17,271 results match your criteria exhibited impaired


The two-component system RstAB regulates production of a polysaccharide capsule with a role in virulence in the marine pathogen Photobacterium damselae subsp. damselae.

Environ Microbiol Rep 2021 Jul 26. Epub 2021 Jul 26.

Departamento de Microbioloxía e Parasitoloxía, Instituto de Acuicultura, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.

The marine bacterium Photobacterium damselae subsp. damselae (Pdd) causes disease in marine animals and in humans. Previous studies demonstrated that mutation of the two-component system RstAB strongly impacts virulence of this pathogen, but the RstAB regulon has not been thoroughly elucidated. Read More

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Dual l-Carnosine/ Nanophytosomes with Synergistically Enhanced Protective Effects against Methylglyoxal-Induced Angiogenesis Impairment.

Mol Pharm 2021 Jul 23. Epub 2021 Jul 23.

Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran 1449614535, Iran.

Microvascular complications are among the major outcomes of patients with type II diabetes mellitus, which are the consequences of impaired physiological functioning of small blood vessels and angiogenic responses in these patients. Overproduction and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl byproduct of glycolysis pathway, has been acclaimed as the main inducer of impaired angiogenic responses and microvascular dysfunction in diabetic patients with uncontrolled hyperglycemia. Hence, an effective approach to overcome diabetes-associated microvascular complications is to neutralize the deleterious activity of enhanced the concentration of MGO in the body. Read More

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Periodontitis induces endothelial dysfunction in mice.

Sci Rep 2021 Jul 22;11(1):14993. Epub 2021 Jul 22.

Charles Perkins Centre, University of Sydney School of Dentistry, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.

The treatment of periodontitis has numerous positive effects on established chronic health conditions, including cardiovascular disease and diabetes. However, ethical considerations do limit the establishment of human trials to investigate whether periodontitis promotes the early stages of chronic conditions. Therefore, the aim of this study was to investigate whether periodontitis induces endothelial dysfunction in hyperlipidemic apolipoprotein E gene-deficient (ApoE) mice. Read More

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Right Ventricular Contraction Patterns in Patients Undergoing Transcatheter Tricuspid Valve Repair for Severe Tricuspid Regurgitation.

JACC Cardiovasc Interv 2021 Jul;14(14):1551-1561

Department of Internal Medicine/Cardiology, Heart Center Leipzig at University of Leipzig and Leipzig Heart Institute, Leipzig, Germany. Electronic address:

Objectives: This study investigated patterns of right ventricular (RV) contraction by using cardiac magnetic resonance (CMR) imaging in patients undergoing transcatheter tricuspid valve repair (TTVR).

Background: The role of RV function in patients with severe tricuspid regurgitation undergoing TTVR is poorly understood.

Methods: Global RV dysfunction was defined as CMR-derived RV ejection fraction (RVEF) ≤45% and longitudinal RV dysfunction was defined as tricuspid annular plane systolic excursion (TAPSE) <17 mm on echocardiography. Read More

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A CREB1-miR-181a-5p loop regulates the pathophysiologic features of bone marrow stromal cells in fibrous dysplasia of bone.

Mol Med 2021 Jul 22;27(1):81. Epub 2021 Jul 22.

Jiangsu Province Key Laboratory of Oral Diseases, Nanjing Medical University, No.136, Hanzhong Road, Nanjing, 210029, Jiangsu Province, China.

Background: Fibrous dysplasia (FD) is a bone marrow stromal cell (BMSC) disease caused by activating mutations of guanine nucleotide-binding protein alpha-stimulating activity polypeptide (GNAS) and is characterized by increased proliferative activity and disrupted osteogenesis of BMSCs. However, the molecular mechanisms regulating the pathophysiologic features of BMSCs in FD remain unknown. This study aimed to identify and verify the roles of the CREB1-miR-181a-5p regulatory loop in FD pathophysiology. Read More

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Assocation Between Leber's Hereditary Optic Neuropathy and MT-ND1 3460G>A Mutation-Induced Alterations in Mitochondrial Function, Apoptosis, and Mitophagy.

Invest Ophthalmol Vis Sci 2021 Jul;62(9):38

Attardi Institute of Mitochondrial Biomedicine, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Purpose: To investigate the molecular mechanism underlying the Leber's hereditary optic neuropathy (LHON)-linked MT-ND1 3460G>A mutation.

Methods: Cybrid cell models were generated by fusing mitochondrial DNA-less ρ0 cells with enucleated cells from a patient carrying the m.3460G>A mutation and a control subject. Read More

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Neuropharmacological Assessment of the Hydroethanolic Leaf Extract of (Ait). R. Br. (Apocynaceae) in Mice.

Scientifica (Cairo) 2021 1;2021:5551380. Epub 2021 Jul 1.

Department of Pharmacology, School of Pharmacy, University of Health and Allied Sciences, Ho, Ghana.

Background: has been widely used traditionally for its analgesic and anti-inflammatory effects. It is also reportedly used in ethnomedicine for mental health disorders including epilepsy even in the absence of supporting scientific data. Thus, the potential of the plant to affect neurological functions was evaluated. Read More

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PsGRASP, a Golgi Reassembly Stacking Protein in , Is Required for Mycelial Growth, Stress Responses, and Plant Infection.

Front Microbiol 2021 8;12:702632. Epub 2021 Jul 8.

Department of Plant Pathology, Nanjing Agricultural University, Nanjing, China.

Golgi reassembly stacking proteins (GRASPs) play important roles in Golgi structure formation, ER stress response, and unconventional secretion in eukaryotic cells. However, GRASP functions in oomycetes haven't been adequately characterized. Here, we report the identification and functional analysis of , a GRASP-encoding gene from the soybean-infecting oomycete . Read More

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Quantitative Evaluation of Gait Changes Using APDM Inertial Sensors After the External Lumbar Drain in Patients With Idiopathic Normal Pressure Hydrocephalus.

Front Neurol 2021 8;12:635044. Epub 2021 Jul 8.

Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, China.

Gait and balance disturbances are common symptoms of idiopathic normal pressure hydrocephalus (iNPH). This study aimed to quantitatively evaluate gait and balance parameters after external lumbar drainage (ELD) using APDM inertial sensors. Two-minute walkway tests were performed in 36 patients with suspected iNPH and 20 healthy controls. Read More

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Childhood Maltreatment Was Correlated With the Decreased Cortical Function in Depressed Patients Under Social Stress in a Working Memory Task: A Pilot Study.

Front Psychiatry 2021 8;12:671574. Epub 2021 Jul 8.

Institute of Mental Health, The Sixth Hospital, Peking University, Beijing, China.

Major depressive disorder (MDD) is a common psychiatric disorder associated with working memory (WM) impairment. Neuroimaging studies showed divergent results of the WM process in MDD patients. Stress could affect the occurrence and development of depression, in which childhood maltreatment played an important role. Read More

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Fronto-parietal network function during cued visual search in the first-episode schizophrenia spectrum.

J Psychiatr Res 2021 Jul 13;141:339-345. Epub 2021 Jul 13.

Clinical Neurophysiology Research Laboratory, Western Psychiatric Hospital, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Western Psychiatric Hospital, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address:

Cognitive impairments account for significant morbidity in schizophrenia and are present at disease onset. Controlled processes are particularly susceptible and may contribute to pervasive selective attention deficits. The present study assessed fronto-parietal attention network (FPAN) functioning during cue presentation on a visual search task in first-episode schizophrenia spectrum patients (FE) and its relation to symptom burden and community functioning. Read More

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Reduced functional connectivity in brain networks underlying paired associates memory encoding in schizophrenia.

Biol Psychiatry Cogn Neurosci Neuroimaging 2021 Jul 22. Epub 2021 Jul 22.

BC Mental Health and Substance Use Research Institute, Provincial Health Services Authority, Vancouver, BC, Canada; Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada. Electronic address:

Background: Deficits in relational episodic memory encoding are characteristic of schizophrenia but whole-brain multivariate analyses of these deficits have been lacking. Open science has provided task-based fMRI data investigating paired associate encoding in schizophrenia, but it has not yet been mobilized to address this gap in the literature. Therefore, in this study we use previously unpublished task fMRI data to conduct the first network-level investigation of impaired relational episodic encoding in schizophrenia. Read More

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Regulation of conidiation, polarity growth, and pathogenicity by MrSte12 transcription factor in entomopathogenic fungus, Metarhizium rileyi.

Fungal Genet Biol 2021 Jul 22:103612. Epub 2021 Jul 22.

Chongqing Engineering Research Center for Fungal Insecticide, School of Life Science, Chongqing University, Chongqing 400030, People's Republic of China. Electronic address:

Metarhizium rileyi, a well-known filamentous biocontrol fungus, is the main pathogen of numerous field pests, especially noctuid pests. To explore the potential factors involved in the fungal pathogenicity, MrSte12, an important and conserved functional transcription factor in mitogen-activated protein kinase pathway was carried out by functional analysis. Homologous recombination was used to disrupt the MrSte12 gene in M. Read More

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In Utero Exposure to Δ9-Tetrahydrocannabinol Leads to Postnatal Catch-Up Growth and Dysmetabolism in the Adult Rat Liver.

Int J Mol Sci 2021 Jul 13;22(14). Epub 2021 Jul 13.

Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond Street, London, ON N6A 5C1, Canada.

The rates of gestational cannabis use have increased despite limited evidence for its safety in fetal life. Recent animal studies demonstrate that prenatal exposure to Δ9-tetrahydrocannabinol (Δ9-THC, the psychoactive component of cannabis) promotes intrauterine growth restriction (IUGR), culminating in postnatal metabolic deficits. Given IUGR is associated with impaired hepatic function, we hypothesized that Δ9-THC offspring would exhibit hepatic dyslipidemia. Read More

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Aerial course stabilization is impaired in motion-blind flies.

J Exp Biol 2021 Jul 23;224(14). Epub 2021 Jul 23.

Circuits - Computation - Models, Max Planck Institute of Neurobiology, Am Klopferspitz 18, Martinsried 82152, Germany.

Visual motion detection is among the best understood neuronal computations. As extensively investigated in tethered flies, visual motion signals are assumed to be crucial to detect and counteract involuntary course deviations. During free flight, however, course changes are also signalled by other sensory systems. Read More

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Sex differences in the impact of parental obesity on offspring cardiac SIRT3 expression, mitochondrial efficiency and diastolic function early in life.

Am J Physiol Heart Circ Physiol 2021 07 23. Epub 2021 Jul 23.

Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS, United States.

Previous studies suggest that parental obesity may adversely impact long-term metabolic health of the offspring. We tested the hypothesis that parental (paternal + maternal) obesity impairs cardiac function in the offspring early in life. Within 1-3 days after weaning, offspring from obese rats fed a high fat diet (HFD-Offs) and age-matched offspring from lean rats (ND-Offs) were submitted to echocardiography and cardiac catheterization for assessment of pressure-volume relationships. Read More

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Impaired SNF2L Chromatin Remodeling Prolongs Accessibility at Promoters Enriched for Fos/Jun Binding Sites and Delays Granule Neuron Differentiation.

Front Mol Neurosci 2021 6;14:680280. Epub 2021 Jul 6.

Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Chromatin remodeling proteins utilize the energy from ATP hydrolysis to mobilize nucleosomes often creating accessibility for transcription factors within gene regulatory elements. Aberrant chromatin remodeling has diverse effects on neuroprogenitor homeostasis altering progenitor competence, proliferation, survival, or cell fate. Previous work has shown that inactivation of the genes, (encoding Snf2h) and (encoding Snf2l) have dramatic effects on brain development. Read More

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Recognition of seizure semiology and semiquantitative FDG-PET analysis of anti-LGI1 encephalitis.

CNS Neurosci Ther 2021 Jul 22. Epub 2021 Jul 22.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China.

Aims: Anti-leucine-rich glioma-inactivated 1 (LGI1) autoimmune encephalitis (AE) is characterized by complex manifestations of seizures. Here, we report a new seizure semiology, attempt to classify the disease by semiology type, and explore the metabolic pattern of each group.

Methods: Anti-LGI1 AE patients were retrospectively screened between May 2014 and September 2019 in our tertiary epilepsy center. Read More

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Evidence of impaired bone quality in men with type 1 diabetes: a cross-sectional study.

Endocr Connect 2021 Jul 1. Epub 2021 Jul 1.

A Stunes, Department of Molecular and Clinical Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

Objective: Type 1 diabetes (T1D) is associated with a substantial fracture risk. Bone mineral density (BMD) is, however, only modestly reduced, suggesting impaired bone microarchitecture and/or bone material properties. Yet, the skeletal abnormalities have, however, not been uncovered. Read More

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Accommodative Response in Patients with Central Field Loss: A Matched Case-Control Study.

Vision (Basel) 2021 Jul 9;5(3). Epub 2021 Jul 9.

Department of Optometry, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia.

: This study was conducted to evaluate the accommodative response in young participants with visual impairment in comparison with visually normal participants. : Fifteen participants with confirmed visual impairment and 30 visually normal participants aged 12-15 years were recruited. Accommodative response was measured using autorefractor (Grand Seiko WV500) at distances of accommodative demand of 33, 25, and 20 cm. Read More

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Nonsymbolic-Magnitude Deficit in Adults With Developmental Dyscalculia: Evidence of Impaired Size Discrimination but Intact Size Constancy.

Psychol Sci 2021 Jul 21:956797621995204. Epub 2021 Jul 21.

Department of Learning Disabilities, University of Haifa.

Although researchers have debated whether a core deficit of nonsymbolic representation of magnitude underlies developmental dyscalculia (DD), research has mostly focused on numerosity processing. We probed the possibility of a general magnitude deficit in individuals with DD and asked whether sensitivity to size varied in contexts of depth ordering and size constancy. We measured full psychometric functions in size-discrimination tasks in 12 participants with DD and 13 control participants. Read More

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Citrullination Alters the Antibacterial and Anti-Inflammatory Functions of the Host Defense Peptide Canine Cathelicidin K9CATH In Vitro.

J Immunol 2021 Jul 19. Epub 2021 Jul 19.

Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institutet, Huddinge, Sweden;

K9CATH is the sole cathelicidin in canines (dogs) and exhibits broad antimicrobial activity against both Gram-positive and Gram-negative bacteria. K9CATH also modulates inflammatory responses and binds to LPS. These activities depend on the secondary structure and a net-positive charge of the peptide. Read More

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Yoga Practitioners Exhibit Higher Parasympathetic Activity and Baroreflex Sensitivity and Better Adaptability to 40 mm Hg Lower-Body Negative Pressure.

Int J Yoga Therap 2021 Jul 19. Epub 2021 Jul 19.

Department of Physiology, All India Institute of Medical Sciences, New Delhi, India.

Yoga has been shown to improve autonomic conditioning in humans, as evidenced by the enhancement of parasym-pathetic activity and baroreflex sensitivity. Therefore, we hypothesized that the experience of yoga may result in adaptation to acute hemodynamic changes. To decipher the long-term effects of yoga on cardiovascular variability, yoga practitioners were compared to yoga-naïve subjects during exposure to -40 mm Hg lower-body negative pressure (LBNP). Read More

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Investigating pupillometry to detect emotional regulation difficulties in post-traumatic stress disorder.

World J Biol Psychiatry 2021 Jul 19:1-9. Epub 2021 Jul 19.

Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.

Objective: Individuals with posttraumatic stress disorder (PTSD) have been found to exhibit emotional regulation difficulties. However, the specific neural mechanisms that underlie these difficulties remain understudied. This study aimed to use pupillometry as an index function of parasympathetic nervous system activation, to investigate the mechanisms underlying emotional regulation difficulties in individuals with PTSD. Read More

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Physiological Alterations in Deletion Mutants of Two Insulin-Like Peptides Encoded in Using CRISPR/Cas9.

Front Physiol 2021 2;12:701616. Epub 2021 Jul 2.

Department of Plant Medicals, Andong National University, Andong, South Korea.

Most insect species encode multiple insulin-like peptides (ILPs) that exhibit functional overlaps in mediating physiological processes such as development and reproduction. Why do they need multiple ILPs? To address this question, we tested a hypothesis of the requirement of multiple ILPs by generating mutants lacking individual ILP genes using the CRISPR/Cas9 technology. Two ILPs (ILP1 and ILP2) in the legume pod borer, , mediate similar physiological processes such as hemolymph sugar level, larval development, and adult reproduction. Read More

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Loss of nocturnal dipping pattern of skin sympathetic nerve activity during and following an extended-duration work shift in residents in training.

J Cardiol 2021 Jul 16. Epub 2021 Jul 16.

Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, 1665 Kongjiang Road, Shanghai 200092, China. Electronic address:

Background: Extended-duration work shifts (EDWSs) might affect the health of physician residents, causing autonomic alteration. Skin sympathetic nerve activity (SKNA) recorded by noninvasive neuro-electrocardiography (neuECG) is used to estimate cardiac sympathetic tone. In this study, we aim to evaluate the impact of EDWSs on nocturnal SKNA assessed in resident doctors. Read More

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The role of early visual experience in the development of spatial-frequency preference in the primary visual cortex.

J Physiol 2021 Jul 18. Epub 2021 Jul 18.

Division of Visual Information Processing, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, 444-8585, Japan.

Key Points: The mature functioning of the primary visual cortex depends on postnatal visual experience, while the orientation/direction preference is established just after eye-opening, independent of visual experience. In this study, we find that visual experience is required for the normal development of spatial frequency (SF) preference in mouse primary visual cortex. We show that age- and experience-dependent shifts in optimal SFs toward higher frequencies occurred similarly in excitatory neurons and parvalbumin-positive interneurons. Read More

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Genetically engineered MAPT 10+16 mutation causes pathophysiological excitability of human iPSC-derived neurons related to 4R tau-induced dementia.

Cell Death Dis 2021 Jul 17;12(8):716. Epub 2021 Jul 17.

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.

Human iPSC lines represent a powerful translational model of tauopathies. We have recently described a pathophysiological phenotype of neuronal excitability of human cells derived from the patients with familial frontotemporal dementia and parkinsonism (FTDP-17) caused by the MAPT 10+16 splice-site mutation. This mutation leads to the increased splicing of 4R tau isoforms. Read More

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Individuals at ultra-high risk of psychosis and first-degree relatives of patients with schizophreniaexperience impaired family functionality and social support deficit in comparison to healthy controls.

Compr Psychiatry 2021 Jul 10;109:152263. Epub 2021 Jul 10.

The Second School of Clinical Medicine, Southern Medical University, Guangdong Province, Guangzhou, China; Guangdong Provincial People's Hospital, Guangdong Academy of MedicalSciences, Guangdong Mental Health Center, Guangdong Province, China. Electronic address:

Aim: The present study was designed to assess the role of family function and social support in the context of different phases of schizophrenia.

Methods: First-episode patients with experiences of schizophrenia (FEP), ultra-high risk for psychosis (UHR), first-degree relatives (FDR) of patients with experiences of schizophrenia, and healthy controls (HC) (40 per group) were subjected to in-person clinical interviews. The results of these interviews were then used to gauge social support and family function using the Perceived Social Support Scale (PSSS) and the Family Adaptability and Cohesion Scales (FACESII-CV). Read More

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SIMP1 modulates salt tolerance by elevating ERAD efficiency through UMP1A-mediated proteasome maturation in plants.

New Phytol 2021 Jul 17. Epub 2021 Jul 17.

Key Laboratory of Bio-resource and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, 610064, China.

Salt stress significantly induces accumulation of misfolded or unfolded proteins in plants. Endoplasmic reticulum (ER)-associated protein degradation (ERAD) and other degradative machineries function in the degradation of these abnormal proteins, leading to enhanced salt tolerance in plants. Here we characterize that a novel receptor-like kinase, Salt Induced Malectin-like domain-containing Protein1 (SIMP1), elevates ERAD efficiency during salt stress through UMP1A, a putative proteasome maturation factor in Arabidopsis. Read More

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