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Sindbis virus infection of mosquito species in the wetlands of northwestern Iran and modeling the probable ecological niches of SINV vectors in the country.

Acta Trop 2021 May 9:105952. Epub 2021 May 9.

Department of Medical Entomology and Vector Control, School of Public Health, Urmia University of Medical Sciences, Urmia, Iran; Social Determinants of Health, Research Center, Urmia University of Medical Sciences, Urmia, Iran. Electronic address:

Sindbis virus (SINV) and Chikungunya virus (CHIKV) are among the most widely spread mosquito-borne viruses worldwide. Due to the key role of mosquitoes in the transmission cycle of vector-borne diseases, models such as Maximum Entropy (MaxEnt) have been used in recent years to predict the environmental suitability and ecological niches of mosquito vectors. Infection of three mosquito species (Anopheles maculipennis s. Read More

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Mechanics of dystrophin deficient skeletal muscles in very young mice and effects of age.

Am J Physiol Cell Physiol 2021 May 12. Epub 2021 May 12.

Department of Medicine, Baylor College of Medicine, Houston, Texas, 77030, United Statesgrid.39382.33.

The MDX mouse is an animal model of Duchenne muscular dystrophy, a human disease marked by an absence of the cytoskeletal protein, dystrophin. We hypothesized that (1) dystrophin serves a complex mechanical role in skeletal muscles by contributing to passive compliance, viscoelastic properties, and contractile force production and (2) age is a modulator of passive mechanics of skeletal muscles of the MDX mouse. Using an in vitro biaxial mechanical testing apparatus, we measured passive length-tension relationships in the muscle fiber direction as well as transverse to the fibers, viscoelastic stress-relaxation curves, and isometric contractile properties. Read More

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Effects of Side-Chain Spacing and Length on Hydration States of Poly(2-methoxyethyl acrylate) Analogues: A Molecular Dynamics Study.

ACS Biomater Sci Eng 2021 May 12. Epub 2021 May 12.

Institute for Materials Chemistry and Engineering, Kyushu University, Fukuoka 819-0395, Japan.

Hydration states of polymers are known to directly influence the adsorption of biomolecules. Particularly, intermediate water (IW) has been found able to prevent protein adsorption. Experimental studies have examined the IW content and nonthrombogenicity of poly(2-methoxyethyl acrylate) analogues with different side-chain spacings and lengths, which are HP ( is the number of backbone carbons in a monomer) and PMCA ( is the number of carbons in-between ester and ether oxygens of the side-chain) series, respectively. Read More

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The Benefits of Spiritual Diaries: A Mixed-Method Study in Korea.

J Relig Health 2021 May 12. Epub 2021 May 12.

College of Nursing, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, Korea.

This mixed study examined the benefits of spiritual diaries in Korea. Quantitatively, differences in spiritual growth and psychological well-being were examined in relation to the frequency of writing spiritual diaries among 385 participating adults. The group who wrote spiritual diaries '5-7 times a week' had significantly higher scores relating to spiritual growth and psychological wellbeing than other groups across the outcome variables. Read More

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Silencing circANKRD36 inhibits streptozotocin-induced insulin resistance and inflammation in diabetic rats by targeting miR-145 via XBP1.

Inflamm Res 2021 May 12. Epub 2021 May 12.

College of Life Sciences, Jiangxi Normal University, No. 99 Ziyang Avenue, Nanchang, 330022, Jiangxi, China.

Background: Diabetes mellitus (DM) is defined as a group of metabolic diseases characterized by hyperglycemia, which results from a deficiency in insulin secretion and/or insulin action. In diabetic patients, type 2 diabetes mellitus (T2DM) is in the majority. We explored the effects of circANKRD36 on streptozotocin (STZ)-induced insulin resistance and inflammation in diabetic rats with the aim of uncovering the underlying mechanism. Read More

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Statistical shape analyses of the brainstem in Chiari patients.

Turk Neurosurg 2020 Dec 14. Epub 2020 Dec 14.

Uludag University Faculty of Medicine, Department of Biostatistics, Bursa, Turkey.

Aim: When cerebellar tonsils are placed ≥ 5 mm below the foramen magnum, the situation is referred to as Chiari malformation Type I (CM-I). The prevalence of CM-I has been reported as 0.6%-1%. Read More

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December 2020

Relationship between physical activity/exercise habits and the frequency of new onset of lifestyle-related diseases after the Great East Japan Earthquake among residents in Fukushima: the Fukushima Health Management Survey.

J Radiat Res 2021 May;62(Supplement_1):i129-i139

Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima-city, Fukushima, Japan.

The effect of exercise habits on the increased incidence of lifestyle-related diseases among residents of the evacuation area in Fukushima Prefecture after the Great East Japan Earthquake is not well characterized. This study examined the influence of exercise habits on the frequency of new onset of lifestyle-related diseases in the aftermath of the earthquake using data from the Fukushima Health Management Survey (FHMS). Of the 32 289 individuals (14 004 men and 18 285 women) aged 40-90 years who underwent one or more health examinations in both 2011-12 and 2014-15, those who knew whether they had any lifestyle diseases and who responded to a questionnaire about their exercise and physical activity habits were included (dyslipidemia, 8017; hypertension, 7173; and diabetes mellitus, 13140 individuals). Read More

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5' Amplification in Neuroblastoma: A Case Report.

Case Rep Oncol 2021 Jan-Apr;14(1):585-591. Epub 2021 Mar 23.

Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA.

Neuroblastoma is the most common cancer in infants younger than 12 months of age, occurring with an incidence of 1 in 100,000 children. The clinical outcome of neuroblastoma ranges from spontaneous regression to treatment-resistant progression and/or metastasis, and accounts for 8-10% of childhood cancer deaths. Segmental chromosomal aberrations, as well as and amplification, are among factors contributing to an unfavorable genomic profile and high-risk disease classification. Read More

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Discordant Quantitative and Visual CT Assessments in the Diagnosis of Emphysema.

Int J Chron Obstruct Pulmon Dis 2021 3;16:1231-1242. Epub 2021 May 3.

University of Iowa, Roy J. and Lucille A. Carver College of Medicine, Department of Internal Medicine, Division of Pulmonary, Critical Care, and Occupational Medicine, Iowa City, IA, USA.

Purpose: Visual assessment of computed tomography (CT) of the lung is routinely employed in the diagnosis of emphysema. Quantitative CT (QCT) can complement visual CT but must be well validated. QCT emphysema is defined as ≥5% of lung volume occupied by low attenuation areas ≤-950 Hounsfield units (LAA-950). Read More

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Confinement effects and acid strength in zeolites.

Nat Commun 2021 May 11;12(1):2630. Epub 2021 May 11.

Department of Chemistry and Applied Biosciences, ETH Zurich, c/o USI Campus, Via Giuseppe Buffi 13, Lugano, Ticino, Switzerland.

Chemical reactivity and sorption in zeolites are coupled to confinement and-to a lesser extent-to the acid strength of Brønsted acid sites (BAS). In presence of water the zeolite Brønsted acid sites eventually convert into hydronium ions. The gradual transition from zeolite Brønsted acid sites to hydronium ions in zeolites of varying pore size is examined by ab initio molecular dynamics combined with enhanced sampling based on Well-Tempered Metadynamics and a recently developed set of collective variables. Read More

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Optimal margins for early stage peripheral lung adenocarcinoma resection.

BMC Cancer 2021 May 11;21(1):533. Epub 2021 May 11.

Wuxi Lung Transplant Center, Wuxi People's Hospital Affiliated to Nanjing Medical University, 299 QingYang Road, Wuxi, 214023, China.

Background: A pathologically confirmed negative margin is required when performing sublobar resection in patients with early stage peripheral lung adenocarcinoma. However, the optimal margin distance to ensure complete tumor resection while preserving healthy lung tissue remains unknown. We aimed to establish a reliable distance range for negative margins. Read More

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Efficacy of Handpiece Mounted Continuous Irrigation System for the Removal of Residual Pulpal Debris During Root Canal Preparation.

Eur J Dent 2021 May 11. Epub 2021 May 11.

Department of Prosthodontics and Dental Implantology, College of Dentistry, King Faisal University, Al Ahsa, Saudi Arabia.

Objective:  The removal of residual pulpal debris (RPD) from the root canal walls, especially in necrotic teeth is important for successful endodontic outcome. The aim of this study was to evaluate the RPD removal efficacy of handpiece mounted continuous irrigation with simultaneous root canal preparation from the apical third of root canals as compared to conventional syringe irrigation (SI).

Materials And Methods:  Ninety extracted teeth were randomly divided into three groups: SI; handpiece mounted continuous irrigation (CI); and both syringe and continuous irrigation (CI+SI). Read More

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Hymenal transections in children found by photocolposcopy in suspected sexual abuse cases is associated with a history of bleeding.

J Forensic Leg Med 2021 May 6;80:102176. Epub 2021 May 6.

Department of Forensic Medicine, University of Southern Denmark, J.B.Winsløws Vej 17B, 5000 Odense C, Denmark. Electronic address:

Objective: To investigate the difference in selected variables between children with and without hymenal transection, which is a healed defect that extends through the entire depth of the posterior hymenal membrane to the vaginal wall.

Materials And Methods: All female children from Southern Denmark who were examined by photocolposcopy in a six-year period were included in a retrospective cohort study. Statistical analyses included a chi-square test and a logistic regression analysis. Read More

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Salt-dependent passive adsorption of IgG1κ-type monoclonal antibodies on hydrophobic microparticles.

Biophys Chem 2021 May 6;275:106609. Epub 2021 May 6.

Center for Interdisciplinary Biosciences, Technology and Innovation Park, P.J. Šafárik University, Trieda SNP 1, 040 11 Košice, Slovakia. Electronic address:

Understanding how antibodies adsorb on solid surfaces is essential for developing effective approaches to control this process. In this study, passive adsorptions on the hydrophobic solid surface of a polystyrene microparticle (MP) of two highly similar IgG1 κ-type monoclonal antibodies (mAbs), rituximab, and trastuzumab, were examined in the presence of Hofmeister salts. Except of kosmotropic salts, the screening of electrostatic interactions using salts reduces the passive adsorption of mAbs on MP. Read More

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The impact of endogenous Avian Leukosis Viruses (ALVE) on production traits in elite layer lines.

Poult Sci 2021 Mar 12;100(6):101121. Epub 2021 Mar 12.

The University of Queensland, Brisbane, Queensland, 4072, Australia.

Avian Leukosis Virus subgroup E (ALVE) integrations are endogenous retroviral elements found in the chicken genome. The presence of ALVE has been reported to have negative impacts on multiple traits, including egg production and body weight. The recent development of rapid, inexpensive and specific ALVE detection methods has facilitated their characterization in elite commercial egg production lines across multiple generations. Read More

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Morphological and molecular characterization of Spirocerca lupi (Nematoda: Spirocercidae) from domestic dogs in Vietnam with reference to Spirocerca vulpis.

Parasitol Int 2021 May 8:102381. Epub 2021 May 8.

Institute of Ecology and Biological Resources, Vietnam Academy of Science and Technology, Ha Noi, Viet Nam; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ha Noi, Viet Nam. Electronic address:

Spirocerca lupi is a common parasitic nematode associated with esophageal cancer of canids. Recent surveys have revealed an increasing number of canids infected with Spirocerca spp. in Africa, Europe and the Americas, and described a new species, Spirocerca vulpis, from red foxes (Vulpes vulpes). Read More

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Assessment of Anti-inflammatory-like, Antioxidant activities and Molecular docking of three Alkynyl-substituted 3-ylidenedihydrobenzo[d] isothiazole 1,1-dioxide derivatives.

Chem Biol Interact 2021 May 8:109513. Epub 2021 May 8.

Center for Oxygen, Research and Development (CORD) and Center for Interdisciplinary Research on Medicine (CIRM) Institute of Chemistry University of Liège, Sart-Tilman (B.6a), 4000 Liège, Belgium.

The presence of enyne and benzoisothiazole functions in the molecular architecture of compounds 1, 2 and 3 were expected to provide biochemical activities. In the present work, we first examined the molecular surface contact of three alkynyl-substituted 3-ylidenedihydrobenzo[d] isothiazole 1,1-dioxides. The analysis of the Hirshfeld surfaces reveals that only compound 3 exhibited a well-defined red spots, indicating intermolecular interactions identified as S-O···H, C-H···O and C-O···H contacts. Read More

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Idiopathic and secondary restless legs syndrome during pregnancy in Japan: Prevalence, clinical features and delivery-related outcomes.

PLoS One 2021 11;16(5):e0251298. Epub 2021 May 11.

Sleep Apnea Center, Kyushu University Hospital, Fukuoka, Japan.

Objective: The aim of this study was to investigate prevalence of idiopathic and secondary restless legs syndrome (RLS) according to pregnancy trimester, and its effects on delivery-related outcomes among pregnant women in Japan.

Methods: This was a single-center, prospective observational study. One hundred eighty-two consecutive pregnant women participated in the study from June 2014 to March 2016. Read More

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Prevalence and risk factors of schistosomiasis among primary school children in four selected regions of The Gambia.

PLoS Negl Trop Dis 2021 May 11;15(5):e0009380. Epub 2021 May 11.

National Public Health Laboratories, Ministry of Health and Social Welfare, Banjul, The Gambia.

Background: The Gambia initiated a control programme for schistosomiasis in 2015. In light of this, recent and comprehensive data on schistosomiasis is required to effectively guide the control programme. This study aimed to evaluate the prevalence and associated risk factors of schistosomiasis among primary school children in The Gambia. Read More

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Reduced Intercalation Energy Barrier by Rich Structural Water in Spinel ZnMnO for High-Rate Zinc-Ion Batteries.

ACS Appl Mater Interfaces 2021 May 11. Epub 2021 May 11.

Department of Chemical and Materials Engineering, National Yunlin University of Science and Technology, 123 University Road, Section 3, Douliou, Yunlin 64002, Taiwan.

Aqueous zinc-ion batteries are considered promising next-generation systems for large-scale energy storage due to low cost, environmental friendliness, and high reversibility of the Zn anode. However, the interfacial charge-transfer resistance for the insertion of divalent Zn into cathode materials is normally high, which limits the kinetics of Zn transfer at the cathode/electrolyte interface. This study reveals the presence of rich structural water in spinel ZnMnO (ZnMnO·0. Read More

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Danger-associated molecular pattern molecules and the receptor for advanced glycation end products enhance ANCA-induced responses.

Rheumatology (Oxford) 2021 May 11. Epub 2021 May 11.

Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, Hammersmith Hospital, London, UK.

Objectives: The pro-inflammatory activities of the calgranulins and HMGB1 can be counteracted by sRAGE the soluble form of their shared receptor. To understand the role of these molecules in AAV and their potential as therapeutic targets we have studied 1) The relationship between these DAMPS and disease activity, 2) The expression of RAGE and sRAGE in biopsy tissue and peripheral blood and 3) The effect of these molecules on ANCA-mediated cytokine production.

Methods: We examined circulating levels of calgranulins (S100A8/A9 and S100A12), HMGB1 and sRAGE by ELISA. Read More

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Bilateral Limbal Stem Cell Alterations in Patients With Unilateral Herpes Simplex Keratitis and Herpes Zoster Ophthalmicus as Shown by In Vivo Confocal Microscopy.

Invest Ophthalmol Vis Sci 2021 May;62(6):12

Eye Hospital, The First Affiliated Hospital of Harbin Medical University, No.143, Yiman Street, Harbin City, Nangang District, Heilongjiang Province, China.

Purpose: The purpose of this study was to investigate the limbal changes in the palisades of Vogt (POV) in patients with herpes simplex keratitis (HSK) and herpes zoster ophthalmicus (HZO) with the application of in vivo confocal microscopy (IVCM).

Methods: We enrolled 35 eyes of 35 consecutive patients with HSK and 4 patients with HZO in this observational study. Thirty-five participants were also recruited from a healthy population as the control group. Read More

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Vanadium aminophenolates in catechol oxidation: conformity with Finke's common catalyst hypothesis.

Dalton Trans 2021 May;50(18):6088-6099

Group of Inorganic Materials Chemistry, Department of Chemistry, University of Turku, FI-20014 Turku, Finland.

Six known aminophenolate vanadium complexes V1-V6 were examined in 3,5-di-tert-butylcatechol (1, 3,5-DTBC) oxidation. From the complexes V1-V5 have been previously shown to demonstrate catechol oxidase (catecholase) like behavior, catalytically oxidizing 1 to 3,5-di-tert-butyl-1,2-benzoquinone (2, 3,5-DTBQ). A critical re-evaluation of V1-V5, including V6 not assessed earlier, in the aerobic oxidation of 1 has revealed that several catechol dioxygenase products are obtained in addition to 2, which is produced partly by autoxidation. Read More

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Nature of phytotoxic interference of alien weed 'Calyptocarpus vialis' against some crop plants.

Environ Monit Assess 2021 May 10;193(6):334. Epub 2021 May 10.

Department of Botany, Panjab University, Chandigarh, 160 014, India.

Calyptocarpus vialis (syn. Synedrella vialis; Asteraceae), a native of the tropical Americas, has acquired an invasive status in the eastern Asia and Africa and, of late, in India. It is an annual herbaceous weed that forms a dominant ground cover due to its prostrate expansion and interferes with the growth of other plant species. Read More

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Lipid signature of neural tissues of marine and terrestrial mammals: consistency across species and habitats.

J Comp Physiol B 2021 May 11. Epub 2021 May 11.

Department of Biology and Marine Biology, University of North Carolina Wilmington, Wilmington, NC, USA.

Marine mammals are exposed to O-limitation and increased N gas concentrations as they dive to exploit habitat and food resources. The lipid-rich tissues (blubber, acoustic, neural) are of particular concern as N is five times more soluble in lipid than in blood or muscle, creating body compartments that can become N saturated, possibly leading to gas emboli upon surfacing. We characterized lipids in the neural tissues of marine mammals to determine whether they have similar lipid profiles compared to terrestrial mammals. Read More

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Prevalence of Angiodysplasia Detected in Upper Gastrointestinal Endoscopic Examinations.

Cureus 2021 Apr 7;13(4):e14353. Epub 2021 Apr 7.

Gastroenterology, Shimane University Hospital, Izumo, JPN.

Background This study was performed to examine the prevalence of asymptomatic angiodysplasia detected in upper gastrointestinal endoscopic examinations and of hereditary hemorrhagic telangiectasia (HHT) suspected cases. Methodology The study participants were 5,034 individuals (3,206 males, 1,828 females; mean age 53.5 ± 9. Read More

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How should external human-machine interfaces behave? Examining the effects of colour, position, message, activation distance, vehicle yielding, and visual distraction among 1,434 participants.

Appl Ergon 2021 May 8;95:103450. Epub 2021 May 8.

Faculty of Mechanical, Maritime and Materials Engineering, Delft University of Technology, Delft, the Netherlands.

External human-machine interfaces (eHMIs) may be useful for communicating the intention of an automated vehicle (AV) to a pedestrian, but it is unclear which eHMI design is most effective. In a crowdsourced experiment, we examined the effects of (1) colour (red, green, cyan), (2) position (roof, bumper, windshield), (3) message (WALK, DON'T WALK, WILL STOP, WON'T STOP, light bar), (4) activation distance (35 or 50 m from the pedestrian), and (5) the presence of visual distraction in the environment, on pedestrians' perceived safety of crossing the road in front of yielding and non-yielding AVs. Participants (N = 1434) had to press a key when they felt safe to cross while watching a random 40 out of 276 videos of an approaching AV with eHMI. Read More

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The thiol-based reduction of Bi(V) and Sb(V) anti-leishmanial complexes.

J Inorg Biochem 2021 Apr 29;221:111470. Epub 2021 Apr 29.

School of Chemistry, Monash University, Clayton, Melbourne, VIC 3800, Australia. Electronic address:

Low molecular weight thiols including trypanothione and glutathione play an important function in the cellular growth, maintenance and reduction of oxidative stress in Leishmania species. In particular, parasite specific trypanothione has been established as a prime target for new anti-leishmania drugs. Previous studies into the interaction of the front-line Sb(V) based anti-leishmanial drug meglumine antimoniate with glutathione, have demonstrated that a reduction pathway may be responsible for its effective and selective nature. Read More

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Methylglyoxal augments uridine diphosphate-induced contraction via activation of p38 mitogen-activated protein kinase in rat carotid artery.

Eur J Pharmacol 2021 May 7:174155. Epub 2021 May 7.

Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa-ku, Tokyo, 142-8501, Japan. Electronic address:

The methylglyoxal elicits diverse adverse effects on the body. Uridine diphosphate, an extracellular nucleotide, plays an important role as a signaling molecule controlling vascular tone. This study aimed to evaluate the relationship between methylglyoxal and uridine diphosphate-induced carotid arterial contraction in rats. Read More

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Embryotoxic effects of Rovral® for early chicken () development.

J Toxicol Environ Health A 2021 May 10:1-17. Epub 2021 May 10.

Instituto Latino-Americano de Ciências da Vida e da Natureza, Universidade Federal Da Integração Latino-Americana (UNILA), Foz Do Iguaçu, Paraná, Brazil.

Rovral® is a fungicide used to control pests that affect various crops and little is known regarding its effects on embryonic development of amniotes. Thus, this study aimed to determine the influence of Rovral® during chicken organogenesis using acute contamination. Fertilized eggs were inoculated with different concentrations of Rovral® (100, 300, 500 or 750 µl/ml), injected into the egg's air chamber. Read More

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