3,561 results match your criteria excellent discrimination


Analysis of Risk Factors and Establishment of a Prediction Model for Endoscopic Primary Bile Reflux: A Single-Center Retrospective Study.

Front Med (Lausanne) 2021 10;8:758771. Epub 2021 Nov 10.

Department of Gastroenterology, School of Medicine, Tongji Hospital, Tongji University, Shanghai, China.

Endoscopic primary bile reflux is one of the main diagnostic criteria for bile reflux gastritis (BRG). Presently, the risk factors and prediction models of endoscopic primary bile reflux (EPBR) in gastropathy patients who cannot or will not undergo endoscopy due to contraindications are not clear. Thus, this study aimed to evaluate the risk factors of EPBR and to establish and verify a prediction model. Read More

View Article and Full-Text PDF
November 2021

CCEDRRN COVID-19 Infection Score (CCIS): development and validation in a Canadian cohort of a clinical risk score to predict SARS-CoV-2 infection in patients presenting to the emergency department with suspected COVID-19.

BMJ Open 2021 Dec 2;11(12):e055832. Epub 2021 Dec 2.

Department of Emergency Medicine, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada.

Objectives: To develop and validate a clinical risk score that can accurately quantify the probability of SARS-CoV-2 infection in patients presenting to an emergency department without the need for laboratory testing.

Design: Cohort study of participants in the Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) registry. Regression models were fitted to predict a positive SARS-CoV-2 test result using clinical and demographic predictors, as well as an indicator of local SARS-CoV-2 incidence. Read More

View Article and Full-Text PDF
December 2021

Estimating the risk of malignancy of adnexal masses: validation of the ADNEX model in the hands of nonexpert ultrasonographers in a gynaecological oncology centre in China.

J Ovarian Res 2021 Dec 2;14(1):169. Epub 2021 Dec 2.

Department of Ultrasound, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, 251 Yaojiayuan Road, Chaoyang District, Beijing, 100026, P.R. China.

Background: This study aims to validate the diagnostic accuracy of the International Ovarian Tumor Analysis (IOTA) the Assessment of Different NEoplasias in the adneXa (ADNEX) model in the preoperative diagnosis of adnexal masses in the hands of nonexpert ultrasonographers in a gynaecological oncology centre in China.

Methods: This was a single oncology centre, retrospective diagnostic accuracy study of 620 patients. All patients underwent surgery, and the histopathological diagnosis was used as a reference standard. Read More

View Article and Full-Text PDF
December 2021

Construction and validation of a prognostic nomogram for anal squamous cell carcinoma.

Cancer Med 2021 Dec 1. Epub 2021 Dec 1.

Department of Radiation Oncology and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Background: Anal squamous cell carcinoma (ASCC) is the main subtype of anal cancer and has great heterogeneity in prognosis. We aimed to construct a nomogram for predicting their 1-, 3-, and 5-year overall survival (OS) rates.

Methods: Patients with ASCC, enrolled between January 1, 2010 and December 31, 2017, were identified from the SEER database. Read More

View Article and Full-Text PDF
December 2021

A Prediction Model for Pediatric Radiographic Pneumonia.

Pediatrics 2021 Dec 1. Epub 2021 Dec 1.

Division of Emergency Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Background: Chest radiographs (CXRs) are frequently used in the diagnosis of community-acquired pneumonia (CAP). We sought to construct a predictive model for radiographic CAP based on clinical features to decrease CXR use.

Methods: We performed a single-center prospective study of patients 3 months to 18 years of age with signs of lower respiratory infection who received a CXR for suspicion of CAP. Read More

View Article and Full-Text PDF
December 2021

Geometric morphometric wing analysis as a tool to discriminate female mosquitoes from different suburban areas of Chiang Mai province, Thailand.

PLoS One 2021 29;16(11):e0260333. Epub 2021 Nov 29.

Department of Parasitology, Center of Insect Vector Study, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Mosquitoes are hematophagous insects that transmit parasites and pathogens with devastating effects on humans, particularly in subtropical regions. Different mosquito species display various behaviors, breeding sites, and geographic distribution; however, they can be difficult to distinguish in the field due to morphological similarities between species and damage caused during trapping and transportation. Vector control methods for controlling mosquito-borne disease epidemics require an understanding of which vector species are present in the area as well as the epidemiological patterns of disease transmission. Read More

View Article and Full-Text PDF
November 2021

Examination of social smoking classifications using a machine learning approach.

Addict Behav 2021 Nov 8:107175. Epub 2021 Nov 8.

Adolescent Health Research Program, Reed College, Department of Psychology, 3203 SE Woodstock Blvd., Portland, OR 97202, United States. Electronic address:

Introduction: Idiosyncratic definitions of social smoking proliferate in the literature, making cross-study comparison challenging. This project investigated and differentiated four distinct classifications of social smoking using traditional modeling techniques as well as a multilayer perceptron artificial network, a novel machine learning approach suited for heterogeneous, multidimensional data.

Methods: One hundred thirty-three adults recruited from a college in the Pacific Northwest and from Amazon Mechanical Turk, age 18 to 25 (48% men; 37% women; 8% nonbinary; 73% white; 24% Hispanic or Latinx), completed a set of self-report measures assessing common variables associated with cigarette use. Read More

View Article and Full-Text PDF
November 2021

DNA Genotyping Based on Isothermal Amplification and Colorimetric Detection by Consumer Electronics Devices.

Methods Mol Biol 2022 ;2393:163-178

Chemistry Department, Universitat Politècnica de València, Valencia, Spain.

The point-of-care testing of DNA biomarkers requires compact biosensing systems and consumer electronic technologies provide fascinating opportunities. Their portability, mass-produced components, and high-performance readout capabilities are the main advantages for the development of novel bioanalytical methods.This chapter describes the detection of single nucleotide polymorphisms (SNP) through methods based on user-friendly optical devices (e. Read More

View Article and Full-Text PDF
January 2022

Multi-Elemental Composition Data Handled by Chemometrics for the Discrimination of High-Value Italian Pecorino Cheeses.

Molecules 2021 Nov 15;26(22). Epub 2021 Nov 15.

Dipartimento di Scienze Fisiche e Chimiche, Università degli Studi dell'Aquila, Via Vetoio, 67010 L'Aquila, Italy.

The multi-elemental composition of three typical Italian Pecorino cheeses, Protected Designation of Origin (PDO) Pecorino Romano (PR), PDO Pecorino Sardo (PS) and Pecorino di Farindola (PF), was determined by Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES). The ICP-OES method here developed allowed the accurate and precise determination of eight major elements (Ba, Ca, Fe, K, Mg, Na, P, and Zn). The ICP-OES data acquired from 17 PR, 20 PS, and 16 PF samples were processed by unsupervised (Principal Component Analysis, PCA) and supervised (Partial Least Square-Discriminant Analysis, PLS-DA) multivariate methods. Read More

View Article and Full-Text PDF
November 2021

Construction of a Luminescent Cadmium-Based Metal-Organic Framework for Highly Selective Discrimination of Ferric Ions.

Molecules 2021 Nov 13;26(22). Epub 2021 Nov 13.

School of Chemistry and Environmental Engineering, Hanshan Normal University, Chaozhou 521041, China.

Fluorescent metal-organic frameworks (MOFs) are ideal materials for sensors because of their adjustable pore size and functional groups, which provide them with favorable metal ion selective recognition. In this paper, a new cadmium-based MOF was synthesized using Cd(NO)·4HO and 3,3',5,5'-biphenyltetracarboxylic acid by solvothermal method. CdBPTC owned three types of channels with dimensions of approximately 8. Read More

View Article and Full-Text PDF
November 2021

Comparative Performance of Four Established Neonatal Disease Scoring Systems in Predicting In-Hospital Mortality and the Potential Role of Thromboelastometry.

Diagnostics (Basel) 2021 Oct 21;11(11). Epub 2021 Oct 21.

Laboratory of Haematology and Blood Bank Unit, "Attiko" Hospital, School of Medicine, National and Kapodistrian University of Athens, 1 Rimini Str., 12462 Athens, Greece.

Background: To compare the prognostic accuracy of the most commonly used indexes of mortality over time and evaluate the potential of adding thromboelastometry (ROTEM) results to these well-established clinical scores.

Methods: The study population consisted of 473 consecutive term and preterm critically-ill neonates. On the first day of critical illness, modified Neonatal Multiple Organ Dysfunction (NEOMOD) scoring system, Score for Neonatal Acute Physiology (SNAP II), Perinatal extension of SNAP (SNAPPE), and SNAPPE II, were calculated and ROTEM standard extrinsically activated (EXTEM) assay was performed simultaneously. Read More

View Article and Full-Text PDF
October 2021

Predictive Ability of European Heart Surgery Risk Assessment System II (EuroSCORE II) and the Society of Thoracic Surgeons (STS) Score for in-Hospital and Medium-Term Mortality of Patients Undergoing Coronary Artery Bypass Grafting.

Int J Gen Med 2021 19;14:8509-8519. Epub 2021 Nov 19.

Department of Cardiovascular Surgery, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.

Objective: To evaluate the powers of European Heart Surgery Risk Assessment System II (EuroSCORE II) and the Society of Thoracic Surgeons (STS) score in predicting in-hospital and medium-term mortality of patients undergoing coronary artery bypass grafting (CABG).

Methods: Totally 1628 Chinese patients were included between January 2000 and January 2018. Their perioperative clinical data were collected and the patients were closely followed up. Read More

View Article and Full-Text PDF
November 2021

Identification and Validation of Pyroptosis-Related lncRNA Signature and Its Correlation with Immune Landscape in Soft Tissue Sarcomas.

Int J Gen Med 2021 16;14:8263-8279. Epub 2021 Nov 16.

Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, People's Republic of China.

Background: Pyroptosis is critically associated with cancer initiation and progression, which can be modulated by diverse long noncoding RNAs (lncRNAs). However, the roles of pyroptosis-related lncRNAs in soft tissue sarcomas (STS) are still largely unknown.

Methods: Our study included a total of 259 STS patients extracted from The Cancer Genome Atlas Sarcoma (TCGA-SARC) dataset. Read More

View Article and Full-Text PDF
November 2021

Target invasion-triggered signal amplification based on duplex-specific nuclease for selective and sensitive detection of miRNAs.

Anal Chim Acta 2022 Jan 28;1189:339182. Epub 2021 Oct 28.

Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical, University, Luzhou, 646000, PR China. Electronic address:

Dysregulation of MicroRNAs (miRNAs) cause various diseases in humans, and developing reliable methods to detect miRNAs is critical for molecular diagnostics and personalized medicine. This study developed a toehold-mediated target invasion combined with duplex-specificity nuclease (DSN)-assisted cyclic signal amplification fluorescent sensor. Herein, we take advantage of toehold-mediated target invasion process to ensure the high selectivity of miRNA determination, coupled with the unique cleavage properties of DSN to improve the sensitivity of the strategy significantly. Read More

View Article and Full-Text PDF
January 2022

Enantioselective recognition of chiral acids by supramolecular interactions with chiral AIEgens.

Chem Commun (Camb) 2021 Nov 23. Epub 2021 Nov 23.

Shenzhen Institute of Aggregate Science and Technology, School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China.

Novel chiral AIEgens bearing optically pure amino groups were synthesized and showed excellent discrimination for a series of chiral acidic compounds and amino acids. Interestingly, after supramolecular assembly with 4-sulfocalix[4]arene, the obtained complexes showed enhanced enantioselectivity for chiral acids. Read More

View Article and Full-Text PDF
November 2021

Derivation and validation of predictive indices for 30-day mortality after coronary and valvular surgery in Ontario, Canada.

CMAJ 2021 Nov;193(46):E1757-E1765

Division of Cardiac Anesthesiology (Sun), University of Ottawa Heart Institute, Ottawa, Ont.; ICES Central (Sun, Chu, Tam, Wang, Fang, Austin, Tusevljak, Lee), Toronto, Ont.; School of Epidemiology and Public Health (Sun), University of Ottawa, Ottawa, Ont.; Sunnybrook Health Sciences Centre (Tam); University Health Network and Peter Munk Cardiac Centre (Feindel, Ouzounian, Lee); Departments of Cardiac Surgery (Tam, Feindel, Ouzounian), Physical Therapy (Chu), Surgery (Feindel), Cardiology (Lee), University of Toronto, Toronto, Ont.; Institute for Health Policy, Management and Evaluation (Austin), University of Toronto, Toronto, Ont.; CorHealth Ontario (Oakes, Alexopoulos), Toronto, Ont.

Background: Coronary artery bypass grafting (CABG) and surgical aortic valve replacement (AVR) are the 2 most common cardiac surgery procedures in North America. We derived and externally validated clinical models to estimate the likelihood of death within 30 days of CABG, AVR or combined CABG + AVR.

Methods: We obtained data from the CorHealth Ontario Cardiac Registry and several linked population health administrative databases from Ontario, Canada. Read More

View Article and Full-Text PDF
November 2021

Self-assembled plasmonic nanoarrays for enhanced bacterial identification and discrimination.

Biosens Bioelectron 2022 Feb 12;197:113778. Epub 2021 Nov 12.

Shanghai Institute for Pediatric Research, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. Electronic address:

The rapid and accurate bacterial testing is a critical step for the management of infectious diseases, but challenges remain largely due to a lack of advanced sensing tools. Here we report the development of highly plasmon-active, biofunctional nanoparticle arrays for simultaneous capture, identification, and differentiation of bacteria by surface-enhanced Raman scattering (SERS). The nanoarrays were facilely prepared through an electrostatic mechanism-controlled self-assembly of metallic nanoparticles at liquid-liquid interfaces, and exhibited high SERS sensitivity beyond femtomole, good reproducibility (relative standard deviation of 2. Read More

View Article and Full-Text PDF
February 2022

Application of Bayesian Decision Tree in Hematology Research: Differential Diagnosis of -Thalassemia Trait from Iron Deficiency Anemia.

Comput Math Methods Med 2021 9;2021:6401105. Epub 2021 Nov 9.

Thalassemia & Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Objective: Several discriminating techniques have been proposed to discriminate between -thalassemia trait (TT) and iron deficiency anemia (IDA). These discrimination techniques are essential clinically, but they are challenging and typically difficult. This study is the first application of the Bayesian tree-based method for differential diagnosis of TT from IDA. Read More

View Article and Full-Text PDF
November 2021

Derivation and Validation of a Risk Score to Predict Mortality of Early Neonates at Neonatal Intensive Care Unit: The END in NICU Score.

Int J Gen Med 2021 12;14:8121-8134. Epub 2021 Nov 12.

Department of Epidemiology and Biostatistics, School of Public Health, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia.

Background: Early neonatal death is death of infants in the first week of life. And 34% to 92% of neonatal deaths happen within 7 days of postnatal period. Thus, the early neonatal period is the most critical time for an infant, requiring different strategies to prevent mortality. Read More

View Article and Full-Text PDF
November 2021

Development and Validation of Prediction Models for Developmental and Intellectual Outcome Following Pediatric Epilepsy Surgery.

Neurology 2021 Nov 18. Epub 2021 Nov 18.

University Medical Center Utrecht, Department of Pediatric Neurology, The Netherlands, member of the ERN EpiCARE.

Background And Objectives: To (1) identify predictors of postoperative intelligence and developmental quotients (IQ/DQ) and (2) develop and validate clinically applicable IQ/DQ prediction models.

Methods: We retrospectively analyzed neuropsychological outcomes and their possible determinants for children treated in Bethel and Utrecht since 1990. We performed separate analyses for patients with IQ and those with only DQ available. Read More

View Article and Full-Text PDF
November 2021

Biomarkers to Predict Response to ICS and LAMA in Adolescents and Adults with Mild Persistent Asthma.

Ann Am Thorac Soc 2021 Nov 18. Epub 2021 Nov 18.

Penn State University College of Medicine, Public Health Sciences, Hershey, Pennsylvania, United States;

Rationale Whether biomarkers can be used to predict response to inhaled corticosteroids (ICS) or long-acting muscarinic antagonists (LAMA) in mild persistent asthma is unclear. Objectives In a pre-specified exploratory analysis of a randomized clinical trial of 295 participants >12 years old with uncontrolled mild persistent asthma, we sought to identify biomarkers of treatment response after 12 weeks of ICS (mometasone 200µg or 220µg twice/day), LAMA (tiotropium 5µg/day), or placebo in adults (>18 years) and adolescents (12-17 years) separately. Methods The primary outcome was a composite outcome of asthma control (treatment failure, asthma control days, and forced expired volume in the first second [FEV1]). Read More

View Article and Full-Text PDF
November 2021

Telephone Interview for Cognitive Status (TICS): Italian adaptation, psychometrics and diagnostics.

Neurol Sci 2021 Nov 18. Epub 2021 Nov 18.

Department of Psychology, University of Milano-Bicocca, Milan, Italy.

Background: Telephone-based cognitive screening (TBCS) is crucial to telehealth care of neurological patients, prevention campaigns, and epidemiological studies on cognitive impairment. The Telephone Interview for Cognitive Status (TICS) is one of the most widespread and psychometrically/diagnostically sound TBCS test, with several versions developed worldwide (e.g. Read More

View Article and Full-Text PDF
November 2021

Identifying patients at increased risk for poor outcomes from heart failure with reduced ejection fraction: the PROMPT-HF risk model.

ESC Heart Fail 2021 Nov 17. Epub 2021 Nov 17.

Ahmanson-UCLA Cardiomyopathy Center, Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA.

Aims: We aimed to develop a risk prediction tool that incorporated both clinical events and worsening health status for patients with heart failure (HF) with reduced ejection fraction (HFrEF). Identifying patients with HFrEF at increased risk of a poor outcome may enable proactive interventions that improve outcomes.

Methods And Results: We used data from a longitudinal HF registry, CHAMP-HF, to develop a risk prediction tool for poor outcomes over the next 6 months. Read More

View Article and Full-Text PDF
November 2021

Automated detection of cecal intubation with variable bowel preparation using a deep convolutional neural network.

Endosc Int Open 2021 Nov 12;9(11):E1778-E1784. Epub 2021 Nov 12.

St. Michael's Hospital, University of Toronto.

Colonoscopy completion reduces post-colonoscopy colorectal cancer. As a result, there have been attempts at implementing artificial intelligence to automate the detection of the appendiceal orifice (AO) for quality assurance. However, the utilization of these algorithms has not been demonstrated in suboptimal conditions, including variable bowel preparation. Read More

View Article and Full-Text PDF
November 2021

Impact of rheumatoid arthritis on sexuality: adaptation and validation of the Qualisex questionnaire for use in Spain.

Rheumatol Int 2021 Nov 16. Epub 2021 Nov 16.

Rheumatology Service, Hospital Universitario Reina Sofía, Cordoba, Spain.

Patients with rheumatoid arthritis (RA) have a significantly increased risk of sexual dysfunction. However, it is not properly included in commonly used questionnaires to assess health-related quality of life in RA. Qualisex is a questionnaire developed in France to assess the impact of RA on patients´ sexual function. Read More

View Article and Full-Text PDF
November 2021

Non-contact screening system based for COVID-19 on XGBoost and logistic regression.

Comput Biol Med 2021 Nov 3:105003. Epub 2021 Nov 3.

Department of Medical Quality Management and Telemedicine, The Second Medical Center of PLA General Hospital, Beijing, China. Electronic address:

Background: The coronavirus disease (COVID-19) effected a global health crisis in 2019, 2020, and beyond. Currently, methods such as temperature detection, clinical manifestations, and nucleic acid testing are used to comprehensively determine whether patients are infected with the severe acute respiratory syndrome coronavirus 2. However, during the peak period of COVID-19 outbreaks and in underdeveloped regions, medical staff and high-tech detection equipment were limited, resulting in the continued spread of the disease. Read More

View Article and Full-Text PDF
November 2021

Performance of a machine-learning algorithm to predict hypotension in mechanically ventilated patients with COVID-19 admitted to the intensive care unit: a cohort study.

J Clin Monit Comput 2021 Nov 13. Epub 2021 Nov 13.

Department of Anesthesiology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.

The Hypotension Prediction Index (HPI) is a commercially available machine-learning algorithm that provides warnings for impending hypotension, based on real-time arterial waveform analysis. The HPI was developed with arterial waveform data of surgical and intensive care unit (ICU) patients, but has never been externally validated in the latter group. In this study, we evaluated diagnostic ability of the HPI with invasively collected arterial blood pressure data in 41 patients with COVID-19 admitted to the ICU for mechanical ventilation. Read More

View Article and Full-Text PDF
November 2021

Development and validation of multivariable prediction models for adverse COVID-19 outcomes in patients with IBD.

BMJ Open 2021 11 12;11(11):e049740. Epub 2021 Nov 12.

Department of Biostatistics, University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, USA.

Objectives: Develop an individualised prognostic risk prediction tool for predicting the probability of adverse COVID-19 outcomes in patients with inflammatory bowel disease (IBD).

Design And Setting: This study developed and validated prognostic penalised logistic regression models using reports to the international Surveillance Epidemiology of Coronavirus Under Research Exclusion for Inflammatory Bowel Disease voluntary registry from March to October 2020. Model development was done using a training data set (85% of cases reported 13 March-15 September 2020), and model validation was conducted using a test data set (the remaining 15% of cases plus all cases reported 16 September-20 October 2020). Read More

View Article and Full-Text PDF
November 2021

Co-Occurrence of Differentiated Thyroid Cancer and Second Primary Malignancy: Correlation with Expression Profiles of Mismatch Repair Protein and Cell Cycle Regulators.

Cancers (Basel) 2021 Oct 31;13(21). Epub 2021 Oct 31.

Department of Medical Research, Cathay General Hospital, Taipei 106, Taiwan.

Some patients with thyroid cancer develop a second primary cancer. Defining the characteristics of patients with double primary cancers (DPCs) is crucial and needs to be followed. In this study, we examine molecular profiles in DPC. Read More

View Article and Full-Text PDF
October 2021

Machine Learning Based Identification of Microseismic Signals Using Characteristic Parameters.

Sensors (Basel) 2021 Oct 20;21(21). Epub 2021 Oct 20.

School of Resources and Safety Engineering, Central South University, Changsha 410083, China.

Microseismic monitoring system is one of the effective means to monitor ground stress in deep mines. The accuracy and speed of microseismic signal identification directly affect the stability analysis in rock engineering. At present, manual identification, which heavily relies on manual experience, is widely used to classify microseismic events and blasts in the mines. Read More

View Article and Full-Text PDF
October 2021