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Efficacy and safety of empagliflozin at different doses in patients with type 2 diabetes mellitus: A network meta-analysis based on randomized controlled trials.

J Clin Pharm Ther 2021 Sep 20. Epub 2021 Sep 20.

Department of Cardio-Thoracic Surgery, The second affiliated hospital of Nanchang University, Nanchang, China.

What Is Known And Objective: As an oral hypoglycaemic drug that significantly reduces cardiovascular risk, empagliflozin is often used in patients with type 2 diabetes mellitus (T2DM). However, the dosage and administration of empagliflozin are still controversial clinically. To determine the most appropriate dose, we performed this network meta-analysis. Read More

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September 2021

Xylanase impact beyond performance: A microbiome approach in laying hens.

PLoS One 2021 20;16(9):e0257681. Epub 2021 Sep 20.

Animal Nutrition and Health, Kemin Europa N.V., Herentals, Antwerp, Belgium.

Anti-nutritional compounds such as non-starch polysaccharides (NSP) are present in viscous cereals used in feed for poultry. Therefore, exogenous carbohydrases are commonly added to monogastric feed to degrade these NSP. Our hypothesis is that xylanase not only improves laying hen performance and digestibility, but also induces a significant shift in microbial composition within the intestinal tract and thereby might exert a prebiotic effect. Read More

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September 2021

WS-WC-WO nano-hollow spheres as an efficient and durable catalyst for hydrogen evolution reaction.

Nano Converg 2021 Sep 20;8(1):28. Epub 2021 Sep 20.

Department of Materials Science and Engineering, Institute of Green Manufacturing Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.

Transition metal dichalcogenides (TMDs), transition metal carbides (TMCs), and transition metal oxides (TMOs) have been widely investigated for electrocatalytic applications owing to their abundant active sites, high stability, good conductivity, and various other fascinating properties. Therefore, the synthesis of composites of TMDs, TMCs, and TMOs is a new avenue for the preparation of efficient electrocatalysts. Herein, we propose a novel low-cost and facile method to prepare TMD-TMC-TMO nano-hollow spheres (WS-WC-WO NH) as an efficient catalyst for the hydrogen evolution reaction (HER). Read More

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September 2021

Cryo-self-assembled silk fibroin sponge as a biodegradable platform for enzyme-responsive delivery of exosomes.

Bioact Mater 2022 Feb 22;8:505-514. Epub 2021 Jun 22.

Department of Sports Medicine, Institute of Sports Medicine of Peking University, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, China.

Although advances in protein assembly preparation have provided a new platform for drug delivery during tissue engineering, achieving long-term controlled exosome delivery remains a significant challenge. Diffusion-dominated exosome release using protein hydrogels results in burst release of exosomes. Here, a fibroin-based cryo-sponge was developed to provide controlled exosome release. Read More

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February 2022

The clinical effects of IABP pumps combined with tirofiban in the treatment of acute myocardial infarction and on patients' serum levels.

Am J Transl Res 2021 15;13(8):9796-9801. Epub 2021 Aug 15.

The Second Department of Cardiology, Lacey People's Hospital Laixi, Qingdao, China.

Objective: To explore the clinical effects of the intra-aortic balloon pump (IABP) combined with tirofiban in the treatment of acute myocardial infarction (AMI) and to analyze the combination's influence on patient serum levels.

Method: 106 patients with AMI admitted to our hospital from February 2017 to February 2018 were recruited as the research cohort. The patients were randomly placed into a control group and an experimental group according to their order of admission, with 53 patients in each group. Read More

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Significant value of XRCC2 and XRCC9 expression in the prognosis of human ovarian carcinoma.

J Cancer 2021 28;12(20):6254-6264. Epub 2021 Aug 28.

Department of obstetrics and gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

The x-ray repair cross-complementing (XRCC) family is essential in DNA repair processes. The predictive roles of XRCCs remain unclear in ovarian carcinomas. Therefore, detecting the relationship between XRCCs expression and ovarian carcinomas prognosis is increasingly pivotal. Read More

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Prognostic Gene Expression Signature in Patients With Distinct Glioma Grades.

Front Immunol 2021 1;12:685213. Epub 2021 Sep 1.

Cellular and Molecular Pathology Laboratory, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco.

Background: Glioma is the most common type of primary brain tumor in adults. Patients with the most malignant form have an overall survival time of <16 months. Although considerable progress has been made in defining the adapted therapeutic strategies, measures to counteract tumor escape have not kept pace, due to the developed resistance of malignant glioma. Read More

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September 2021

Impact of the COVID-19 Pandemic on Higher Education: Characterizing the Psychosocial Context of the Positive and Negative Affective States Using Classification and Regression Trees.

Front Psychol 2021 1;12:714397. Epub 2021 Sep 1.

Department of Clinical Psychology and Psychobiology, Universitat de Barcelona, Barcelona, Spain.

Our aim is to analyze the extent to which the psychosocial aspects can characterize the affective states of the teachers, administrative staff, and undergraduate and postgraduate students during the quarantine. A questionnaire was answered by 1,328 people from the community of the (UB), Spain. The survey was partially designed , collecting indicators related to sociodemographic variables, the impact of COVID on the subjects or in their personal context, the psychosocial context of coexistence and perceived social support, characteristics related to the physical context during the quarantine, and labor conditions. Read More

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September 2021

Why Do Some Rainbow Trout Genotypes Grow Better With a Complete Plant-Based Diet? Transcriptomic and Physiological Analyses on Three Isogenic Lines.

Front Physiol 2021 1;12:732321. Epub 2021 Sep 1.

INRAE, Université de Pau et des Pays de l'Adour, E2S UPPA, NUMEA, Saint-Pée-sur-Nivelle, France.

Within the context of a growing aquaculture production coupled with a plateau of the production in the main components of aquafeeds (fish oil and fishmeal), recent studies have typically focused on replacing these feedstuffs with terrestrial plant ingredients for cultured carnivorous aquatic species, such as rainbow trout (). Substitution rates without adverse effects have, however, reached their limit. One potential way forward would be to take advantage of the genetic variability that exists in the salmonid population. Read More

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September 2021

Treatment planning comparison between dynamic wave arc and volumetric modulated arc therapies for prostate-cancer treatment.

Med Dosim 2021 Sep 16. Epub 2021 Sep 16.

Hiroshima High-Precision Radiotherapy Cancer Center, 3-2-2, Futabanosato, Higashi-ku Hiroshima 732-0057, Japan; Department of Radiation Oncology, Graduate School of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.

The aim of this study was to compare the quality of dynamic wave arc (DWA) and coplanar volumetric modulated arc therapy (co-VMAT) plans for the treatment of localized prostate cancer. The planning target volume (PTV)-rectum, a section of the PTV comprising the PTV minus that of the rectum, received 78 Gy in 39 fractions as the mean dose to the PTV-rectum. The DWA and co-VMAT plans were generated for each patient using the RayStation treatment planning system for the Vero4DRT system. Read More

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September 2021

Comparative analysis of daily and hourly temperature variability in association with all-cause and cardiorespiratory mortality in 45 US cities.

Environ Sci Pollut Res Int 2021 Sep 19. Epub 2021 Sep 19.

School of Public Health, Hubei University of Medicine, Shiyan, 442000, China.

Temperature variability (TV) has been widely associated with increased mortality risk and burden. Extensive researches have used the standard deviations of several days' daily maximum and minimum temperatures or hourly mean temperatures as daily and hourly TV measures (TV and TV). However, comparative analysis of daily and hourly TV related to cardiorespiratory mortality is still limited. Read More

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September 2021

Corn starch and methylcellulose edible films incorporated with fireweed (Chamaenerion angustifolium L.) extract: Comparison of physicochemical and antioxidant properties.

Int J Biol Macromol 2021 Sep 16. Epub 2021 Sep 16.

Department of Biochemistry and Food Chemistry, Faculty of Food Sciences and Biotechnology, University of Life Sciences in Lublin, Skromna 8, 20-704 Lublin, Poland.

The properties of edible films derived from corn starch (CS) and methylcellulose (MC) supplemented with fireweed extract (FE; 0.0125-0.05% w/w) were analyzed. Read More

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September 2021

Recent amplification of microsatellite-associated miniature inverted-repeat transposable elements in the pineapple genome.

BMC Plant Biol 2021 Sep 18;21(1):424. Epub 2021 Sep 18.

Texas A&M AgriLife Research Center at Dallas, Texas A&M University System, Dallas, TX, 75252, USA.

Background: Miniature inverted-repeat transposable elements (MITEs) are non-autonomous DNA transposable elements that play important roles in genome organization and evolution. Genome-wide identification and characterization of MITEs provide essential information for understanding genome structure and evolution.

Results: We performed genome-wide identification and characterization of MITEs in the pineapple genome. Read More

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September 2021

Peptide DR8 analogs alleviate pulmonary fibrosis via suppressing TGF-β1 mediated epithelial-mesenchymal transition and ERK1/2 pathway in vivo and in vitro.

Eur J Pharm Sci 2021 Sep 16:106009. Epub 2021 Sep 16.

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066, Lanzhou University, Lanzhou 730000, China. Electronic address:

Pulmonary fibrosis is a chronic progressive lung disease that lacks effective treatments in clinic. It is characterized by repair disorder of epithelial cells, formation of fibroblast foci as well as destruction of alveolar structure. Previously we first determined that parent peptide DR8 (DHNNPQIR-NH) has anti-fibrotic activity in bleomycin-induced mice. Read More

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September 2021

Role of AcndtA in cleistothecium formation, osmotic stress response, pigmentation and carbon metabolism of Aspergillus cristatus.

Fungal Biol 2021 Oct 6;125(10):749-763. Epub 2021 May 6.

Guizhou Key Laboratory of Agricultural Biotechnology, Guiyang, Guizhou, 550006, China; Institute of Biotechnology, Guizhou Academy of Agricultural Sciences, Guiyang, Guizhou, 550006, China; Innovative Institute for Plant Health, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, 510225, China. Electronic address:

As the dominant fungus during the fermentation of Fuzhuan brick tea, Aspergillus cristatus is easily induced to undergo a sexual cycle under low-salt stress. However, the underlying regulatory mechanism of sexual reproduction is unclear. Here, we report a P53-like transcription factor AcndtA, which encodes an NDT80 DNA binding protein and regulates fungal reproduction, pigmentation and the stress response. Read More

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October 2021

Hydrated electrons mediated in-situ construction of cubic phase CdS/Cd thin layer on a millimeter-scale support for photocatalytic hydrogen evolution.

J Colloid Interface Sci 2021 Sep 8;607(Pt 1):769-781. Epub 2021 Sep 8.

TJU-NIMS International Collaboration Laboratory, Tianjin University, No. 92 Weijin Road, Nankai District, Tianjin 300072, People's Republic of China; International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.

In this study, non-noble metal Cd decorated cubic phase CdS (CdS/Cd) thin layer on a millimeter-scale chitosan-Mg(OH) xerogel beads (CMB) were elaborately designed and successfully synthesized via facile hydrated electrons (e) assistant strategy. The in-situ formation of metallic Cd was driven by e generated from UV/NaSO process. Owing to metallic Cd, [email protected]/Cd exhibited better visible-light absorption ability and more efficient separation capability for photo-induced carriers, its hydrogen production efficiency was about threefold improved compared to [email protected] Read More

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September 2021

A novel methylenemalononitrile-BODIPY-based fluorescent probe for highly selective detection of hydrogen peroxide in living cells.

Eur J Med Chem 2021 Sep 6;226:113828. Epub 2021 Sep 6.

School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen, 518107, PR China. Electronic address:

Hydrogen peroxide (HO) plays vital roles in oxidative stress and signal transduction in living organisms, and its abnormal levels could be linked to many diseases. Despite numerous efforts spent, it is still urgent and of high importance to develop better HO probes with good selectivity, high sensitivity and low backgrounds. To this end, a novel boron dipyrromethene (BODIPY)-based fluorescent probe with an electron-withdrawing methylenemalononitrile at the meso position has been rationally designed, successfully synthesized and investigated for detection of HO in aqueous solutions and living cells, which exhibited high selectivity and sensitivity, fluorescent "turn-on" phenomenon at 540 nm, and ratiometric changes from 506 to 540 nm. Read More

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September 2021

Innovative Therapies for Neuroblastoma: The Surprisingly Potent Role of Iron Chelation in Up-Regulating Metastasis and Tumor Suppressors and Down-Regulating the Key Oncogene, N-myc.

Pharmacol Res 2021 Sep 15:105889. Epub 2021 Sep 15.

Centre for Cancer Cell Biology and Drug Discovery, Griffith Institute for Drug Discovery, Griffith University, Nathan, Brisbane, Queensland, 4111, Australia; Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan. Electronic address:

Iron is an indispensable requirement for essential biological processes in cancer cells. Due to the greater proliferation of neoplastic cells, their demand for iron is considerably higher relative to normal cells, making them highly susceptible to iron depletion. Understanding this sensitive relationship led to research exploring the effect of iron chelation therapy for cancer treatment. Read More

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September 2021

Antimycobacterial activity of acetone extract and isolated metabolites from folklore medicinal lichen Usnea laevis Nyl. against drug-sensitive and multidrug-resistant tuberculosis strains.

J Ethnopharmacol 2021 Sep 15;282:114641. Epub 2021 Sep 15.

UCB Pharma S.A., Allée de la Recherche 60, 1070, Brussels, Belgium; Pharmaceutical Sciences Department, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, 530003, Andhra Pradesh, India. Electronic address:

Ethnopharmacological Relevance: Tuberculosis (Tb) is one of the most infectious diseases caused by Mycobacterium tuberculosis (M.t) with almost 2 million deaths yearly. Although many Tb control programs have been organised, there is an elevated number of Tb cases due to the appearance of extremely drug-resistant and multidrug-resistant (MDR) Tb strains. Read More

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September 2021

Eye-preserving therapies for advanced retinoblastoma: a multicenter cohort of 1678 patients in China.

Ophthalmology 2021 Sep 15. Epub 2021 Sep 15.

Department of Ophthalmology, Hainan Eye Hospital and Key laboratory of ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University.

Purpose: Multiple eye-preserving treatments have been widely used in China for the last 15 years, however, controversy remains on using eye-preserving therapies for advanced retinoblastoma (The International Intraocular Retinoblastoma Classification: groups D and E). This study attempts to estimate the impact of eye-preserving therapies for the long-term prognosis of advanced retinoblastoma with regard to overall survival and ocular salvage.

Design: A retrospective cohort study covering all 31 provinces (38 retinoblastoma treating centers) of Chinese mainland. Read More

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September 2021

Better together: Cross-tolerance induced by warm acclimation and nitrate exposure improved the aerobic capacity and stress tolerance of common carp Cyprinus carpio.

Ecotoxicol Environ Saf 2021 Sep 14;225:112777. Epub 2021 Sep 14.

University of Antwerp, Department of Biology, Systemic Physiological and Ecotoxicological Research (SPHERE), Groenenborgerlaan 171, 2020 Antwerp, Belgium.

Climate warming is a threat of imminent concern that may exacerbate the impact of nitrate pollution on fish fitness. These stressors can individually affect the aerobic capacity and stress tolerance of fish. In combination, they may interact in unexpected ways where exposure to one stressor may heighten or reduce the resilience to another stressor and their interactive effects may not be uniform across species. Read More

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September 2021

Screening and verification of CYP3A4 inhibitors from Bushen-Yizhi formula to enhance the bioavailability of osthole in rat plasma.

J Ethnopharmacol 2021 Sep 14;282:114643. Epub 2021 Sep 14.

Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China; Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. Electronic address:

Ethnopharmacological Relevance: With the features of multiple-components and targets as well as multifunction, traditional Chinese medicine (TCM) has been widely used in the prevention and treatment of various diseases for a long time. During the application of TCM, the researches about bioavailability enhancement of the bioactive constituents in formula are flourishing. Bushen-Yizhi formula (BSYZ), a TCM prescription with osthole (OST) as one of the main bioactive ingredients, have been widely used to treat kidney deficiency, mental retardation and Alzheimer's disease. Read More

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September 2021

A Clinico-radiographic comparative evaluation of 1% Metformin gel plus Platelet Rich Fibrin over Platelet Rich Fibrin alone in Treatment of Grade II Furcation Defects: A Randomized Controlled Double-blind Clinical Trial.

J Periodontol 2021 Sep 17. Epub 2021 Sep 17.

Department of Periodontics & Implantology, VSPM Dental College and Research Centre, Nagpur, India.

Background: The present study was aimed to evaluate and compare the effects of 1%MF plus PRF over PRF alone in treatment of Grade II furcation defects, clinically and radiographically by using CBCT.

Material And Methods: This split-mouth clinical trial randomly allotted 21 patients with 42 bilateral Grade II furcation defects into two groups. Group I was treated with PRF alone while Group II with 1%MF gel and PRF. Read More

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September 2021

Achieving Enhanced Photochromic Property of Diarylethene Through Host-Guest Interaction in Aqueous Solution.

Chemistry 2021 Sep 17. Epub 2021 Sep 17.

Wuhan University of Science and Technology, School of Chemistry and Chemical Engineering, 947# Heping Road, 430081, Wuhan, CHINA.

Diarylethene (DTE) has been widely used in fluorescence probes, molecular logic gates, optical data-storage devices owing to the excellent photochromic property, while constructing high-performance photochromic DTE in aqueous media remains a big challenge. Herein we present several host-guest systems formed between cucurbit[ n ]uril (CB[ n ], n = 7, 8, 10) and two water-soluble DTE derivatives 1 and 2 . It was found that host-guest interactions not only affect the photophysical properties of photochromic guests, also make great differences on the photoreaction process. Read More

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September 2021

Cetuximab-AgS quantum dots for fluorescence imaging and highly effective combination of ALA-based photodynamic/chemo-therapy of colorectal cancer cells.

Nanoscale 2021 Sep 17;13(35):14879-14899. Epub 2021 Sep 17.

Koc University, Graduate School of Materials Science and Engineering, Rumelifeneri Yolu, Sariyer, 34450, Istanbul, Turkey.

Colorectal cancer (CRC) has a poor prognosis and urgently needs better therapeutic approaches. 5-Aminolevulinic acid (ALA) induced protoporphyrin IX (PpIX) based photodynamic therapy (PDT) is already used in the clinic for several cancers but not yet well investigated for CRC. Currently, systemic administration of ALA offers a limited degree of tumour selectivity, except for intracranial tumours, limiting its wider use in the clinic. Read More

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September 2021

Clinical diagnosis and treatment of breast cancer with brain metastases and establishment of a prognostic model: a 10-year, single-center, real-world study of 559 cases.

Ann Transl Med 2021 Aug;9(16):1331

Department of Breast Disease, Henan Breast Cancer Center, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China.

Background: This study involved a retrospective analysis of 559 metastatic breast cancer (MBC) patients with brain metastasis (BM). We aimed to establish the effectiveness of different preferred treatment methods and factors affecting overall survival following BM diagnosis (BMOS) and explore the feasibility of systemic treatment for MBC patients with BM.

Methods: Univariate and multivariate analyses were used to assess the efficacy of different preferred treatments and other factors associated with BMOS, and a nomogram was then established based on the results of the univariate analysis. Read More

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Genetic diversity and structure of one of the most endangered freshwater fish species in Mexico: (Miller, 1950) and recognition of its evolutionarily significant units.

PeerJ 2021 27;9:e11952. Epub 2021 Aug 27.

Colección Nacional de Peces, Departamento de Zoología. Instituto de Biología, Ciudad de México, Mexico.

The endangered Chiapas killifish is an endemic freshwater species that lives in four subbasins of the Grijalva and Usumacinta basins, and one of the most geographically restricted species of the Produndulidae family. The species was originally described as endemic to springs in the high limestone plateau in San Cristóbal de Las Casas in the Río Amarillo subbasin (upper Grijalva basin). However, it was recently recorded in the Jataté and Tzaconejá subbasins in the upper Usumacinta basin, thereby expanding its known distribution range. Read More

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Hemodynamic Responses in Carotid Bifurcation Induced by Enhanced External Counterpulsation Stimulation in Healthy Controls and Patients With Neurological Disorders.

Front Physiol 2021 31;12:717080. Epub 2021 Aug 31.

Department of Cardiology, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, China.

Enhanced external counterpulsation is a Food and Drug Administration-approved, non-invasive, assisted circulation therapy for ischemic cardiovascular and cerebrovascular diseases. Previous studies have confirmed that EECP stimulation induces largely different cerebral hemodynamic responses in patients with ischemic stroke and healthy controls. However, the underlying mechanisms remain uncertain. Read More

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Clinical characteristics of non-radiographic versus radiographic axial spondyloarthritis in Asia and non-radiographic axial spondyloarthritis in other regions: results of the cross-sectional ASAS-COMOSPA study.

RMD Open 2021 09;7(3)

Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.

Objectives: To delineate characteristics of non-radiographic axial spondyloarthritis (nr-axSpA) in Asia versus non-Asian regions, and compare radiographic axSpA (r-axSpA) with nr-axSpA within Asia.

Methods: Data were collected from the Assessment of SpondyloArthritis international Society-COMOrbidities in SPondyloArthritis database. Categorising patients by region, we compared clinical characteristics between nr-axSpA from Asia vs elsewhere (Europe, the Americas and Africa). Read More

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September 2021

Protective effects of hesperidin through attenuation of Ki67 expression against DMBA-induced breast cancer in female rats.

Life Sci 2021 Sep 14;285:119957. Epub 2021 Sep 14.

Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India. Electronic address:

Aims: Doxorubicin (Dox) is routinely used for breast cancer treatment but toxicity and drug resistance limit its use. The objective of the study was to investigate the protective effects of hesperidin alone and in combination with doxorubicin against experimentally induced breast cancer in female rats.

Methods: Breast cancer (BC) was induced by administration of 7,12-dimethylbenz(a)anthracene (DMBA) through subcutaneous injection into the 3rd right mammary gland of female Wistar rats. Read More

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September 2021