594,621 results match your criteria examined signs


The triangular cord ratio and the presence of a cystic lesion in the triangular cord. Suggested new ultrasound findings in the early diagnosis of Biliary Atresia.

Pediatr Surg Int 2021 Sep 15. Epub 2021 Sep 15.

Department of Pediatric Surgery, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki, Kanagawa, 216-8511, Japan.

Background: In biliary atresia (BA), the ultrasonic triangular cord (TC) sign is positive at ≥ 3 mm, but sometimes there is BA even if it is ≤ 3 mm. For improving the ultrasonographic diagnosis, we have established a new evaluation, adding the ratio of the anterior/posterior thickness (TC ratio) in the hyperechoic area and the presence of a cystic lesion in the triangular cord (TCC).

Methods: We examined 24 cases of suspected BA who demonstrated acholic stools from 2006 to 2020. Read More

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September 2021

Factors Associated With Changes in Pregnancy Intention Among Women Who Were Mothers of Young Children in New York City Following the COVID-19 Outbreak.

JAMA Netw Open 2021 Sep 1;4(9):e2124273. Epub 2021 Sep 1.

Division of Environmental Pediatrics, Department of Pediatrics, NYU Langone Medical Center, New York, New York.

Importance: Early evidence shows a decrease in the number of US births during the COVID-19 pandemic, yet few studies have examined individual-level factors associated with pregnancy intention changes, especially among diverse study populations or in areas highly affected by COVID-19 in the US.

Objective: To study changes in pregnancy intention following the outbreak of the COVID-19 pandemic and identify factors possibly associated with these changes.

Design, Setting, And Participants: A cross-sectional, population-based study was conducted among women who were currently pregnant or had delivered a live infant and responded to a survey emailed to 2603 women (n = 1560). Read More

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September 2021

The perception of stress, behavior in stressful situations and mental health of bank employees within a German-Ukrainian comparative study.

Int J Occup Med Environ Health 2021 Aug 31. Epub 2021 Aug 31.

Otto-von-Guericke-University, Magdeburg, Germany (Institute of Occupational Medicine, Medical Faculty).

Objectives: The banking sector is a branch of the global labor market that is increasingly facing stress. This can have some negative effects on mental and physical health. The aim of the study was to examine the management of stress and the assessment of mental health in 2 European countries. Read More

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Characteristics and dose-effect relationship of clinical gamma-hydroxybutyrate intoxication: A case series.

J Forensic Sci 2021 Sep 15. Epub 2021 Sep 15.

Department of Toxicology, Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Gamma-Hydroxybutyrate (GHB) overdoses cause respiratory depression, coma, or even death. Symptoms and severity of poisoning depend on blood-concentrations and individual factors such as tolerance. A retrospective case study was conducted, evaluating GHB intoxication cases. Read More

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September 2021

The relation between sleep quality, sleep quantity, and gastrointestinal problems among colorectal cancer survivors: result from the PROFILES registry.

Support Care Cancer 2021 Sep 14. Epub 2021 Sep 14.

Department of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands.

Purpose: Common residual symptoms among survivors of colorectal cancer (CRC) are sleep difficulties and gastrointestinal symptoms. Among patients with various gastrointestinal (inflammatory) diseases, sleep quality has been related to gastrointestinal symptoms. For CRC survivors, this relation is unclear; therefore, we examined the association between sleep quality and quantity with gastrointestinal symptoms among CRC survivors. Read More

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September 2021

The Pattern of Superficial Lymphadenopathy on Fine Needle Aspiration Cytology in Clinical Practice in Islamabad.

Cureus 2021 Aug 10;13(8):e17075. Epub 2021 Aug 10.

Medical Affairs and Clinical Research, Hilton Pharma Pvt. Ltd., Karachi, PAK.

Background:  In adults, lymph nodes are not normally palpable. A number of patients with asymptomatic lymphadenopathy never visit physicians for the condition, and thus, this important sign is often missed by the medical practitioner if it is not the presenting complaint. The incidence of lymphadenopathy is suggested to be increasing. Read More

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The association between serum uric acid and features of metabolic disturbances in young adults.

Arch Med Sci 2021 12;17(5):1277-1285. Epub 2020 Mar 12.

Department of Toxicology, Faculty of Pharmacy with the Division of Laboratory Diagnostics, Wroclaw Medical University, Wroclaw, Poland.

Introduction: The increase in the number of people affected by different metabolic disturbances, especially among young people, is alarming. It seems worthwhile to reappraise the usefulness of commonly used laboratory parameters potentially associated with metabolic and metabolically obese normal weight syndrome. Serum uric acid may be considered as an indicator and/or a predictor of metabolic disorders. Read More

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Nadir CA-125 has prognostic value for recurrence, but not for survival in patients with ovarian cancer.

Sci Rep 2021 Sep 14;11(1):18190. Epub 2021 Sep 14.

Department of Gynecologic Oncology, The Maria Sklodowska-Curie National Research Institute Of Oncology, Roentgen Street 5, 02-781, Warsaw, Poland.

The objective of this study was to evaluate the nadir CA-125 in patients with epithelial ovarian cancer. A total of 168 patients who achieved complete remission (no clinical and radiological signs, CA-125 ≤ 35 U/ml) after first-line treatment were enrolled in the study. The relationship between CA-125 and survival was examined by applying generalized additive models to the Cox proportional hazards model. Read More

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September 2021

Parity associates with chromosomal damage in uterine leiomyomas.

Nat Commun 2021 Sep 14;12(1):5448. Epub 2021 Sep 14.

Department of Medical and Clinical Genetics and Applied Tumor Genomics Research Program University of Helsinki, Helsinki, Finland.

Mechanical forces in a constrained cellular environment were recently established as a facilitator of chromosomal damage. Whether this could contribute to tumorigenesis is not known. Uterine leiomyomas are common neoplasms that display relatively few chromosomal aberrations. Read More

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September 2021

Ventilatory Ratio Threshold for Unassisted Breathing: A Retrospective Exploratory Analysis.

Respir Care 2021 Sep 14. Epub 2021 Sep 14.

Department of Intensive Care, University Hospital of Heraklion and University of Crete Medical School, Greece.

Background: The ventilatory ratio (VR) is a simple index of ventilatory efficiency and dead space. Because increased dead space and high ventilatory demands impose a limitation to unassisted ventilation, and may predispose patients to injurious strong efforts during assisted ventilation, evaluation of the VR could provide helpful information during weaning. We hypothesize that there is a threshold of VR associated with tolerance of unassisted breathing. Read More

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September 2021

Disease and economic burden increase with systemic lupus erythematosus severity 1 year before and after diagnosis: a real-world cohort study, United States, 2004-2015.

Lupus Sci Med 2021 Sep;8(1)

BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, Maryland, USA.

Objective: To assess the economic burden of patients with SLE by disease severity in the USA 1 year before and after diagnosis.

Methods: Patients aged ≥18 years with a first SLE diagnosis (index date) between January 2005 and December 2014 were identified from administrative commercial claims data linked to electronic medical records (EMRs). Disease severity during the year after diagnosis was classified as mild, moderate, or severe using claims-based algorithms and EMR data. Read More

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September 2021

A Randomized Controlled Trial Evaluating the Effectiveness of Supported Employment Integrated in Primary Care.

Psychiatr Serv 2021 Sep 15:appips202000926. Epub 2021 Sep 15.

Research Service, Department of Veterans Affairs (VA) Medical Center, Tuscaloosa, Alabama (Davis, Mumba, Toscano, Pilkinton, Blansett, McCall, MacVicar); Department of Psychiatry and Behavioral Neurobiology, University of Alabama School of Medicine, Birmingham (Davis); Capstone College of Nursing, University of Alabama, Tuscaloosa (Mumba); Department of Psychiatry and Behavioral Medicine, University of Alabama College of Community Health Sciences, Tuscaloosa (Pilkinton); Department of Biostatistics, University of Alabama at Birmingham, Birmingham (Bartolucci).

Objectives: Mental health issues can cause serious problems in occupational functioning, including higher rates of unemployment. Individual placement and support (IPS) is an evidence-based supported employment intervention that is typically integrated within a mental health setting; however, many primary care patients view referral to a mental health clinic as stigmatizing. Thus, this study examined whether delivery of IPS in a primary care setting provides an effective treatment option and avoids unnecessary delays in obtaining competitive employment. Read More

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September 2021

A network analysis and empirical validation of executive deficits in patients with psychosis and their healthy siblings.

Schizophr Res 2021 Sep 11;237:122-130. Epub 2021 Sep 11.

Navarra Institute for Health Research (IdiSNA), Pamplona, Spain; Mental Health Department, Servicio Navarro de Salud Osasunbidea, Pamplona, Spain.

Background: Psychopathological symptoms and cognitive impairment are core features of patients with psychotic disorders. Executive dysfunctions are commonly observed and typically assessed using tests like the Wisconsin Card Sorting Test (WCST). However, the structure of executive deficits remains unclear, and the underlying processes may be different. Read More

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September 2021

Changing age-specific trends in incidence, comorbidities and mortality of hospitalised heart failure in Western Australia between 2001 and 2016.

Int J Cardiol 2021 Sep 11. Epub 2021 Sep 11.

School of Population and Global Health, The University of Western Australia, Crawley, Western Australia, Australia.

Background: Incident heart failure (HF) hospitalisation rates in most high-income countries are stable or declining. However, HF incidence may be increasing in younger people linked to changing risk factor profiles in the general population. We examined age and sex-specific patterns of incidence, comorbidities and mortality of hospitalised HF in Western Australia (WA) between 2001 and 2016. Read More

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September 2021

Proteomic profiling of extracellular vesicles and particles reveals the cellular response to cisplatin in NSCLC.

Thorac Cancer 2021 Sep 14. Epub 2021 Sep 14.

Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.

Background: Cisplatin-based chemotherapy is a therapeutic strategy against non-small cell lung cancer (NSCLC). However, cancers relapse after chemotherapy due to a dormant state of residual cancer cells. Extracellular vesicles and particles (EVPs) are active carriers of proteins and nucleic acid. Read More

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September 2021

Subareolar Tissue Biopsy Predicts Occult Nipple Involvement in Nipple-Sparing Mastectomies.

Am J Clin Pathol 2021 Sep 14. Epub 2021 Sep 14.

Department of Pathology and Laboratory Medicine, New York, NY, USA.

Objectives: Subareolar tissue is examined during nipple-sparing mastectomy (NSM) to minimize the risk of occult malignancy within the preserved nipple. A positive subareolar tissue biopsy typically warrants subsequent nipple excision. We study the factors associated with a positive subareolar tissue biopsy, the rate of residual malignancy in subsequent nipple excisions, and the value of subareolar tissue biopsy intraoperative frozen section (IOF). Read More

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September 2021

Ictal vocalizations are relatively common in myoclonic-atonic seizures associated with Doose syndrome: an audio-video-polygraphic analysis.

Epileptic Disord 2021 Sep 14. Epub 2021 Sep 14.

Department of Pediatrics, Tokyo Women's Medical University, Tokyo 162, Japan.

The aim of this study was to investigate ictal vocalizations associated with myoclonic (MS) and myoclonic-atonic seizures (MAS) in patients with myoclonic epilepsy in infants (MEI) and epilepsy with myoclonic-atonic seizures (EMAS, Doose syndrome), respectively. Subjects were retrospectively recruited among patients with MEI and EMAS for whom ictal video-polygraphs were recorded between 1990 and 2019. We reviewed all MS and MAS in order to estimate how often they were associated with vocalizations, and analyze the temporal relationship between vocalizations and spike-wave complexes (SWCs) and myoclonic EMG potentials based on simultaneous examination of the polygraphs and sound signals. Read More

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September 2021

Circular RNA PUM1 (CircPUM1) attenuates trophoblast cell dysfunction and inflammation in recurrent spontaneous abortion via the MicroRNA-30a-5p (miR-30a-5p)/JUNB axis.

Bioengineered 2021 Dec;12(1):6878-6890

Department of Gynecology and Obstetrics, The Third Affiliated Hospital of Soochow University, Changzhou, China.

Recurrent spontaneous abortion (RSA) is a threat to human reproductive health worldwide. CircPUM1 has been reported to participate in the pathogenesis of various diseases. However, there has been no report on its association with RSA yet. Read More

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December 2021

species in the male reproductive organs and the fresh and frozen semen of the Hungarian native goose.

Avian Pathol 2021 Sep 14:1-19. Epub 2021 Sep 14.

National Centre of Biodiversity and Gene Conservation, Institute for Animal Gene Conservation, 2100, Gödöllő, Isaszegi út 200, Hungary.

The objective of this study was to clarify whether the most-common species of Mycoplasma are capable of being detected in the reproductive organs and the cloaca, as well as in the semen of asymptomatic native Hungarian male geese. As it is necessary for the semen of that breed to be preserved pathogen-free in an gene-conservation program, the presence of and sources of infection, as well as prevention of the survival of pathogens following semen cryopreservation are key issues.10 asymptomatic, two-year-old ganders were tested. Read More

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September 2021

Clinical Utility of Circulating Tumor Cells in the Early Detection of Lung Cancer in Patients with a Solitary Pulmonary Nodule.

Technol Cancer Res Treat 2021 Jan-Dec;20:15330338211041465

Zhuhai People's Hospital (Zhuhai hospital affiliated with Jinan University), Zhuhai, China.

Lung cancer is the most common cancer and can appear as a solitary pulmonary nodule. Early detection of lung cancer in this patient population would be beneficial for the disease management. In this study, the potential application of circulating tumor cells (CTCs) on early detection of lung cancer in this population was investigated. Read More

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September 2021

Correlation and Diagnostic Value of Serum Cys-C, RBP4, and NGAL with the Condition of Patients with Traumatic Acute Kidney Injury.

Evid Based Complement Alternat Med 2021 3;2021:4990941. Epub 2021 Sep 3.

The Affiliated Nanhua Hospital, Department of Nursing, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.

There is a lack of targeted biomarkers that can diagnose Acute Kidney Injury (AKI) early and accurately, which leads to deterioration of renal function and even death in patients who do not receive timely and effective treatment. In recent years, an increasing number of studies have shown that AKI-related markers such as cystatin C (Cys-C) and retinol-binding protein (RBP) can be used for early diagnosis of AKI to a certain extent. A total of 262 subjects were included in this study, of which 132 patients with traumatic AKI were enrolled in one group and named as the AKI group; 130 healthy subjects were enrolled in another group and named as the healthy group. Read More

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September 2021

School environment and physical activity in adolescents from São Paulo city.

Sci Rep 2021 Sep 13;11(1):18118. Epub 2021 Sep 13.

Departamento de Medicina Preventiva, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

We examined the association of physical activity (PA) facilities and access to school with total PA and domain-specific PA in adolescents. We enrolled 2610 adolescents (mean: 14.9 years) from Sao Paulo city. Read More

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September 2021

Factors Affecting Cancer Prevention Behaviors and Cancer Screening in First-Degree Relatives of Breast and Colorectal Cancer Patients in Korea: A Cross-Sectional Study.

Res Theory Nurs Pract 2021 Sep 13. Epub 2021 Sep 13.

Mo-Im Kim Nursing Research Institute, Yonsei University College of Nursing, Seoul, Republic of Korea.

Background: First-degree relatives (FDRs) of cancer patients have a high risk of cancer due to a similar lifestyle and genetic predisposition. However, previous studies rarely examined the level of cancer prevention behaviors and screening and affecting factors in cancer patients' FDRs.

Purpose: This study aimed to describe the levels of cancer knowledge, attitudes toward cancer, cancer worry, perceived cancer risk, and cancer prevention behaviors and cancer screening in FDRs of breast and colorectal cancer patients. Read More

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September 2021

Higher blood high density lipoprotein and apolipoprotein A1 levels are associated with reduced risk of developing amyotrophic lateral sclerosis.

J Neurol Neurosurg Psychiatry 2021 Sep 13. Epub 2021 Sep 13.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK

Background: Premorbid body mass index, physical activity, diabetes and cardiovascular disease have been associated with an altered risk of developing amyotrophic lateral sclerosis (ALS). There is evidence of shared genetic risk between ALS and lipid metabolism. A very large prospective longitudinal population cohort permits the study of a range of metabolic parameters and the risk of subsequent diagnosis of ALS. Read More

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September 2021

Septic arthritis in the end-stage renal disease population.

J Investig Med 2021 Sep 13. Epub 2021 Sep 13.

Department of Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA

Septic arthritis is important to consider in any patient who presents with joint pain because it is a medical emergency with an 11% fatality rate. Diagnosis and treatment may improve prognosis; however, many patients do not regain full joint function. In patients with end-stage renal disease (ESRD), immune dysfunction due to uremia and chronic vascular access leads to increased risk of infection. Read More

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September 2021

Improving turnaround times for HLA-B*27 and HLA-B*57:01 gene testing: a Barts Health NHS Trust quality improvement project.

BMJ Open Qual 2021 09;10(3)

Clinical Transplantation Laboratory, Barts Health NHS Trust, London, UK.

Among other tests, Barts Health NHS Trust clinical transplantation laboratory conducts two important gene-detection tests: human leucocyte antigen (HLA)-B*27 ('B27', associated with the diagnosis of ankylosing spondylitis) and HLA-B*57:01 ('B57', associated with prediction of abacavir hypersensitivity disorder). The turnaround time (TaT) from sample receipt to return of results is important to clinicians and their patients but was not monitored. Furthermore, we anticipated an imminent increase in demand from a forthcoming pathology service merger, together with long-term increases with the rise of personalised genetic medicine. Read More

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September 2021

Resting state EEG in youth with ASD: age, sex, and relation to phenotype.

J Neurodev Disord 2021 Sep 13;13(1):33. Epub 2021 Sep 13.

Center on Child Health, Behavior and Development, Seattle Children's Research Institute, 1920 Terry Ave, CURE-03, Seattle, WA, 98101, USA.

Background: Identification of ASD biomarkers is a key priority for understanding etiology, facilitating early diagnosis, monitoring developmental trajectories, and targeting treatment efforts. Efforts have included exploration of resting state encephalography (EEG), which has a variety of relevant neurodevelopmental correlates and can be collected with minimal burden. However, EEG biomarkers may not be equally valid across the autism spectrum, as ASD is strikingly heterogeneous and individual differences may moderate EEG-behavior associations. Read More

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September 2021

Evaluation of Patients with Rheumatic Diseases Admitted at Emergency Department: Five-Year Analysis in a Single Center.

Int J Clin Pract 2021 Sep 13:e14837. Epub 2021 Sep 13.

Department of Emergency Medicine, School of Medicine, Düzce University, Düzce, Turkey.

Background: Chronic inflammatory diseases can lead to emergency admissions with various acute complications.Unfortunately,there is limited data on emergency admissions due to rheumatologic diseases.

Objectives: To evaluate the patients with rheumatic diseases presenting to the ED. Read More

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September 2021

Efficacy of systemic therapies in men with metastatic castration resistant prostate cancer harboring germline ATM versus BRCA2 mutations.

Prostate 2021 Sep 13. Epub 2021 Sep 13.

Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

Background: Among men with metastatic prostate cancer, about 10% have germline alterations in DNA damage response genes. Most studies have examined BRCA2 alone or an aggregate of BRCA1/2 and ATM. Emerging data suggest that ATM mutations may have distinct biology and warrant individual evaluation. Read More

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September 2021

Lack of association of FKBP5 SNPs and haplotypes with susceptibility and treatment response phenotypes in Han Chinese with major depressive disorder: A pilot case-control study (STROBE).

Medicine (Baltimore) 2021 Sep;100(36):e26983

University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.

Abstract: The identification of single-nucleotide polymorphisms (SNPs) in genes putatively related to pathophysiological processes in major depressive disorder (MDD) might improve both diagnosis and personalized treatment strategies eventually leading to more effective interventions. Considering the important role of the glucocorticoid receptor and the related FK506 binding protein 51 (FKBP51) in the pathophysiology of MDD, we aimed to investigate putative associations between variants of FKBP5, the coding gene of FKBP51, with antidepressant treatment resistance and MDD susceptibility.Nine common SNPs of the FKBP5 gene prioritized based on location and, putative or known functions were genotyped in Han Chinese population, including MDD patients with or without antidepressant-treatment resistance and healthy controls. Read More

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September 2021