41,577 results match your criteria exercise capacity


How does cervical spinal cord injury impact the cardiopulmonary response to exercise?

Respir Physiol Neurobiol 2021 Jun 9:103714. Epub 2021 Jun 9.

International Collaboration on Repair Discoveries, Vancouver, BC, V5Z 1M9, Canada; Canadian Sport Institute - Pacific, Victoria, BC, V9E 2C5, Canada; Faculty of Medicine, University of British Columbia, Kelowna, BC, V1Y 1T3, Canada. Electronic address:

We compared cardiopulmonary responses to arm-ergometry, in individuals with cervical spinal cord injury (C-SCI) and able-bodied controls. We hypothesized that individuals with C-SCI would have higher respiratory frequency (f) but lower tidal volume (VT) at a given work rate and dynamically hyperinflate during exercise, whereas able-bodied individuals would not. Participants completed pulmonary function testing, an arm-ergometry test to exhaustion, and a sub-maximal exercise test consisting of four-minute stages at 20, 40, 60, and 80% peak work rate. Read More

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Efficacy of aqua-based plyometric exercises in the rehabilitation of patients with juvenile dermatomyositis: A randomized crossover pilot study.

Int J Rheum Dis 2021 Jun 12. Epub 2021 Jun 12.

Department of Physical Therapy for Pediatrics, Faculty of Physical Therapy, Cairo University, Giza, Egypt.

Background: Patients with juvenile dermatomyositis (JDM) experience muscle weakness, tiredness, and loss of energy, which restrict their abilities in performance of their daily living activities.

Objective: To explore the effect of aquatic-based plyometric (Aqua-PLYO) exercises on muscle strength, fatigue, and functional ability in patients with JDM.

Methods: This was a randomized, single-blind, crossover pilot study that included 16 patients with JDM (age 13. Read More

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Loss of the transcriptional repressor Rev-erbα upregulates metabolism and proliferation in cultured mouse embryonic fibroblasts.

Sci Rep 2021 Jun 11;11(1):12356. Epub 2021 Jun 11.

Department of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, 185 Meeting Street, Providence, RI, 02912, USA.

The transcriptional repressor Rev-erbα is known to down-regulate fatty acid metabolism and gluconeogenesis gene expression. In animal models, disruption of Rev-erbα results in global changes in exercise performance, oxidative capacity, and blood glucose levels. However, the complete extent to which Rev-erbα-mediated transcriptional repression of metabolism impacts cell function remains unknown. Read More

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Effect of Strength Versus Strength and Endurance Upper Limb Exercise Training in Patients With Chronic Obstructive Pulmonary Disease: A RANDOMIZED CLINICAL TRIAL.

J Cardiopulm Rehabil Prev 2021 Jun 10. Epub 2021 Jun 10.

Department of Health Sciences, School of Sciences, European University Cyprus, Nicosia, Cyprus (Drs Karagiannis and Savva and Ms Matheou); Aspetar, Orthopaedic and Sports Medicine Hospital, Doha, Qatar (Dr Korakakis); Respiratory Clinic, Nicosia General Hospital, Nicosia, Cyprus (Dr Adamide); Private Doctor, Nicosia, Cyprus (Dr Georgiou); Physiotherapy Department, Nicosia General Hospital, and Department of Life and Health Sciences, School of Sciences and Engineering, University of Nicosia, Nicosia, Cyprus (Ms Prodromou); and School of Medicine, European University Cyprus, Nicosia, Cyprus (Dr Xanthos).

Purpose: Pulmonary rehabilitation (PR) including exercise training improves muscle strength, exercise capacity, and health-related quality of life in patients with chronic obstructive pulmonary disease (COPD). However, the evidence of the effect of upper limb exercise training (ULET) on activities of daily living (ADL) is sparse. This study investigated the effect of two different types of ULET on ADL in addition to standard PR. Read More

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Prediction of underwater residual lung volume in healthy men and women.

Clin Physiol Funct Imaging 2021 Jun 11. Epub 2021 Jun 11.

Department of Kinesiology, University of Alabama, Tuscaloosa, AL, USA.

Regression equations are commonly used to predict residual lung volume (RV) during underwater weighing when measurement is not practical. However, the equations currently available were derived from on-land measures of RV and may account for changes in lung capacity during submersion, thus leading to inaccuracies in assessment of percent body fat (%BF). The purpose of this study was to 1) develop a new equation (RV ) for the prediction of underwater RV, 2) cross-validate RV and compare it to existing RV equations, and 3) compare the effects of RV and existing equations on underwater %BF. Read More

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Web-Based Self-management Program (SPACE for COPD) for Individuals Hospitalized With an Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Nonrandomized Feasibility Trial of Acceptability.

JMIR Mhealth Uhealth 2021 Jun 11;9(6):e21728. Epub 2021 Jun 11.

Centre for Exercise and Rehabilitation Science, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.

Background: Hospital admissions due to the acute exacerbation of chronic obstructive pulmonary disease (AECOPD) are costly for individuals and health services. Pulmonary rehabilitation (PR) is known to reduce hospital readmissions when delivered after hospitalization, but the uptake and completion of PR following hospitalization remains poor (<10% of those eligible in the UK audit data). A web-based platform of the SPACE (Self-management Program of Activity Coping and Education) for COPD (chronic obstructive pulmonary disease) has previously shown promising results in patients with stable COPD but has not been tested following an AECOPD. Read More

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Exercise, cancer and cardiovascular disease: what should clinicians advise?

Cardiovasc Endocrinol Metab 2021 Jun 3;10(2):62-71. Epub 2020 Sep 3.

Division of Cardiology, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA.

Cardiovascular disease is one of the leading causes of morbidity and mortality in persons with cancer. The elevated risk is thought to derive from the combination of cardiovascular risk factors and direct cardiotoxicity from cancer therapies. Exercise may be a potential strategy to counteract these toxicities and maintain cardiovascular reserve. Read More

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Efficiency of an Optimized Care Organization in Fibromyalgia Patients: The From Intent to Move (FIMOUV) Study Protocol of a Randomized Controlled Trial.

Front Public Health 2021 25;9:554291. Epub 2021 May 25.

University Lyon, UJM-Saint-Etienne Sainbiose Laboratory, INSERM U1059, Saint-Étienne, France.

Fibromyalgia (FM) is characterized by multiple symptoms including pain, fatigue, and sleep disorders, altering patient's quality of life. In the absence of effective pharmacological therapy, the last European guidelines recommend a multidisciplinary management based on exercise and education. Thus, our main objective was to measure the effectiveness of a healthcare organization offering a specific program of adapted physical activity combined with a therapeutic education program for FM patients. Read More

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Deciphering the constrained total energy expenditure model in humans by associating accelerometer-measured physical activity from wrist and hip.

Sci Rep 2021 Jun 10;11(1):12302. Epub 2021 Jun 10.

PROFITH "PROmoting FITness and Health Through Physical Activity" Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Crta Alfcar s/n, 18011, Granada, Spain.

The constrained total energy expenditure (TEE) model posits that progressive increases in physical activity (PA) lead to increases in TEE; but after certain PA threshold, TEE plateaus. Then, a compensatory reduction in the expenditure of non-essential activities constrains the TEE. We hypothesized that high PA levels as locomotion associate with a compensatory attenuation in arm movements. Read More

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Fourteen days of smoking cessation improves muscle fatigue resistance and reverses markers of systemic inflammation.

Sci Rep 2021 Jun 10;11(1):12286. Epub 2021 Jun 10.

Department of Life Sciences, Centre of Musculoskeletal Sciences and Sport Medicine, Manchester Metropolitan University, John Dalton Building; Chester Street, Manchester, M1 5GD, UK.

Cigarette smoking has a negative effect on respiratory and skeletal muscle function and is a risk factor for various chronic diseases. To assess the effects of 14 days of smoking cessation on respiratory and skeletal muscle function, markers of inflammation and oxidative stress in humans. Spirometry, skeletal muscle function, circulating carboxyhaemoglobin levels, advanced glycation end products (AGEs), markers of oxidative stress and serum cytokines were measured in 38 non-smokers, and in 48 cigarette smokers at baseline and after 14 days of smoking cessation. Read More

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Effects of multicomponent exercise program with progressive phases on functional capacity, fitness, quality of life, dual-task and physiological variables in older adults: Randomized controlled trial protocol.

Rev Esp Geriatr Gerontol 2021 Jun 7. Epub 2021 Jun 7.

Department of Sport Science, Faculty of Sport Sciences, Catholic University of Murcia, Spain; Health, Physical Activity, Fitness and Motor Control Performance Research Group (GISAFFCOM), Spain.

Introduction: The multicomponent exercise program must be carried out in phases, due to the low tolerance of the old adults to prolonged efforts, since their functional reserve is reduced. The aim of study is investigate the effects of Multicomponent on Progressive Phases Program on functional capacity, fitness, quality of life, dual-task and physiological variables in the elderly.

Methods: This is a randomized controlled trial protocol with blind examiners. Read More

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Feasibility of an Intradialytic Combined Exercise Program Targeting Older Adults With End-Stage Renal Disease.

J Aging Phys Act 2021 Jun 9:1-10. Epub 2021 Jun 9.

Intradialytic exercise is feasible and yields substantial clinical benefits in middle-aged patients. However, evidence is scarce in older hemodialysis patients.

Objective: To assess the feasibility and clinical benefits of supervised, intradialytic exercise in older patients. Read More

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Exogenous parathyroid hormone attenuates ovariectomy-induced skeletal muscle weakness in vivo.

Bone 2021 Jun 7:116029. Epub 2021 Jun 7.

Department of Orthopaedic Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan, Department of Orthopaedic Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.

Osteoporosis commonly affects the elderly and is associated with significant morbidity and mortality. Loss of bone mineral density induces muscle atrophy and increases fracture risk. However, muscle lipid content and droplet size are increased by aging and mobility impairments, inversely correlated with muscle function, and a cause of reduced motor function. Read More

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Associations of regional and network functional connectivity with exercise-induced low back pain.

J Pain 2021 Jun 7. Epub 2021 Jun 7.

Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, 32610; Center for Pain Research and Behavioral Health, University of Florida, Gainesville, FL 32610. Electronic address:

Musculoskeletal pain is an aversive experience that exists within a variety of conditions and can result in significant impairment for individuals. Gaining greater understanding of the factors related to pain vulnerability and resilience to musculoskeletal pain may help target at-risk individuals for early intervention. This analysis builds on our previous work identifying regions where greater gray matter density (GMD) was associated with lower pain following standardized, exercise induced musculoskeletal injury. Read More

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Contemporary Medical Management of Peripheral Artery Disease.

Circ Res 2021 Jun 10;128(12):1868-1884. Epub 2021 Jun 10.

Heart and Vascular Center, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (M.A.C.).

Peripheral artery disease (PAD) is a manifestation of systemic atherosclerosis. Modifiable risk factors including cigarette smoking, dyslipidemia, diabetes, poor diet quality, obesity, and physical inactivity, along with underlying genetic factors contribute to lower extremity atherosclerosis. Patients with PAD often have coexistent coronary or cerebrovascular disease, and increased likelihood of major adverse cardiovascular events, including myocardial infarction, stroke and cardiovascular death. Read More

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Astaxanthin supplementation enhances metabolic adaptation with aerobic training in the elderly.

Physiol Rep 2021 Jun;9(11):e14887

Department of Radiology, University of Washington, Seattle, WA, USA.

Endurance training (ET) is recommended for the elderly to improve metabolic health and aerobic capacity. However, ET-induced adaptations may be suboptimal due to oxidative stress and exaggerated inflammatory response to ET. The natural antioxidant and anti-inflammatory dietary supplement astaxanthin (AX) has been found to increase endurance performance among young athletes, but limited investigations have focused on the elderly. Read More

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Cardiopulmonary Exercise Testing with Echocardiography to Identify Mechanisms of Unexplained Dyspnea.

J Cardiovasc Transl Res 2021 Jun 10. Epub 2021 Jun 10.

Department of Cardiology, Hartcentrum, Jessa Hospital, Stadsomvaart 10, 3500, Hasselt, Belgium.

Little data is available about the pathophysiological mechanisms of unexplained dyspnea and their clinical meaning. Consecutive patients with unexplained dyspnea underwent prospective standardized cardiopulmonary exercise testing with echocardiography (CPETecho). Patients were grouped as having normal exercise capacity (peak VO > 80% with respiratory exchange [RER] > 1. Read More

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Effect of portable non-invasive ventilation on thoracoabdominal volumes in recovery from intermittent exercise in patients with COPD.

J Appl Physiol (1985) 2021 06 10. Epub 2021 Jun 10.

Department of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle Upon-Tyne, United Kingdom.

Background: We previously showed that use of portable non-invasive ventilation (pNIV) during recovery periods within intermittent exercise improved breathlessness and exercise tolerance in COPD patients compared to pursed-lip breathing (PLB). However, in a minority of patients recovery from dynamic hyperinflation (DH) was better with PLB, based on inspiratory capacity. We further explored this using Optoelectronic Plethysmography to assess total and compartmental thoracoabdominal volumes. Read More

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Short term intensified training temporarily impairs mitochondrial respiratory capacity in elite endurance athletes.

J Appl Physiol (1985) 2021 06 10. Epub 2021 Jun 10.

Department of Physiology, Nutrition and Biomechanics, Åstrand Laboratory, Swedish School of Sport and Health Sciences, Stockholm, Sweden.

Aim: The maintenance of healthy and functional mitochondria is the result of a complex mitochondrial turnover and herein quality-control program which includes both mitochondrial biogenesis and autophagy of mitochondria. The aim of this study was to examine the effect of an intensified training load on skeletal muscle mitochondrial quality control in relation to changes in mitochondrial oxidative capacity, maximal oxygen consumption and performance in highly trained endurance athletes.

Methods: 27 elite endurance athletes performed high intensity interval exercise followed by moderate intensity continuous exercise 3 days per week for 4 weeks in addition to their usual volume of training. Read More

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Prehabilitation exercise therapy for cancer: A systematic review and meta-analysis.

Cancer Med 2021 Jun 10. Epub 2021 Jun 10.

Department of Radiation Oncology, Penn State Cancer Institute, Hershey, PA, USA.

Objective: The purpose of this study was to determine the impact of prehabilitation exercise intervention with respect to (1) acceptability, feasibility, and safety; and (2) physical function, measured by 6-minute-walk test (6MWT).

Data Sources: PRISMA guidelines were used to systematically search PubMed, Embase, and CINAHL databases evaluating prehabilitation exercise interventions.

Study Selection: The inclusion criteria were studies investigating patients who underwent surgery for their cancer and underwent prehabilitation exercise. Read More

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Motivational interviewing with community-dwelling older adults after hip fracture (MIHip): protocol for a randomised controlled trial.

BMJ Open 2021 Jun 9;11(6):e047970. Epub 2021 Jun 9.

La Trobe University College of Science Health and Engineering, Bundoora, Victoria, Australia.

Introduction: Community-dwelling people recovering from hip fracture have the physical capacity to walk in their community but lack the confidence to do so. The primary aim of this trial is to determine whether motivational interviewing increases time spent walking at 12 months in community-dwelling people after hip fracture compared with an attention placebo control group. Secondary aims are to evaluate cost effectiveness, patient and health service outcomes and to complete a process evaluation. Read More

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10-Weeks of resistance training improves sleep quality and cardiac autonomic control in persons with multiple sclerosis.

Disabil Rehabil 2021 Jun 9:1-9. Epub 2021 Jun 9.

Department of Health and Human Performance, Faculty of Physical Activity and Sport Science-INEF, LFE Research Group, Madrid, Spain.

Purpose: To examine the acute and chronic effects of 10-weeks of progressive resistance training on sleep quality and sleeping heart rate variability in persons with Multiple Sclerosis (pwMS).

Methods: Eighteen pwMS (age = 44.8 ± 10. Read More

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Blood Oxygen Carrying Capacity Determines Cardiorespiratory Fitness in Middle-Age and Older Women and Men.

Med Sci Sports Exerc 2021 Jun 7. Epub 2021 Jun 7.

Libin Cardiovascular Institute of Alberta, University of Calgary, Canada Institute of Mountain Emergency Medicine, Eurac Research, Italy Department of Cardiac Sciences, Cumming School of Medicine, Calgary, Canada Faculty of Kinesiology, University of Calgary, Canada.

Purpose: Whether blood oxygen (O2) carrying capacity plays a substantial role in determining cardiorespiratory fitness, a strong predictor of mortality, remains uncertain in women and elderly individuals due to the scarcity of experimental investigations. This study experimentally assessed the role of blood O2 carrying capacity on cardiorespiratory fitness in middle-aged and older individuals.

Methods: Healthy women and men (n=31, 35-76 yr) matched by age and fitness were recruited. Read More

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Skeletal Muscle Mitochondrial Function following a 100-km Ultramarathon: A Case Study in Monozygotic Twins.

Med Sci Sports Exerc 2021 Jun 7. Epub 2021 Jun 7.

Nutrition, Dietetics and Food Science, Brigham Young University, Provo, UT Exercise Sciences, Brigham Young University, Provo, UT.

Purpose: Very little research has investigated the effects of ultra-endurance exercise on the bioenergetic status of muscle. The primary objective of this case study was to characterize the changes that occur in skeletal muscle mitochondria in response to a 100-km ultramarathon in monozygotic twins. A second objective was to determine whether mitochondrial function is altered by consuming a periodized low-carbohydrate, high-fat diet (LCHFD) during training compared to a high-carbohydrate diet. Read More

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[Effects of physical exercise on aerobic fitness and cognition in older women with type 2 diabetes mellitus].

Rev Med Chil 2021 Jan;149(1):37-44

Universidad Católica del Maule, Talca, Chile.

Background: Among older people, physical exercise improves cognitive function, aerobic fitness, and thus functional independence.

Aim: To determine the effects of a walking training program on aerobic fitness and cognitive function in older women with type 2 diabetes mellitus.

Material And Methods: An experimental study was carried out in 76 women with type 2 diabetes mellitus aged between 64 and 78 years. Read More

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January 2021

Exploring Tai Chi Exercise and Mind-Body Breathing in Patients with COPD in a Randomized Controlled Feasibility Trial.

COPD 2021 Jun 9:1-11. Epub 2021 Jun 9.

Division of General Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

In this pilot feasibility randomized controlled trial, participants with moderate to severe COPD were randomized to a 12-week tai chi or MBB intervention. Participants were assessed at baseline, 12 weeks, and 24 weeks. Feasibility, as assessed by intervention adherence, was the primary outcome. Read More

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[Views and practices of women living with HIV/AIDS on reproduction, sexuality, and rights].

Cad Saude Publica 2021 4;37(6):e00169720. Epub 2021 Jun 4.

Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil.

The article analyzes the views and practices on reproduction, sexuality, and rights of women living with HIV/AIDS (WLWA). This qualitative study was based on interviews at two moments, 2013 and 2018, with seven WLWA seen at HIV/AIDS referral services in Rio de Janeiro, Brazil. The study examined the opinions and experiences on motherhood, affective-sexual relations, feminism, and sexual and reproductive rights. Read More

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A split-label design for simultaneous measurements of perfusion in distant slices by pulsed arterial spin labeling.

Magn Reson Med 2021 Jun 9. Epub 2021 Jun 9.

C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.

Purpose: Multislice arterial spin labeling (ASL) MRI acquisitions are currently challenging in skeletal muscle because of long transit times, translating into low-perfusion SNR in distal slices when large spatial coverage is required. However, fiber type and oxidative capacity vary along the length of healthy muscles, calling for multislice acquisitions in clinical studies. We propose a new variant of flow alternating inversion recovery (FAIR) that generates sufficient ASL signal to monitor exercise-induced perfusion changes in muscle in two distant slices. Read More

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High Incidence of Bronchospastic Response to a Stair Climbing Exercise.

Cureus 2021 May 4;13(5):e14843. Epub 2021 May 4.

Institute of Sport Science and Innovations, Lithuanian Sports University, Kaunas, LTU.

Background While it is increasingly recognized that exercise-induced bronchoconstriction (EIB) affects a substantial proportion of sport participants, the relation of EIB incidence and severity to the type and intensity of exertion remains under-investigated. The aim of this study was to establish the incidence and severity of EIB during a stair race, a highly demanding all-out effort exercise. We hypothesized that a large proportion of participants would develop EIB to this particular high-intensity competition, and that among the predisposing factors, severity of EIB would depend on the level of exertion. Read More

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The benefit of exercise-based rehabilitation programs in patients with pulmonary hypertension: a systematic review and meta-analysis of randomized controlled trials.

Pulm Circ 2021 Apr-Jun;11(2):20458940211007810. Epub 2021 May 27.

Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Several studies have suggested that exercise capacity and quality of life are reduced in patients with pulmonary hypertension, and exercise-based rehabilitation can improve exercise capacity and quality of life in patients with pulmonary hypertension. The aim of this study is to assess the efficacy and safety of exercise-based rehabilitation in patients with pulmonary hypertension through a meta-analysis of randomized controlled trials. We searched PubMed, Embase, Medline, and the Cochrane Central Register of Controlled Trials up to November 2018. Read More

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