123,691 results match your criteria exhibited increased


Differences in kinetic metabolomics in Eisenia fetida under single and dual exposure of imidacloprid and dinotefuran at environmentally relevant concentrations.

J Hazard Mater 2021 May 8;417:126001. Epub 2021 May 8.

Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China. Electronic address:

Metabolomic responses of earthworms to neonicotinoids are important for understanding their molecular-level toxicity and assessing their ecological risks, but little is known until now. We investigated impact of imidacloprid (IMI, 52.6 ng/g) and dinotefuran (DIN, 52. Read More

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Nitrogen cascade in the agriculture-food-environment system of the Yangtze Delta, 1998-2018.

Sci Total Environ 2021 May 7;787:147442. Epub 2021 May 7.

Center for Material Cycles and Waste Management Research, National Institute for Environmental Studies, Tsukuba 305-8506, Japan.

The nitrogen (N) cascade in rural areas of Changshu County should be measured and evaluated due to the large increase in anthropogenic disturbances in China's Yangtze Delta. Here, we developed a village-scale N flow model using Changshu County and its towns as a case study. The model included four subsystems and was used to describe the driving forces behind the N cascade from agricultural food production and household consumption to the environment (agriculture-food-environment) system. Read More

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Sleep architectural dysfunction and undiagnosed obstructive sleep apnea after chronic ischemic stroke.

Sleep Med 2021 Apr 15;83:45-53. Epub 2021 Apr 15.

The Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia; University of Melbourne, Melbourne, VIC, Australia.

Objective/background: Sleep-wake dysfunction is bidirectionally associated with the incidence and evolution of acute stroke. It remains unclear whether sleep disturbances are transient post-stroke or are potentially enduring sequelae in chronic stroke. Here, we characterize sleep architectural dysfunction, sleep-respiratory parameters, and hemispheric sleep in ischemic stroke patients in the chronic recovery phase compared to healthy controls. Read More

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Calcium modified basalt fiber bio-carrier for wastewater treatment: Investigation on bacterial community and nitrogen removal enhancement of bio-nest.

Bioresour Technol 2021 May 7;335:125259. Epub 2021 May 7.

School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, China; Institute of Environmental Health and Ecological Security, Jiangsu University, Zhenjiang, Jiangsu 212013, China. Electronic address:

Modified basalt fiber (MBF) is a sustainable material studied as novel wastewater treatment bio-carrier recently. This work studied the effects of calcium modification on the bacterial affinity of modified fiber (Ca-MBF), bacterial community, and nitrogen removal performance. Results showed that Ca-MBF with hydrophilic (62. Read More

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Age, Gender, and Laterality of Retinal Vascular Occlusion: A Retrospective Study from the IRIS® Registry.

Ophthalmol Retina 2021 May 12. Epub 2021 May 12.

Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

Purpose: Retinal vascular occlusion is a leading cause of profound irreversible visual loss, but the understanding of the disease is insufficient. We systematically investigated the age, gender, and laterality at the onset of retinal artery occlusion (RAO) and retinal vein occlusion (RVO) in the IRIS® Registry (Intelligent Research in Sight).

Design: A retrospective registry cohort. Read More

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Total IgE variability is associated with future asthma exacerbations: a one-year prospective cohort study.

J Allergy Clin Immunol Pract 2021 May 12. Epub 2021 May 12.

Airway Physiology and Imaging Group and the Woolcock Emphysema Centre, The Woolcock Institute of Medical Research, Sydney, NSW, Australia; Discipline of Medical Sciences, School of Life Sciences, University of Technology Sydney, Sydney, NSW, Australia.

Background: Few prospective studies have investigated the relationship between IgE variability and risk of asthma exacerbations (AEs).

Objective: To explore the relationship between IgE variability and AEs.

Methods: Recruited patients with stable asthma underwent two serum total IgE tests within a month (at screening [baseline IgE] and one-month) to obtain coefficient of variation (CV) of base-10 log-transformed IgE. Read More

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Polyketides produced by the entomopathogenic fungus Metarhizium anisopliae induce Candida albicans growth.

Fungal Genet Biol 2021 May 12:103568. Epub 2021 May 12.

Centro de Biotecnologia, Programa de Pós-graduação em Biologia Celular e Molecular, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address:

Metarhizium anisopliae is an important entomopathogenic species and model for arthropod-fungus interaction studies. This fungus harbors a diverse arsenal of unexplored secondary metabolite biosynthetic gene clusters, which are suggested to perform diverse roles during host interaction and soil subsistence as a saprophytic species. Here we explored an unusual carnitine acyltransferase domain-containing highly reducing polyketide synthase found in the genome of M. Read More

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Emerging role of glutamate in the pathophysiology and therapeutics of Gulf War illness.

Life Sci 2021 May 12:119609. Epub 2021 May 12.

Department of Neuroscience, College of Medicine, The Ohio State University, Columbus, OH, USA. Electronic address:

Gulf War illness (GWI) is a chronic and multi-symptomatic disorder affecting veterans who served in the Gulf War. The commonly reported symptoms in GWI veterans include mood problems, cognitive impairment, muscle and joint pain, migraine/headache, chronic fatigue, gastrointestinal complaints, skin rashes, and respiratory problems. Neuroimaging studies have revealed significant brain structure alterations in GWI veterans, including subcortical atrophy, decreased volume of the hippocampus, reduced total grey and white matter, and increased brain white matter axial diffusivity. Read More

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TRPC1-mediated Ca signaling enhances intestinal epithelial restitution by increasing α4 association with PP2Ac after wounding.

Physiol Rep 2021 May;9(9):e14864

Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.

Gut epithelial restitution after superficial wounding is an important repair modality regulated by numerous factors including Ca signaling and cellular polyamines. Transient receptor potential canonical-1 (TRPC1) functions as a store-operated Ca channel in intestinal epithelial cells (IECs) and its activation increases epithelial restitution by inducing Ca influx after acute injury. α4 is a multiple functional protein and implicated in many aspects of cell functions by modulating protein phosphatase 2A (PP2A) stability and activity. Read More

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Growth of Flavobacterium columnare Genomovars in the Presence or Lack of Supplemental Cations.

Curr Microbiol 2021 May 15. Epub 2021 May 15.

National Center for Cool and Cold Water Aquaculture USDA/ARS, 11861 Leetown Rd., Kearneysville, WV, 25430, USA.

Flavobacterium columnare is a problematic pathogen for the aquaculture industry where isolates are classified by genomovars. Suspended growth in a low nutrient media, like tryptone yeast extract salts, is a common method used for laboratory study. The presence of calcium and magnesium is the factor contributing to growth, virulence, and biofilm formation for F. Read More

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Oxidative Stress and Postmortem Meat Quality in Crossbred Lambs.

J Anim Sci 2021 May 15. Epub 2021 May 15.

Department of Animal Science, University of Nebraska-Lincoln, Lincoln, United States.

The objective of this study was to evaluate effects of different levels of lipopolysaccharide (LPS)-mediated oxidative stress on fresh meat quality. Crossbred lambs (n = 29) were blocked by weight and fed a standard finishing ration for the duration of the study. Lambs were individually housed and treatment groups were administered one of three intravenous injections every 72 h across a three-injection (9-day) cycle: saline control (Control), 50 ng LPS/kg bodyweight (BW) (LPS50), or 100 ng LPS/kg BW (LPS100). Read More

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IFN-alpha receptor deficiency enhances host resistance to oral Salmonella enterica serovar Typhimurium infection during murine pregnancy.

Am J Reprod Immunol 2021 May 15:e13454. Epub 2021 May 15.

Division of Life Sciences, Human Health Therapeutics, National Research Council Canada, Ottawa, ON, Canada, K1A 0R6.

Problem: Maternal tolerance during pregnancy increases the risk of infection with certain intracellular pathogens. Systemic Salmonella enterica serovar Typhimurium (S.Tm) infection during pregnancy in normally-resistant 129X1/SvJ mice leads to severe placental infection, fetal and maternal death. Read More

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Serum exosomes accelerate diabetic wound healing by promoting angiogenesis and ECM formation.

Cell Biol Int 2021 May 14. Epub 2021 May 14.

Department of Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, School of Life Sciences and Biopharmaceuticals, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong Province, China.

Non-healing wounds in diabetes remain a global clinical and research challenge. Exosomes are primary mediators of cell paracrine action, which are shown to promote tissue repair and regeneration. In this study, we investigated the effects of serum derived exosomes (Serum-Exos) on diabetic wound healing and its possible mechanisms. Read More

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Effect of exogenous silicon and methyl jasmonate on the alleviation of cadmium-induced phytotoxicity in tomato plants.

Environ Sci Pollut Res Int 2021 May 15. Epub 2021 May 15.

School of Environmental Science and Engineering, Shaanxi University of Science & Technology, Xi'an, 710021, People's Republic of China.

In the present study, a hydroponic experiment was performed to evaluate the effect of exogenous silicon (Si) and methyl jasmonate (MeJA) on the mitigation of Cd toxicity in tomato seedlings. The results revealed that Cd-stressed plants exhibited growth inhibition, increased lipid peroxidation, and impaired photosynthetic pigment accumulation. However, Si and MeJA applied alone or in combination significantly ameliorated the above-mentioned adverse effects induced by Cd. Read More

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The inner membrane protein LapB is required for adaptation to cold stress in an LpxC-independent manner.

J Microbiol 2021 May 15. Epub 2021 May 15.

Department of Biological Sciences, Myongji University, Yongin, 17058, Republic of Korea.

The inner membrane protein lipopolysaccharide assembly protein B (LapB) is an adaptor protein that activates the proteolysis of LpxC by an essential inner membrane metalloprotease, FtsH, leading to a decrease in the level of lipopolysaccharide in the membrane. In this study, we revealed the mechanism by which the essential inner membrane protein YejM regulates LapB and analyzed the role of the transmembrane domain of LapB in Escherichia coli. The transmembrane domain of YejM genetically and physically interacted with LapB and inhibited its function, which led to the accumulation of LpxC. Read More

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Alternative regulatory mechanism for the maintenance of bone homeostasis via STAT5-mediated regulation of the differentiation of BMSCs into adipocytes.

Exp Mol Med 2021 May 14. Epub 2021 May 14.

Department of Pharmacology, Chonnam National University Medical School, Gwangju, 61469, Republic of Korea.

STAT5 is a transcription factor that is activated by various cytokines, hormones, and growth factors. Activated STAT5 is then translocated to the nucleus and regulates the transcription of target genes, affecting several biological processes. Several studies have investigated the role of STAT5 in adipogenesis, but unfortunately, its role in adipogenesis remains controversial. Read More

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Omega-3 fatty acid-rich fish oil supplementation prevents rosiglitazone-induced osteopenia in aging C57BL/6 mice and in vitro studies.

Sci Rep 2021 May 14;11(1):10364. Epub 2021 May 14.

Department of Biological and Environmental Sciences, Qatar University, Doha, Qatar.

Rosiglitazone is an effective insulin-sensitizer, however associated with bone loss mainly due to increased bone resorption and bone marrow adiposity. We investigated the effect of the co-administration of fish oil rich in omega-3 fatty acids (FAs) on rosiglitazone-induced bone loss in C57BL/6 mice and the mechanisms underlying potential preventive effect. Mice fed the iso-caloric diet supplemented with fish oil exhibited significantly higher levels of bone density in different regions compared to the other groups. Read More

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Foliar architecture and physio-biochemical plasticity determines survival of Typha domingensis pers. Ecotypes in nickel and salt affected soil.

Environ Pollut 2021 May 7;286:117316. Epub 2021 May 7.

Department of Botany, Government College University, Faisalabad, Pakistan. Electronic address:

Six ecotypes of Typha domingensis Pers. Jahlar (E), Sheikhupura (E), Sahianwala (E), Gatwala (E), Treemu (E) and Knotti (E) from different ecological regions were collected to evaluate the leaf anatomical and biochemical attributes under different levels of salinity and nickel stress viz; L (control), L (100 mM + 50 mg kg), L (200 mM + 100 mg kg) and L (300 mM + 150 mg kg). Presence of salt and Ni in rooting medium consistently affected growth, anatomical and physio-biochemical attributes in all Typha ecotypes. Read More

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Mesoporous cellulose-chitosan composite hydrogel fabricated via the co-dissolution-regeneration process as biosorbent of heavy metals.

Environ Pollut 2021 May 7;286:117324. Epub 2021 May 7.

Department of Biological Systems Engineering, University of Wisconsin-Madison, 460 Henry Mall, Madison, WI, 53706, USA. Electronic address:

Developing low-cost and high-performance biosorbent for water purification continues drawing more and more attention. In this study, cellulose-chitosan composite hydrogels were fabricated via a co-dissolution and regeneration process using a molten salt hydrate (a 60 wt% aqueous solution of LiBr) as a solvent. The addition of chitosan not only introduced functionality for metal adsorption but also increased the specific surface area and improved the mechanical strength of the composite hydrogel, compared to pure cellulose hydrogel. Read More

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Effects of Single-Dose Versus Hypofractionated Focused Radiation on Vertebral Body Structure and Biomechanical Integrity: Development of A Rabbit Radiation-Induced Vertebral Compression Fracture Model.

Int J Radiat Oncol Biol Phys 2021 May 11. Epub 2021 May 11.

Johns Hopkins University School of Medicine, Department of Neurosurgery, Baltimore, MD, USA. Electronic address:

Purpose: Vertebral compression fracture (VCF) is a common complication of spinal stereotactic body radiation therapy. Development of an in vivo model is crucial to fully understand how focal radiation treatment affects vertebral integrity and biology at various dose fractionation regimens. We present a clinically-relevant animal model to analyze the effects of localized, high-dose radiation on vertebral microstructure and mechanical integrity. Read More

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Quaternary ammonium silane-reinforced agar/polyacrylamide composites for packaging applications.

Int J Biol Macromol 2021 May 11. Epub 2021 May 11.

Department of Fiber System Engineering, Yeungnam University, South Korea. Electronic address:

Agar/polyacrylamide/quaternary ammonium silane-based (A/P/QAS-based) composite films were developed for food and biomedical packaging applications. The structural, optical, and surface morphological properties of the A/P and A/P/QAS composites were characterized by various characterization techniques in terms of thermogravimetric analysis, differential scanning calorimetry analyses, mechanical and rheological properties. Results showed that the 5% gravimetric loss (57. Read More

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The bone is the major source of high circulating intact fibroblast growth factor-23 in acute murine polymicrobial sepsis induced by cecum ligation puncture.

PLoS One 2021 14;16(5):e0251317. Epub 2021 May 14.

Department of Biomedical Sciences, University of Veterinary Medicine Vienna, Vienna, Austria.

Fibroblast growth factor-23 (FGF23), a bone-produced hormone, plays a critical role in mineral homeostasis. Human diseases associated with excessive intact circulating FGF23 (iFGF23) result in hypophosphatemia and low vitamin D hormone in patients with normal kidney function. In addition, there is accumulating evidence linking FGF23 with inflammation. Read More

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Characterization of performance and disinfection resilience of nonwoven filter materials for use in 3D-printed N95 respirators.

J Occup Environ Hyg 2021 May 14:1-12. Epub 2021 May 14.

Department of Internal Medicine, Iowa City Veterans Administration Healthcare and the University of Iowa, Iowa City, IA.

The COVID-19 pandemic has caused a high demand for respiratory protection among health care workers in hospitals, especially surgical N95 filtering facepiece respirators (FFRs). To aid in alleviating that demand, a survey of commercially available filter media was conducted to determine whether any could serve as a substitute for an N95 FFR while held in a 3D-printed mask (Stopgap Surgical Face Mask from the NIH 3D Print Exchange). Fourteen filter media types and eight combinations were evaluated for filtration efficiency, breathing resistance (pressure drop), and liquid penetration. Read More

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Cotton Textile/Iron Oxide Nanozyme Composites with Peroxidase-like Activity: Preparation, Characterization, and Application.

ACS Appl Mater Interfaces 2021 May 14. Epub 2021 May 14.

Department of Nanobiotechnology, Biology Centre, ISB, CAS, Na Sadkach 7, 370 05 Ceske Budejovice, Czech Republic.

At present, both native and immobilized nanoparticles are of great importance in many areas of science and technology. In this paper, we have studied magnetic iron oxide nanoparticles and their aggregates bound on woven cotton textiles employing two simple modification procedures. One modification was based on the treatment of textiles with perchloric-acid-stabilized magnetic fluid diluted with methanol followed by drying. Read More

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Carboxymethyl konjac glucomannan coating on multilayered emulsions for improved bioavailability and targeted delivery of curcumin.

Food Funct 2021 May 14. Epub 2021 May 14.

College of Food Science and Engineering, Qingdao Agricultural University, Qingdao 266109, PR China.

Curcumin was entrapped in multilayered emulsions to increase its stability and bioavailability. Curcumin emulsion stabilized by whey protein isolate (WPI) was coated with chitosan (CHI) or carboxymethyl konjac glucomannan (CMKGM) alone to form secondary emulsions and their combination in sequence to form the tertiary emulsion, in which, the polyelectrolyte concentrations were 1.0% WPI for the primary emulsion, 0. Read More

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Karyotypic complexity, TP53 pathogenic variants, and increased number of variants on Next-Generation Sequencing are associated with disease progression in a North American Adult T-Cell Leukemia/Lymphoma cohort.

Int J Lab Hematol 2021 May 14. Epub 2021 May 14.

Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.

Introduction: Adult T-Cell Leukemia/Lymphoma (ATLL) is an aggressive T-cell malignancy without known characteristic cytogenetic abnormalities. Recurrent mutations in TP53, APC, and epigenetic and histone-modifying genes have been identified in North American ATLL. Their roles in disease progression are not yet fully elucidated. Read More

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Adult neurogenic process in the subventricular zone-olfactory bulb system is regulated by Tau protein under prolonged stress.

Cell Prolif 2021 May 14:e13027. Epub 2021 May 14.

School of Medicine, Life and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal.

Objectives: The area of the subventricular zone (SVZ) in the adult brain exhibits the highest number of proliferative cells, which, together with the olfactory bulb (OB), maintains constant brain plasticity through the generation, migration and integration of newly born neurons. Despite Tau and its malfunction is increasingly related to deficits of adult hippocampal neurogenesis and brain plasticity under pathological conditions [e.g. Read More

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A novel consensus bacterial 6-phytase variant totally replaced supplemental inorganic phosphate from one day of age in both male and female broilers.

Br Poult Sci 2021 May 14. Epub 2021 May 14.

Danisco Animal Nutrition (IFF), Willem Einthovenstraat 4, 2342 BH Oegstgeest, The Netherlands.

1. This study tested the capacity of a novel consensus bacterial 6-phytase variant (PhyG) to totally replace dietary supplemental inorganic phosphate (Pi) in broilers from one day of age, using a phased dosing strategy for the phytase and a phased reduction in phytate content of the diet. A 2x2 factorial arrangement including two treatments and two genders was used. Read More

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Increased cocaine motivation in tree shrews is modulated by striatal dopamine D1 receptor-mediated upregulation of Ca 1.2.

Addict Biol 2021 May 13:e13053. Epub 2021 May 13.

CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.

The progressively increased motivation for cocaine during abstinence is closely associated with the dysfunction of dopamine (DA) system. As DA receptors also dynamically regulate L-type calcium channels (LTCCs), in this study we examined how DA receptors (D1R or D2R) and LTCCs (Ca 1.2 or Ca 1. Read More

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Trehalose supplementation enhanced the biocontrol efficiency of Sporidiobolus pararoseus Y16 through increased oxidative stress tolerance and altered transcriptome.

Pest Manag Sci 2021 May 13. Epub 2021 May 13.

School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, Jiangsu, People's Republic of China.

Background: In the process of biological control, the antagonistic yeasts contend with various stresses that negatively influence yeasts' biocontrol efficiency. In the current study, we investigated the effect of trehalose supplementation on the biocontrol efficiency and oxidative stress tolerance of Sporidiobolus pararoseus Y16.

Results: S. Read More

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