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Effects of the sodium-glucose cotransporter 2 inhibitor empagliflozin on vascular function in patients with chronic heart failure.

ESC Heart Fail 2021 Sep 20. Epub 2021 Sep 20.

Department of Nephrology and Hypertension, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg (FAU), Ulmenweg 18, Erlangen, 91054, Germany.

Aims: Impairment of vascular function contributes to the progression of chronic heart failure (HF) by increasing the afterload. Treatment with selective sodium-glucose cotransporter 2 (SGLT2) inhibitors improves the prognosis of HF, but the precise mechanisms remain unclear. The aim of this study was to analyse the effect of empagliflozin on vascular function in patients with HF. Read More

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September 2021

Efficacy and safety of empagliflozin at different doses in patients with type 2 diabetes mellitus: A network meta-analysis based on randomized controlled trials.

J Clin Pharm Ther 2021 Sep 20. Epub 2021 Sep 20.

Department of Cardio-Thoracic Surgery, The second affiliated hospital of Nanchang University, Nanchang, China.

What Is Known And Objective: As an oral hypoglycaemic drug that significantly reduces cardiovascular risk, empagliflozin is often used in patients with type 2 diabetes mellitus (T2DM). However, the dosage and administration of empagliflozin are still controversial clinically. To determine the most appropriate dose, we performed this network meta-analysis. Read More

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September 2021

Scaling the Steep Learning Curve of Total Hip Replacement Surgery.

Vet Comp Orthop Traumatol 2021 Sep 20;34(5). Epub 2021 Sep 20.

Sydney School of Veterinary Science, University of Sydney, Sydney, Australia.

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September 2021

Correlation between Perfusion Index and Left Ventricular Output in Healthy Late Preterm Infants.

Am J Perinatol 2021 Sep 20. Epub 2021 Sep 20.

Department of Pediatric Cardiology, Sıtkı Koçman University School of Medicine, Muğla, Turkey.

Aim:  The perfusion index (PI) is a noninvasive marker derived from photoelectric plethysmographic signals in pulse oximetry in the evaluation of peripheral perfusion. This study was aimed to determine the correlation between PI and left ventricular output (LVO) in healthy late preterm infants at 48 hour of life.

Methods:  With new generation pulse oximeter (MASIMO Rad 7 Oximeter) pre- and post-ductal PI values were recorded from healthy late preterm babies at the 48 hour of life. Read More

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September 2021

Fibrinogen-to-Albumin Ratio in Familial Mediterranean Fever: Association with Subclinical Inflammation.

Klin Padiatr 2021 Sep 20. Epub 2021 Sep 20.

Pediatric Nephrology, Celal Bayar University School of Medicine, Manisa, Turkey.

Background: Familial Mediterranean fever (FMF) is the most seen monogenic periodic fever syndrome characterised by bouts of fever and serositis. It is known that subclinical inflammation (SI) can persist in the symptom-free period and lead to amyloidosis even under colchicine treatment. This study aimed to evaluate the role of the fibrinogen-to-albumin ratio (FAR) in FMF and its correlation with SI. Read More

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September 2021

[Norms of the German Version of the Highly Sensitive Person Scale (HSPS-G) - Self-Assessment Scale on a German-Speaking Sample].

Psychother Psychosom Med Psychol 2021 Sep 20. Epub 2021 Sep 20.

Professur für Persönlichkeitspsychologie und Psychologische Diagnostik, Helmut-Schmidt-Universität Universität der Bundeswehr Hamburg, Deutschland.

Problem: The German version of the Highly Sensitive Person Scale (HSPS-G) is an instrument for the assessment of sensitivity. Validity of the scale was confirmed in prior research (Konrad & Herzberg, 2017). This paper provides norm values of the HSPS-G for German-speaking countries. Read More

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September 2021

Lung volume head ratio: A potential parameter for prediction of respiratory distress in newborn.

Am J Perinatol 2021 Sep 20. Epub 2021 Sep 20.

Neonatology, Kalawati Saran Children's Hospital, New Delhi, India.

Objective: To evaluate the role of fetal lung biometry profile including fetal lung volume head ratio (LVHR) in predicting the occurrence of respiratory distress (RD) in early preterm newborn.

Material And Method: Prospective analytical cohort study was done to evaluate the clinical value of fetal sonographic measures such as the total lung area (TLA), total lung volume (TLV), total lung area head ratio (TLHR), lung volume head ratio (LVHR) was measured in pregnant women between 30 to 34 week gestation , expected to deliver within the next 72 hours. The cases with RD were compared with controls who had normal outcome. Read More

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September 2021

Importance of Hip-Spine Syndrome in Hip Arthroplasty: Influence on the Outcome and Therapeutic Consequences.

Z Orthop Unfall 2021 Sep 20. Epub 2021 Sep 20.

Clinic and Polyclinic for Orthopaedics and Sports Orthopaedics, Klinikum Rechts der Isar of the Technical University of Munich, Germany.

Correct interaction between the spine, pelvis, and hip is an essential condition for successful progress after total hip replacement. Spinal pathologies, such as degeneration, fractures, and spinopelvic imbalance with and without lumbar fusions, are closely associated with an increased risk of impingement or even dislocation of the prosthesis. To significantly reduce this risk, various parameters are required to quantify the risk groups. Read More

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September 2021

[Inflammatory Bowel Disease - Challenges in the Workplace and Support for Coping with Disease].

Rehabilitation (Stuttg) 2021 Sep 20. Epub 2021 Sep 20.

Institut für Sozialmedizin und Epidemiologie, Universität zu Lübeck, Lübeck.

Purpose: Patients with inflammatory bowel diseases (IBD) are often impaired in their ability to be employed due to IBD symptoms. The aim of this study was to explore work-related problems and support requested by IBD patients and develop rehabilitation programs meeting their needs.

Methods: A total of 235 IBD patients (97 rehabilitants, 138 outpatients) completed a questionnaire assessing disease-specific impairments, work-related concerns and the need for support services. Read More

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September 2021

Efficient construction of a linkage map and haplotypes for Mentha suaveolens using sequence capture.

G3 (Bethesda) 2021 Sep;11(9)

Department of Plant Biology and Genome Center, University of California, Davis, Davis, CA 95616, USA.

The sustainability of many crops is hindered by the lack of genomic resources and a poor understanding of natural genetic diversity. Particularly, application of modern breeding requires high-density linkage maps that are integrated into a highly contiguous reference genome. Here, we present a rapid method for deriving haplotypes and developing linkage maps, and its application to Mentha suaveolens, one of the diploid progenitors of cultivated mints. Read More

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September 2021

Improved Apis mellifera reference genome based on the alternative long-read-based assemblies.

G3 (Bethesda) 2021 Sep;11(9)

Institute of Biochemistry and Genetics, Ufa Federal Research Center of Russian Academy of Sciences, Ufa 450054, Russia.

Apis mellifera L., the western honey bee is a major crop pollinator that plays a key role in beekeeping and serves as an important model organism in social behavior studies. Recent efforts have improved on the quality of the honey bee reference genome and developed a chromosome-level assembly of 16 chromosomes, two of which are gapless. Read More

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September 2021

Transcriptomic and photosynthetic responses to grafting of the Nod1 gene in nodulated and non-nodulated soybeans.

G3 (Bethesda) 2021 Sep;11(9)

Soybean Research Institute/National Center for Soybean Improvement, Ministry of Agriculture/Key Laboratory of Biology and Genetic Improvement of Soybean/Ministry of Agriculture/National Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing 210095, China.

Legume plants form symbiotic relationships with rhizobia to convert N2 into ammonia, and the nodulation status can affect plant development including photosynthesis. However, the relationship between nitrogen fixation and photosynthesis during carbon and nitrogen metabolism remains unclear. This study was undertaken to unravel regulation of nodulation and photosynthesis using a spontaneous nonnodulated soybean mutant by grafting. Read More

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September 2021

Quantitative accuracy in total-body imaging using the uEXPLORER PET/CT scanner.

Phys Med Biol 2021 Sep 20. Epub 2021 Sep 20.

Department of Radiology, UC Davis Health System, 4860 Y Street, Suite 3100, Sacramento, CA 95817, USA, Sacramento, California, 95817, UNITED STATES.

Absolute quantification of regional tissue concentration of radioactivity in PET is a critical parameter-of-interest across various clinical and research applications and is affected by a complex interplay of factors including scanner calibration, data corrections, and image reconstruction. The emergence of long AFOV PET systems widens the dynamic range accessible to PET and creates new opportunities in reducing scan time and radiation dose, delayed or low radioactivity imaging, as well as kinetic modeling of the entire human. However, these imaging regimes impose challenging conditions for accurate quantification due to constraints from image reconstruction, low count conditions, as well as large and rapidly changing radioactivity distribution across a large AFOV. Read More

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September 2021

Controlled co-delivery system of magnesium and lanthanum ions for vascularized bone regeneration.

Biomed Mater 2021 Sep 20. Epub 2021 Sep 20.

Beijing University of Chemical Technology, Beisanhuan East Road, Chaoyang District, Beijing, 100029, CHINA.

For craniofacial bone regeneration, how to promote vascularized bone regeneration is still a significant problem, and the controlled release of trace elements vital to osteogenesis has attracted attention. In this study, a ion co-delivery system was developed to promote angiogenesis and osteogenesis. Magnesium ions (Mg) and lanthanum ions (La) were thus selected as biosignal molecules because Mgcan promote angiogenesis and both of them can enhance bone formation. Read More

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September 2021

Seroepidemiology of TORCH Infections among 1.7 Million Women of Childbearing Age in Rural China: A Population-Based Cross-Sectional Study.

Am J Trop Med Hyg 2021 Sep 20. Epub 2021 Sep 20.

Department of Clinical Laboratory Medicine, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing, China.

We conducted a national seroepidemiological study of the TORCH (Toxoplasma gondii [TOX], Rubella [RV], Cytomegalovirus [CMV], and Herpes Simplex Virus) in rural women to provided updated baseline data on TORCH prevalence. A total of 1,541,329 women of childbearing age were gathered from 2010 to 2012 in China. Of these, 858,072 women were tested positive for anti-RV IgG antibodies, 602,251 women were tested positive for anti-CMV antibodies, and 40,055 women were tested positive for anti-TOX antibodies. Read More

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September 2021

Endothelial Progenitor Cell Function in Patients With Coronary Chronic Total Occlusion and its Relationship With Collateral Circulation.

J Invasive Cardiol 2021 Sep 17. Epub 2021 Sep 17.

Cardiology Department, Clinic Cardiovascular Institute, Hospital Clínic, IDIBAPS, Barcelona, Spain.

Aim: To evaluate the relationship between endothelial progenitor cell (EPC) count and function and collateral circulation in coronary chronic total occlusions (CTOs).

Methods: A total of 20 consecutive patients with successfully treated CTO lesions were included during a period of 12 months. EPC count and function were evaluated by flow cytometry and colony-forming unit (CFU) analysis at baseline (before percutaneous coronary intervention) and at 1-year follow-up. Read More

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September 2021

Effects of different nutritional conditions on accumulation and distribution of Cr in Coix lacryma-jobi L. in Cr-contaminated constructed wetland.

Ecotoxicol Environ Saf 2021 Sep 17;225:112763. Epub 2021 Sep 17.

Agriculture college of Guangxi University, Nanning 530005, China. Electronic address:

In this research, micro Coix lacryma-jobi L. vertical flow constructed wetlands (VFCWs) were set up using domestic sewage (DWS) and 1/2 Hoagland nutrient solution (HNS) as VFCWs water sources. 0, 20 mg L and 40 mg L of Cr (in the form of KCrO) were added into the water sources separately in order to study the response of Coix lacryma-jobi L. Read More

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September 2021

Growth performance, nutrient digestibility, blood parameters, and carcass characteristics by lambs fed an oregano and cobalt blend.

Animal 2021 Sep 17;15(10):100365. Epub 2021 Sep 17.

Key Laboratory for Sheep, Goat and Cattle Germplasm and Straw Feed in Gansu Province, Gansu Academy of Agricultural Science, Lanzhou, Gansu 730070, China; Institute of Agricultural and Economic Informant Ion, Gansu Academy of Agricultural Sciences, Lanzhou, Gansu 730070, China.

Shifting ruminal fermentation via feeding a blend of oregano (Organum vulgare L.) essential oils and Co-lactate (EOC; Rum-A-Fresh, Ralco, Inc. Marshall, MN) could improve lamb growth and carcass performance. Read More

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September 2021

Can TKA outcomes be predicted with computational simulation? Generation of a patient specific planning tool.

Knee 2021 Sep 17;33:38-48. Epub 2021 Sep 17.

360MedCare, Sydney 2073, Australia.

Background: Computer simulations of knee movement allow Total Knee Arthroplasty (TKA) dynamic outcomes to be studied. This study aims to build a model predicting patient reported outcome from a simulation of post-operative TKA joint dynamics.

Methods: Landmark localisation was performed on 239 segmented pre-operative computerized tomography (CT) scans to capture patient specific soft tissue attachments. Read More

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September 2021

Response of Calamagrostis angustifolia to burn frequency and seasonality in the Sanjiang Plain wetlands (Northeast China).

J Environ Manage 2021 Sep 17;300:113759. Epub 2021 Sep 17.

Key Laboratory of Wetland Ecology and Environment, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Shengbei Street 4888, 130102, Changchun, China. Electronic address:

Fire is an important disturbance in many wetlands, which are key carbon reservoirs at both regional and global scales. However, the effects of fire on wetland vegetation biomass and plant carbon dynamics are poorly understood. We carried out a burn experiment in a Calamagrostis angustifolia wetland in Sanjiang Plain (Northeast China), which is widespread wetland type in China and frequently exposed to fire. Read More

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September 2021

Active head lifting from supine in infancy in the general population: Red flag or not?

Early Hum Dev 2021 Sep 7;163:105466. Epub 2021 Sep 7.

University of Groningen, University Medical Centre Groningen, Department of Paediatrics, Developmental Neurology, Groningen, the Netherlands.

Background: Previously it had been had reported that active head lifting from supine (AHLS) in high-risk infants was associated with lower cognitive scores in the second year. AHLS was generally accompanied by stereotyped leg movements.

Aims: To examine in a standardized way whether AHLS with or without stereotyped leg movements in the general population is associated with prenatal, perinatal, neonatal and socio-economic risk factors or with lower scores on concurrent infant tests. Read More

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September 2021

Promoting resilience and lower stress in nurses and improving inpatient experience through emotional intelligence training in China: A randomized controlled trial.

Nurse Educ Today 2021 Sep 6;107:105130. Epub 2021 Sep 6.

Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. Electronic address:

Background: Emotional intelligence training relieves stress and promotes resilience among nurses. Previous studies have not sufficiently explored the effect of emotional intelligence training among nurses on the experience of inpatients under their care.

Objective: To explore the effects of emotional intelligence training on emotional intelligence, resilience, and perceived stress among nurses and examine how training affects inpatient experience. Read More

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September 2021

Exposure to widespread drinking water chemicals, blood inflammation markers, and colorectal cancer.

Environ Int 2021 Sep 17;157:106873. Epub 2021 Sep 17.

ISGlobal, Barcelona, Spain; CIBER epidemiología y salud pública (CIBERESP), Madrid, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.

Background: Trihalomethanes (THMs) and nitrate are widespread chemicals in drinking water associated with colorectal cancer risk but mechanisms are not well understood.

Objectives: We explored the association between exposure to THMs and nitrate in drinking water and inflammation markers, and the link with colorectal cancer risk.

Methods: A subset of 198 colorectal cancer cases and 205 controls from the multicase-control study MCC-Spain were included. Read More

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September 2021

A concise review towards defining the exposome of oesophageal cancer in sub-Saharan Africa.

Environ Int 2021 Sep 17;157:106880. Epub 2021 Sep 17.

Department of Bioanalysis, Centre of Excellence in Mycotoxicology and Public Health, Ghent University, Ghent, Belgium; MYTOX-SOUTH, International Thematic Network, Ghent University, Ghent, Belgium; CRIG, Cancer Research Institute Ghent, Ghent, Belgium.

Context: Oesophageal cancer (EC) is among the common causes of illness and death among all cancers worldwide. Advanced EC has a poor prognosis, with worse outcomes observed in low-income settings. Oesophageal squamous cell carcinoma (ESCC) is the most common EC histology reported globally, with the highest ESCC incidence rates in the 'Asian Belt' and the African EC corridor. Read More

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September 2021

Getting butts off the beach: Policy alone is not effective at reducing cigarette filter litter on beaches in Maui, Hawai'i.

Mar Pollut Bull 2021 Sep 17;173(Pt A):112937. Epub 2021 Sep 17.

Pacific Whale Foundation, Wailuku, HI, USA; Pacific Whale Foundation Australia, Urangan, QLD, Australia.

Cigarette filters are made of non-biodegradable plastic and are one of the top littered items worldwide. Here, we determine if policy implementation is an effective strategy for reducing cigarette filter litter on beaches in Maui, Hawai'i by comparing cigarette filter counts before and after a policy banning tobacco use was implemented. We use a before-after control-impact (BACI) design to investigate whether changes in cigarette filter accumulation at an impact site, where tobacco use was banned, decreased relative to counts at a control site, where tobacco use was not banned. Read More

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September 2021

Quantification of 397 pesticide residues in different types of commercial teas: Validation of high accuracy methods and quality assessment.

Food Chem 2021 Aug 31;370:130986. Epub 2021 Aug 31.

Faculty of Environmental and Food Engineering, Nguyen Tat Thanh University, Ho Chi Minh City, Viet Nam. Electronic address:

Analytical methods with high sensitivity and accuracy were successfully validated for the quantification of 397 pesticides in different types of tea. For the UPLC-MS/MS method, 191 pesticides of 200 ones in total had "soft" matrix effects and could be quantified by calibration curves in the solvent. For the GC-MS/MS method, matrix-matched calibration curves were established on a mixed blank including white, green, oolong and black organic teas. Read More

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Transanal endoscopic microsurgical submucosal dissection (TEM-ESD): A novel approach to the local treatment of early rectal cancer.

Surg Oncol 2021 Sep 13;39:101662. Epub 2021 Sep 13.

Surgery Department, Karlsruhe Municipal Hospital, Moltkestrasse 90, 76133, Karlsruhe, Germany.

Background: Complete local resection is currently the treatment of choice for low-risk early rectal cancer; however, the ideal resection technique for such tumours is still debated. Transanal endoscopic microsurgical submucosal dissection (TEM-ESD) is a new technique which combines the ergonomic advantages of transanal endoscopic microsurgery (TEM) with the minimally invasive approach of endoscopic submucosal dissection (ESD). The aim of our study was to assess the feasibility, safety, and long-term outcomes of TEM-ESD in treating early rectal cancer. Read More

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September 2021

In silico screening of ssDNA aptamer against Escherichia coli O157:H7: A machine learning and the Pseudo K-tuple nucleotide composition based approach.

Comput Biol Chem 2021 Aug 27;95:107568. Epub 2021 Aug 27.

Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address:

This study was planned to in silico screening of ssDNA aptamer against Escherichia coli O157:H7 by combination of machine learning and the PseKNC approach. For this, firstly a total numbers of 47 validated ssDNA aptamers as well as 498 random DNA sequences were considered as positive and negative training data respectively. The sequences then converted to numerical vectors using PseKNC method through Pse-in-one 2. Read More

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Prenatal exposure to paraquat and nanoscaled TiO aerosols alters the gene expression of the developing brain.

Chemosphere 2021 Sep 16;287(Pt 3):132253. Epub 2021 Sep 16.

IGFL, Functional Genomics of Thyroid Hormone Signaling Group, Lyon, France. Electronic address:

Nanopesticides are innovative pesticides involving engineered nanomaterials in their formulation to increase the efficiency of plant protection products, while mitigating their environmental impact. Despite the predicted growth of the nanopesticide use, no data is available on their inhalation toxicity and the potential cocktail effects between their components. In particular, the neurodevelopmental toxicity caused by prenatal exposures might have long lasting consequences. Read More

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September 2021

Comparative study on polychlorinated biphenyl sorption to activated carbon and biochar and the influence of natural organic matter.

Chemosphere 2021 Sep 13;287(Pt 3):132239. Epub 2021 Sep 13.

Department of Civil and Environmental Engineering, School of Civil Engineering, Beijing Jiaotong University, Beijing, 100044, China.

The sorption isotherms of polychlorinated biphenyls (PCBs) on carbons (coal based activated carbon named AC and hardwood derived biochar named BC) and natural organic matter (NOM) loaded carbons were examined and carbon-water partition coefficients (K) were calculated. The purpose was to accurately predict the effectiveness of in-situ carbon treatments on the sediment impacted with hydrophobic organic chemicals (HOCs). For 1 month sorption, AC K values were significantly higher than BC, corresponding to the much larger surface area (particularly in mesopores) for AC. Read More

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September 2021