50,250 results match your criteria exhibit increased


MUC5AC serves as the nexus for β-catenin/c-Myc interplay to promote glutamine dependency during pancreatic cancer chemoresistance.

Gastroenterology 2021 Sep 14. Epub 2021 Sep 14.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center; Fred and Pamela Buffett Cancer Center, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA.. Electronic address:

Background And Aims: A major clinical challenge for pancreatic cancer (PC) patients is metabolic adaptation. Neoplastic cells harboring molecular perturbations suffice for their increased anabolic demand and nucleotide biosynthesis to acquire chemoresistance. The mucin 5AC expressed de novo in malignant pancreas promotes cancer cell stemness and is significantly associated with poor patient survival. Read More

View Article and Full-Text PDF
September 2021

Common tumor-suppressive signaling of thyroid hormone receptor beta in breast and thyroid cancer cells.

Mol Carcinog 2021 Sep 17. Epub 2021 Sep 17.

Department of Pharmacology, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.

The thyroid hormone receptor beta (TRβ) is a tumor suppressor in multiple types of solid tumors, most prominently in breast and thyroid cancer. An increased understanding of the molecular mechanisms by which TRβ abrogates tumorigenesis will aid in understanding the core tumor-suppressive functions of TRβ. Here, we restored TRβ expression in the MDA-MB-468 basal-like breast cancer cell line and perform RNA-sequencing to determine the TRβ-mediated changes in gene expression and associated signaling pathways. Read More

View Article and Full-Text PDF
September 2021

Dynamical Phase Transitions in Quantum Reservoir Computing.

Phys Rev Lett 2021 Sep;127(10):100502

Instituto de Física Interdisciplinar y Sistemas Complejos (IFISC, UIB-CSIC), Campus Universitat de les Illes Balears, E-07122 Palma de Mallorca, Spain.

Closed quantum systems exhibit different dynamical regimes, like many-body localization or thermalization, which determine the mechanisms of spread and processing of information. Here we address the impact of these dynamical phases in quantum reservoir computing, an unconventional computing paradigm recently extended into the quantum regime that exploits dynamical systems to solve nonlinear and temporal tasks. We establish that the thermal phase is naturally adapted to the requirements of quantum reservoir computing and report an increased performance at the thermalization transition for the studied tasks. Read More

View Article and Full-Text PDF
September 2021

Assessing Membrane Fluidity and Visualizing Fluid Membrane Domains in Bacteria Using Fluorescent Membrane Dyes.

Bio Protoc 2018 Oct 20;8(20):e3063. Epub 2018 Oct 20.

Bacterial Cell Biology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands.

Membrane fluidity is a key parameter of bacterial membranes that undergoes quick adaptation in response to environmental challenges and has recently emerged as an important factor in the antibacterial mechanism of membrane-targeting antibiotics. The specific level of membrane fluidity is not uniform across the bacterial cell membrane. Rather, specialized microdomains associated with different cellular functions can exhibit fluidity values that significantly deviate from the average. Read More

View Article and Full-Text PDF
October 2018

ω3PUFAs improve hepatic steatosis in postnatal overfed rats and HepG2 cells by inhibiting acetyl-CoA carboxylase.

Food Sci Nutr 2021 Sep 22;9(9):5153-5165. Epub 2021 Jul 22.

Department of Child Health Care Children's Hospital of Nanjing Medical University Nanjing China.

Postnatal overfeeding can lead to persistent increases in hepatic lipid synthesis and the risk of nonalcoholic fatty liver disease (NAFLD) in adulthood. The ω3 polyunsaturated fatty acids (ω3PUFAs) exhibit beneficial effects on NAFLD. Here, we employed a rat model and an in vitro HepG2 cell model to investigate whether fish oil (FO) affects hepatic lipid synthesis due to postnatal overfeeding. Read More

View Article and Full-Text PDF
September 2021

Sitagliptin Reduces Endothelial Dysfunction and Apoptosis Induced by High-Fat Diet and Palmitate in Thoracic Aortas and Endothelial Cells via ROS-ER Stress-CHOP Pathway.

Front Pharmacol 2021 31;12:670389. Epub 2021 Aug 31.

Department of Biochemistry and Molecular Biology, Hefei, China.

Macrovascular disease is tightly associated with obesity-induced metabolic syndrome. Sitagliptin (SIT), an orally stable selective inhibitor of Dipeptidyl peptidase-4 (DPP-4), has protective effects on endothelium. However, the mechanisms enabling SIT to exhibit resistance to diet-induced obesity (DIO) related with reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress in the aorta and endothelial cells have not been reported yet. Read More

View Article and Full-Text PDF

Conventional measures of intrinsic excitability are poor estimators of neuronal activity under realistic synaptic inputs.

PLoS Comput Biol 2021 Sep 16;17(9):e1009378. Epub 2021 Sep 16.

Neuronal Cell Biology Research Group, Eötvös Loránd University, Budapest, Hungary.

Activity-dependent regulation of intrinsic excitability has been shown to greatly contribute to the overall plasticity of neuronal circuits. Such neuroadaptations are commonly investigated in patch clamp experiments using current step stimulation and the resulting input-output functions are analyzed to quantify alterations in intrinsic excitability. However, it is rarely addressed, how such changes translate to the function of neurons when they operate under natural synaptic inputs. Read More

View Article and Full-Text PDF
September 2021

Perturbation-based balance assessment: Examining reactive balance control in older adults with mild cognitive impairments.

Physiol Int 2021 Sep 16. Epub 2021 Sep 16.

Department of Physical Therapy, The University of Illinois at Chicago, Chicago, Illinois, USA.

Background: Older adults with mild cognitive impairment (OAwMCI) present subtle balance and gait deficits along with subjective memory decline. Although these presentations might not affect activities of daily living (ADLs), they attribute to a two-folded increase in falls. While changes occurring in volitional balance control during ADLs have been extensively examined among OAwMCI, reactive balance control, required to recover from external perturbations, has received little attention. Read More

View Article and Full-Text PDF
September 2021

The Mystery of Energy Compensation.

Authors:
Lewis G Halsey

Physiol Biochem Zool 2021 Nov-Dec;94(6):380-393

AbstractThe received wisdom on how activity affects energy expenditure is that the more activity is undertaken, the more calories will have been burned by the end of the day. Yet traditional hunter-gatherers, who lead physically hard lives, burn no more calories each day than Western populations living in labor-saving environments. Indeed, there is now a wealth of data, both for humans and other animals, demonstrating that long-term lifestyle changes involving increases in exercise or other physical activities do not result in commensurate increases in daily energy expenditure (DEE). Read More

View Article and Full-Text PDF
September 2021

A geometric morphometric assessment of shape variation in adult pelvic morphology.

Authors:
Samantha L Cox

Am J Phys Anthropol 2021 Sep 15. Epub 2021 Sep 15.

Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Objectives: In humans, the pelvis is the most sexually dimorphic skeletal element and is often utilized in aging and sexing remains. The pelvis has become greatly relied upon in anthropological research (e.g. Read More

View Article and Full-Text PDF
September 2021

Lead (Pb)-induced oxidative stress mediates sex-specific autistic-like behaviour in Drosophila melanogaster.

Mol Neurobiol 2021 Sep 15. Epub 2021 Sep 15.

Department of Zoology, School of Biological Sciences, Central University of Kerala, Tejaswini Hills, Periya, 671320, Kasaragod, India.

Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental disorder characterised by three main behavioural symptoms: abnormal social interaction, verbal and non-verbal communication impairments, and repetitive and restricted activities or interests. Even though the exact aetiology of ASD remains unknown, studies have shown a link between genetics and environmental pollutants. Heavy metal lead (Pb), the environmental pollutant, is associated with ASD. Read More

View Article and Full-Text PDF
September 2021

Clinical study of central cholinergic pathway damage in two mild cognitive impairment patients.

Neurol Sci 2021 Sep 16. Epub 2021 Sep 16.

Department of Neurology, Guihang Guiyang Hospital, Guiyang, Guizhou, China.

Objectives: To explore the role of the central cholinergic system in amnestic mild cognitive impairment (aMCI) and mild vascular cognitive impairment (vMCI).

Methods: Twenty-five aMCI patients and 25 vMCI patients were enrolled in this study, and 25 healthy people were chosen as a control group. All participants performed a set of cognitive function scales and were subjected to a brain MRI. Read More

View Article and Full-Text PDF
September 2021

Angiogenic Secretion Profile of Valvular Interstitial Cells Varies With Cellular Sex and Phenotype.

Front Cardiovasc Med 2021 30;8:736303. Epub 2021 Aug 30.

Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States.

Angiogenesis is a hallmark of fibrocalcific aortic valve disease (CAVD). An imbalance of pro- and anti-angiogenic factors is thought to play a role in driving this disease process, and valvular interstitial cells (VICs) may act as a significant source of these factors. CAVD is also known to exhibit sexual dimorphism in its presentation, and previous work suggested that VICs may exhibit cellular-scale sex differences in the context of angiogenesis. Read More

View Article and Full-Text PDF

Activation of β3-adrenoceptor increases the number of readily releasable glutamatergic vesicle via activating Ca/calmodulin/MLCK/myosin II pathway in the prefrontal cortex of juvenile rats.

Sci Rep 2021 Sep 15;11(1):18300. Epub 2021 Sep 15.

School of Life Science, Nanchang University, Nanchang, 330031, China.

It is well known that β3-adrenoceptor (β3-AR) in many brain structures including prefrontal cortex (PFC) is involved in stress-related behavioral changes. SR58611A, a brain-penetrant β3-AR subtypes agonist, is revealed to exhibit anxiolytic- and antidepressant-like effects. Whereas activation of β3-AR exerts beneficial effects on cognitive function, the underlying cellular and molecular mechanisms have not been fully determined. Read More

View Article and Full-Text PDF
September 2021

X-linked immunodeficient (XID) mice exhibit high susceptibility to Cryptococcus gattii infection.

Sci Rep 2021 Sep 15;11(1):18397. Epub 2021 Sep 15.

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-900, Brazil.

Cryptococcosis is an opportunistic disease caused by the fungus Cryptococcus neoformans and Cryptococcus gattii. It starts as a pulmonary infection that can spread to other organs, such as the brain, leading to the most serious occurrence of the disease, meningoencephalitis. The humoral response has already been described in limiting the progression of cryptococcosis where the B-1 cell seems to be responsible for producing natural IgM antibodies, crucial for combating fungal infections. Read More

View Article and Full-Text PDF
September 2021

Loss of Christianson Syndrome Na+/H+ Exchanger 6 () Causes Abnormal Endosome Maturation and Trafficking Underlying Lysosome Dysfunction in Neurons.

J Neurosci 2021 Sep 7. Epub 2021 Sep 7.

Department of Molecular Biology, Cell Biology and Biochemistry; and Carney Institute for Brain Science, Brown University, Laboratories for Molecular Medicine, 70 Ship Street, Providence, RI;

Loss-of-function mutations in endosomal Na/H exchanger 6 (NHE6) cause the X-linked neurologic disorder Christianson syndrome (CS). Patients exhibit symptoms associated with both neurodevelopmental and neurodegenerative abnormalities. While loss of NHE6 has been shown to over-acidify the endosome lumen, and is associated with endolysosome neuropathology, NHE6-mediated mechanisms in endosome trafficking and lysosome function have been understudied. Read More

View Article and Full-Text PDF
September 2021

Arginine vasopressin in the medial amygdala causes greater post-stress recruitment of hypothalamic vasopressin neurons.

Mol Brain 2021 Sep 15;14(1):141. Epub 2021 Sep 15.

School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore.

Arginine vasopressin (AVP) is expressed in both hypothalamic and extra-hypothalamic neurons. The expression and role of AVP exhibit remarkable divergence between these two neuronal populations. Polysynaptic pathways enable these neuronal groups to regulate each other. Read More

View Article and Full-Text PDF
September 2021

Urban proximity while breeding is not a predictor of perfluoroalkyl substance contamination in the eggs of brown pelicans.

Sci Total Environ 2021 Sep 4;803:150110. Epub 2021 Sep 4.

U.S. Geological Survey South Carolina Cooperative Fish and Wildlife Research Unit, Department of Forestry and Environmental Conservation, Clemson University, Clemson, SC 29634, USA.

Identifying sources of exposure to chemical stressors is difficult when both target organisms and stressors are highly mobile. While previous studies have demonstrated that populations of some organisms proximal to urban centers may display increased burdens of human-created chemicals compared to more distal populations, this relationship may not be universal when applied to organisms and stressors capable of transboundary movements. We examined eggs of brown pelicans (Pelecanus occidentalis), a nearshore seabird with daily movements ranging from local to 50 km and annual migrations ranging from year-round residency to 1500 km. Read More

View Article and Full-Text PDF
September 2021

MiR-200c-3p aggravates gastric cell carcinoma via KLF6.

Genes Genomics 2021 Sep 15. Epub 2021 Sep 15.

Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, Jiangsu Province, People's Republic of China.

Background: Gastric cell carcinoma (GCC) is a common and high-incidence malignant gastrointestinal cancer that seriously threatens human life and safety. Evidences suggest that microRNAs (miRNAs) exhibit an essential role in regulating the occurrence and development of GCC, while the effects and possible mechanisms remain to be further explored.

Objective: This study was designed to explore whether miR-200c-3p exerted its functional role in the growth and metastasis of GCC, and investigate the possible mechanisms. Read More

View Article and Full-Text PDF
September 2021

Stromal cell-derived factor (SDF)-1α and platelet-rich plasma enhance bone regeneration and angiogenesis simultaneously in situ in rabbit calvaria.

J Mater Sci Mater Med 2021 Sep 15;32(9):125. Epub 2021 Sep 15.

Department of Orthopedic Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, 150001, PR China.

The current study aimed to evaluate the effects of chemokine stromal cell-derived factor (SDF)-1α and platelet-rich plasma (PRP) on bone formation and angiogenesis, and to assess whether SDF-1α and PRP could function synergistically. Four evenly distributed defects (8 mm in diameter) were generated in the calvarial bones of New Zealand white rabbits. All rabbits received four treatment regimens containing autogenous bone particles (AB), SDF-1α, or PRP. Read More

View Article and Full-Text PDF
September 2021

2-Thiazolines: an update on synthetic methods and catalysis.

Org Biomol Chem 2021 Sep 15;19(35):7497-7517. Epub 2021 Sep 15.

Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán C.P. 04510, CdMx, Mexico.

2-Thiazolines are important building blocks in organic synthesis and are of great importance in many areas of chemistry. At the end of the last century, the use of 2-thiazolines increased in a significant way, especially in synthesis and catalysis. This review highlights the synthetic and catalytic value of 2-thiazolines in the last two decades. Read More

View Article and Full-Text PDF
September 2021

Flavonoids from Pall. fruits prevent high-fat diet-induced obesity and liver injury modulation of the gut microbiota in mice.

Food Funct 2021 Sep 15. Epub 2021 Sep 15.

College of Food and Bioengineering, South China University of Technology, Guangzhou, 510640, China.

Pall. (RDP) fruits are popularly consumed as beverages and healthy food in China because of their various beneficial activities. In particular, flavonoids are one of the major active ingredients of RDP fruits with predominant pharmacological effects. Read More

View Article and Full-Text PDF
September 2021

Amygdalar endocannabinoids are affected by predator odor stress in a sex-specific manner and modulate acoustic startle reactivity in female rats.

Neurobiol Stress 2021 Nov 3;15:100387. Epub 2021 Sep 3.

Department of Physiology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA.

Understanding sex differences in behavioral and molecular effects of stress has important implications for understanding the vulnerability to chronic psychiatric disorders associated with stress response circuitry. The amygdala is critical for emotional learning and generating behavioral responses to stressful stimuli, and preclinical studies indicate that amygdalar endocannabinoid (eCB) signaling regulates emotional states. This study measured eCB contents in the basolateral (BLA) and central (CeA) amygdala of male and female rats exposed to predator odor stress (bobcat urine) and tested for contextual avoidance 24 h later. Read More

View Article and Full-Text PDF
November 2021

Anti-neuroinflammatory activity of 6,7-dihydroxy-2,4-dimethoxy phenanthrene isolated from Dioscorea batatas Decne partly through suppressing the p38 MAPK/NF-κB pathway in BV2 microglial cells.

J Ethnopharmacol 2021 Sep 11:114633. Epub 2021 Sep 11.

Institute of Agricultural Science and Technology, Kyungpook National University, Daegu, 41566, South Korea; School of Food Science and Biotechnology, Kyungpook National University, Daegu, 41566, South Korea. Electronic address:

Ethnopharmacological Relevance: . The rhizome of Dioscorea batatas Decne (called Chinses yam) widely distributed in East Asian countries including China, Japan, Korea and Taiwan has long been used in oriental folk medicine owing to its tonic, antitussive, expectorant and anti-ulcerative effects. It has been reported to have anti-inflammatory, antioxidative, cholesterol-lowering, anticholinesterase, growth hormone-releasing, antifungal and immune cell-stimulating activities. Read More

View Article and Full-Text PDF
September 2021

Multistate Nonvolatile Metamirrors with Tunable Optical Chirality.

ACS Appl Mater Interfaces 2021 Sep 14. Epub 2021 Sep 14.

Laboratory of Micro-Nano Optics, College of Physics and Electronic Engineering, Sichuan Normal University, Chengdu 610101, P. R. China.

Compared with conventional mirrors that behave as isotropic electromagnetic (EM) reflectors, metamirrors composed of periodically aligned artificial meta-atoms exhibit increased degrees of freedom for EM manipulations. However, the functionality of most metamirrors is fixed by design, and how to achieve active EM control is still elusive. Here, we propose a multistate metamirror based on the nonvolatile phase change material GeSbTe (GST) with four distinct functionalities that can be realized in the infrared region by exploiting the temperature-activated phase transition. Read More

View Article and Full-Text PDF
September 2021

HIV Tat Protein Induces Myocardial Fibrosis Through TGF-β1-CTGF Signaling Cascade: A Potential Mechanism of HIV Infection-Related Cardiac Manifestations.

Cardiovasc Toxicol 2021 Sep 14. Epub 2021 Sep 14.

Department of Pharmacology (State-Province Key Laboratories of Biomedicine- Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, 150081, People's Republic of China.

Human immunodeficiency virus (HIV) infection is a risk factor of cardiovascular diseases (CVDs). HIV-infected patients exhibit cardiac dysfunction coupled with cardiac fibrosis. However, the reason why HIV could induce cardiac fibrosis remains largely unexplored. Read More

View Article and Full-Text PDF
September 2021

Coordination variability during running in adolescents with autism spectrum disorder.

Autism 2021 Sep 14:13623613211044395. Epub 2021 Sep 14.

Old Dominion University, USA.

Lay Abstract: Walking and running are popular forms of physical activity that involve the whole body (pelvis/legs and arms/torso) and are coordinated by the neuromuscular system, generally without much conscious effort. However, autistic persons tend not to engage in sufficient amounts of these activities to enjoy their health benefits. Recent reports indicate that autistic individuals tend to experience altered coordination patterns and increased variability during walking tasks when compared to non-autistic controls. Read More

View Article and Full-Text PDF
September 2021

Higher Trimethylamine--Oxide Plasma Levels with Increasing Age Are Mediated by Diet and Trimethylamine-Forming Bacteria.

mSystems 2021 Sep 14:e0094521. Epub 2021 Sep 14.

Microbial Interactions and Processes Research Group, Helmholtz Centre for Infection Researchgrid.7490.a, Braunschweig, Germany.

The gut microbiota-dependent metabolite trimethylamine--oxide (TMAO) is linked to an increased risk for cardiovascular diseases. Trimethylamine (TMA), which is subsequently oxidized to TMAO in the liver, is formed by intestinal bacteria via distinct biochemical routes from dietary precursors that are enriched in animal product-based foods. To get a full picture of the entire process of the diet > gut microbiota > TMAO axis, we quantified potential TMA-forming gut bacteria and plasma metabolites using gene-targeted assays and targeted metabolomics on a subsample ( = 425) of a German population-based cohort study. Read More

View Article and Full-Text PDF
September 2021

The effect of prepregnancy body mass index on maternal micronutrient status: a meta-analysis.

Sci Rep 2021 Sep 13;11(1):18100. Epub 2021 Sep 13.

National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.

The relationship between prepregnancy body mass index (BMI) and maternal micronutrient status is inconsistent and has not received sufficient attention. This meta-analysis aimed to evaluate the effect of prepregnancy BMI on micronutrient levels in pregnant women. PubMed, Embase, Web of Science, and the Cochrane Library were searched for articles that contained information on micronutrient levels and prepregnancy BMI. Read More

View Article and Full-Text PDF
September 2021

Interferon-β suppresses inflammatory pain through activating µ-opioid receptor.

Mol Pain 2021 Jan-Dec;17:17448069211045211

Department of Anesthesiology, Chi Mei Medical Center, Tainan City, Taiwan.

Interferons (IFNs) are cytokines secreted by infected cells that can interfere with viral replication. Besides activating antiviral defenses, type I IFNs also exhibit diverse biological functions. IFN-β has been shown to have a protective effect against neurotoxic and inflammatory insults on neurons. Read More

View Article and Full-Text PDF
September 2021