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Indoleamine-2,3-Dioxygenase Activates Wnt/β-Catenin Inducing Kidney Fibrosis after Acute Kidney Injury.

Gerontology 2021 Jun 15:1-9. Epub 2021 Jun 15.

Department of Nephrology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.

Introduction: As disorder of tryptophan metabolism is common in CKD, the rate-limiting enzyme of tryptophan, indoleamine-2,3-dioxygenase (IDO), has been reported to be involved in CKD, while the accurate mechanism remains unknown. This study was designed to explore correlations between IDO and kidney fibrosis after ischemia-reperfusion injury (IRI).

Methods: Wild-type (WT) mice and IDO knockout (IDO-/-) mice were divided into the sham group and acute kidney injury (AKI) group. Read More

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A bionic soft tongue driven by shape memory alloy and pneumatics.

Bioinspir Biomim 2021 Jun 15. Epub 2021 Jun 15.

Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, No.96, JinZhai Road Baohe District, Hefei, 230026, CHINA.

Soft grippers have exhibited considerable advantages owing to their flexible deformation, compliant operation, and safe interaction with the objects. The ability to grip solid and liquid objects can greatly expand the application range of the soft grippers. Dogs stick out their tongues and then curl backward to form a ladle shape for eating food and drinking water. Read More

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Two-photon calcium imaging of neuronal and astrocytic responses: the influence of electrical stimulus parameters and calcium signaling mechanisms.

J Neural Eng 2021 Jun 15. Epub 2021 Jun 15.

School of Biomedical Engineering, Tianjin Medical University, Heping District, Tianjin, 300070, CHINA.

Objective: Electrical brain stimulation has been used to ameliorate symptoms associated with neurologic and psychiatric disorders. The astrocytic activation and its interaction with neurons may contribute to the therapeutic effects of electrical stimulation. However, how the astrocytic activity is affected by electrical stimulation and its calcium signaling mechanisms remain largely unknown. Read More

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Hierarchical CoFe LDH/MOF nanorods array with strong coupling effect grown on carbon cloth enables efficient oxidation of water and urea.

Nanotechnology 2021 Jun 15. Epub 2021 Jun 15.

School of Environmental and Chemical Engineering, Shanghai University, Shangda Road 99, Shanghai, 200444, CHINA.

The construction of bifunctional non-noble electrocatalyst for oxygen evolution reaction (OER) and urea oxidation reaction (UOR) is urgent for overall water and urea splitting. Herein, a facile one-step chemical etching- reconstruction strategy is presented for fabricating one-dimensional hierarchical nanorods array composed of CoFe layered double hydroxide (LDH)/MOF supported on carbon cloth as OER and UOR catalysts. By precisely controlling the etching rate, the ligands from Co-MOFs are partially removed, and corresponding metal centers coordinates with hydroxyl ions to generate ultrathin amorphous CoFe LDH nanosheets. Read More

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Photodiode Behaviors of the AgSbSNanocrystals in a Schottky structure.

Nanotechnology 2021 Jun 15. Epub 2021 Jun 15.

Selcuk Universitesi, Department of Biotechnology, Konya, 42130, TURKEY.

Cubic phase AgSbSnanocrystals (NCs) were synthesized by hot-injection method, and they were inserted between the Al and-Si to fabricate Al/AgSbS/-Si photodiode by the thermal evaporation method. AgSbSnanocrystals were characterized by XRD, SEM and TEM instruments to confirm the crystal phase, surface morphology as well as crystalline size. The XRD pattern revealed the cubic crystalline structure of the AgSbS. Read More

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Evaluation of lorcaserin as an anticonvulsant in juvenile Fmr1 knockout mice.

Epilepsy Res 2021 May 27;175:106677. Epub 2021 May 27.

Mercer University, College of Pharmacy, Department of Pharmaceutical Sciences, 3001 Mercer University Drive, Atlanta, GA, 30341, USA. Electronic address:

Recent preclinical and clinical studies suggest that lorcaserin, a preferential serotonin 2C receptor (5-HTR) agonist that was approved for the treatment of obesity, possesses antiepileptic properties. Here, we tested whether lorcaserin (1, 3, 5.6, 10 mg/kg) is prophylactic against audiogenic seizures (AGSs) in juvenile Fmr1 knockout mice, a mouse model of fragile X syndrome (FXS). Read More

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Biological effects induced by doses of mammographic screening.

Phys Med 2021 Jun 12;87:90-98. Epub 2021 Jun 12.

Department of Radiological Sciences (LCR), State University of Rio de Janeiro (UERJ), Pavilhão Haroldo Lisboa da Cunha, Rua São Francisco Xavier, 524, Maracanã, Rio de Janeiro, RJ CEP 20550-900, Brazil.

Purpose: Mammography is the diagnostic imaging practice used in screening to detect early lesions suspected of malignancy. It uses a low energy X-ray beam in which a low dose in the order of 2-3 mGy is delivered to patient breast cells. However, it has been speculated that it could lead to significant cell damage, when compared to conventional X-ray. Read More

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Synthesis and evaluation of trypanocidal activity of derivatives of naturally occurring 2,5-diphenyloxazoles.

Bioorg Med Chem 2021 Jun 12;42:116253. Epub 2021 Jun 12.

Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.

African trypanosomiasis is a zoonotic protozoan disease affecting the nervous system. Various natural products reportedly exhibit trypanocidal activity. Naturally occurring 2,5-diphenyloxazoles present in Oxytropis lanata, and their derivatives, were synthesized. Read More

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Identification of natural compounds extracted from crude drugs as novel inhibitors of hepatitis C virus.

Biochem Biophys Res Commun 2021 Jun 11;567:1-8. Epub 2021 Jun 11.

Department of Virology II, National Institute of Infectious Diseases, 162-8640, Tokyo, Japan. Electronic address:

Natural product-derived crude drugs are expected to yield an abundance of new drugs to treat infectious diseases. Hepatitis C virus (HCV) is an oncogenic virus that significantly impacts public health. In this study, we sought to identify anti-HCV compounds in extracts of natural products. Read More

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Microplastic degradation methods and corresponding degradation mechanism: Research status and future perspectives.

J Hazard Mater 2021 Jun 10;418:126377. Epub 2021 Jun 10.

Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural University, Guangzhou 510642, China; Institute of Eco-Environmental Research, Guangxi Academy of Sciences, Nanning 530007, China. Electronic address:

Microplastics (MPs) pollution has become a global environmental concern because of their severe threat to biota. However, limited studies on the elimination of MPs pollution were reported. The conventional treatment methods were not suitable for MPs owing to their smaller size than plastic items. Read More

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Efficient heavy metal removal from water by alginate-based porous nanocomposite hydrogels: The enhanced removal mechanism and influencing factor insight.

J Hazard Mater 2021 Jun 8;418:126358. Epub 2021 Jun 8.

School of Hydraulic Engineering, Changsha University of Science & Technology, Changsha 410114, China; Key Laboratory of Dongting Lake Aquatic Eco-Environmental Control and Restoration of Hunan Province, Changsha 410114, China. Electronic address:

Novel porous alginate-based nanocomposite hydrogels were prepared by incorporating polyaniline-polypyrrole modified graphene oxide ([email protected]) as reinforcing fillers into the alginate matrix ([email protected]/SA) for Cr(VI) and Cu(II) removal from water. Different in-situ co-polymerization functionalized GO with Py-to-An mass ratios of monomers (from nil to 1:1) and contents of [email protected] (from nil to 2.0%(w/v)) were embedded into the alginate backbone to improve the sorption performance. Read More

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Combined toxicity of nano-TiO and Cd to Scenedesmus obliquus: Effects at different concentration ratios.

J Hazard Mater 2021 Jun 9;418:126354. Epub 2021 Jun 9.

Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.

The continuous release of manufactured nanomaterials (MNMs) to environments raised concerns on their combined toxicological risks with co-existing contaminants, since MNMs might severely alter the environmental behavior and fate of the contaminants. In this study, the combined toxicity of nano-sized titanium dioxide (nTiO) and cadmium (Cd) to the green alga Scenedesmus obliquus and the underlying physicochemical mechanisms were investigated for the first time at different concentration ratios of Cd to nTiO to closely mimic the realistic environment scenarios where the concentration ratios of nTiO to other contaminants are constantly changing. Our results suggested that under the co-exposure to different concentration ratios of Cd to nTiO, the co-exposure contaminants exhibited three different combined toxicity modes (antagonistic, partially additive, and synergistic). Read More

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Effect of hyperspectral image-based initial conditions on improving short-term algal simulation of hydrodynamic and water quality models.

J Environ Manage 2021 Jun 12;294:112988. Epub 2021 Jun 12.

School of Civil and Environmental Engineering, Konkuk University, Seoul 05029, Republic of Korea. Electronic address:

Hydrodynamic and water quality modeling have provided valuable simulation results that have enhanced the understanding of the spatial and temporal distribution of algal blooms. Typical model simulations are performed with point-based observational data that are used to configure initial and boundary conditions, and for parameter calibration. However, the application of such conventional modeling approaches is limited due to cost, labor, and time constraints that preclude the retrieval of high-resolution spatial data. Read More

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Peroxiredomin-4 ameliorates lipotoxicity-induced oxidative stress and apoptosis in diabetic cardiomyopathy.

Biomed Pharmacother 2021 Jun 12;141:111780. Epub 2021 Jun 12.

Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China. Electronic address:

Diabetic cardiomyopathy (DCM), one severe complication in the diabetes, leads to high mortality in the diabetic patients. However, the understanding of molecular mechanisms underlying DCM is far from completion. Herein, we investigated the disease-related differences in the proteomes of DCM based on db/db mice and verified the protective roles of peroxiredoxin-4 (Prdx4) in H9c2 cardiomyocytes treated by palmitic acid (PA). Read More

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Synthesis and pharmacological evaluation of pomalidomide derivatives useful for sickle cell disease treatment.

Bioorg Chem 2021 Jun 10;114:105077. Epub 2021 Jun 10.

São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara 14800-903, Brazil. Electronic address:

Fetal hemoglobin (HbF) induction constitutes a valuable and validated approach to treat the symptoms of sickle cell disease (SCD). Here, we synthesized pomalidomide-nitric oxide (NO) donor derivatives (3a-f) and evaluated their suitability as novel HbF inducers. All compounds demonstrated different capacities of releasing NO, ranging 0. Read More

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Glioblastoma-specific anticancer activity of newly synthetized 3,5-disubstituted isoxazole and 1,4-disubstituted triazole-linked tyrosol conjugates.

Bioorg Chem 2021 Jun 8;114:105071. Epub 2021 Jun 8.

University of Monastir, Faculty of Science of Monastir, Laboratory of Heterocyclic, Chemistry, Natural Products and Reactivity, TeamMedicinal Chemistry and Natural, Products (LR11ES39), Department of Chemistry, Avenue of Environment, 5019 Monastir, Tunisia. Electronic address:

Two series of 3,5-disubstituted isoxazoles (6a-e) and 1,4-disubstituted triazoles (8a-e) derivatives have been synthesized from tyrosol (1), a natural phenolic compound, detected in several natural sources such as olive oil, and well-known by its wide spectrum of biological activities. Copper-catalyzed microwave-assisted 1,3-dipolar cycloaddition reactions between tyrosol-alkyne derivative 2 and two series of aryl nitrile oxides (5a-e) and azides (7a-e) regiospecifically afforded 3,5-disubstituted isoxazoles (6a-e) and 1,4-triazole derivatives (8a-e), respectively in quantitative yields. Synthesized compounds were purified and characterized by spectroscopic means including 1D and 2D NMR techniques and HRMS analysis. Read More

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The crucial role of heavy metals on the interaction of engineered nanoparticles with polystyrene microplastics.

Water Res 2021 Jun 1;201:117317. Epub 2021 Jun 1.

Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, HKSAR, P.R.China; HKBU Institute of Research and Continuing Education, Shenzhen Virtual University Park, Shenzhen, P.R.China. Electronic address:

Despite continuous research on microplastics (MPs), studies exploring the complexity of interaction between MPs and other aqueous constituents in multi-solute systems are scarce. In this study, the uptake and release of nanoceria (CeNPs) by various polystyrene MPs (PSMPs) were investigated. Results showed that PSMPs in the presence of heavy metals (HMs) exhibited a substantially higher sorption affinity for isotropic charged CeNPs than PSMPs alone; this enhanced affinity was attributed to the formation of PSMP-HM-CeNP complexes. Read More

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Groundwater bacterial communities evolve over time in response to recharge.

Water Res 2021 May 26;201:117290. Epub 2021 May 26.

Aquatic Geomicrobiology, Institute of Biodiversity, Friedrich Schiller University Jena, Germany; German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, Germany. Electronic address:

Time series analyses are a crucial tool for uncovering the patterns and processes shaping microbial communities and their functions, especially in aquatic ecosystems. Subsurface aquatic environments are perceived to be more stable than surface oceans and lakes, due to the lack of sunlight, the absence of photosysnthetically-driven primary production, low temperature variations, and oligotrophic conditions. However, periodic groundwater recharge should affect the structure and succession of groundwater microbiomes. Read More

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Microbial degradation of azo dyes by textile effluent adapted, Enterobacter hormaechei under microaerophilic condition.

Microbiol Res 2021 Jun 9;250:126805. Epub 2021 Jun 9.

Geobiotechnology Laboratory, National College (Autonomous), (Affiliated to Bharathidasan University), Tiruchirapalli, Tamil Nadu, 620001, India; PG and Research Department of Botany, National College (Autonomous), Tiruchirapalli, Tamil Nadu, 620001, India.

Landmark and sustainable eco-friendly dye treatment processes are highly desirous to ameliorate their effect on the environment. The present study investigated the azo dye degradation efficiency of adapted Enterobacter hormaechei SKB 16 from textile effluent polluted soil in optimized culture conditions. The adapted bacteria strain was identified by standard microbiological and molecular techniques. Read More

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Clinicopathological characteristics of androgen receptor splicing variant 7 (AR-V7) expression in patients with castration resistant prostate cancer: A systematic review and meta-analysis.

Transl Oncol 2021 Jun 12;14(9):101145. Epub 2021 Jun 12.

Cancer center, Zhejiang University, Hangzhou, Zhejiang Province 310058, China. Electronic address:

Background:  Studies have shown that AR-V7 may be correlated with the poor prognosis of castration resistant prostate cancer (CRPC), however, clinicopathological characteristics of AR-V7 have not been fully elucidated.

Objective: This study aimed at evaluating the clinicopathological features of AR-V7 in CRPC patients.

Materials And Methods: To evaluate the clinicopathological features of AR-V7 in CRPC patients. Read More

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Socially unstable conditions experienced during development prime female Octodon degus to shape the phenotype of their own offspring.

Horm Behav 2021 Jun 12;134:105011. Epub 2021 Jun 12.

Department of Biology, Geology, and Environmental Sciences, University of Tennessee at Chattanooga, Chattanooga, TN 37403, USA.

Because residents and immigrants from group living species may experience fitness costs associated with permanent changes in group membership, we examined the hypothesis that females experiencing socially unstable or socially stable conditions during development compensate these costs by shaping the phenotype of their own offspring differently. Groups of adult females experiencing either socially stable or unstable conditions in the early social environment were assigned to either socially stable or unstable conditions in the social environment as adults. We quantified affiliative and agonistic interactions among the females during pregnancy and lactation of the focal female, maternal and allomaternal care, hypothalamic-anterior pituitary-adrenal axis (HPA) acute stress response, and early offspring growth. Read More

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Human spatial navigation: Neural representations of spatial scales and reference frames obtained from an ALE meta-analysis.

Neuroimage 2021 Jun 12:118264. Epub 2021 Jun 12.

Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education; School of Psychology, Center for Studies of Psychological Application, and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, Guangdong, 510631, China. Electronic address:

Humans use different spatial reference frames (allocentric or egocentric) to navigate successfully toward their destination in different spatial scale spaces (environmental or vista). However, it remains unclear how the brain represents different spatial scales and different spatial reference frames. Thus, we conducted an activation likelihood estimation (ALE) meta-analysis of 47 fMRI articles involving human spatial navigation. Read More

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Seneca Valley virus induces immunodepressionin suckling piglets by selective apoptosis of B lymphocytes.

Microb Pathog 2021 Jun 12:105022. Epub 2021 Jun 12.

Comparative Pathology Shared Resources Laboratory, Masonic Cancer Center, University of Minnesota, Saint Paul, MN, USA. Electronic address:

Seneca Valley virus (SVV) is the causative agent of an emerging infectious vesicular disease in swine that is clinically indistinguishable from other vesicular diseases of swine. This study utilized healthy suckling piglets (control) and SVV-naturally infected suckling piglets to determine the effects of SVV on lymphoid tissues and determined the SVV RNA load by quantitative RT-PCR (qRT-PCR). Furthermore, immunohistochemistry (IHC) analyses were performed to quantify the expression of T and B cell lymphocytes, natural killer cells, cleaved caspase 3, and ki-67. Read More

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Impact of protocatechuic acid on high fat diet-induced metabolic syndrome sequelae in rats.

Eur J Pharmacol 2021 Jun 12:174257. Epub 2021 Jun 12.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.

The study aimed to assess the possible protective impact of protocatechuic acid (PCA) on high fat diet (HFD)-induced metabolic syndrome (Mets) sequelae in rats. Forty-two male Sprague-Dawley (SD) rats were randomly grouped as follows: CTR group; PCA group; HFD group; HFD-PCA group and HFD-MET group. Rats were fed on standard diet or HFD for 14 weeks. Read More

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Possible involvement of agmatine in neuropharmacological actions of metformin in diabetic mice.

Eur J Pharmacol 2021 Jun 12:174255. Epub 2021 Jun 12.

Division of Neuroscience, Department of Pharmacology, Shrimati Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur, M.S, India, 441 002. Electronic address:

The risk of psychiatric and neurological disorders is significantly higher in patients with diabetes mellitus. Diabetic patients are more susceptible to depression, anxiety and memory impairment as compared with non-diabetic individuals. Metformin, a biguanide used for the management of type 2 diabetes mellitus (T2DM), promotes neurogenesis, enhances spatial memory function and protects the brain against oxidative imbalance beyond its effect on glucose metabolism. Read More

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Kaempferol inhibits benign prostatic hyperplasia by resisting the action of androgen.

Eur J Pharmacol 2021 Jun 12:174251. Epub 2021 Jun 12.

Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Poyang Lake Road 10, Tianjin 301617, China; Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Poyang Lake Road 10, Tianjin 301617, China; Laboratory of Pharmacology of TCM Formulae Co-Constructed By the Province-Ministry, Tianjin University of TCM, Poyang Lake Road 10, Tianjin 301617, China. Electronic address:

Kaempferol is a natural compound that inhibits tumor development in androgenic related prostate cancer. However, it is still not clear about its phyto-androgenic activity and whether it suppresses testosterone-induced benign prostatic hyperplasia (BPH) development. In this study, molecular docking, cellular immunofluorescence staining, chromatin immunoprecipitation and dual luciferase reporter assay were performed to investigate the androgenic activity of kaempferol. Read More

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Highly efficient uranium (VI) capture from aqueous solution by means of a hydroxyapatite-biochar nanocomposite: Adsorption behavior and mechanism.

Environ Res 2021 Jun 12:111518. Epub 2021 Jun 12.

Guangdong Provincial Key Laboratory for Radionuclides Pollution Control and Resources, School of Environmental Science and Engineering, Guangzhou University, Guangzhou, 510006, China; School of Civil Engineering, Guangzhou University, Guangzhou, 510006, PR China. Electronic address:

The exploration and rational design of easily separable and highly efficient sorbents with the sufficient capability of retaining radioactive and toxic uranium U(VI) is paramount. In this study, a hydroxyapatite (HAP) biochar nanocomposite (BR/HAP) was successfully fabricated from rice straw biochar (BR), to be used as a new and efficient adsorbent for removing U(VI) from aqueous solution. Both BR and the BR/HAP composite were characterized via Brunauer-Emmett-Teller (BET), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and X-ray photo electron spectroscopy (XPS) techniques. Read More

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Discontinued alcohol consumption elicits withdrawal symptoms in honeybees.

Biol Lett 2021 Jun 16;17(6):20210182. Epub 2021 Jun 16.

Institute of Systematics and Evolution of Animals, Polish Academy of Sciences, Sławkowska 17, 31-016 Kraków, Poland.

The honeybee continues to be developed as a model species in many research areas, including studies related to the effects of alcohol. Here, we investigate whether workers display one of the key features of alcoholism, namely withdrawal symptoms. We show that workers fed for a prolonged time on food spiked with ethanol, after discontinuation of access to such food, exhibited a marked increase in the consumption of ethanol and a slight increase in mortality. Read More

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Resveratrol reduces drug resistance of SCLC cells by suppressing the inflammatory microenvironment and the STAT3/VEGF pathway.

FEBS Open Bio 2021 Jun 15. Epub 2021 Jun 15.

Department of Thoracic Surgery, Laizhou People's Hospital, Wuli Street, Laizhou City, Shandong, China, 261400.

DNA-damaging agents, such as adriamycin, are widely used for the treatment of small cell lung cancer (SCLC). However, drug resistance is one of the major challenges for treatment of SCLC. Herein, we investigated the mechanisms underlying drug resistance in SCLC cells and the effects of resveratrol (Res) on drug resistance. Read More

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Long-term effectiveness of 6 mm micro-rough implants in various indications: A 4.5 to 18.2-year retrospective study.

Clin Oral Implants Res 2021 Jun 15. Epub 2021 Jun 15.

Department of Oral Surgery & Stomatology, School of Dental Medicine, University of Bern, Switzerland.

Objectives: To evaluate the long-term effectiveness of 6 mm implants in various indications with a micro-rough surface after 4.6-18.2 years in function and to assess key factors associated with implant survival, success and biological/technical complications. Read More

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