2,145 results match your criteria examined individualized


Clearance of buprenorphine during pregnancy and neonatal outcomes.

Arch Womens Ment Health 2021 Apr 16. Epub 2021 Apr 16.

Department of Psychiatry, University of Wisconsin, Madison, WI, USA.

Buprenorphine is emerging as the preferred pharmacologic treatment for opioid use disorder during pregnancy. We examined the relative plasma clearance of buprenorphine (BUP) across pregnancy. Pregnant women with opioid use disorder participating in a prospective, observational study from 2013 to 2016 on stress in pregnancy who were receiving BUP for opioid use disorder were included. Read More

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Individualized brain development and cognitive outcome in infants with congenital heart disease.

Brain Commun 2021 23;3(2):fcab046. Epub 2021 Mar 23.

Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.

Infants with congenital heart disease are at risk of neurodevelopmental impairments, the origins of which are currently unclear. This study aimed to characterize the relationship between neonatal brain development, cerebral oxygen delivery and neurodevelopmental outcome in infants with congenital heart disease. A cohort of infants with serious or critical congenital heart disease ( = 66;  = 62 born ≥37 weeks) underwent brain MRI before surgery on a 3T scanner situated on the neonatal unit. Read More

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Patient-derived organoids as a predictive biomarker for treatment response in cancer patients.

NPJ Precis Oncol 2021 Apr 12;5(1):30. Epub 2021 Apr 12.

Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

Effective predictive biomarkers are needed to enable personalized medicine and increase treatment efficacy and survival for cancer patients, thereby reducing toxic side effects and treatment costs. Patient-derived organoids (PDOs) enable individualized tumour response testing. Since 2018, 17 publications have examined PDOs as a potential predictive biomarker in the treatment of cancer patients. Read More

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Lung Transplant from ECMO: Current Results and Predictors of Post-transplant Mortality.

Curr Transplant Rep 2021 Apr 6:1-11. Epub 2021 Apr 6.

Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke Medical Center, Durham, NC USA.

Purpose Of Review: We examined data from the last 5 years describing extracorporeal life support (ECLS) as a bridge to lung transplantation. We assessed predictors of survival to transplantation and post-transplant mortality.

Recent Findings: The number of lung transplants performed worldwide is increasing. Read More

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Visualization of Intracranial Pressure Insults After Severe Traumatic Brain Injury: Influence of Individualized Limits of Reactivity.

Acta Neurochir Suppl 2021 ;131:7-10

Academic Neurosurgery, University of Cambridge, Cambridge, UK.

Cerebral perfusion pressure (CPP) lower limits of reactivity can be determined almost continuously after severe traumatic brain injury (TBI), and deviation below the lower limit carries important prognostic information. In this study, we used a recently derived coloured contour method for visualizing intracranial pressure (ICP) insults to describe the influence of having a CPP above the CPP lower limits of reactivity after severe TBI. In a cohort of 729 patients, we examined the relationship between ICP insults and the 6-month Glasgow Outcome Scale score, using colour-coded plots, as described previously. Read More

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January 2021

Pharmacogenetic predictors of nevirapine pharmacokinetics in Ghanaian children living with HIV with or without TB coinfection.

Infect Genet Evol 2021 Apr 8:104856. Epub 2021 Apr 8.

Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, United States. Electronic address:

Nevirapine (NVP) is a non-nucleoside reverse transcriptase inhibitor that is used in the treatment of human immunodeficiency virus (HIV) infection in children younger than 3 years old. Identifying genetic predictors of NVP pharmacokinetics (PK) in young children is important because inter-individual variability in NVP concentrations contributes to variable treatment response and the information may be used to individualize dosing decisions. We examined the relationship between genetic variations in relevant drug disposition genes and NVP PK parameters in Ghanaian children living with HIV eligible to initiate NVP-based antiretroviral therapy. Read More

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Factors influencing physical activity participation among people living with or beyond cancer: a systematic scoping review.

Int J Behav Nutr Phys Act 2021 Apr 6;18(1):50. Epub 2021 Apr 6.

Centre for Public Health, Queen's University Belfast, Institute of Clinical Sciences, Block B, Royal Victoria Hospital, Belfast, BT12 6BA, UK.

Background: It has been posited that physical activity (PA) has the potential to improve health outcomes and the health-related quality of life of people living with or beyond cancer. Despite the well-documented health benefits of PA, there is a low level of PA among cancer patients. A systematic scoping review was conducted to investigate attitudes, perceptions, preferences and barriers vs. Read More

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A Field Test of Opportunities for Teen Dating Violence Disclosure in School-Based Relationship Education Programs.

J Interpers Violence 2021 Apr 6:8862605211001478. Epub 2021 Apr 6.

RTI International, Research Triangle Park, NC, USA.

School-based relationship education programs offer an opportunity to identify youth who are experiencing teen dating violence (TDV), support their safety, and connect them with individualized services or referrals. However, no research has tested the feasibility or accuracy of approaches to create opportunities for TDV disclosure in the context of school-based programs. The current study presents the results of a field test comparing three tools used to provide opportunities for TDV disclosure (two questionnaire-style tools and one universal education discussion guide). Read More

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Plasma biomarkers for prediction of early tumor recurrence after resection of pancreatic ductal adenocarcinoma.

Sci Rep 2021 Apr 5;11(1):7499. Epub 2021 Apr 5.

Department of General and Visceral Surgery, Medical Center and Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.

Pancreatic ductal adenocarcinoma (PDAC) is a disease with a very unfavorable prognosis. Surgical resection represents the only potentially curative treatment option, but recurrence after complete resection is almost certain. In an exploratory attempt we here aimed at identifying preoperative plasma protein biomarkers with the potential to predict early recurrence after resection of PDAC. Read More

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Oxaliplatin neuropathy: Predictive values of skin biopsy, QST and nerve conduction.

J Neuromuscul Dis 2021 Apr 1. Epub 2021 Apr 1.

Research Unit for Neurology, Odense University Hospital, Odense, Denmark; University of Southern Denmark, Odense, Denmark.

Background: Oxaliplatin-induced peripheral neuropathy negatively affects the quality of life for patients with gastrointestinal cancers and may cause neuropathic pain. Measures of peripheral nerve structure or function, such as intraepidermal nerve fiber density (IENFD) during treatment could reduce neuropathy severity through individualized dose reduction.

Objective: The aim was to evaluate the predictive values of IENFD, quantitative sensory testing (QST), and nerve conduction studies (NCS) for significant neuropathy and neuropathic pain. Read More

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Cognitive Differences in the Older Adults Living in the General Community: Gender and Mental Occupational State Study.

Int J Environ Res Public Health 2021 Mar 17;18(6). Epub 2021 Mar 17.

Department of Physiatry and Nursing, Health Sciences Faculty, University of Zaragoza, 50009 Zaragoza, Spain.

Older adults are particularly vulnerable to cognitive impairment with age, and gender differences are remarkable. However, there is very little evidence to identify both baseline cognitive and occupational gender differences prior to older adults' retirement to design more efficient personalized cognitive interventions. This descriptive observational study examined gender differences in initial cognitive performance in 367 older adults with subjective memory complaints from a primary healthcare center in Zaragoza (Spain). Read More

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Policy Implications, Eligibility, and Demographic Characteristics of People With Intellectual Disability Who Access Self-Directed Funding in the United States.

Intellect Dev Disabil 2021 Apr;59(2):123-140

Renata Tichá, Research and Training Center on Community Living, Institute on Community Integration, University of Minnesota, US.

This study identifies factors (state of residence, personal characteristics, and living situation) associated with access to self-directed funding (SDF) for adults with intellectual disability in the United States. Data from 10,033 participants from 26 states in the 2012-2013 National Core Indicators Adult Consumer Survey were analyzed. We examined state, age group, residence type, disability diagnoses, mental health status, and type of disability support funding used. Read More

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Children's Exposure to Violence across Contexts in Relation to Posttraumatic Stress Symptoms.

Psychol Violence 2020 Mar 27;10(2):182-191. Epub 2019 Jun 27.

Loyola University Chicago.

Objective: Children in low-income, urban neighborhoods are at high risk of exposure to violence (ETV) across settings and subsequent posttraumatic stress symptoms (PTSS). Little research has examined how multiple forms of ETV co-occur and relate to variations in children's posttraumatic responses. Furthermore, previous research primarily uses variable-centered methods, which can obscure person-level differences. Read More

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Agreement between heart rate deflection point and maximal lactate steady state in young adults with different body masses.

Physiol Int 2021 Mar 20. Epub 2021 Mar 20.

3Active Life Lab, South-Eastern Finland University of Applied Sciences, Mikkeli, Finland.

We examined the agreement between heart rate deflection point (HRDP) variables with maximal lactate steady state (MLSS) in a sample of young males categorized to different body mass statuses using body mass index (BMI) cut-off points. One hundred and eighteen young males (19.9 ± 4. Read More

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Cue responsiveness as a measure of emerging language ability in aphasia.

Top Stroke Rehabil 2021 Mar 24:1-13. Epub 2021 Mar 24.

School of Health and Rehabilitation Sciences, MGH Institute of Health Professions, Boston, Massachusetts, USA.

: Prior research suggests that initial aphasia severity, lesion size, and lesion location are the most salient factors in predicting recovery outcomes. While these factors provide important prognostic information, information that is individualized and readily available to clinicians is limited. Deficits in naming are common to all aphasia types and are routinely targeted in aphasia assessment and treatment, with cues provided to facilitate lexical retrieval. Read More

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Predicting morbidity and mortality using automated milk feeders: A scoping review.

J Dairy Sci 2021 Mar 16. Epub 2021 Mar 16.

Department of Population Medicine, University of Guelph, Guelph, ON, Canada N1G 2W1. Electronic address:

Automated milk feeders (AMF) are computerized systems that provide producers with a tool that can be used to more efficiently raise dairy calves and allow for easier implementation of a high plane of nutrition during the milk feeding phase. Automated milk feeders also have the ability to track individualized behavioral data, such as milk consumption, drinking speed, and the number of rewarded and unrewarded visits to the feeder, that could potentially be used to predict disease development. The objective of this scoping review was to characterize the body of literature investigating the use of AMF data to predict morbidity and mortality in dairy calves during the preweaning stage. Read More

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Assessing stable validity and reliability of the Japanese version of the individualized supported employment fidelity scale: A replication.

Neuropsychopharmacol Rep 2021 Mar 18. Epub 2021 Mar 18.

Department of Community Mental Health & Law, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.

Background: The Japanese version of the individualized Supported Employment Fidelity scale (JiSEF) was developed by modifying the 25-item Individual Placement and Support Fidelity Scale (IPS-25). While a preliminary study partly confirmed the concurrent validity with vocational outcomes, this replication study aimed to examine the stability of the concurrent validity and the inter-rater reliability of the JiSEF and to test its convergent validity with IPS-25.

Methods: Fidelity assessments were conducted in 2016 (n = 17), 2017 (n = 13), and 2018 (n = 18) to examine the employment rate and the fidelity scores at the agency level. Read More

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Can Individualized-Targeted Computerized Cognitive Training Benefit Adults with HIV-Associated Neurocognitive Disorder? The Training on Purpose Study (TOPS).

AIDS Behav 2021 Mar 18. Epub 2021 Mar 18.

UAB Center for Research on Applied Gerontology, University of Alabama at Birmingham, Birmingham, AL, USA.

Half of people with HIV (PWH) have HIV-associated neurocognitive disorder (HAND). This study examined whether cognition can be improved using a framework targeting impaired individual cognitive domains in PWH with HAND. In this two-group pre-post experimental design study, 88 adults with HAND were randomized to either: (1) a no-contact control group (n = 40) or (2) the Individualized-Targeted Cognitive Training group (n = 48). Read More

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Therapeutic drug monitoring of valproic acid using a dried plasma spot sampling device.

J Mass Spectrom 2021 Apr 10;56(4):e4603. Epub 2020 Aug 10.

Department of Pharmacy, The First Hospital of Jilin University, Changchun, China.

Valproic acid (VPA) dosing needs to be individualized for epilepsy patients through therapeutic drug monitoring (TDM). The patients must show up in the clinic at the therapeutic window time to venipuncture sample. Dried plasma spot (DPS) sampling is an alternative way to replace conventional venipuncture sampling. Read More

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Integrating Genomic Screening into Primary Care: Provider Experiences Caring for Latino Patients at a Community-Based Health Center.

J Prim Care Community Health 2021 Jan-Dec;12:21501327211000242

Mayo Clinic, Rochester, MN, USA.

Introduction: Minority communities have had limited access to advances in genomic medicine. Mayo Clinic and Mountain Park Health Center, a Federally Qualified Health Center in Phoenix, Arizona, partnered to assess the feasibility of offering genomic screening to Latino patients receiving care at a community-based health center. We examined primary care provider (PCP) experiences reporting genomic screening results and integrating those results into patient care. Read More

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Individualized Placement and Support Supported Employment for Justice-involved Homeless and Unemployed Veterans.

Med Care 2021 Apr;59(Suppl 2):S195-S198

Dallas VA Research Corporation, Dallas, TX.

Background: Homelessness is a significant issue affecting the general US population. Two subsets of the population overrepresented in the US homeless population are justice involved individuals and Veterans. However, relatively little research has addressed alleviating homelessness in justice-involved Veterans (JIV). Read More

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miR-325-3p, a novel regulator of osteoclastogenesis in osteolysis of colorectal cancer through targeting S100A4.

Mol Med 2021 03 10;27(1):23. Epub 2021 Mar 10.

Daping Hospital of Army Medical University, Chongqing, 400042, People's Republic of China.

Background: To investigate effect of microRNA-325-3p (miR-325-3p) on bone metastasis of colorectal cancer (CRC) and the precise role on osteoclastogenesis.

Methods: CT-26 cells were injected into tibias to establish bone metastatic model of CRC in vivo. AgomiR-325-3p or antagomir-325-3p were injected in tail-veins of Balb/c mice to interfere the osteoclastogenesis and bone metastasis of CRC. Read More

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Antituberculosis Drugs (Rifampicin and Isoniazid) Induce Liver Injury by Regulating NLRP3 Inflammasomes.

Mediators Inflamm 2021 19;2021:8086253. Epub 2021 Feb 19.

Nanchong Key Laboratory of Individualized Drug Therapy, Nanchong, Sichuan, China.

Patients being treated for pulmonary tuberculosis often suffer liver injury due to the effects of anti-TB drugs, and the underlying mechanisms for those injuries need to be clarified. In this study, rats and hepatic cells were administrated isoniazid (INH) and rifampin (RIF) and then treated with NLRP3-inflammasome inhibitors (INF39 and CP-456773) or NLRP3 siRNA. Histopathological changes that occurred in liver tissue were examined by H&E staining. Read More

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February 2021

An Assessment of the Feasibility and Effectiveness of Distance Learning for Students With Severe Developmental Disabilities and High Behavioral Needs.

Behav Anal Pract 2021 Mar 1:1-17. Epub 2021 Mar 1.

Port View Preparatory, 1361 Valencia Avenue, Tustin, CA 92780 USA.

Schools across the country closed their doors during the COVID-19 pandemic. These measures impacted all students, as schools, educators, and families grappled with the realities of transitioning to distance-learning platforms. The research on distance learning is still in its early phases. Read More

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SLC26A9 SNP rs7512462 is not associated with lung disease severity or lung function response to ivacaftor in cystic fibrosis patients with G551D-CFTR.

J Cyst Fibros 2021 Mar 2. Epub 2021 Mar 2.

Department of Genetic Medicine, Johns Hopkins University (JHU), Baltimore, MD, 21205, USA. Electronic address:

Background: The CFTR modulator ivacaftor has been variably effective in treating individuals with cystic fibrosis (CF) who harbor CFTR gating variants such as G551D, as well as other classes of CFTR variants when used with other modulators. Because CFTR genotype does not fully explain this variability, defining genetic modifiers of response to modulator therapy is of particular interest to the field of individualized CF drug therapy. Previous studies have proposed that a variant in SLC26A9 (rs7512462) is associated with lung disease severity and with response to treatment with ivacaftor in individuals with CF who carry G551D or gating variants. Read More

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Synchronous Colorectal Cancer: Improving Accuracy of Detection and Analyzing Molecular Heterogeneity-The Main Keys for Optimal Approach.

Diagnostics (Basel) 2021 Feb 15;11(2). Epub 2021 Feb 15.

Department of Pathology, 'George Emil Palade' University of Medicine, Pharmacy, Sciences and Technology, 530149 Targu Mures, Romania.

Background: In patients with synchronous colorectal cancer (SCRC), understanding the underlying molecular behavior of such cases is mandatory for designing individualized therapy. The aim of this paper is to highlight the importance of transdisciplinary evaluation of the pre- and post-operative assessment of patients with SCRCs, from imaging to molecular investigations.

Methods: Six patients with SCRCs presented with two carcinomas each. Read More

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February 2021

Asymmetry of Muscle Mass Distribution and Grip Strength in Professional Handball Players.

Int J Environ Res Public Health 2021 Feb 16;18(4). Epub 2021 Feb 16.

Departament of Physical Anthropology, University School of Physical Education, 51-612 Wrocław, Poland.

Handball is among the disciplines that impose a significant degree of asymmetry on the body movement. The aim of the study is to assess the influence of physical effort on the occurrence of asymmetry in body musculature and in isometric strength of handball players. The study examined 36 professional handball players. Read More

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February 2021

Individualized education focusing on self-management improved the knowledge and self-management behaviour of elderly people with atrial fibrillation: A randomized controlled trial.

Int J Nurs Pract 2021 Mar 4:e12902. Epub 2021 Mar 4.

School of Nursing, Hanyang University, Seoul, South Korea.

Aim: This study examined the effect of an individualized educational intervention on the knowledge, attitudes and self-management ability after 12 weeks for outpatients with atrial fibrillation.

Methods: A randomized control-group pretest-post-test experimental design was used. Elderly outpatients with atrial fibrillation aged over 65 years were recruited from a university hospital in Korea. Read More

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Counseling, contraception, and conception rates in patients undergoing bariatric surgery: A retrospective review.

Contraception 2021 Feb 28. Epub 2021 Feb 28.

Department of Obstetrics and Gynecology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States.

Objectives: To determine conception rates, contraceptive use patterns, and frequency of counseling regarding pregnancy recommendations in patients undergoing bariatric surgery.

Study Design: Using a database of bariatric surgery patients at our institution, we identified female patients aged 18 to 45 who underwent surgery from 2013 to 2018. Patient charts were reviewed for demographic information, documentation of counseling regarding pregnancy recommendations, conception during the postoperative period, and pre and postoperative contraception use. Read More

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February 2021

Functional benefits of co-occurring autistic symptoms in schizophrenia is delimited by symptom severity.

J Psychiatr Res 2021 Feb 22;137:48-54. Epub 2021 Feb 22.

Schizophrenia Research and Clinical Unit, Department of Clinical Neurosciences, IRCCS San Raffaele Scientific Institute, Milan, Italy; School of Psychology, Vita-Salute San Raffaele University, Milan, Italy.

Background: Impairments in daily functioning characterize both autism spectrum disorder and schizophrenia. Research has shown that a subsample of schizophrenia patients presents autistic symptoms, leading to the hypothesis that their co-occurrence would be associated with a 'double dose' of deficit. A growing body of research examined this hypothesis by looking at the joint effect of autistic and positive psychotic symptoms, and yielded contrasting results, ranging from benefits to adverse effects. Read More

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February 2021