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Assessment of the effects of four crosslinking agents on gelatin hydrogel for myocardial tissue engineering applications.

Biomed Mater 2021 May 11. Epub 2021 May 11.

College of Biomedical Engineering, Sichuan University, No.24 South Section 1, Yihuan Road,, Chengdu, 610065, CHINA.

Cardiomyocyte (CM) transplantation is a promising option for regenerating infarcted myocardium. However, poor cell survival and residence rates reduce the efficacy of cell transplantation. Gelatin (GA) hydrogel as a frequently-used cell carrier is a possible approach to increase the survival rate of CMs. Read More

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Reuse solution of hardness industrial circulating cooling water: Targeted ion-selective electro-adsorption by functionalized electrode.

Chemosphere 2021 May 3;280:130748. Epub 2021 May 3.

College of Environmental Science and Engineering, Beijing Forestry University, Beijing, 100083, PR China. Electronic address:

A low-cost, efficient and environmentally friendly hardness ion selective electro-adsorption system for high-hardness industrial circulating cooling water reuse was constructed to simultaneously realize a high salt removal rate and hardness ion (Ca and Mg) selection. Multiply modified graphite carbon felt (GCF) materials for both negative and positive electrodes were proposed simply and economically, and an electro-adsorption system for hardness control was assembled. The multiple modified GCF (GCF) materials were characterized by SEM, BET and FT-IR and the electrochemical performance was tested by CV and EIS; surface properties were studied by Zeta potential; the hardness ion removal selectivity and operational stability of the electro-adsorption system were tested. Read More

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Sonochemically prepared hierarchical MFI-type zeolites as active catalysts for catalytic ethanol dehydration.

Ultrason Sonochem 2021 May 3;74:105581. Epub 2021 May 3.

Faculty of Chemical Engineering and Technology, Cracow University of Technology, Warszawska 24, 31-155 Cracow, Poland.

In this paper, the ultrasonic-assisted desilication technique was reported as an attractive and efficient way for the preparation of hierarchical zeolites with MFI structure type. The prepared materials were used as active catalysts for the dehydration of ethanol into diethyl ether and ethylene. For all catalysts, the selectivity to diethyl ether was ca 95% or higher up to 210 °C, with catalytic activity in the range of 40-68%. Read More

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Natural community of macroalgae from chromium-contaminated site for effective remediation of Cr(VI)-containing leachates.

Sci Total Environ 2021 May 4;786:147501. Epub 2021 May 4.

Department of Physical Geography, University of Wrocław, ul. W. Cybulskiego 34, 50-205 Wrocław, Poland.

The natural macroalgal community, which developed in the unique and extremely Cr(VI)-polluted aquatic reservoir situated near a historical chromium-waste landfill, was studied in order to recognize the main mechanisms of Cr(VI) detoxification by the algal species. The conducted taxonomic analysis revealed mixed composition of the filamentous forms of algae and showed that three species of Tribonema, namely T. vulgare, T. Read More

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Key Factors Governing the Reconstitution Time of High Concentration Lyophilized Protein Formulations.

Eur J Pharm Biopharm 2021 May 8. Epub 2021 May 8.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT 06269, USA; Institute of Materials Science, University of Connecticut, Storrs, CT 06269, USA. Electronic address:

Lyophilized protein formulations containing highly concentrated proteins often have long and variable reconstitution times. Reconstitution time is dependent on a number of factors in a complex manner. Furthermore, factors influencing the reconstitution of partially crystalline cakes are reportedly different from those of amorphous cakes. Read More

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EphA4 is highly expressed in the atria of heart and its deletion leads to atrial hypertrophy and electrocardiographic abnormalities in rats.

Life Sci 2021 May 8:119595. Epub 2021 May 8.

Key Laboratory of Human Disease Comparative Medicine, National Health Commission of China (NHC), Institute of Laboratory Animal Science, Peking Union Medicine College, Chinese Academy of Medical Sciences, Beijing 100021, China. Electronic address:

Aims: EphA4 is a member of the Eph receptor family, and expressed mainly in central nervous system (CNS), which is involved in CNS development and multiple diseases. Due to the variability in EphA4 expression, we wondered if EphA4 is expressed in other tissues, and what role does EphA4 play?

Materials And Methods: We generated an EphA4 knockout (KO) rat line with red fluorescent marker protein encoded by the mCherry cassette inserted downstream of the EphA4 promoter as a reporter. Using this system, we observed high expression of EphA4 in the heart atria and in the brain. Read More

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Effects of sacrificial coordination bonds on the mechanical performance of lignin-based thermoplastic elastomer composites.

Int J Biol Macromol 2021 May 8. Epub 2021 May 8.

School of Chemistry and Chemical Engineering, Guangdong Engineering Research Center for Green Fine Chemicals, South China University of Technology, Wushan Road 381, Guangzhou, Guangdong 510640, China.

The coordination-based energy sacrificial bonds have been constructed in the interphase between lignin and polyolefin elastomer which has been demonstrated as an effective method to prepare high performance lignin-based thermoplastic elastomers (TPEs). Here, we proposed a strategy of adjusting the strength and toughness of lignin-based TPEs by using different nitrogen heterocyclic compounds as reactive assistants and Fe or Zn as metal coordination centers to construct coordination bonds between lignin and polyethylene elastomer matrix. It was demonstrated that 3-Amino-1,2,4-triazole with three nitrogen atoms in the heterocyclic ring and one nitrogen branch chain could form the most efficient coordination bond system which generated the best mechanical performance. Read More

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Computed tomography-based delta-radiomics analysis for discriminating radiation pneumonitis in patients with esophageal cancer after radiation therapy.

Int J Radiat Oncol Biol Phys 2021 May 8. Epub 2021 May 8.

Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China. Electronic address:

Purpose: To construct a computed tomography (CT)-based delta-radiomics nomogram and corresponding risk classification system for individualized and accurate estimation of severe acute radiation pneumonitis (SARP) in patients with esophageal cancer (EC) after radiation therapy (RT).

Methods And Materials: 400 EC patients were enrolled from two independent institutions, and were divided into the training (n = 200) and validation cohorts (n = 200). 850 radiomics features of lung were extracted from treatment planning images, including the positioning CT before RT (CT) and the resetting CT after receiving 40-45Gy (CT). Read More

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Morphology modulation and performance optimization of nanopetal-based Ag-modified BiOCO as an inactivating photocatalytic material.

Environ Res 2021 May 8:111256. Epub 2021 May 8.

Key Laboratory of Ship-Machinery Maintenance and Manufacture for Ministry of Transport, Dalian Maritime University, Dalian 116026, P. R. China.

The use of photocatalytic technology to kill bacteria on marine vessel surface coatings has been paid more attention by research scholars. In this paper, petal-like microspheres with Ag nanoparticles were prepared by a simple one-step process combining the hydrothermal method and photodeposition. The 0. Read More

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Non-invasive preimplantation genetic testing for putative mosaic blastocysts: a pilot study.

Hum Reprod 2021 May 11. Epub 2021 May 11.

Department of Obstetrics and Gynecology, Reproductive Medicine Center, the First Affiliated Hospital of Anhui Medical University, Anhui, China.

Study Question: What is the potential of applying non-invasive preimplantation genetic testing (niPGT) for chromosome abnormalities in blastocysts reported with a mosaic trophectoderm (TE) biopsy?

Summary Answer: niPGT of cell-free DNA in blastocyst culture medium exhibited a good diagnostic performance in putative mosaic blastocysts.

What Is Known Already: Advances in niPGT have demonstrated the potential reliability of cell-free DNA as a resource for genetic assessment, but information on mosaic embryos is scarce because the mosaicism may interfere with niPGT. In addition, the high incidence of mosaicism reported in the context of PGT and the viability of mosaic blastocysts raise questions about whether mosaicism really exists. Read More

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Establishment of soil strength in a nourished wetland using thin layer placement of dredged sediment.

PLoS One 2021 11;16(5):e0251420. Epub 2021 May 11.

US Army Corps of Engineers, Research and Development Center, Vicksburg, Mississippi, United States of America.

Coastal wetlands are experiencing accelerated rates of fragmentation and degradation due to sea-level rise, sediment deficits, subsidence, and salt-water intrusion. This reduces their ability to provide ecosystem benefits, such as wave attenuation, habitat for migratory birds, and a sink for carbon and nitrogen cycles. A deteriorated back barrier wetland in New Jersey, USA was nourished through thin layer placement (TLP) of dredged sediment in 2016. Read More

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Novel hyaluronic acid oligosaccharide-loaded and CD44v6-targeting oxaliplatin nanoparticles for the treatment of colorectal cancer.

Drug Deliv 2021 Dec;28(1):920-929

Department of General Surgery, The Second Hospital of Lanzhou University, Lanzhou, PR China.

Oxaliplatin resistance is one of the main causes of failed colorectal cancer treatment, followed by recurrence and metastasis. In this study, we found that colorectal cancer cells secrete a high level of hyaluronic acid (HA), which interacts with its receptor CD44v6 to mediate colorectal cancer resistance to chemotherapy. HA oligosaccharide (oHA) is a degradation product of HA. Read More

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December 2021

Deazapurine Nucleoside Analogues for the Treatment of .

ACS Infect Dis 2021 May 11. Epub 2021 May 11.

Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, U.K.

Trichomoniasis is the most common nonviral sexually transmitted disease in humans, but treatment options are limited. Here, we report a resorufin-based drug sensitivity assay for high-throughput microplate-based screening under hypoxic conditions. A 5203-compound enamine kinase library and several specialized compound series were tested for the inhibition of growth at 10 μM with ' values of >0. Read More

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Three-Dimensional Micropatterning Deters Early Bacterial Adherence and Can Eliminate Colonization.

ACS Appl Mater Interfaces 2021 May 11. Epub 2021 May 11.

Department of Mechanical and Aerospace Engineering, Monash University, Clayton, Victoria 3800, Australia.

Developing strategies to prevent bacterial infections that do not rely on the use of drugs is regarded globally as an important means to stem the tide of antimicrobial resistance, as argued by the World Health Organization (WHO) (Mendelson, M.; Matsoso, M. P. Read More

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LncRNA NCK1-AS1 exerts oncogenic property in gastric cancer by targeting the miR-22-3p/BCL9 axis to activate the Wnt/β-catenin signaling.

Environ Toxicol 2021 May 11. Epub 2021 May 11.

Department of Gastroenterology, Jinhu People's Hospital, Huaian, Jiangsu, China.

Long noncoding RNAs (lncRNAs) exert crucial effects on the development of many malignancies, including gastric cancer. Herein, we investigated the role of lncRNA noncatalytic region of tyrosine kinase adaptor protein 1 (NCK1) divergent transcript (NCK1-DT, also known as NCK1-AS1) in gastric cancer. Reverse transcription quantitative polymerase chain reaction demonstrated that NCK1-AS1 exhibited high expression in gastric cancer tissues and cells. Read More

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Antiproliferative potential of Andean Berry (Vaccinium meridionale Swartz) juice in combination with Aspirin in human SW480 colon adenocarcinoma cells.

J Food Biochem 2021 May 11:e13760. Epub 2021 May 11.

Escuela de Nutrición y Dietética, Universidad de Antiquia, Medellín, Colombia.

Andean Berry (Vaccinium meridionale Sw.) is a South American fruit rich in phytochemicals with promising anti-cancer properties as co-adjuvants to nonsteroidal anti-inflammatory drugs such as Aspirin. This study aimed to evaluate the antiproliferative potential of Andean Berry Juice (ABJ) in combination with Aspirin in human SW480 colon adenocarcinoma cells. Read More

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[Analysis and prenatal diagnosis of FMR1 gene mutations among patients with unexplained mental retardation].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2021 May;38(5):439-445

Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, Hunan 410078, China.

Objective: To analyze the (CGG)n repeats of FMR1 gene among patients with unexplained mental retardation.

Methods: For 201 patients with unexplained mental retardation, the (CGG)n repeats of the FMR1 gene were analyzed by PCR and FragilEase PCR. Prenatal diagnosis was provided to carriers of pre- and full-mutations. Read More

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Accelerated Evolution of H7N9 Subtype Influenza Virus under Vaccination Pressure.

Virol Sin 2021 May 11. Epub 2021 May 11.

National Avian Influenza Para-Reference Laboratory (Guangzhou), College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.

No avian H7N9 outbreaks have occurred since the introduction of H7N9 inactivated vaccine in the fall of 2017. However, H7N9 is still prevalent in poultry. To surveil the prevalence, genetic characteristics, and antigenic changes of H7N9, over 7000 oropharyngeal and cloaca swab specimens were collected from live poultry markets and farms in 15 provinces of China from 2017 to 2019. Read More

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Abnormalities in emotional and motor reactions among young prehypertensive individuals: employing continuous blood pressure analysis.

J Hypertens 2021 May 10. Epub 2021 May 10.

Department of Psychology, School of Psychological Sciences The Integrated Brain and Behavior Research Center (IBBR) School of Public Health, University of Haifa Department of Nephrology and Hypertension, Shamir Medical Center (Assaf Harofeh), Sackler School of Medicine, Tel Aviv University Sagol Center for Hyperbaric Medicine and Research, Shamir Medical Center (Assaf Harofeh), Tel Aviv, Israel.

Background: Essential hypertension is an important risk factor for cerebrovascular diseases and a major cause of premature death in industrialized societies. A predisposing factor for essential hypertension is prehypertension: blood pressure (BP) values at rest that are at the higher end of the normal range. Abnormally enhanced cardiovascular responses to motor and emotional tasks have been found as predictors of essential hypertension. Read More

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Pd-Doping-Induced Oxygen Vacancies in One-Dimensional Tungsten Oxide Nanowires for Enhanced Acetone Gas Sensing.

Anal Chem 2021 May 11. Epub 2021 May 11.

State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China.

Metal oxide semiconductors (MOS) with different nanostructures have been widely used as gas sensing materials due to the tunable interface structures and properties. However, further improvement of the sensing sensitivity and selectivity is still challenging in this area. Constructing appropriate heterogeneous interface structures and oxygen vacancies is one of the important strategies to tune the sensing properties of MOS. Read More

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Alteration of fibrin hydrogel gelation and degradation kinetics through addition of azo dyes.

J Biomed Mater Res A 2021 May 11. Epub 2021 May 11.

Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA.

Fibrin is a degradable biopolymer with an excellent clinical safety profile. Use of higher mechanical strength fibrin hydrogels is limited by the rapid rate of fibrin polymerization. We recently demonstrated the use of higher mechanical strength (fibrinogen concentrations >30 mg/ml) fibrin scaffolds for surgical implantation of cells. Read More

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Global distribution of IRC7 alleles in Saccharomyces cerevisiae populations: a genomic and phenotypic survey within the wine clade.

Environ Microbiol 2021 May 10. Epub 2021 May 10.

Department of Genetics, Physiology and Microbiology. Unit of Microbiology. Biology Faculty, Complutense University of Madrid, Madrid, 28040, Spain.

The adaptation to the different biotic and abiotic factors of wine fermentation has led to the accumulation of numerous genomic hallmarks in Saccharomyces cerevisiae wine strains. IRC7, a gene encoding a cysteine-S-β-lyase enzyme related volatile thiols production in wines, has two alleles: a full-length allele (IRC7 ) and a mutated one (IRC7 ), harbouring a 38 bp-deletion. Interestingly, IRC7 -encoding a less active enzyme - appears widespread amongst wine populations. Read More

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The thermodynamic stability, potential toxicity, and speciation of metals and metalloids in Tehran runoff, Iran.

Environ Geochem Health 2021 May 10. Epub 2021 May 10.

Department of Environmental Engineering, School of Environment, College of Engineering, University of Tehran, P.O. Box 14155-6135, Tehran, Iran.

Surface runoff is the most significant source of water in dry cities like Tehran. The surface runoff is polluted by heavy metals, which their risk level is a function of their speciation. Herein, Tehran runoff quality and the speciation of metals and metalloids were investigated. Read More

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Zebrafish mbnl mutants model physical and molecular phenotypes of myotonic dystrophy.

Dis Model Mech 2021 May 11. Epub 2021 May 11.

Institute of Molecular Biology.

The muscleblind RNA binding proteins (MBNL1, MBNL2, and MBNL3) are highly conserved across vertebrates and are important regulators of RNA alternative splicing. Loss of MBNL protein function through sequestration by CUG or CCUG RNA repeats is largely responsible for the phenotypes of the human genetic disorder myotonic dystrophy (DM). We generated the first stable zebrafish (Danio rerio) models of DM-associated MBNL loss of function through mutation of the three zebrafish mbnl genes. Read More

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Diversity and distribution of viruses inhabiting the deepest ocean on Earth.

ISME J 2021 May 10. Epub 2021 May 10.

State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.

As the most abundant biological entities on the planet, viruses significantly influence the overall functioning of marine ecosystems. The abundance, distribution, and biodiversity of viral communities in the upper ocean have been relatively well studied, but our understanding of viruses in the hadal biosphere remains poor. Here, we established the oceanic trench viral genome dataset (OTVGD) by analysing 19 microbial metagenomes derived from seawater and sediment samples of the Mariana, Yap, and Kermadec Trenches. Read More

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Ultrasonication-mediated nitrogen-doped multiwalled carbon nanotubes involving carboxy methylcellulose composite for solid-state supercapacitor applications.

Sci Rep 2021 May 10;11(1):9918. Epub 2021 May 10.

Department of Environmental Engineering, Inha University, 100 Inha-ro, Nam-gu, Incheon, 22212, South Korea.

In this study, a novel nanohybrid composite containing nitrogen-doped multiwalled carbon nanotubes/carboxymethylcellulose (N-MWCNT/CMC) was synthesized for supercapacitor applications. The synthesized composite materials were subjected to an ultrasonication-mediated solvothermal hydrothermal reaction. The synthesized nanohybrid composite electrode material was characterized using analytical methods to confirm its structure and morphology. Read More

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Bilayer and three dimensional conductive network composed by SnCl reduced rGO with CNTs and GO applied in transparent conductive films.

Sci Rep 2021 May 10;11(1):9891. Epub 2021 May 10.

Tianjin Key Laboratory of Advanced Fibers and Energy Storage, School of Material Science and Engineering, Tiangong University, Tianjin, 300387, China.

Graphene oxide (GO), reduced graphene oxide (rGO) and carbon nanotubes (CNTs) have their own advantages in electrical, optical, thermal and mechanical properties. An effective combination of these materials is ideal for preparing transparent conductive films to replace the traditional indium tin oxide films. At present, the preparation conditions of rGO are usually harsh and some of them have toxic effects. Read More

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Development and characterization of two equine formulations towards SARS-CoV-2 proteins for the potential treatment of COVID-19.

Sci Rep 2021 05 10;11(1):9825. Epub 2021 May 10.

Facultad de Microbiología, Instituto Clodomiro Picado, Universidad de Costa Rica, San José, Costa Rica.

In the current global emergency due to SARS-CoV-2 outbreak, passive immunotherapy emerges as a promising treatment for COVID-19. Among animal-derived products, equine formulations are still the cornerstone therapy for treating envenomations due to animal bites and stings. Therefore, drawing upon decades of experience in manufacturing snake antivenom, we developed and preclinically evaluated two anti-SARS-CoV-2 polyclonal equine formulations as potential alternative therapy for COVID-19. Read More

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Circulating lipid and lipoprotein profiles and their correlation to cardiac function and cardiovascular outcomes in patients with acute myocardial infarction.

J Investig Med 2021 May 10. Epub 2021 May 10.

Department of Cardiovascular Medicine, Xi'an Jiaotong University Medical College First Affiliated Hospital, Xi'an, China

Recent studies showed that lipoproteins represent major risk factors, both positive and negative, for atherosclerotic cardiovascular disease. The aim of the present study was to describe the relationship between plasma lipid profile and cardiac function and cardiovascular outcomes in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). Two independent groups of subjects including a total of 797 patients diagnosed of AMI undergoing PCI admitted to the First Affiliated Hospital of Xi'an Jiaotong University were included in the present study. Read More

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Biological and biochemical evaluation of isatin-isoniazid hybrids as bactericidal candidates against .

Antimicrob Agents Chemother 2021 May 10. Epub 2021 May 10.

Centre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier, 1919 route de Mende, 34293, Montpellier, France.

Tuberculosis remains a leading cause of mortality among infectious diseases worldwide, prompting the need to discover new drugs to fight this disease. We report herein, the design, synthesis and anti-mycobacterial activity of isatin-mono/bis-isoniazid hybrids. Most of the compounds exhibited very high activity against with minimal inhibitory concentrations in the range of 0. Read More

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