3,402 results match your criteria exclusion transplanted

Left atrial strain by speckle tracking predicts atrial fibrosis in patients undergoing heart transplantation.

Eur Heart J Cardiovasc Imaging 2021 Jun 12. Epub 2021 Jun 12.

Department of Public Health and Clinical Medicine, Umeå University and Heart Centre, Umeå, Sweden.

Aims: In patients with heart failure (HF), chronically raised left ventricular (LV) filling pressures lead to progressive left atrial (LA) dysfunction and fibrosis. We aimed to assess the correlation of LA reservoir strain (peak atrial longitudinal strain, PALS) by speckle tracking echocardiography (STE) and LA fibrosis assessed by myocardial biopsy in patients undergoing heart transplantation (HTx).

Methods And Results: Forty-eight patients with advanced HF [mean age 51. Read More

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Postoperative incision scars and cosmetic satisfaction of living liver donors.

Medicine (Baltimore) 2021 Jun;100(23):e26187

Department of General Surgery, Changhua Christian Hospital, Changhua.

Abstract: Cosmetic appearance is a major concern for living donors. However, little is known about the impact of a surgical scar on body image changes in living liver donors. The aim of this study was to identify potential factors that cause displeasing upper midline incision scar, and to evaluate the overall satisfaction regarding body image and scarring after living donor hepatectomy. Read More

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Uterine Transplantation Using Living Donation: A Cross-sectional Study Assessing Perceptions, Acceptability, and Suitability.

Transplant Direct 2021 Mar 18;7(3):e673. Epub 2021 Feb 18.

West London Gynaecological Cancer Centre, Hammersmith Hospital, Imperial College NHS Trust, London, United Kingdom.

A uterine transplantation is a nonvital, quality-of-life-enhancing solid organ transplant. Given improvements in donor risk profile and the anticipated shortage of suitable deceased donors, nondirected donation could facilitate sustainability as uterine transplantation moves from research into the clinical realm. The aim of this article is to determine perceptions and identify motivations of potential nondirected living uterus donors and assess acceptability and suitability. Read More

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Auxiliary liver transplantation for management of acute liver failure in children - Systematic review.

Transplant Rev (Orlando) 2021 Jun 1;35(4):100631. Epub 2021 Jun 1.

Faculty of Medicine, University of Coimbra, Portugal; Department of Pediatric Surgery, Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, Portugal; Pediatric Liver Transplantation, Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, Portugal.

Introduction: Liver transplantation (LT) remains the standard of care in the treatment of acute pediatric liver failure (PALF) for the replacement of a severely damaged native liver in patients who are unlikely to recover. However, this is burdened by the consequences of long-term immunosuppression. Auxiliary partial liver orthotopic transplantation (APOLT) has emerged as a possible improved approach, by providing a graft that assures liver function until the regeneration of the native liver occurs, and then allows for possible progression to immunosuppression withdrawal. Read More

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A Clinical Perspective on the Dietary Therapies for Pediatric Eosinophilic Esophagitis: The Gap Between Research and Daily Practice.

Front Immunol 2021 19;12:677859. Epub 2021 May 19.

Allergy and Immunology Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.

Pediatric eosinophilic esophagitis (ped-EoE) is an immune-mediated pathology affecting 34 per 100.000 children. It is characterized by an esophageal inflammation caused by an immune response towards food antigens that come into contact with the esophageal lining. Read More

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Fecal Microbiota Transplantation Is Safe for Clostridiodies difficile Infection in Patients with Solid Tumors Undergoing Chemotherapy.

Dig Dis Sci 2021 Jun 4. Epub 2021 Jun 4.

Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 9, New York, NY, 10065, USA.

Background: Recurrent Clostridiodies difficile infection (CDI) contributes to morbidity and mortality in cancer patients. Fecal microbiota transplantation (FMT) has been proven to be effective in treatment of recurrent CDI, but immunocompromised patients have been excluded from prospective studies due to safety concerns. The aim of this study was to investigate the safety of FMT for recurrent CDI in immunocompromised patients with solid tumor malignancy undergoing chemotherapy. Read More

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Predictive utility of fibrinogen in acute kidney injury in living donor liver transplantation: A propensity score-matching analysis.

PLoS One 2021 4;16(6):e0252715. Epub 2021 Jun 4.

Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Background: This study investigated the association between the fibrinogen level and the risk of acute kidney injury (AKI) in patients who have undergone living donor liver transplantation (LDLT).

Patients And Methods: A total of 676 patients who underwent LDLT were analyzed retrospectively. Exclusion criteria included a history of severe kidney dysfunction, emergency operation, deceased donor, ABO-incompatible transplantation, and missing data. Read More

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Impaired anti-SARS-CoV-2 Humoral and Cellular Immune Response induced by Pfizer-BioNTech BNT162b2 mRNA Vaccine in Solid Organ Transplanted Patients.

Am J Transplant 2021 May 31. Epub 2021 May 31.

IRCCS-ISMETT, Palermo, Italy.

SARS-CoV-2 vaccine is considered the primary health strategy able to end the current COVID-19 pandemic. This viral infection impacts more severely solid organ transplant recipients (SOTRs) than general population, but the effect of vaccination in this subgroup of immunosuppressed patients is not known due to their exclusion from vaccination trials. Preliminary reports suggest a lower antibody production after BNT162b2 Pfizer/BioNTech mRNA-vaccine , but no data are currently available on the elicited virus-specific T cell responses. Read More

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Serum cholesterol predicts transplant-free survival in cirrhotic patients undergoing transjugular intrahepatic portosystemic shunt.

Dig Liver Dis 2021 May 26. Epub 2021 May 26.

Digestive Disease Department, Clinic University Hospital of Valencia, Valencia, Spain.

Background: Malnutrition is frequent in patients with cirrhosis and has been associated with poor prognosis. The Model for End-stage Liver Disease (MELD) score was created to predict survival after Transjugular Intrahepatic Porto-systemic Shunt (TIPS) but lacks a nutritional parameter.

Aims: To evaluate the prognostic value of serum cholesterol in patients with cirrhosis undergoing TIPS and to develop a prognostic score to predict survival. Read More

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Postinfection Irritable Bowel Syndrome Following Clostridioides difficile Infection: A Systematic-review and Meta-analysis.

J Clin Gastroenterol 2021 May 28. Epub 2021 May 28.

Division of Gastroenterology and Hepatology Division of Endocrinology, Mayo Clinic, Rochester, MN.

Background: Postinfection irritable bowel syndrome (PI-IBS) affects ~14% patients after acute bacterial enterocolitis.

Aim: The aim of this study was to conduct a systematic review and meta-analysis to find the prevalence of PI-IBS following Clostridioides difficile infection (CDI).

Methods: We systematically searched Medline, Embase, and Web of Science from inception through January 20, 2020 for cohort studies assessing PI-IBS following CDI. Read More

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Comparison of Allogeneic Stem Cell Transplant and Autologous Stem Cell Transplant in Refractory or Relapsed Peripheral T-Cell Lymphoma: A Systematic Review and Meta-analysis.

JAMA Netw Open 2021 May 3;4(5):e219807. Epub 2021 May 3.

Department of Hematology, The First Affiliated Hospital of Gannan Medical University, Jiangxi, People's Republic of China.

Importance: Hematopoietic stem cell transplant (HSCT) is an advisable option for refractory or relapsed peripheral T-cell lymphoma (R/R-PTCL), but whether allogeneic HSCT or autologous HSCT is more beneficial is unknown.

Objective: To compare the effectiveness and safety of allogeneic HSCT vs autologous HSCT in patients with R/R-PTCL.

Data Sources: A systematic search of the PubMed, Embase, the Cochrane Central Register of Controlled Trials, Wanfang, and China National Knowledge Infrastructure databases with the search items refractory or relapsed peripheral T-cell lymphoma, ASCT/autologous stem-cell transplantation, allo-HSCT/allogeneic stem-cell transplantation, therapeutic effect, and treatment was conducted for articles published from January 12, 2001, to October 1, 2020. Read More

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Active and passive immunization with myelin basic protein as a window for treatment of spinal cord injury; A systematic review and meta-analysis.

Int J Clin Pract 2021 May 27:e14406. Epub 2021 May 27.

Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Objective: Spinal cord injury (SCI), as a dangerous central nervous system damage, continues to threaten communities by imposing various disabilities and costs. These damages may be prevented by adjusting the immune system response using Myelin Basic Protein (MBP) immunization. As a result, the current study is designed to review and analyze the evidence on this subject. Read More

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Liquid biopsies: donor-derived cell-free DNA for the detection of kidney allograft injury.

Nat Rev Nephrol 2021 May 24. Epub 2021 May 24.

Department of Clinical Pharmacology, University Medical Center Goettingen, Goettingen, Germany.

In kidney transplantation, the use of minimally invasive damage biomarkers that are more sensitive and specific than plasma creatinine will be crucial to enable early, actionable detection or exclusion of structural kidney damage due to acute or chronic rejection. Donor-derived cell-free DNA (dd-cfDNA), which can be quantified, for example, through next-generation sequencing, droplet digital PCR and quantitative PCR, is a candidate biomarker with great potential for enabling comprehensive monitoring of allograft injury. dd-cfDNA has a favourable overall diagnostic performance for the detection of rejection and its high negative predictive value might be especially useful for avoiding unnecessary biopsies. Read More

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Antibody-Mediated Rejection and Lung Transplantation.

Semin Respir Crit Care Med 2021 Jun 24;42(3):428-435. Epub 2021 May 24.

Division of Pulmonary and Critical Care, Washington University School of Medicine, Saint Louis, Missouri.

Antibody-mediated rejection (AMR) is now a widely recognized form of lung allograft rejection, with mounting evidence for AMR as an important risk factor for the development of chronic lung allograft dysfunction and markedly decreased long-term survival. Despite the recent development of the consensus diagnostic criteria, it remains a challenging diagnosis of exclusion. Furthermore, even after diagnosis, treatment directed at pulmonary AMR has been nearly exclusively derived from practices with other solid-organ transplants and other areas of medicine, such that there is a significant lack of data regarding the efficacy for these in pulmonary AMR. Read More

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Long-term safety and outcomes in hereditary tyrosinaemia type 1 with nitisinone treatment: a 15-year non-interventional, multicentre study.

Lancet Diabetes Endocrinol 2021 May 20. Epub 2021 May 20.

Swedish Orphan Biovitrum (Sobi), Stockholm, Sweden. Electronic address:

Background: Since the EU approval of nitisinone in 2005, prognosis for patients with hereditary tyrosinaemia type 1 has changed dramatically, with patients living with the disease now reaching adulthood for the first time in history. This study aimed to assess the long-term safety and outcomes of nitisinone treatment in patients with hereditary tyrosinaemia type 1.

Methods: We did a non-interventional, non-comparative, multicentre study in 77 sites across 17 countries in Europe and collected retrospective and prospective longitudinal data in patients with hereditary tyrosinaemia type 1 who were treated with oral nitisinone during the study period (Feb 21, 2005, to Sept 30, 2019). Read More

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The Advantage of the Supercooling Storage Method for Transplantable Sources: Human Umbilical Vessel Endothelial Cells and Mouse Skin Grafts.

Transplant Proc 2021 May 15. Epub 2021 May 15.

Department of Companion Animals, Yeonsung University, Gyeonggi-do, Republic of Korea. Electronic address:

Background: The safety and efficacy of preserving transplantable tissue depends on multiple factors including temperature, length of preservation, and types of solvent. Supercooling storage, in which the preservation temperature goes below the freezing point without actual freezing of the tissue, has the potential to substantially extend the preservation time of cells, tissues, and organs. Herein we studied the effect of supercooling storage on preserving the viability of transplantable biomaterials. Read More

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Revisiting the Surgical Management of Giant Hepatic Hemangiomas: Enucleation Versus Anatomical Resection?

J Clin Exp Hepatol 2021 May-Jun;11(3):321-326. Epub 2020 Oct 2.

Centre Hépato-Biliaire, AH-HP Hôpital Paul Brousse, Villejuif, France.

Background: Resection is rarely indicated in giant hepatic hemangiomas (HHs) that are symptomatic. Enucleation (EN), compared with anatomical resection (AR), is considered the better technique to resect them as EN has been reported to have lower morbidity while conserving the normal liver tissue. But no study has yet clearly established the superiority of EN over AR. Read More

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October 2020

Circulating Donor Lung-Specific Exosome Profiles Enable Noninvasive Monitoring of Acute Rejection in a Rodent Orthotopic Lung Transplantation Model.

Transplantation 2021 May 14. Epub 2021 May 14.

Division of Cardiovascular Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts Still Pond Cytomics LLC, West Chester, Pennsylvania Institute for Environmental Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA Division of Cardiac Surgery, Department of Surgery, Yale University School of Medicine, New Haven, Connecticut Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania Departments of Surgery, Pathology & Immunology, Washington University, St. Louis, Missouri Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania Department of Molecular and Cellular Medicine, Tokyo Medical University, Japan.

Objective: There is a critical need for development of biomarkers to noninvasively monitor for lung transplant rejection. We investigated the potential of circulating donor lung-specific exosome profiles for time sensitive diagnosis of acute rejection in a rat orthotopic lung transplant model.

Methods: Left lungs from Wistar transgenic rats expressing human CD63-GFP, an exosome marker, were transplanted into fully MHC-mismatched Lewis recipients or syngeneic controls. Read More

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Does laparoscopic hepatectomy offer benefits for patients with COPD? A propensity score analysis.

HPB (Oxford) 2021 Apr 27. Epub 2021 Apr 27.

Department of Liver Surgery, Center of Liver Transplantation, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China. Electronic address:

Background: To date, it remains unclear whether laparoscopic hepatectomy (LH) is safe and feasible for patients with chronic obstructive pulmonary disease (COPD). Thus, we compared the perioperative outcomes of LH versus open hepatectomy (OH) in this special cohort of patients.

Methods: Between February 2014 and October 2020, 162 patients who underwent hepatectomy met the inclusion and exclusion criteria of this study. Read More

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The prevalence of renal stone and outcomes of conservative treatment in kidney transplantation: A systematic review and meta-analysis.

Urol J 2021 May 8. Epub 2021 May 8.

Urology Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Nephrolithiasis is a rare complication in transplanted kidneys and limited information is available about its therapeutic options. This study aimed to review the conservative management of urinary lithiasis and its outcomes in renal transplanted patients.

Methods: A systematic review and meta-analysis of the scientific literature were performed in the Medline, Scopus, and Embase databases. Read More

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Efficacy of mesenchymal stem cell transplantation therapy for type 1 and type 2 diabetes mellitus: a meta-analysis.

Stem Cell Res Ther 2021 May 6;12(1):273. Epub 2021 May 6.

Department of Hematology, Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, Guizhou Province, China.

Background: This meta-analysis was first conducted to evaluate the efficacy and safety of transplantation of mesenchymal stem cells in the treatment of type 1 and type 2 diabetes mellitus (T1DM and T2DM).

Methods: We systematically searched PubMed, ScienceDirect, Google Scholar, CNKI, EMBASE, Web of Science, MEDLINE, and the Cochrane Library for studies published from the establishment of the databases to November 2020. Two researchers independently screened the identified studies, based on inclusion and exclusion criteria. Read More

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Health-related quality of life, workability, and return to work of patients after liver transplantation.

Langenbecks Arch Surg 2021 May 6. Epub 2021 May 6.

Transplant Center Graz, Graz, Austria.

Background: Health-related quality of life (HrQoL) and workability are related parameters to measure success of therapy. Both have been insufficiently explored in patients after liver transplantation (LT). Particularly little is known about patients' attitude to return to work, employment status before LT, and how frequently there is any employment at any time after LT. Read More

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Dynamic α-Fetoprotein Response and Outcomes After Liver Transplant for Hepatocellular Carcinoma.

JAMA Surg 2021 Jun;156(6):559-567

Multi-Organ Transplant and HPB Surgical Oncology, Division of General Surgery, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.

Importance: Accurate preoperative prediction of hepatocellular carcinoma (HCC) recurrence after liver transplant is the mainstay of selection tools used by transplant-governing bodies to discern candidacy for patients with HCC. Although progress has been made, few tools incorporate objective measures of tumor biological characteristics, resulting in inclusion of patients with high recurrence rates and exclusion of others who could otherwise be cured.

Objective: To externally validate the New York/California (NYCA) score, a recently published multi-institutional US HCC selection tool that was the first model incorporating a dynamic α-fetoprotein response (AFP-R) and compare the validated score with currently accepted HCC selection tools, namely, the Milan Criteria (MC), the French-AFP (F-AFP), and Metroticket 2. Read More

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Microbiota-mediated protection against antibiotic-resistant pathogens.

Genes Immun 2021 May 4. Epub 2021 May 4.

MRC Centre for Molecular Bacteriology and Infection, Department of Infectious Disease, Imperial College London, London, UK.

Colonization by the microbiota provides one of our most effective barriers against infection by pathogenic microbes. The microbiota protects against infection by priming immune defenses, by metabolic exclusion of pathogens from their preferred niches, and through direct antimicrobial antagonism. Disruption of the microbiota, especially by antibiotics, is a major risk factor for bacterial pathogen colonization. Read More

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Treatment strategies for osteochondral lesions of the talus: A review of the recent evidence.

Foot (Edinb) 2021 Jun 20;47:101805. Epub 2021 Apr 20.

East Kent Hospitals NHS University Foundation Trust, Ashford, United Kingdom.

Background: There has been no consensus regarding the treatment of osteochondral lesions of the talus, there has been many attempts to formulate a treatment pathway, with multiple proposed modalities and adjuncts used.

Objectives: The aim of this paper was to investigate the evidence published in the recent history, identify the relevant papers, review and summarize the findings, to help clarify the available operative treatment options and their respective efficacies based on the level of evidence provided.

Study Design & Methods: A literature search through electronic databases MEDLINE and EMBASE was done, these databases were screened for publications and papers form June 2004 to June 2019. Read More

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The association of childhood trauma, lifetime stressful events and general psychopathological symptoms in euthymic bipolar patients and healthy subjects.

J Affect Disord 2021 Jun 16;289:66-73. Epub 2021 Apr 16.

Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, via Francesco Sforza 28, Milano, Italy; Department of Pathophysiology and Transplantation, University of Milan, Via Francesco Sforza 35, 20122 Milano, Italy.

Background: Psychopathological symptoms during euthymia in Bipolar Disorder (BD) affect quality of life and predispose to the occurrence of new acute episodes, however only few studies investigated potential risk-factors. This study aims to explore the association between childhood trauma (CT), lifetime stressful events (SLEs) and psychopathological symptoms in BD patients during euthymia and controls (HC).

Methods: A total of 261 participants (93 euthymic patients with BD, 168 HC) were enrolled. Read More

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Administration Timing and Efficacy of Tocilizumab in Patients With COVID-19 and Elevated IL-6.

Front Mol Biosci 2021 15;8:651662. Epub 2021 Apr 15.

Department of Infection Diseases No. 1, The Maternal and Child Health Hospital of Hubei Province, Wuhan, China.

Background: Tocilizumab (TCZ), an interleukin-6 receptor antibody, has previously been used for treating patients with the coronavirus disease 2019 (COVID-19), but there is a lack of data regarding the administration timing of TCZ.

Objectives: This study aimed to evaluate the timing and efficacy of TCZ in the treatment of patients with COVID-19.

Methods: Laboratory-confirmed patients with COVID-19 with an elevated interleukin-6 (IL-6) level (>10 pg/ml) were offered TCZ intravenously for compassionate use. Read More

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ACG Clinical Guideline: Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury.

Am J Gastroenterol 2021 05;116(5):878-898

University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Idiosyncratic drug-induced liver injury (DILI) is common in gastroenterology and hepatology practices, and it can have multiple presentations, ranging from asymptomatic elevations in liver biochemistries to hepatocellular or cholestatic jaundice, liver failure, or chronic hepatitis. Antimicrobials, herbal and dietary supplements, and anticancer therapeutics (e.g. Read More

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Accuracy of Smart Scales on Weight and Body Composition: Observational Study.

JMIR Mhealth Uhealth 2021 04 30;9(4):e22487. Epub 2021 Apr 30.

Physiologie-Explorations Fonctionnelles, Fédération Hospitalo-Universitaire APOLLO (Personalised medicine in chronic cardiovascular, respiratory, renal diseases and organ transplantation), Hôpital Bichat Claude Bernard, Assistance Publique Hôpitaux de Paris, Paris, France.

Background: Smart scales are increasingly used at home by patients to monitor their body weight and body composition, but scale accuracy has not often been documented.

Objective: The goal of the research was to determine the accuracy of 3 commercially available smart scales for weight and body composition compared with dual x-ray absorptiometry (DEXA) as the gold standard.

Methods: We designed a cross-sectional study in consecutive patients evaluated for DEXA in a physiology unit in a tertiary hospital in France. Read More

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[Relevance of oesophageal biopsies during graft-versus-host disease].

Ann Pathol 2021 Jun 27;41(3):300-309. Epub 2021 Apr 27.

Service d'anatomie pathologique-tumorothèque de Picardie, université de Picardie-Jules-Verne, CHU d'Amiens Site Nord, place Victor-Pauchet, 80000 Amiens cedex 1, France.

Introduction: Graft-versus-host disease (GVHD) is a complication of hematopoietic stem cell transplantation. It frequently affects the digestive tract. Oesophageal damage is not part of its typical clinical picture. Read More

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