22,714 results match your criteria exhibit multiple


Dysregulation of Non-coding RNAs mediates Cisplatin Resistance in Hepatocellular Carcinoma and therapeutic strategies.

Pharmacol Res 2021 Sep 17:105906. Epub 2021 Sep 17.

Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui Provincial Hospital, Hefei, Anhui, 230001, P.R. China. Electronic address:

Hepatocellular carcinoma (HCC) is the fourth major contributor to cancer-related deaths worldwide, and patients mostly have poor prognosis. Although several drugs have been approved for the treatment of HCC, cisplatin (CDDP) is still applied in treatment of HCC as a classical chemotherapeutic drug. Unfortunately, the emergence of CDDP resistance has caused HCC patients to exhibit poor drug response. Read More

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September 2021

Application in Anticounterfeiting for Multistimuli Smart Luminescent Materials Based on MOF-on-MOF.

Inorg Chem 2021 Sep 20. Epub 2021 Sep 20.

Department of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo, Henan 454000, P. R. China.

The generation of smart responsive materials that can perform multiple drastic optical outputs upon different triggers provides a good platform to encode and hide the information and create multilevel security. In this paper, a smart multiresponsive MOF-on-MOF material was reported using one MOF () as a platform to grow on the outer layer, combining different emitter centers such as anthracene (ANT) and lanthanide ions (Ln) confined into two MOFs. Due to the existence of ANT in the pores of , this composite material can exhibit reversible photoswitching behavior under a 365 nm ultraviolet (UV) lamp and enable "resetting and reusing" dynamic anticounterfeiting application. Read More

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September 2021

Monitoring of Glucose Using Ultrasound-Induced Resonance in Implantable Smart Hydrogel Microstructures.

ACS Sens 2021 Sep 20. Epub 2021 Sep 20.

Departments of Electrical and Computer Engineering, Materials Science & Engineering, and Biomedical Engineering, University of Utah, Salt Lake City, Utah 84112, United States.

A novel glucose sensor is presented using smart hydrogels as biocompatible implantable sensing elements, which eliminates the need for implanted electronics and uses an external medical-grade ultrasound transducer for readout. The readout mechanism uses resonance absorption of ultrasound waves in glucose-sensitive hydrogels. glucose concentration changes in the interstitial fluid lead to swelling or deswelling of the gels, which changes the resonance behavior. Read More

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September 2021

Responsive Dual-Targeting Exosome as a Drug Carrier for Combination Cancer Immunotherapy.

Research (Wash D C) 2021 31;2021:9862876. Epub 2021 Aug 31.

College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, China.

Recently, combination immunotherapy, which incorporates the activation of the immune system and inhibition of immune escape, has been proved to be a new powerful strategy for more efficient tumor suppression compared to monotherapy. However, the major challenge is how to integrate multiple immune drugs together and efficiently convey these drugs to tumor sites. Although a variety of nanomaterials have been exploited as carriers for targeting tumor issues and the delivery of multiple drugs, their potential toxicity, immune rejection, and stability are still controversial for clinical application. Read More

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End-Stage Renal Disease-Related Accelerated Immune Senescence: Is Rejuvenation of the Immune System a Therapeutic Goal?

Front Med (Lausanne) 2021 3;8:720402. Epub 2021 Sep 3.

Inserm, UMR1098, Federation Hospitalo-Universitaire INCREASE, Besançon, France.

End-stage renal disease (ESRD) patients exhibit clinical features of premature ageing, including frailty, cardiovascular disease, and muscle wasting. Accelerated ageing also concerns the immune system. Patients with ESRD have both immune senescence and chronic inflammation that are resumed in the so-called inflammaging syndrome. Read More

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September 2021

Congenital Disorders of Deficiency in Glycosaminoglycan Biosynthesis.

Front Genet 2021 3;12:717535. Epub 2021 Sep 3.

Department of Pathobiochemistry, Faculty of Pharmacy, Meijo University, Nagoya, Japan.

Glycosaminoglycans (GAGs) including chondroitin sulfate, dermatan sulfate, and heparan sulfate are covalently attached to specific core proteins to form proteoglycans, which are distributed at the cell surface as well as in the extracellular matrix. Proteoglycans and GAGs have been demonstrated to exhibit a variety of physiological functions such as construction of the extracellular matrix, tissue development, and cell signaling through interactions with extracellular matrix components, morphogens, cytokines, and growth factors. Not only connective tissue disorders including skeletal dysplasia, chondrodysplasia, multiple exostoses, and Ehlers-Danlos syndrome, but also heart and kidney defects, immune deficiencies, and neurological abnormalities have been shown to be caused by defects in GAGs as well as core proteins of proteoglycans. Read More

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September 2021

Genetic inference of the mating system of free-ranging domestic dogs.

Behav Ecol 2021 Jul-Aug;32(4):646-656. Epub 2021 Apr 2.

Museum and Institute of Zoology, Polish Academy of Sciences, ul. Nadwiślańska 108, 80-680 Gdańsk, Poland.

Domestication has greatly changed the social and reproductive behavior of dogs relative to that of wild members of the genus which typically exhibit social monogamy and extended parental care. Unlike a typical gray wolf pack that consists of a single breeding pair and their offspring from multiple seasons, a group of free-ranging dogs (FRDs) can include multiple breeding individuals of both sexes. To understand the consequences of this shift in reproductive behavior, we reconstructed the genetic pedigree of an FRD population and assessed the kinship patterns in social groups, based on genome-wide single-nucleotide polymorphism genotypes. Read More

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Trapped ion mobility spectrometry time-of-flight mass spectrometry for high throughput and high resolution characterization of human milk oligosaccharide isomers.

Anal Chim Acta 2021 Oct 26;1180:338878. Epub 2021 Jul 26.

Sorbonne Université, Faculté des Sciences et de l'Ingénierie, Institut Parisien de Chimie Moléculaire (IPCM), 75005, Paris, France. Electronic address:

The microbiome and immune system of infants are shaped by various bioactive components of human breastmilk, notably human milk oligosaccharides (HMOs). HMOs represent the third component of breastmilk and exhibit extremely high structural diversity with many isomers. Here, we propose a high throughput and high resolution approach to characterize main oligosaccharides present in breastmilk with high identification level thanks to ion mobility spectrometry. Read More

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October 2021

Impact of Injection Frequency of Adipose-Derived Stem Cells on Allogeneic Skin Graft Survival Outcomes in Mice.

Cell Transplant 2021 Jan-Dec;30:9636897211041966

Department of Plastic and Reconstructive Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.

Previous studies indicated that mesenchymal stem cells (MSCs) exhibit immunomodulatory properties in composite tissue allotransplantation. However, due to the high immunogenicity of skin, although the single administration of MSCs improves survival of the skin allotransplant, immune rejection is still inevitable. The aim of our study was to evaluate whether multiple administrations of MSCs would improve immune tolerance in the allogeneic skin graft, compared to that with a single administration in a mouse model. Read More

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September 2021

Icariin attenuates bleomycin-induced pulmonary fibrosis by targeting Hippo/YAP pathway.

Biomed Pharmacother 2021 Sep 15;143:112152. Epub 2021 Sep 15.

Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China; Institutes of Integrative Medicine, Fudan University, Shanghai, China. Electronic address:

Pulmonary fibrosis is a manifestation of the progression of interstitial pulmonary disease. Icariin (ICA) has been found to exhibit protective effects on multiple chronic diseases like diabetes, liver, heart, and renal fibrosis. Here, a systemic pharmacological study was designed to investigate whether ICA treatment alleviates bleomycin (BLM)-induced pulmonary fibrosis. Read More

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September 2021

Baculovirus infection affects caterpillar chemoperception.

Insect Biochem Mol Biol 2021 Sep 15:103648. Epub 2021 Sep 15.

Department of Genetics, Instituto de Biotecnología i Biomedicina (ERI-BIOTECMED), Universitat de València, 46100, Burjassot (Valencia), Spain. Electronic address:

Baculoviruses are double-stranded DNA entomopathogenic viruses that infect predominantly insects of the order Lepidoptera. Research in the last decade has started to disentangle the mechanisms underlying the insect-virus interaction, particularly focusing on the effects of the baculovirus infection in the host's physiology. Among crucial physiological functions, olfaction has a key role in reproductive tasks, food source detection and enemy avoidance. Read More

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September 2021

Prevalence and multilocus sequence typing of Clostridium perfringens isolated from retail chicken products and diseased chickens in Tai'an region, China.

Vet Med Sci 2021 Sep 18. Epub 2021 Sep 18.

Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Tai'an, Shandong Agricultural University, China.

Background: Clostridium perfringens is an important zoonotic microorganism, which can cause diseases in animals and humans under suitable conditions. Contamination of C. perfringens in chicken products has been reported worldwide, but the genetic diversity and relationship of isolates were seldom analyzed. Read More

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September 2021

Aromatase and non-aromatase neurons in the zebra finch secondary auditory forebrain are indistinct in their song-driven gene induction and intrinsic electrophysiological properties.

Eur J Neurosci 2021 Sep 17. Epub 2021 Sep 17.

Center for Neuroendocrine Studies, University of Massachusetts, Amherst, MA.

Estrogens support major brain functions including cognition, reproduction, neuroprotection, and sensory processing. Neuroestrogens are synthesized within some brain areas by the enzyme aromatase and can rapidly modulate local circuit functions, yet the cellular physiology and sensory-response profiles of aromatase neurons are essentially unknown. In songbirds, social and acoustic stimuli drive neuroestrogen elevations in the auditory forebrain caudomedial nidopallium (NCM). Read More

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September 2021

The hedgehog signaling pathway is expressed in the adult mouse hypothalamus and modulated by fasting.

eNeuro 2021 Sep 16. Epub 2021 Sep 16.

Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202 USA

The hedgehog signaling pathway is best known for its role in developmental patterning of the neural tube and limb bud. More recently, hedgehog signaling has been recognized for its roles in growth of adult tissues and maintenance of progenitor cell niches. However, the role of hedgehog signaling in fully differentiated cells like neurons in the adult brain is less clear. Read More

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September 2021

Developmental Changes in Gaze Behavior and the Effects of Auditory Emotion Word Priming in Emotional Face Categorization.

Multisens Res 2021 Sep 16:1-21. Epub 2021 Sep 16.

Department of Developmental Psychology, Justus-Liebig-Universität Gießen, 35394 Giessen, Germany.

Social interactions often require the simultaneous processing of emotions from facial expressions and speech. However, the development of the gaze behavior used for emotion recognition, and the effects of speech perception on the visual encoding of facial expressions is less understood. We therefore conducted a word-primed face categorization experiment, where participants from multiple age groups (six-year-olds, 12-year-olds, and adults) categorized target facial expressions as positive or negative after priming with valence-congruent or -incongruent auditory emotion words, or no words at all. Read More

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September 2021

Application of MXenes for water treatment and energy-efficient desalination: A review.

J Hazard Mater 2021 Aug 29;423(Pt B):127050. Epub 2021 Aug 29.

Nano Surface Texturing Lab, Department of Metallurgical and Materials Engineering, Defence Institute of Advanced Technology (DU), Pune, India. Electronic address:

MXenes are a new type of two-dimensional (2D) material which are rapidly gaining traction for a range of environmental, chemical and medical applications. MXenes and MXene-composites exhibit high surface area, superlative chemical stability, thermal conductivity, hydrophilicity and are environmentally compatible. Consequently, MXenes have been successfully employed for hydrogen storage, semiconductor manufacture and lithium ion batteries. Read More

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Common tumor-suppressive signaling of thyroid hormone receptor beta in breast and thyroid cancer cells.

Mol Carcinog 2021 Sep 17. Epub 2021 Sep 17.

Department of Pharmacology, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.

The thyroid hormone receptor beta (TRβ) is a tumor suppressor in multiple types of solid tumors, most prominently in breast and thyroid cancer. An increased understanding of the molecular mechanisms by which TRβ abrogates tumorigenesis will aid in understanding the core tumor-suppressive functions of TRβ. Here, we restored TRβ expression in the MDA-MB-468 basal-like breast cancer cell line and perform RNA-sequencing to determine the TRβ-mediated changes in gene expression and associated signaling pathways. Read More

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September 2021

Faster rates of molecular sequence evolution in reproduction-related genes and in species with hypodermic sperm morphologies.

Mol Biol Evol 2021 Sep 17. Epub 2021 Sep 17.

University of Basel, Department of Environmental Sciences, Zoological Institute, Vesalgasse 1, 4051 Basel, Switzerland.

Sexual selection drives the evolution of many striking behaviours and morphologies, and should leave signatures of selection at loci underlying these phenotypes. However, while loci thought to be under sexual selection often evolve rapidly, few studies have contrasted rates of molecular sequence evolution at such loci across lineages with different sexual selection contexts. Furthermore, work has focused on separate sexed animals, neglecting alternative sexual systems. Read More

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September 2021

Identification of the Ferroptosis-Associated Gene Signature to Predict the Prognostic Status of Endometrial Carcinoma Patients.

Comput Math Methods Med 2021 7;2021:9954370. Epub 2021 Sep 7.

Department of Obstetrics and Gynecology, Putuo People's Hospital, Tongji University School of Medicine, Shanghai, China.

Endometrial carcinoma (EC) is one of the most common gynecological carcinomas. As previously described, ferroptosis was reported to exhibit a significant association with the development of malignant neoplasms. Nevertheless, there are few studies towards the association between the implication of ferroptosis-related genes (FRGs) and the prognostic status of patients with EC. Read More

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September 2021

Modulation of Glial Function in Health, Aging, and Neurodegenerative Disease.

Front Cell Neurosci 2021 31;15:718324. Epub 2021 Aug 31.

Neuroscience Training Program, University of Wisconsin, Madison, WI, United States.

In the central nervous system (CNS), glial cells, such as microglia and astrocytes, are normally associated with support roles including contributions to energy metabolism, synaptic plasticity, and ion homeostasis. In addition to providing support for neurons, microglia and astrocytes function as the resident immune cells in the brain. The glial function is impacted by multiple aspects including aging and local CNS changes caused by neurodegeneration. Read More

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Neuro-immune signatures in chronic low back pain subtypes.

Brain 2021 Sep 16. Epub 2021 Sep 16.

Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.

We recently showed that patients with different chronic pain conditions (such as chronic low back pain, fibromyalgia, migraine, and Gulf War Illness) demonstrated elevated brain and/or spinal cord levels of the glial marker 18 kDa translocator protein, which suggests that neuroinflammation might be a pervasive phenomenon observable across multiple etiologically heterogeneous pain disorders. Interestingly, the spatial distribution of this neuroinflammatory signal appears to exhibit a degree of disease specificity (e.g. Read More

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September 2021

Functionally diverse heteromeric traps for ligands of the transforming growth factor-β superfamily.

Sci Rep 2021 Sep 15;11(1):18341. Epub 2021 Sep 15.

Acceleron Pharma, Cambridge, MA, USA.

Ligands of the transforming growth factor-β (TGF-β) superfamily are important targets for therapeutic intervention but present challenges because they signal combinatorially and exhibit overlapping activities in vivo. To obtain agents capable of sequestering multiple TGF-β superfamily ligands with novel selectivity, we generated soluble, heterodimeric ligand traps by pairing the extracellular domain (ECD) of the native activin receptor type IIB (ActRIIB) alternately with the ECDs of native type I receptors activin receptor-like kinase 4 (ALK4), ALK7, or ALK3. Systematic analysis of these heterodimeric constructs by surface plasmon resonance, and comparison with their homodimeric counterparts, revealed that each type I receptor partner confers a distinct ligand-binding profile to the heterodimeric construct. Read More

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September 2021

Insights into the evolutionary origin of the pineal color discrimination mechanism from the river lamprey.

BMC Biol 2021 Sep 16;19(1):188. Epub 2021 Sep 16.

Department of Biology and Geosciences, Graduate School of Science, Osaka City University, Osaka, 558-8585, Japan.

Background: Pineal-related organs in cyclostomes, teleosts, amphibians, and reptiles exhibit color opponency, generating antagonistic neural responses to different wavelengths of light and thereby sensory information about its "color". Our previous studies suggested that in zebrafish and iguana pineal-related organs, a single photoreceptor cell expressing both UV-sensitive parapinopsin and green-sensitive parietopsin generates color opponency in a "one-cell system." However, it remains unknown to what degree these opsins and the single cell-based mechanism in the pineal color opponency are conserved throughout non-mammalian vertebrates. Read More

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September 2021

Development of non-transgenic glyphosate tolerant wheat by TILLING.

PLoS One 2021 15;16(9):e0245802. Epub 2021 Sep 15.

Arcadia Biosciences, Davis, California, United States of America.

Glyphosate (N-phosphonomethyl-glycine) is the world's most widely used broad spectrum, post-emergence herbicide. It inhibits the chloroplast-targeted enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS; EC 2.5. Read More

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September 2021

Infrared rainbow trapping via optical Tamm modes in an one-dimensional dielectric chirped photonic crystals.

Opt Lett 2021 Sep;46(18):4566-4569

The phenomenon of trapping a broad spectrum of light is known as "rainbow trapping" and is achieved by using all-dielectric, hybrid metallo-dielectric, or all-metallic configurations. The latter architectures allow strong confinement but exhibit very high ohmic losses. This results in practical lifetimes of trapped modes to less than 1 ps. Read More

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September 2021

Parallel evolution of morphological traits and body shape in littoral and pelagic brook charr, Salvelinus fontinalis, along a gradient of interspecific competition.

Oecologia 2021 Sep 15. Epub 2021 Sep 15.

Research Centre for Watershed-Aquatic Ecosystem Interactions, Université du Québec à Trois-Rivières, C. P. 500, Trois-Rivières, QC, G9A 5H7, Canada.

The parallel evolution of similar ecotypes in response to comparable environmental conditions is believed to reveal the importance of divergent selection in phenotypic diversifying processes. Systems characterized by the presence of multiple replicate populations expressing resource polymorphism thus provide an ideal opportunity to address the occurrence and factors affecting the parallel evolution of ecotypes. Previous studies have shown that brook charr (Salvelinus fontinalis) exhibit resource polymorphism in some Canadian Shield lakes, where a littoral ecotype feeds mainly on zoobenthos and a pelagic ecotype feeds mostly on zooplankton. Read More

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September 2021

Light-driven photoswitching of quinazoline analogues of combretastatin A-4 as an effective approach for targeting skin cancer cells.

Org Biomol Chem 2021 Sep 15;19(35):7670-7677. Epub 2021 Sep 15.

N. D. Zelinsky Institute of Organic Chemistry, RAS, Moscow, Russian Federation.

A novel quinazoline series of photoswitchable combretastatin A-4 (CA-4) analogues were synthesized and their photochemical properties and antiproliferative activity against A431 epidermoid carcinoma cells were studied. It was found that quinazoline analogues, in contrast to the majority of the known CA-4, exhibit high antiproliferative activity in the -form as well. Photoswitching of the -form to the -form resulted in a multiple (9-fold) increase in antiproliferative activity. Read More

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September 2021

Coarse-grained simulations of ionic liquid materials: from monomeric ionic liquids to ionic liquid crystals and polymeric ionic liquids.

Phys Chem Chem Phys 2021 Sep 15;23(35):19435-19456. Epub 2021 Sep 15.

Department of Materials and Environmental Chemistry, Arrhenius Laboratory, Stockholm University, SE-10691 Stockholm, Sweden.

Ionic liquid (IL) materials are promising electrolytes with striking physicochemical properties for energy and environmental applications. Heterogeneous structures and transport quantities of monomeric and polymeric ILs are intrinsically intercorrelated and span multiple spatiotemporal scales, which is more feasible for coarse-grained (CG) simulations than atomistic modelling. Herein we constructed a novel CG model for ethyl-imidazolium tetrafluoroborate ILs with varied cation alkyl chains ranging from C to C, and the interaction parameters were validated against representative static and dynamic properties that were obtained from atomistic reference simulations and experimental characterizations at relevant thermodynamic states. Read More

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September 2021

Characterization of recombinant murine GDE4 and GDE7, enzymes producing lysophosphatidic acid and/or cyclic phosphatidic acid.

J Biochem 2021 Sep 15. Epub 2021 Sep 15.

Department of Biochemistry, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan.

GDE4 and GDE7 are membrane-bound enzymes that exhibit lysophospholipase D (lysoPLD) activities. We found that GDE7 produced not only lysophosphatidic acid (LPA) but also cyclic phosphatidic acid (cPA) from lysophospholipids by a transphosphatidylation reaction. In contrast, GDE4 produced only LPA. Read More

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September 2021

Contrasting sources and fate of nitrogen compounds in different groundwater systems in the Central Yangtze River Basin.

Environ Pollut 2021 Sep 6;290:118119. Epub 2021 Sep 6.

State Environmental Protection Key Laboratory of Source Apportionment and Control of Aquatic Pollution, Hubei Key Laboratory of Yangtze Catchment Environmental Aquatic Science, China University of Geosciences, Wuhan, 430078, China; School of Environmental Studies, State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan, 430078, China.

Although groundwater nitrogen pollution has been widely studied, the control of hydrogeological conditions on behavior of nitrogen compounds has been poorly understood. In this study, multiple stable isotopes (N/C/H/O), spectral characteristics of DOM coupled with water chemistry were used to reveal the sources and fate of nitrate and ammonium in three subareas with different hydrogeological conditions in the Central Yangtze River Basin. We identified three contrasting patterns of nitrogen sources and fate in groundwater controlled by different aquifer features. Read More

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September 2021