5 results match your criteria exists pathobiont

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The microbial and host factors that govern Candida gastrointestinal colonization and dissemination.

Curr Opin Microbiol 2021 Jun 7;63:29-35. Epub 2021 Jun 7.

Department of Pediatrics, University of Texas, Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pediatrics, Division of Hematology/Oncology, University of Texas, Southwestern Medical Center, Dallas, TX, USA; Department of Microbiology, University of Texas, Southwestern Medical Center, Dallas, TX, USA; Harold C. Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

Candida species are among the most prevalent and abundant members of the gut mycobiota, with Candida albicans (CA) being the most prominent member. CA colonizes numerous mucosal surfaces, most notably the gastrointestinal (GI) and genitourinary tracts. In a healthy host, CA is a pathobiont that exists as a commensal but can become pathogenic if the host's immune system becomes suppressed. Read More

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Establishes Commensalism in Germ-Free Mice Through the Reversible Downregulation of Virulence Gene Expression.

Front Immunol 2021 3;12:666088. Epub 2021 May 3.

Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, South Korea.

The intestine harbors a complex community of bacterial species collectively known as commensal microbiota. Specific species of resident bacteria, as known as pathobiont, have pathogenic potential and can induce apparent damage to the host and intestinal inflammation in a certain condition. However, the host immune factors that permit its commensalism under steady state conditions are not clearly understood. Read More

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Effects of nasopharyngeal microbiota in respiratory infections and allergies.

Clin Exp Pediatr 2021 Apr 15. Epub 2021 Apr 15.

Division of Pediatric Infectious Diseases, Departments of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.

The human microbiome, which consists of a collective cluster of commensal, symbiotic, and pathogenic microorganisms living in the human body, plays a key role in host health and immunity. The human nasal cavity harbors commensal bacteria that suppress the colonization of opportunistic pathogens. However, dysbiosis of the nasal microbial community is associated with many diseases, such as acute respiratory infections including otitis media, sinusitis and bronchitis and allergic respiratory diseases including asthma. Read More

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High carriage of adherent invasive in wildlife and healthy individuals.

Gut Pathog 2018 14;10:23. Epub 2018 Jun 14.

Lille Inflammation Research International Center, UMR 995 Inserm, Lille University, CHRU Lille, Lille, France.

Background: Adherent invasive (AIEC) are suspected to be involved in the pathogenesis of inflammatory bowel diseases. Since AIEC was first described in 1999, despite important progress on its genomic and immune characterizations, some crucial questions remain unanswered, such as whether there exists a natural reservoir, or whether there is asymptomatic carriage. The ECOR collection, including strains isolated mainly from the gut of healthy humans and animals, constitutes an ideal tool to investigate AIEC prevalence in healthy condition. Read More

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Adherent-invasive Escherichia coli (AIEC) in pediatric Crohn's disease patients: phenotypic and genetic pathogenic features.

BMC Res Notes 2014 Oct 22;7:748. Epub 2014 Oct 22.

Department of Public Health and Infectious Diseases, 'Sapienza' University of Rome, Rome, Italy.

Background: Adherent-invasive Escherichia coli (AIEC) have been implicated in the ethiopathogenesis of Crohn's disease (CD). In this study, we analyzed a collection of intestinal mucosa-associated E. coli isolates, presenting AIEC phenotypes, isolated from biopsies of CD pediatric patients and non-inflammatory bowel diseases (IBD) controls, in order to investigate their genetic and phenotypic pathogenic features. Read More

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October 2014
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