Hypertension 2021 Jul 19:HYPERTENSIONAHA12117396. Epub 2021 Jul 19.
From the School of Human Development and Health, Institute of Developmental Sciences Building, Faculty of Medicine, University of Southampton, United Kingdom (R.M., N.K., E.A., G.C.B., K.M.G., M.A.H.).
Increases in aortic pulse wave velocity, a measure of arterial stiffness, can lead to elevated systolic blood pressure and increased cardiac afterload in adulthood. These changes are detectable in childhood and potentially originate in utero, where an adverse early life environment can alter DNA methylation patterns detectable at birth. Here, analysis of epigenome-wide methylation patterns using umbilical cord blood DNA from 470 participants in the Southampton's Women's Survey identified differential methylation patterns associated with systolic blood pressure, pulse pressure, arterial distensibility, and descending aorta pulse wave velocity measured by magnetic resonance imaging at 8 to 9 years. Read More