48,024 results match your criteria examined arterial

Metabolic syndrome is not associated to an increased risk of low bone mineral density in men at risk for osteoporosis.

J Endocrinol Invest 2021 Jul 27. Epub 2021 Jul 27.

Department of Clinical Medicine and Surgery, Federico II University, 80131, Naples, Italy.

Purpose: We have recently demonstrated a significant association between osteoporosis (Op) and metabolic syndrome (MetS) in Caucasian women examined by Dual-energy X-ray absorptiometry (DXA) for suspected Op. This cross-sectional study was performed to evaluate the association between MetS and Op in Caucasian men enrolled in the same geographical area, with identical criteria and in the same time range.

Methods: Among subjects enrolled in the SIMON study, we selected the medical records of all free-living men who performed a contextual evaluation of both bone mineral density (BMD) by DXA and MetS constitutive elements (arterial blood pressure, waist circumference, serum levels of triglycerides, high-density lipoprotein cholesterol, and fasting glucose). Read More

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Impact of brain natriuretic peptide for predicting long-term life expectancy and cardiovascular or limb events in peripheral arterial disease.

Int Angiol 2021 Jul 27. Epub 2021 Jul 27.

Department of Cardiovascular Medicine, Cardiovascular Hospital of Central Japan (Kitakanto Cardiovascular Hospital), Shibukawa, Gunma, Japan.

Background: Brain natriuretic peptide (BNP) is introduced as a predictor of the degree of ventricular dysfunction and is associated with mortality. There are limited reports on the relationship of BNP with long-term all-cause death (AD) and cardiovascular or limb events in peripheral artery disease (PAD). We examined the relationship between BNP level and these events in PAD patients. Read More

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Dichloroacetate inhibits the degeneration of decellularized cardiovascular implants.

Eur J Cardiothorac Surg 2021 Jul 23. Epub 2021 Jul 23.

Department of Cardiovascular Surgery and Research Group for Experimental Surgery, Heinrich Heine University, Medical Faculty, Duesseldorf, Germany.

Objectives: Intima hyperplasia is a major issue of biological cardiovascular grafts resulting in progressive in vivo degeneration that particularly decreases the durability of coronary and peripheral vascular bypasses. Previously, dichloroacetate (DCA) has been reported to prevent the formation of hyperplastic intima in injured arteries. In this study, the effect of DCA on the neointima formation and degeneration of decellularized small-caliber implants was investigated in a rat model. Read More

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Contingent screening in the stratification of pregnancy care based on risk of preeclampsia at 19-24 weeks' gestation.

Ultrasound Obstet Gynecol 2021 Jul 26. Epub 2021 Jul 26.

Harris Birthright Research Centre for Fetal Medicine, King's College, London, UK.

Objectives: To explore the possibility of carrying out routine screening for preeclampsia (PE) with delivery at <28, <32, <36 weeks' gestation by maternal factors, uterine artery pulsatility index (UtA-PI) and mean arterial pressure (MAP) in all pregnancies and reserving measurements of placental growth factor (PLGF) and soluble fms-like tyrosine kinase-1 (sFLT-1) for only a subgroup of the population.

Methods: This was a prospective observational study in two UK maternity hospitals involving 37886 women with singleton pregnancies attending for routine assessment at 19-24 weeks' gestation. The improvement in performance of screening for PE, at fixed risk cut-offs, by the addition of serum PlGF and sFLT-1 to screening by maternal factors, UtA-PI and MAP was estimated. Read More

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[Value of maximum area stenosis combined with perivascular fat attenuation index in predicting hemodynamically significant coronary artery disease].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Jul;41(7):988-994

Department of Cardiology, Sixth Medical Center of Chinese PLA General Hospital, Beijing 100048, China.

Objective: To investigate the combined value of coronary computed tomography angiography (CCTA) indicators and perivascular fat attenuation index (FAI) in predicting hemodynamically significant coronary artery disease.

Methods: We retrospectively analyzed the data of patients undergoing CCTA in Chinese PLA General Hospital from 2017 to 2019, who were also examined for fractional flow reserve (FFR) with invasive coronary angiography within one month before inclusion. The CCTA indicators at the vascular level were measured, including plaque distribution, coronary artery calcification score, lesion length, maximum diameter stenosis, maximum area stenosis (MAS), total plaque burden (TPB), perivascular FAI, and CT-FFR based on machine learning. Read More

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Exercise Training Duration and Intensity Are Associated With Thicker Carotid Intima-Media Thickness but Improved Arterial Elasticity in Active Children and Adolescents.

Front Cardiovasc Med 2021 8;8:618294. Epub 2021 Jul 8.

Institute of Preventive Pediatrics, TUM Department of Sport and Health Science, Technical University of Munich, Munich, Germany.

Even though exercise generally has a positive effect on health, intensive exercise can have adverse effects on the vascular system of adults. This study aimed to investigate the association between training duration and intensity and vascular structure and function in 427 physically active children and adolescents (14.0 ± 1. Read More

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Multiple-Tissue and Multilevel Analysis on Differentially Expressed Genes and Differentially Correlated Gene Pairs for HFpEF.

Front Genet 2021 8;12:668702. Epub 2021 Jul 8.

Department of Cardiovascular, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.

Heart failure with preserved ejection fraction (HFpEF) is a complex disease characterized by dysfunctions in the heart, adipose tissue, and cerebral arteries. The elucidation of the interactions between these three tissues in HFpEF will improve our understanding of the mechanism of HFpEF. In this study, we propose a multilevel comparative framework based on differentially expressed genes (DEGs) and differentially correlated gene pairs (DCGs) to investigate the shared and unique pathological features among the three tissues in HFpEF. Read More

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Exposure to Perfluoroalkyl Chemicals and Cardiovascular Disease: Experimental and Epidemiological Evidence.

Front Endocrinol (Lausanne) 2021 9;12:706352. Epub 2021 Jul 9.

Department of Medicine, University of Verona, Verona, Italy.

Polyfluoro- and perfluoro-alkyl substances (PFAS) are organic chemicals extensively used worldwide for industry and consumer products. Due to their chemical stability, PFAS represent a major cause of environmental pollution. PFAS accumulate in animal and human blood and tissues exerting their toxicity. Read More

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Cardiac Output Assessments in Anesthetized Children: Dynamic Capnography Versus Esophageal Doppler.

Anesth Analg 2021 Jul 22. Epub 2021 Jul 22.

Maquet Critical Care AB, Solna, Sweden.

Background: The objective of this study was to compare esophageal Doppler cardiac output (COEDM) against the reference method effective pulmonary blood flow cardiac output (COEPBF), for agreement of absolute values and ability to detect change in cardiac output (CO) in pediatric surgical patients. Furthermore, the relationship between these 2 methods and noninvasive blood pressure (NIBP) parameters was evaluated.

Methods: Fifteen children American Society of Anesthesiology (ASA) I and II (median age, 8 months; median weight, 9 kg) scheduled for surgery were investigated in this prospective observational cohort study. Read More

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Stereological analysis of liver, spleen and bone of Leishmania infantum-experimentally infected hamsters.

Exp Parasitol 2021 Jul 21;228:108137. Epub 2021 Jul 21.

Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Leishmaniasis is remaining as one of the important health problems of many countries around the world. The histopathology of the disease and the effects of the parasite on various tissues have not yet been fully elucidated. The current study aimed to evaluate the stereological features of the liver, spleen, and bone of hamsters infected with Leishmania infantum. Read More

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Cryopreservation moderates the thrombogenicity of arterial allografts during storage.

PLoS One 2021 22;16(7):e0255114. Epub 2021 Jul 22.

Department of Vascular and Endovascular Surgery, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.

Introduction: Management of vascular infections represents a major challenge in vascular surgery. The use of cryopreserved vascular allografts could be a feasible therapeutic option, but the optimal conditions for their production and use are not precisely defined.

Aims: To evaluate the effects of cryopreservation and the duration of storage on the thrombogenicity of femoral artery allografts. Read More

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Analysis of F-Sodium Fluoride Positron Emission Tomography Signal Sources in Atherosclerotic Minipigs Shows Specific Binding of F-Sodium Fluoride to Plaque Calcifications.

Arterioscler Thromb Vasc Biol 2021 Jul 22:ATVBAHA121316075. Epub 2021 Jul 22.

Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (P.N., C.V., A.M.-C., L.G.-C., R.A.M., S.E., J.M., J.F.B.).

Objective: F-sodium fluoride (F-NaF) positron emission tomography (PET) imaging is thought to visualize active atherosclerotic plaque calcification. This is supported by the binding of F-NaF to plaque calcification ex vivo, but no prior studies have examined binding of F-NaF to human-like plaque in vivo. Our aim was to validate the specificity of F-NaF PET for plaque calcifications in atherosclerotic minipigs. Read More

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Short-Term Impact of Iron Deficiency in Different Subsets of Patients with Precapillary Pulmonary Hypertension from an Eastern European Pulmonary Hypertension Referral Center.

Int J Gen Med 2021 12;14:3355-3366. Epub 2021 Jul 12.

Department of Cardiology II, County Emergency Clinical Hospital, Targu Mures, 540042, Romania.

Background: Over the last few decades, interest in the role of iron status in pulmonary hypertension (PH) has grown considerably due to its potential impact on symptoms, exercise capacity (as assessed by the 6-minute walk distance [6MWD]), prognosis, and mortality. The aim of the present study was to identify iron deficiency (ID) prevalence in specific precapillary PH subgroups of Romanian patients and its short-term impact on 6MWD.

Patients And Methods: Complete datasets from 25 precapillary PH adults were examined and included in the analysis. Read More

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Histological changes after pulmonary artery banding for retraining of subpulmonary left ventricle.

Ann Thorac Surg 2021 Jul 17. Epub 2021 Jul 17.

Cardiac Registry, Departments of Cardiology, Pathology, and Cardiac Surgery, Boston Children's Hospital, Boston, MA; Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA.

Background: Patients with congenitally corrected transposition of the great arteries (ccTGA) with intact ventricular septum (IVS) or d-looped transposition of the great arteries (DTGA) with IVS post atrial switch operation often develop left ventricular dysfunction after anatomical repair despite prior retraining of the morphologically left ventricle (mLV) using pulmonary artery banding (PAB). We examined histopathological changes in such mLV.

Methods: Capillary density, myocyte diameter, and interstitial fibrous area in the mLV were retrospectively evaluated in postmortem or explanted heart specimens obtained from patients with ccTGA/IVS or DTGA/IVS post atrial switch operation after PAB for retraining and compared with those of patients with normal cardiac anatomy, ccTGA/IVS or DTGA/IVS without PAB, and ccTGA or DTGA with high mLV pressure using generalized estimating equations models. Read More

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A review of the effects of ticagrelor on adenosine concentration and its clinical significance.

Pharmacol Rep 2021 Jul 20. Epub 2021 Jul 20.

Faculty of Pharmacy, University of Malaya, 50603, Kuala Lumpur, Malaysia.

Background: Ticagrelor is an oral antiplatelet drug that can reversibly bind to the platelet P2Y12 receptor. Ticagrelor is metabolized mainly by CYP3A4 and produces a rapid blood concentration-dependent platelet inhibitory effect. Unlike other P2Y12 receptor antagonists, many clinical features of ticagrelor are not related to P2Y12 receptor antagonism. Read More

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Associations of Genetically Predicted Lipoprotein (a) Levels with Cardiovascular Traits in Individuals of European and African Ancestry.

Circ Genom Precis Med 2021 Jul 20. Epub 2021 Jul 20.

Department of Cardiovascular Medicine & Gonda Vascular Center, Mayo Clinic, Rochester, MN.

- Lipoprotein (a) [Lp(a)] levels are higher in individuals of African ancestry (AA) than in individuals of European ancestry (EA). We examined associations of genetically predicted Lp(a) levels with 1) atherosclerotic cardiovascular disease (ASCVD) subtypes: coronary heart disease (CHD), cerebrovascular disease (CVD), peripheral artery disease (PAD), and abdominal aortic aneurysm (AAA); and 2) non-ASCVD phenotypes, stratified by ancestry. - We performed 1) Mendelian randomization (MR) analyses for previously reported cardiovascular associations, and 2) phenome-wide MR (MR-PheWAS) analyses for novel associations. Read More

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Tree nut consumption and prevalence of carotid artery plaques: The National Heart, Lung, and Blood Institute Family Heart Study.

Eur J Nutr 2021 Jul 19. Epub 2021 Jul 19.

Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Purpose: While tree nut consumption has been shown to be cardioprotective, a few studies have examined the relationship between tree nut consumption and carotid atherosclerosis. We tested the hypothesis that tree nut consumption would be inversely related with carotid atherosclerosis in adults.

Methods: We cross-sectionally analyzed data from 4536 participants of the National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study conducted in the United States. Read More

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Forehead Regional Oxygen Saturation (rSO2)-Related Ear-Level Arterial Pressure and Lower Thigh rSO2 in the Steep Trendelenburg Position with CO2 Pneumoperitoneum and the Beach Chair Position.

Cureus 2021 Jun 16;13(6):e15687. Epub 2021 Jun 16.

Department of Anesthesiology, Tokyo Women's Medical University, School of Medicine, Tokyo, JPN.

Introduction Regional oxygen saturation (rSO2) reflects tissue perfusion. This observational study aimed to examine the change in the forehead and lower thigh rSO2 associated with intraoperative posture, anesthesia regimen, or mean arterial pressure (mAP) at heart and external auditory meatus (ear) levels. Methods Patients undergoing robot-assisted laparoscopic radical prostatectomy in the Trendelenburg position at 30° with pneumoperitoneum (TPP) or arthroscopic shoulder surgery in the beach chair position at 70° (BCP) under desflurane-remifentanil (D/R) or propofol-remifentanil (P/R) anesthesia were examined. Read More

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BAPN-induced rodent model of aortic dissecting aneurysm and related complications.

J Thorac Dis 2021 Jun;13(6):3643-3651

Department of Cardiac Surgery, Tianjin Chest Hospital, Tianjin, China.

Background: The aim of this study was to investigate the effects of beta-aminopropionitrile (BAPN) on the arterial walls of rodents, and to analyze the gross or pathological changes of arterial and other tissues of rodents treated with BAPN at different concentrations or doses.

Methods: Eighteen SPF SD rats (4-5-week old) were divided into three groups: SD-0.2 (Group A), SD-0. Read More

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Leptin Receptor Blockade Attenuates Hypertension, but Does Not Affect Ventilatory Response to Hypoxia in a Model of Polygenic Obesity.

Front Physiol 2021 2;12:688375. Epub 2021 Jul 2.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Background: Obesity can cause hypertension and exacerbates sleep-disordered breathing (SDB). Leptin is an adipocyte-produced hormone, which increases metabolic rate, suppresses appetite, modulates control of breathing, and increases blood pressure. Obese individuals with high circulating levels of leptin are resistant to metabolic and respiratory effects of leptin, but they appear to be sensitive to hypertensive effects of this hormone. Read More

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Influence of Maternal Lifestyle and Diet on Perinatal DNA Methylation Signatures Associated With Childhood Arterial Stiffness at 8 to 9 Years.

Hypertension 2021 Jul 19:HYPERTENSIONAHA12117396. Epub 2021 Jul 19.

From the School of Human Development and Health, Institute of Developmental Sciences Building, Faculty of Medicine, University of Southampton, United Kingdom (R.M., N.K., E.A., G.C.B., K.M.G., M.A.H.).

Increases in aortic pulse wave velocity, a measure of arterial stiffness, can lead to elevated systolic blood pressure and increased cardiac afterload in adulthood. These changes are detectable in childhood and potentially originate in utero, where an adverse early life environment can alter DNA methylation patterns detectable at birth. Here, analysis of epigenome-wide methylation patterns using umbilical cord blood DNA from 470 participants in the Southampton's Women's Survey identified differential methylation patterns associated with systolic blood pressure, pulse pressure, arterial distensibility, and descending aorta pulse wave velocity measured by magnetic resonance imaging at 8 to 9 years. Read More

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Assessment of toe brachial index validity in diabetic patients - interim results.

Vnitr Lek 2021 ;67(E-4):3-8

Introduction: The toe brachial index (TBI) is recommended for the detection of lower extremity arterial disease (LEAD) in case of reduced efficacy of the ankle brachial index (ABI), which most often occurs in diabetics. In this case, TBI is expected to give more accurate results. There are not many studies dealing with the use of TBI specifically in diabetics and the results are different. Read More

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Cerebral Arterial Bifurcations Harboring D Type Aneurysm are more Asymmetrical than those with C Type Aneurysm.

J Stroke Cerebrovasc Dis 2021 Jul 15;30(9):105972. Epub 2021 Jul 15.

Center of Medical Research, Shijiazhuang People's Hospital, Fangbei Road, Shijiazhuang, Hebei Province 050011, China. Electronic address:

Objectives: This study was designed to determine aneurysm deviation and to compare anatomical differences of bifurcations harboring C and D-type aneurysms.

Materials And Methods: A total of 198 arterial bifurcations harboring aneurysms were enrolled in this study, including 58 anterior cerebral arteries (ACAs), 64 middle cerebral arteries (MCAs), 19 basilar arteries (BAs), and 57 internal carotid artery-posterior communicating arteries (ICA-PComAs). Aneurysms were defined as C type if the neck was located on the extension of the parent artery midline and D type if it was not, then, aneurysm deviation was examined. Read More

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Vascular Diagnostic and Surgical Treatments Before Lower Limb Amputations in Patients with Arterial Vascular Diseases: A Population Based Study from 2013 to 2015 in Germany.

Eur J Vasc Endovasc Surg 2021 Jul 14. Epub 2021 Jul 14.

Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.

Objective: Patients with peripheral artery disease (PAD) have an increased risk of lower limb amputation. Given the international wide variance in major amputations, the high mortality rates and follow up costs as well as the significantly reduced quality of life of patients with amputations, vascular diagnostics and vascular surgery treatments are of great importance for lower limb preservation in patients with PAD. This study examines these guideline based procedures in patients before a first lower limb amputation and PAD. Read More

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Inhibition of mitochondrial reactive oxygen species improves coronary endothelial function after cardioplegic hypoxia/reoxygenation.

J Thorac Cardiovasc Surg 2021 Jun 26. Epub 2021 Jun 26.

Division of Cardiothoracic Surgery, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI. Electronic address:

Objective: Cardioplegic ischemia-reperfusion and diabetes mellitus are correlated with coronary endothelial dysfunction and inactivation of small conductance calcium-activated potassium channels. Increased reactive oxidative species, such as mitochondrial reactive oxidative species, may contribute to oxidative injury. Thus, we hypothesized that inhibition of mitochondrial reactive oxidative species may protect coronary small conductance calcium-activated potassium channels and endothelial function against cardioplegic ischemia-reperfusion-induced injury. Read More

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Potential determinants of the E/e' ratio in non-dialysis compared with dialysis patients.

Nephrology (Carlton) 2021 Jul 17. Epub 2021 Jul 17.

Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Aim: We hypothesized that arterial function and N-terminal natriuretic peptide (NT-proBNP) levels as a marker of volume overload, relate differently to E/e' as an index of diastolic function in dialysis compared with non-dialysis patients with chronic kidney disease. We further examined whether cardiovascular risk factors attenuated these relationships.

Methods: We assessed cardiovascular risk factors and determined arterial function indices by applanation tonometry using SphygmoCor software and E/e' by echocardiography in 103 (62 non-dialysis and 41 dialysis) patients. Read More

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Radiomics-Based Machine Learning Classification for Glioma Grading Using Diffusion- and Perfusion-Weighted Magnetic Resonance Imaging.

J Comput Assist Tomogr 2021 Jul 13. Epub 2021 Jul 13.

From the Department of Medical Technology, Osaka University Hospital Department of Medical Physics and Engineering, Division of Health Sciences, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Objective: The aim of this study was to evaluate various radiomics-based machine learning classification models using the apparent diffusion coefficient (ADC) and cerebral blood flow (CBF) maps for differentiating between low-grade gliomas (LGGs) and high-grade gliomas (HGGs).

Methods: Fifty-two glioma patients, including 18 LGGs (grade II) and 34 HGGs (grade III/IV), were examined using a 3.0-T magnetic resonance scanner. Read More

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Voltage-Gated Potassium Channel Dysfunction in Dorsal Root Ganglia Contributes to the Exaggerated Exercise Pressor Reflex in Rats with Chronic Heart Failure.

Am J Physiol Heart Circ Physiol 2021 Jul 16. Epub 2021 Jul 16.

Department of Anesthesiology, grid.266813.8University of Nebraska Medical Center, Omaha, NE, United States.

An exaggerated exercise pressor reflex (EPR) causes excessive sympatho-excitation and exercise intolerance during physical activity in the chronic heart failure (CHF) state. Muscle afferent sensitization contributes to the genesis of the exaggerated EPR in CHF. However, the cellular mechanisms underlying muscle afferent sensitization in CHF remain unclear. Read More

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Antioxid Redox Signal 2021 Jul 16. Epub 2021 Jul 16.

University of Debrecen, Pediatrics, Debrecen, Hungary;

Aim: Infiltration of red blood cells in atherosclerosis is correlated with the development of complicated lesions. In this study, we examined whether oxidation of hemoglobin (Hb) contributes to transformation of lesions towards a progressive phenotype.

Results: We observed that macrophages engulf then internalize ferrylHb generated in hemorrhagic transformed plaques via hemoglobin-haptoglobin receptor (CD163 receptor). Read More

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The effect of melatonin on incretin hormones - results from experimental and randomized clinical studies.

J Clin Endocrinol Metab 2021 Jul 15. Epub 2021 Jul 15.

Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.

Context: Glucose homeostasis is under circadian control through both endocrine and intracellular mechanisms with several lines of evidence suggesting that melatonin affects glucose homeostasis.

Objective: To evaluate the acute in-vivo and in-situ effects of melatonin on secretion of the incretin hormones, GLP-1 and GIP, and their impact on β-cell insulin secretion.

Design: A human randomized, double-blinded, placebo-controlled crossover study combined with a confirmatory in-situ study of perfused rat intestines. Read More

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