regulating ROS Scavenging System and Ca Signal Transduction.

Front Plant Sci 2021 28;12:693690. Epub 2021 Jun 28.

State Key Laboratory of Cotton Biology/Institute of Cotton Research of Chinese Academy of Agricultural Sciences/Research Base, Zhengzhou University/Key Laboratory for Cotton Genetic Improvement, MOA, Anyang, China.

As one of the cash crops, cotton is facing the threat of abiotic stress during its growth and development. It has been reported that melatonin is involved in plant defense against salt stress, but whether melatonin can improve cotton salt tolerance and its molecular mechanism remain unclear. We investigated the role of melatonin in cotton salt tolerance by silencing melatonin synthesis gene and exogenous melatonin application in upland cotton. Read More

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Possible role of exogenous melatonin in preventing more serious COVID-19 infection in patients with type 2 diabetes mellitus.

Rev Assoc Med Bras (1992) 2021 Jul 9. Epub 2021 Jul 9.

Universidade Federal de Minas Gerais, Postgraduate Program in Neurosciences - Belo Horizonte, Brazil.

COVID-19 infection is more severe in patients with type 2 diabetes mellitus (DM2). The severity of this viral infection is associated with an intense inflammatory activity. DM2 is a disease that also determines a greater degree of systemic inflammation. Read More

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Exogenous melatonin improves the salt tolerance of cotton by removing active oxygen and protecting photosynthetic organs.

BMC Plant Biol 2021 Jul 10;21(1):331. Epub 2021 Jul 10.

State Key Laboratory of North China Crop Improvement and Regulation/Key Laboratory of Crop Growth regulation of Hebei Province/College of Agronomy, Hebei Agricultural University, Baoding, 071001, Hebei, China.

Background: As damage to the ecological environment continues to increase amid unreasonable amounts of irrigation, soil salinization has become a major challenge to agricultural development. Melatonin (MT) is a pleiotropic signal molecule and indole hormone, which alleviates the damage of abiotic stress to plants. MT has been confirmed to eliminate reactive oxygen species (ROS) by improving the antioxidant system and reducing oxidative damage under adversity. Read More

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Effects Of Exogenous Melatonin On Sleep And Circadian Rhythms In Women With Premenstrual Dysphoric Disorder.

Sleep 2021 Jul 8. Epub 2021 Jul 8.

Centre For Study And Treatment Of Circadian Rhythms, Douglas Mental Health University Institute, Mcgill University, Montreal, Quebec, Canada.

We previously found normal polysomnographic (PSG) sleep efficiency, increased slow wave sleep (SWS) and a blunted melatonin secretion in women with premenstrual dysphoric disorder (PMDD) compared to controls. Here, we investigated the effects of exogenous melatonin in five patients previously studied. They took 2 mg of slow-release melatonin 1 hour before bedtime during their luteal phase (LP) for three menstrual cycles. Read More

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Exogenous melatonin induces drought stress tolerance by promoting plant growth and antioxidant defence system of soybean plants.

AoB Plants 2021 Aug 9;13(4):plab026. Epub 2021 Jun 9.

School of Applied Biosciences, Kyungpook National University, 41566Republic of Korea.

Melatonin is an indolamine bioactive molecule that regulates a wide range of physiological processes during plant growth and enhances abiotic stress tolerance. Here we examined the putative role of exogenous melatonin application (foliar or root zone) in improving drought stress tolerance in soybean seedlings. Pre-treatment of soybean seedlings with melatonin (50 and 100 µM) was found to significantly mitigate the negative effects of drought stress on plant growth-related parameters and chlorophyll content. Read More

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Enhanced Synergistic-Antioxidant Activity of Melatonin and Tretinoin by Co-encapsulation into Amphiphilic Chitosan Nanocarriers: During Mice In Vitro Matured Oocyte/Morula-Compact Stage Embryo Culture Model.

Reprod Sci 2021 Jul 6. Epub 2021 Jul 6.

Nano Drug Delivery Melearch Center, Faculty of Pharmacy, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

The use of exogenous antioxidants or the combination of them during in vitro oocyte/embryo culture media is reasonable. Co-delivery by nanocarrier has been designed to overcome the limitations of combining them traditionally. In this work, amphiphilic chitosan nanocarrier (ACN) was applied to co-encapsulate melatonin (Mel) and tretinoin (TTN) by the self-assembled method and evaluate their synergistic antioxidant efficacy in mice oocytes/embryos. Read More

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Melatonin mediates monochromatic light-induced expression of somatostatin in the hypothalamus and pituitary of chicks.

Poult Sci 2021 Aug 28;100(8):101285. Epub 2021 May 28.

Laboratory of Anatomy of Domestic Animal, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China. Electronic address:

Melatonin (MEL) plays an important role in regulating growth and development of organisms and the cellular metabolism. This study was conducted to explore the role of MEL in mediating monochromatic light-induced secretion of somatostatin (SST) in the hypothalamus and pituitary in chicks. Pinealectomy models of newly hatched broilers were exposed to white (WL), red (RL), green (GL), and blue (BL) lights. Read More

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The use of melatonin to mitigate the adverse metabolic side effects of antipsychotics.

Handb Clin Neurol 2021 ;179:371-382

Lindner Center of HOPE Research Institute, Lindner Center of HOPE, Mason, OH, United States; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, United States.

Antipsychotic drugs are efficacious first-line treatments for many individuals diagnosed with a psychiatric illness. However, their adverse metabolic side-effect profile, which resembles the metabolic syndrome, represents a significant clinical problem that increases morbidity and limits treatment adherence. Moreover, the mechanisms involved in antipsychotic-induced adverse metabolic effects (AMEs) are unknown and mitigating strategies and interventions are limited. Read More

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Melatonin and the circadian system: Keys for health with a focus on sleep.

Handb Clin Neurol 2021 ;179:331-343

Institute of Cellular and Integrative Neurosciences, CNRS, University of Strasbourg, Strasbourg, France.

Melatonin (MLT), secreted during the night by the pineal gland, is an efferent hormonal signal of the master circadian clock located in the suprachiasmatic nucleus (SCN). Consequently, it is a reliable phase marker of the SCN clock. If one defines as "chronobiotic," a drug able to influence the phase and/or the period of the circadian clock, MLT is a very potent one. Read More

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Melatonin increases leaf disease resistance and saponin biosynthesis in Panax notogiseng.

J Plant Physiol 2021 Aug 26;263:153466. Epub 2021 Jun 26.

Laboratory of Sustainable Utilization of Panax notoginseng Resources, State Administration of Traditional Chinese Medicine, Key Laboratory of Panax notoginseng in Yunnan Province, Panax notoginseng Research Institute in Yunnan Province, Faculty of Life Science and Technology, Kunming University of Science and Technology, 650500, Kunming, Yunnan, China. Electronic address:

Panax notoginseng (Bruk.) FH Chen is a valuable traditional herb in China, with saponins being the main medicinal components in its roots. However, leaf diseases are a major factor limiting growth and production of P. Read More

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The effects of melatonin on the healing of burn wounds in pinealectomized rats.

Ulus Travma Acil Cerrahi Derg 2021 Jul;27(4):395-401

Department of Plastic, Reconstructive and Aesthetic Surgery, Necmettin Erbakan University Meram Faculty of Medicine, Konya-Turkey.

Background: The present study aims to investigate the favorable effects of melatonin on burn wound healing in rats.

Methods: In this study, forty Wistar-albino-type male rats were divided into four groups. Group 1 was the control group, Group 2 rats were treated using exogenous melatonin, Group 3 rats were pinealectomized, and Group 4 rats were pinealectomized then treated with exogenous melatonin. Read More

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The Role of Melatonin on NLRP3 Inflammasome Activation in Diseases.

Antioxidants (Basel) 2021 Jun 24;10(7). Epub 2021 Jun 24.

Izmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, 35340 Izmir, Turkey.

NLRP3 inflammasome is a part of the innate immune system and responsible for the rapid identification and eradication of pathogenic microbes, metabolic stress products, reactive oxygen species, and other exogenous agents. NLRP3 inflammasome is overactivated in several neurodegenerative, cardiac, pulmonary, and metabolic diseases. Therefore, suppression of inflammasome activation is of utmost clinical importance. Read More

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Pre- and Post-harvest Melatonin Application Boosted Phenolic Compounds Accumulation and Altered Respiratory Characters in Sweet Cherry Fruit.

Front Nutr 2021 9;8:695061. Epub 2021 Jun 9.

Laboratory of Pomology, Department of Horticulture, School of Agriculture, Aristotle University of Thessaloniki, Thessaloniki, Greece.

The aim of the present study was to investigate the impact of exogenous melatonin (0. 5 mM) application through pre-harvest foliar spray and postharvest immersion, alone or in combination, on ripening parameters of sweet cherry (cv. Ferrovia) fruit and their relationship with bioactive compounds and gene expression at harvest as well after cold storage (0°C) for 12 days and subsequent room temperature (20°C) exposure for 8 h. Read More

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International Expert Opinions and Recommendations on the Use of Melatonin in the Treatment of Insomnia and Circadian Sleep Disturbances in Adult Neuropsychiatric Disorders.

Front Psychiatry 2021 10;12:688890. Epub 2021 Jun 10.

Département de psychiatrie et d'addictologie, AP-HP, GHU Paris Nord, DMU Neurosciences, Hopital Bichat - Claude Bernard, Paris, France.

Insomnia and circadian rhythm disorders, such as the delayed sleep phase syndrome, are frequent in psychiatric disorders and their evaluation and management in early stages should be a priority. The aim of this paper was to express recommendations on the use of exogenous melatonin, which exhibits both chronobiotic and sleep-promoting actions, for the treatment of these sleep disturbances in psychiatric disorders. To this aim, we conducted a systematic review according to PRISMA on the use of melatonin for the treatment of insomnia and circadian sleep disorders in neuropsychiatry. Read More

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Endogenous melatonin levels and therapeutic use of exogenous melatonin in tension type headache: A systematic review.

Rev Neurol (Paris) 2021 Jun 21. Epub 2021 Jun 21.

Department of Neurology, University Hospital of Larissa, School of Medicine, University of Thessaly, Biopolis, Mezourlo Hill, 41100 Larissa, Greece.

Background-purpose: A bidirectional relationship appears to connect tension-type headache (TTH) and circadian dysregulation. The present systematic review examined the published evidence for melatonin (MT) supplementation in the prophylaxis of TTH. Initially, we reviewed case-control studies investigating nocturnal MT or 6-sulphatoxymelatonin (aMT6s, a urine-discarded metabolite) in TTH individuals and healthy controls (HC). Read More

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[Pathogenetically oriented approach to prevention of retinopathy of prematurity (experimental study)].

Vestn Oftalmol 2021 ;137(3):26-31

Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russia.

Intraperitoneal injections of exogenous melatonin during the development of the retinal vascular system in experimental rats has been shown in a number of experimental studies on the model of EROP to prevent the appearance of histological signs of the development of experimental retinopathy of prematurity (EROP), stabilize the blood-retinal barrier and have a pronounced antioxidant effect, but pathogenetic basis for these phenomena hasn't been studied.

Purpose: To study the influence mechanism of melatonin and its analogues on the development of EROP at the preclinical stage of the pathological process to substantiate new approaches to prevention of ROP.

Material And Methods: The study included 42 Wistar rat pups (84 eyes) divided into 6 groups: control group, experimental group (rat pups with EROP), experimental groups who underwent injections of melatonin and its analogues K-148, AL-3, K-096. Read More

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The potential role of melatonin in retarding intervertebral disc ageing and degeneration: A systematic review.

Ageing Res Rev 2021 Jun 15;70:101394. Epub 2021 Jun 15.

Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:

Intervertebral disc degeneration (IDD) is a common degenerative disease of the musculoskeletal system that develops with age. It is regarded as the main cause of chronic low back pain in the elderly. IDD has various causes, including ageing, mechanical overloading, and nutritional deficiency. Read More

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Adjuvant use of melatonin for relieving symptoms of painful diabetic neuropathy: results of a randomized, double-blinded, controlled trial.

Eur J Clin Pharmacol 2021 Jun 13. Epub 2021 Jun 13.

Department of Clinical Pharmacy, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.

Purpose: The trial aimed to investigate the effectiveness of exogenous melatonin as an adjuvant to pregabalin for relief of pain in patients suffering from painful diabetic neuropathy (PDN).

Patients And Methods: This randomized, double-blind, placebo-controlled trial was carried out between October 2019 and December 2020 in an outpatient specialty clinic in Iran. One-hundred-three type 2 diabetic patients suffering from PDN were randomized into either the melatonin group (n = 52) or the placebo group (n = 51). Read More

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Melatonin influences the early growth stage in Zoysia japonica Steud. by regulating plant oxidation and genes of hormones.

Sci Rep 2021 Jun 11;11(1):12381. Epub 2021 Jun 11.

College of Grassland Science, Beijing Forestry University, Beijing, 100083, China.

Zoysia japonica is a commonly used turfgrass species around the world. Seed germination is a crucial stage in the plant life cycle and is particularly important for turf establishment and management. Experiments have confirmed that melatonin can be a potential regulator signal in seeds. Read More

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Possible benefits of exogenous melatonin for individuals on dialysis: a narrative review on potential mechanisms and clinical implications.

Naunyn Schmiedebergs Arch Pharmacol 2021 Aug 7;394(8):1599-1611. Epub 2021 Jun 7.

Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Prevention of oxidative stress and inflammation in chronic kidney disease patients (CKD) on dialysis may reduce dialysis-associated complications. Administration of powerful antioxidants may improve the consequences of peritoneal dialysis (PD) and hemodialysis (HD). This narrative review aimed to show the potential therapeutic effects of melatonin (MLT) on the consequences of CKD patients receiving HD or PD. Read More

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Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway.

J Nanobiotechnology 2021 Jun 6;19(1):170. Epub 2021 Jun 6.

Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, No. 188 Shizi Street, Suzhou, 215006, Jiangsu, China.

Background: Inflammatory osteolysis after total joint replacement (TJR) may cause implant failure, periprosthetic fractures, and be a severe threat to global public health. Our previous studies demonstrated that melatonin had a therapeutic effect on wear-particles induced osteolysis. Gut microbiota is closely related to bone homeostasis, and has been proven to be affected by melatonin. Read More

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Exogenous melatonin decreases circadian misalignment and body weight among early types.

J Pineal Res 2021 Jun 6:e12750. Epub 2021 Jun 6.

Department of Health, Life Cycles and Society, School of Public Health, University of São Paulo, São Paulo, Brazil.

Shift workers experience chronic circadian misalignment, which can manifest itself in reduced melatonin production, and has been associated with metabolic disorders. In addition, chronotype modulates the effect of night shift work, with early types presenting greater circadian misalignment when working night shift as compared to late types. Melatonin supplementation has shown positive results reducing weight gain in animal models, but the effect of exogenous melatonin in humans on body weight in the context of shift work remains inconsistent. Read More

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Clock-controlled arylalkylamine N-acetyltransferase (aaNAT) regulates circadian rhythms of locomotor activity in the American cockroach, Periplaneta americana, via melatonin/MT2-like receptor.

J Pineal Res 2021 Jun 6:e12751. Epub 2021 Jun 6.

Graduate School of Natural Science and Technology, Graduate School of Agricultural Science, Kobe University, Kobe, Japan.

Melatonin (MEL) orchestrates daily and seasonal rhythms (eg, locomotion, sleep/wake cycles, and migration among other rhythms) in diverse organisms. We investigated the effects of pharmacological doses (0.03-1 mM) of exogenous MEL intake in the cockroach, Periplaneta americana, on locomotor activity. Read More

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Fertility responses of melatonin-treated gilts before and during the follicular and early luteal phases when there are different temperatures and lighting conditions in the housing area.

Anim Reprod Sci 2021 Jul 15;230:106769. Epub 2021 May 15.

Department of Animal Science, University of Illinois, Urbana, IL, 61801, United States. Electronic address:

This study was conducted to determine whether exogenous melatonin affected gilt fertility when there were different housing temperature and lighting conditions. Prepubertal gilts (n = 72) were fed (MEL, 5 mg/day) or not fed (CON) melatonin while housed in rooms where temperatures (31.0 ± 1 °C) and daily lighting (240 lx) duration differed: 8 (8 H); 16 (16 H); or 24 (24 H) h in winter and summer replicates. Read More

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Exogenous melatonin reduces water deficit-induced oxidative stress and improves growth performance of Althaea rosea grown on coal mine spoils.

Environ Sci Pollut Res Int 2021 Jun 5. Epub 2021 Jun 5.

College of Economics and Management, Northwest A&F University, Yangling, 712100, Shaanxi, China.

Coal mining activities are responsible for significant land degradation and often long-term irreversible effects on ecosystem functioning. To better understand how coal mined sites could be re-vegetated and ecosystem functioning restored, we address the role of the signalling hormone melatonin, which controls plant growth and development under adverse environmental conditions. We assessed the effects of exogenous melatonin on the plant species Althaea rosea by measuring morphological growth attributes, photosynthetic efficiency, reactive oxygen species (ROS)-induced oxidative damage and antioxidant defence developed by the seedlings when grown on coal-mined spoils under various water regimes. Read More

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