15,591 results match your criteria excellent yields


Organocatalytic enantioselective aza-Friedel-Crafts reaction between benzothiazolimines and 2-naphthols for the preparation of chiral 2'-aminobenzothiazolomethyl naphthols.

Org Biomol Chem 2021 Sep 15;19(35):7690-7694. Epub 2021 Sep 15.

Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, P.R. China.

A bifunctional cinchona squaramide catalyzed enantioselective aza-Friedel-Crafts reaction between 2-naphthols and benzothiazolimines has been developed, and a series of chiral 2'-aminobenzothiazolomethyl naphthols with potential antiproliferative and anthelmintic activities have been successfully and effectively prepared in good to excellent yields (up to 98%) with excellent enantioselectivities (up to >99% ee) even in a scale-up preparation under mild conditions. Read More

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September 2021

Microwave-accelerated and efficient synthesis of structurally diverse -(2,2-diphenylvinyl)-β-oxoamides.

Org Biomol Chem 2021 Sep 15;19(35):7678-7689. Epub 2021 Sep 15.

State Key Laboratory of Chemical Resource Engineering, Department of Organic Chemistry, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, P. R. China.

-(2,2-Diphenylvinyl)-β-oxoamides are both the structural moiety of biologically active compounds and important synthetic intermediates. Structurally diverse -(2,2-diphenylvinyl)-β-oxoamides are prepared efficiently from 2-diazo-1,3-dicarbonyl compounds and -alkyl-2,2-diphenylaziridines an electrophilic ring opening reaction under two different reaction conditions of reflux and microwave irradiation. 2-Diazo-1,3-dicarbonyl compounds undergo the Wolff rearrangement under heating to generate α-oxoketenes, which electrophilically react with -alkylaziridines to directly produce structurally diverse -(2,2-diphenylvinyl)-β-oxoamides in good to excellent yields under microwave irradiation. Read More

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September 2021

Palladium-catalyzed difunctionalization/dearomatization of -benzylacrylamides with α-carbonyl alkyl bromides: facile access to azaspirocyclohexadienones.

Org Biomol Chem 2021 Sep 15;19(35):7602-7606. Epub 2021 Sep 15.

School of Materials and Chemical Engineering, Hunan Provincial Key Laboratory of Environmental Catalysis & Waste Recycling, Hunan Institute of Engineering, Xiangtan, 411104, China.

An efficient palladium-catalyzed difunctionalization/dearomatization of -benzylacrylamides with α-carbonyl alkyl bromides as alkyl radical precursors has been described. Various α-carbonyl alkyl bromides, including α-bromoalkyl esters and ketones, reacted smoothly to provide important azaspirocyclohexadienones in moderate to excellent yields. In addition, mechanistic studies suggested that the reaction proceeded a radical pathway. Read More

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September 2021

Fluorescent glutamine and asparagine as promising probes for chemical biology.

Org Biomol Chem 2021 Sep 15;19(35):7695-7700. Epub 2021 Sep 15.

Department of Chemistry, Birla Institute of Technology and Science, Pilani 333031, Rajasthan, India.

Fluorescent probes have become valuable tools in chemical biology, providing interesting inferences for unfolding the complexities of natural biochemical processes. In this study, we report the synthesis and characterization of fluorescent labelled glutamine (Gln) and asparagine (Asn) derivatives traceless Staudinger ligation, which exhibited high fluorescence quantum yields, excellent photostabilities and emission of blue fluorescence in the visible region. The successful permeation of these fluorescent amino acids into cellular components proved their potential as fluorescent probes for chemical biology. Read More

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September 2021

Ring Expansion Fluorination of Unactivated Cyclopropanes Mediated by a New Monofluoroiodane(III) Reagent.

Angew Chem Int Ed Engl 2021 Sep 15. Epub 2021 Sep 15.

Nankai University, State Key Laboratory of Elemento-Organic Chemistry, Weijin road 94, 300071, Tianjin, CHINA.

Herein, we report a new strategy for carbon-carbon bond scission and intramolecular ring expansion fluorination of unactivated cyclopropanes, which was accomplished with a new hypervalent fluoroiodane(III) reagent 1 developed in our laboratory. This novel method delivers medicinally relevant 4-fully substituted fluoropiperidines in moderate to high yields with excellent regio- and diastereoselectivity. Reagent 1 , which has an N -acetylbenziodazole framework, was readily synthesized via three steps in 76% overall yield and was characterized by NMR spectroscopy and X-ray crystallography. Read More

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September 2021

In-situ catalytic upgrading of bio-oil from rapid pyrolysis of biomass over hollow HZSM-5 with mesoporous shell.

Bioresour Technol 2021 Sep 2;341:125874. Epub 2021 Sep 2.

Graduate School of Science and Technology, Hirosaki University, 1-Bunkyocho, Hirosaki 036-8560, Japan; Energy Conversion Engineering Laboratory, Institute of Regional Innovation, Hirosaki University, 2-1-3, Matsubara, Aomori 030-0813, Japan. Electronic address:

To solve the issue of narrow micropores in traditional protonic type Zeolite Socony Mobil-5 (HZSM-5) catalysts in the restricting of large-molecular reactants/products diffusion, hollow HZSM-5 with a mesoporous shell was prepared using a hydrothermal method combined with a tetrapropylammonium hydroxide (TPAOH) treatment process. Applying for in-situ catalyst upgrading of bio-oil from rapid pyrolysis of biomass, the obtained most efficient catalyst of Hollow(30)-TP resulted in aromatic hydrocarbon yields in the range of 78.49-78. Read More

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September 2021

Glycan remodeled erythrocytes facilitate antigenic characterization of recent A/H3N2 influenza viruses.

Nat Commun 2021 Sep 14;12(1):5449. Epub 2021 Sep 14.

Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, 3584 CG, The Netherlands.

During circulation in humans and natural selection to escape antibody recognition for decades, A/H3N2 influenza viruses emerged with altered receptor specificities. These viruses lost the ability to agglutinate erythrocytes critical for antigenic characterization and give low yields and acquire adaptive mutations when cultured in eggs and cells, contributing to recent vaccine challenges. Examination of receptor specificities of A/H3N2 viruses reveals that recent viruses compensated for decreased binding of the prototypic human receptor by recognizing α2,6-sialosides on extended LacNAc moieties. Read More

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September 2021

Electrochemical Deoxygenative Thiolation of Preactivated Alcohols and Ketones.

Org Lett 2021 Sep 14. Epub 2021 Sep 14.

State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

This work describes an electrochemically promoted nickel-catalyzed deoxygenative thiolation of alcohols and ketones under mild conditions. Excellent substrate tolerance and good chemical yields can be achieved by graphene/nickel foam electrodes in an undivided cell. Further study to gain mechanistic insight into this electrochemical cross-coupling has been carried out. Read More

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September 2021

Palladium-Catalyzed Distal -C-H Functionalization of Arylacetic Acid Derivatives.

Org Lett 2021 Sep 14. Epub 2021 Sep 14.

Department of Chemistry, Indian Institute of Technology Hyderabad, Kandi, Sangareddy 502285, Telangana, India.

Herein, we present -C-H olefination on derivatives of phenylacetic acids by tethering with a simple nitrile-based template through palladium catalysis. Notably, the versatility of the method is evaluated with a wide range of phenylacetic acid derivatives for obtaining the -olefination products in fair to excellent yields with outstanding selectivities under mild conditions. Significantly, the present strategy is successfully exemplified for the synthesis of drugs/natural product analogues (naproxen, ibuprofen, paracetamol, and cholesterol). Read More

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September 2021

Hydrosilylative reduction of primary amides to primary amines catalyzed by a terminal [Ni-OH] complex.

Chem Commun (Camb) 2021 Sep 14;57(73):9204-9207. Epub 2021 Sep 14.

Department of Chemistry and Center for Environmental Science and Engineering, Indian Institute of Technology Kanpur, Kanpur 208016, India.

A terminal [Ni-OH] complex 1, supported by triflamide-functionalized NHC ligands, catalyzes the hydrosilylative reduction of a range of primary amides into primary amines in good to excellent yields under base-free conditions with key functional group tolerance. Catalyst 1 is also effective for the reduction of a variety of tertiary and secondary amides. In contrast to literature reports, the reactivity of 1 towards amide reduction follows an inverse trend, , 1° amide > 3° amide > 2° amide. Read More

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September 2021

Selective Electrochemical Oxygenation of Alkylarenes to Carbonyls.

Org Lett 2021 Sep 13. Epub 2021 Sep 13.

Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Xinjiang, Uygur Autonomous Region 832000, China.

An efficient electrochemical method for benzylic C(sp)-H bond oxidation has been developed. A variety of methylarenes, methylheteroarenes, and benzylic (hetero)methylenes could be converted into the desired aryl aldehydes and aryl ketones in moderate to excellent yields in an undivided cell, using O as the oxygen source and lutidinium perchlorate as an electrolyte. On the basis of cyclic voltammetry studies, O labeling experiments, and radical trapping experiments, a possible single-electron transfer mechanism has been proposed for the electrooxidation reaction. Read More

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September 2021

Rational Utilization of Intramolecular Hydrogen Bonds to Achieve Blue TADF with EQEs of Nearly 30% and Single Emissive Layer All-TADF WOLED.

ACS Appl Mater Interfaces 2021 Sep 13. Epub 2021 Sep 13.

State Key Laboratory of Fine Chemicals, College of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian, 116024, China.

A series of highly efficient blue thermally activated delayed fluorescence (TADF) compounds, SON-Cz, SON-BuCz, and SON-PhCz, were developed. Pyridinyl was introduced as the bridging unit between carbazole donors and sulfone acceptor. Intramolecular hydrogen bonds between the pyridine N atom and carbazole H atoms were detected in single crystals, which suppressed the twisting of carbazole rings and dramatically increased the molecular rigidity. Read More

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September 2021

A facile aptamer immobilization strategy to fabricate a robust affinity monolith for highly specific in-tube solid-phase microextraction.

Analyst 2021 Sep 13;146(18):5732-5739. Epub 2021 Sep 13.

Institute of Food Safety and Environment Monitoring, Fuzhou University, Fuzhou, 350108, P.R. China.

Developing a functional affinity monolithic column towards in-tube solid-phase microextraction (IT-SPME) for selective sample pretreatment is critical. Herein, a high-performance capillary affinity monolithic column with an ultra-high aptamer coverage density was rapidly fabricated a simple adsorption strategy, in which aptamers with natural sequences were directly immobilized on an ammonium-based strongly cationic matrix. Limitations of the traditional biological or covalent methods such as time-consuming modification reactions, special requirement of active groups ( -NH and -SH) on the aptamer, and low aptamer coverage density levels were avoided. Read More

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September 2021

Metal-free Three-Component Synthesis of 1,2,3-Triazoline-4-sulfonamides.

J Org Chem 2021 Sep 13. Epub 2021 Sep 13.

Saint Petersburg State University, Saint Petersburg 199034, Russian Federation.

A new type of diazo compounds, namely, CH-diazomethane sulfonamides (generated from readily available α-acetyl-α-diazomethane sulfonamides), was employed in a 1,3-dipolar cycloaddition reaction with imines (also formed from primary amines and aldehydes). The reaction gave hitherto undescribed 1,5-disubstituted 1,2,3-triazoline-4-sulfonamides, which were obtained in good to excellent yields with complete trans diastereoselectivity. These new sulfonamides based on the nonaromatic 1,2,3-triazoline core are rather attractive from a medicinal chemistry standpoint in light of the strong emphasis recently put on the nonflat, more saturated (higher Fsp3) scaffolds for lead-generation libraries. Read More

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September 2021

Palladium-catalyzed carbonylation of iminoquinones and aryl iodides to access aryl -amino benzoates.

Org Biomol Chem 2021 Sep 13. Epub 2021 Sep 13.

Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 116023 Dalian, Liaoning, China.

A palladium-catalyzed carbonylation of iminoquinones and aryl iodides has been developed for the construction of aryl -amino benzoates. Using benzene-1,3,5-triyl triformate (TFBen) as the CO source, the reaction proceeded well to give various aryl -amino benzoates in good to excellent yields. Additionally, control experiments were conducted to gain more insights into the reaction mechanism. Read More

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September 2021

Brønsted Acid Catalyzed Oxocarbenium-Olefin Metathesis/Rearrangements of 1-Isochromene Acetals with Vinyl Diazo Compounds.

J Am Chem Soc 2021 Sep 11. Epub 2021 Sep 11.

Department of Chemistry, The University of Texas at San Antonio, San Antonio, Texas 78249, United States.

An oxocarbenium-olefin cross metathesis occurs during Brønsted acid catalyzed reactions of 1-isochromene acetals with vinyl diazo compounds. Formally a carbonyl-alkene [2 + 2]-cyclization between isobenzopyrylium ions and the vinyl group of vinyl diazoesters, the retro-[2 + 2] cycloaddition produces a tethered alkene and a vinyl diazonium ion that, upon loss of dinitrogen, undergoes a highly selective carbocationic cascade rearrangements to diverse products whose formation is controlled by reactant substituents. Polysubstituted benzobicyclo[3. Read More

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September 2021

Metal-Organic Frameworks as Versatile Media for Polymer Adsorption and Separation.

Acc Chem Res 2021 Sep 10. Epub 2021 Sep 10.

Department of Applied Chemistry, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

ConspectusMolecular recognition is of paramount importance for modern chemical processes and has now been achieved for small molecules using well-established host-guest chemistry and adsorption-science principles. In contrast, technologies for recognizing polymer structure are relatively undeveloped. Conventional polymer separation methods, which are mostly limited in practice to size-exclusion chromatography and reprecipitation, find it difficult to recognize minute structural differences in polymer structures as such small structural alterations barely influence the polymer characteristics, including molecular size, polarity, and solubility. Read More

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September 2021

Ni-Catalyzed Regioselective Hydroarylation of 1-Aryl-1,3-Butadienes with Aryl Halides.

Chemistry 2021 Sep 10. Epub 2021 Sep 10.

Shanghai Jiaotong University: Shanghai Jiao Tong University, School of Chemistry and Chemical Engineering, CHINA.

An efficient nickel-catalyzed regioselective hydroarylation of 1,3-dienes with aryl halides and a silane has been developed, affording a range of allylic arenes in good to excellent yields under mild conditions. This method exhibits broad substrate scope, and excellent functional group tolerance. Late-stage modification of complex architectures was demonstrated. Read More

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September 2021

SAr Radiofluorination with In Situ Generated [F]Tetramethylammonium Fluoride.

J Org Chem 2021 Sep 10. Epub 2021 Sep 10.

Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.

This report describes a method for the nucleophilic radiofluorination of (hetero)aryl chlorides, (hetero)aryl triflates, and nitroarenes using a combination of [F]KF·K and MeNHCO for the in situ formation of a strongly nucleophilic fluorinating reagent (proposed to be [F]MeNF). This method is applied to 24 substrates bearing diverse functional groups, and it generates [F](hetero)aryl fluoride products in good to excellent radiochemical yields in the presence of ambient air/moisture. The reaction is applied to the preparation of F-labeled HQ-415 for potential (pre)clinical use. Read More

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September 2021

synthesis of FeO nanosphere/CoO nanowire-connected reduced graphene oxide hybrid networks for high-performance supercapacitors.

Nanoscale 2021 Sep 10. Epub 2021 Sep 10.

Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, 30013, Taiwan.

Three-dimensional (3D) hybrid networks consisting of reduced graphene oxide (rGO) sheets interconnected by CoO nanowires (rGO/CoO), followed by the decoration of FeO nanospheres (NSs) (rGO/[email protected]), were demonstrated by a facile hydrothermal method, with which the rGO/CoO networks acted as nucleation sites for the synthesis of FeO NSs. The intimate contacts between rGO, CoO NWs and FeO NSs, which result in an excellent conductive behavior, provide a unique structure with huge potential for electrochemical property promoted electrochemical supercapacitors. The rGO/[email protected] hybrid networks as electrodes exhibit a high capacitance of 784 F g at 1 A g with 83% retention of the initial capacitance as the current density increases from 1 to 10 A g, which is explained by the graphene-based interconnected structure owing to the advantages of accommodating the volume expansion between CoO NWs and FeO NSs. Read More

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September 2021

Improving the Rice Photosynthetic Efficiency and Yield by Editing via CRISPR/Cas9 System.

Int J Mol Sci 2021 Sep 2;22(17). Epub 2021 Sep 2.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Life Sciences, South China Agricultural University, Guangzhou 510642, China.

Rice ( L.) is an important food crop species in China. Cultivating high-yielding rice varieties that have a high photosynthetic efficiency is an important goal of rice breeding in China. Read More

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September 2021

Application of Polyamines and Amino Acid Derivatives Based on 2-Azabicycloalkane Backbone in Enantioselective Aldol Reaction.

Molecules 2021 Aug 26;26(17). Epub 2021 Aug 26.

Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50370 Wrocław, Poland.

Carbon-carbon bond forming reactions, such as aldol reaction and condensation, belong to extremely desired transformations as manifested by >25,000 entries in SciFinder. Their stereoselective variant requires the use of an appropriate catalyst with a strictly defined structure. Hence, chiral 2-azabicycloalkane-based catalysts were designed, synthesized and tested in a stereoselective aldol reaction between cyclic/acyclic ketone and -nitrobenzaldehyde both in organic and aqueous media. Read More

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Sodium sulphide promoted synthesis of fused quinoline at room temperature.

Org Biomol Chem 2021 Sep 9. Epub 2021 Sep 9.

Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India.

A novel, simple and eco-friendly strategy for the synthesis of thiopyrano[4,3-]quinolin-1-ones and pyrrolo[3,4-]quinolin-1-ones from 2-alkynylquinoline-3-carbonitriles and sodium sulphide (NaS·9HO) under catalyst-free conditions at room temperature has been described. In this reaction, a readily available inorganic salt (NaS·9HO) serves as the sulphur source and leads to the generation of diverse functionalized thiopyrano[4,3-]quinolin-1-ones and pyrrolo[3,4-]quinolin-1-ones in moderate to excellent yields through sulfuration, annulation, and aerial oxidation. Read More

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September 2021

The photoredox-catalyzed hydrosulfamoylation of styrenes and its application in the novel synthesis of naratriptan.

Chem Commun (Camb) 2021 Sep 9;57(72):9140-9143. Epub 2021 Sep 9.

State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, China.

The hydrosulfamoylation of diverse aryl olefins provides facile access to alkylsulfonamides. Here we report a novel protocol utilizing radical-mediated addition and a thiol-assisted strategy to achieve the hydrosulfamoylation of diverse styrenes in modest to excellent yields under mild and economic reaction conditions. The methodology was found to provide an efficient and convenient approach for the synthesis of the anti-migraine drug naratriptan and it also can be used for the late-stage functionalization of natural products or medicines. Read More

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September 2021

Generation of zwitterionic trifluoromethyl -allylic ylides and their use in switchable divergent annulations.

Chem Commun (Camb) 2021 Sep 9;57(72):9056-9059. Epub 2021 Sep 9.

Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.

The previously unreported zwitterionic -allylic ylide species from the corresponding Morita-Baylis-Hillman carbonates of trifluoromethyl ketones and acrylonitrile are generated under the catalysis of cinchona-derived tertiary amines, and subsequently participate in switchable asymmetric [3+2] or [4+1] annulations with 1-azadienes in chemo-, regio-, and stereodivergent manners catalyst or substrate control. A diverse range of frameworks, having a trifluoromethylated all-carbon quaternary stereogenic centre or a tetrasubstituted alkene moiety, are generally constructed in good yields with excellent enantioselectivity. Read More

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September 2021

One-Pot Multicomponent Coupling Reaction of Catechols, Benzyl Alcohols/Benzyl Methyl Ethers, and Ammonium Acetate toward Synthesis of Benzoxazoles.

ACS Omega 2021 Aug 18;6(34):22395-22399. Epub 2021 Aug 18.

Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran.

The multicomponent coupling reaction of catechol, ammonium acetate, and benzyl alcohol/benzyl methyl ether in the presence of a Fe(III) catalyst precursor afforded benzoxazole derivatives in good to excellent yields. The notable features of this protocol are abundant availability of the catalyst system, large-scale synthesis, high diversity, and high yields of products. Read More

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Enantioselective Synthesis of Nitrogen-Nitrogen Biaryl Atropisomers via Copper-Catalyzed Friedel-Crafts Alkylation Reaction.

J Am Chem Soc 2021 Sep 8. Epub 2021 Sep 8.

College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, Shandong 266071, China.

Nitrogen-nitrogen bonds containing motifs are ubiquitous in natural products and bioactive compounds. However, the atropisomerism arising from a restricted rotation around an N-N bond is largely overlooked. Here, we describe a method to access the first enantioselective synthesis of N-N biaryl atropisomers via a Cu-bisoxazoline-catalyzed Friedel-Crafts alkylation reaction. Read More

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September 2021

The Regiocontrollable Enantioselective Synthesis of Chiral Trifluoromethyl-Containing Spiro-Pyrrolidine-Pyrazolone Compounds via Amino-Regulated 1,3-Proton Migration Reaction.

J Org Chem 2021 Sep 8;86(18):13011-13024. Epub 2021 Sep 8.

Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.

An amino-controlled regiodivergent asymmetric synthesis of CF-containing spiro-pyrrolidine-pyrazolone compounds is described. With alkaloid-derived squaramide as catalyst, the 1,3-dipolar cycloaddition of α,β-unsaturated pyrazolone with diethyl 2-((2,2,2-trifluoroethyl)imino) malonate offered adducts in excellent yields, dr, and ee. While the cyclohexanediamine-derived squaramide was employed, the reaction afforded a series of structure isomers through a switched umpolung reaction. Read More

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September 2021

Catalytic Asymmetric (3 + 3) Cycloaddition of Oxyallyl Zwitterions with α-Diazomethylphosphonates.

Org Lett 2021 Sep 8;23(18):7295-7300. Epub 2021 Sep 8.

Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.

The unique structure of oxyallyls represents a significant challenge for their catalytic asymmetric applications. Herein, an unprecedented chiral imidodiphosphoric acid-catalytic enantioselective (3 + 3) cycloaddition between oxyallyl zwitterions generated from α-haloketones and α-diazomethylphosphonates was developed. Pharmaceutically interesting chiral pyridazine-4()-ones were obtained in up to 98% yields with excellent stereoselectivities (up to 99% ee, > 99:1 dr). Read More

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September 2021

Efficient access to aliphatic esters by photocatalyzed alkoxycarbonylation of alkenes with alkyloxalyl chlorides.

Nat Commun 2021 Sep 7;12(1):5328. Epub 2021 Sep 7.

School of Pharmaceutical and Materials Engineering & Institute for Advanced Studies, Taizhou University, Taizhou, China.

Aliphatic esters are essential constituents of biologically active compounds and versatile chemical intermediates for the synthesis of drugs. However, their preparation from readily available olefins remains challenging. Here, we report a strategy to access aliphatic esters from olefins through a photocatalyzed alkoxycarbonylation reaction. Read More

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September 2021