196,382 results match your criteria examination revealed

The hot cross bun sign in corticobasal degeneration.

Neuropathology 2021 Jul 28. Epub 2021 Jul 28.

Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Nagakute, Japan.

The hot cross bun (HCB) sign encompasses a cross-shaped hyperintensity area in the pons on axial T2-weighted magnetic resonance imaging (MRI). The HCB sign is characteristic of multiple system atrophy (MSA) and has occasionally been observed in other neurological disorders. Here, we report an autopsied case of corticobasal degeneration (CBD) that showed the HCB sign. Read More

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Desmoplastic Small Round Cell Tumor of the Submandibular Gland: A Case Report and Literature Review.

ORL J Otorhinolaryngol Relat Spec 2021 Jul 28:1-6. Epub 2021 Jul 28.

Department of Pathology, Maoming People's Hospital, Maoming, China.

Desmoplastic small round cell tumor (DSRCT) is a rare and aggressively malignant tumor mostly occurring in the abdominal and pelvic cavity of young patients. However, few cases had been reported concerning DSRCT occurring in the head and neck region. We presented a rare case of DSRCT of the right submandibular in a 25-year-old man. Read More

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CRB1-associated retinal dystrophies: a prospective natural history study in anticipation of future clinical trials.

Am J Ophthalmol 2021 Jul 25. Epub 2021 Jul 25.

Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands; Department of Ophthalmology, Amsterdam UMC, Academic Medical Center, Amsterdam, the Netherlands. Electronic address:

Purpose: To describe the natural disease course of CRB1-associated retinal dystrophies, and to identify clinical endpoints for future clinical trials.

Design: Single center, prospective case series.

Methods: An investigator-initiated nationwide collaborative study that included 22 patients with CRB1-associated retinal dystrophies. Read More

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Right atrial papillary fibroelastoma arising from the Chiari network detected by echocardiography: a case report and literature review.

Cardiovasc Pathol 2021 Jul 25:107372. Epub 2021 Jul 25.

Department of Ultrasound, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China; Department of Ultrasound, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences. Electronic address:

Purpose: To improve our understanding of cardiac papillary fibroelastoma(PFE)and provide evidence for its treatment and prognosis.

Materials And Methods: We report a 54-year-old Chinese male who was hospitalized for a 14-day headache with a previous vertebral aneurysm history. A right atrial mass arising from the CN was detected by echocardiography and complete tumor resection was performed finally. Read More

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Targeting Mycobacterium tuberculosis response to environmental cues for the development of effective antitubercular drugs.

PLoS Biol 2021 Jul 28;19(7):e3001355. Epub 2021 Jul 28.

Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, United States of America.

Sensing and response to environmental cues, such as pH and chloride (Cl-), is critical in enabling Mycobacterium tuberculosis (Mtb) colonization of its host. Utilizing a fluorescent reporter Mtb strain in a chemical screen, we have identified compounds that dysregulate Mtb response to high Cl- levels, with a subset of the hits also inhibiting Mtb growth in host macrophages. Structure-activity relationship studies on the hit compound "C6," or 2-(4-((2-(ethylthio)pyrimidin-5-yl)methyl)piperazin-1-yl)benzo[d]oxazole, demonstrated a correlation between compound perturbation of Mtb Cl- response and inhibition of bacterial growth in macrophages. Read More

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Use of Recombinant Factor VIIa for Bleeding Control in Treatment of Acute Extremity Compartment Syndrome Secondary to Primary Myelofibrosis: A Case Report.

JBJS Case Connect 2021 Jul 28;11(3). Epub 2021 Jul 28.

Department of Orthopedics and Traumatology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Case: A 40-year-old man was admitted to our emergency department with a painful and swollen calf. There was no history of significant trauma, and the physical examination revealed a pulseless, swollen left lower leg. Clinical history revealed a diagnosis of primary myelofibrosis, and magnetic resonance imaging showed a rupture of the gastrocnemius medial head. Read More

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A Giant Diving Ranula Extending to the Skull Base in Pediatric Age.

J Craniofac Surg 2021 Jul-Aug 01;32(5):e515-e517

Department of Oto-Rhino-Laryngology and Head and Neck Surgery, Faculty of Medicine, Suleyman Demirel University.

Abstract: Ranula is a retention cyst that develops from the salivary glands. It has 2 subtypes, oral and diving. There are differences in the clinical features of ranula subtypes. Read More

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Overlooked Binary Compounds Uncovered in the Reinspection of the La-Au System: Synthesis, Crystal Structures, and Electronic Properties of LaAu, LaAu, and LaAu.

Inorg Chem 2021 Jul 28. Epub 2021 Jul 28.

Department of Materials and Environmental Chemistry, Stockholm University, Svante Arrhenius väg 16 C, 10691 Stockholm, Sweden.

Although compound formation between two elements is well studied, thorough investigations make it possible to uncover new binary compounds. A re-examination of the La-Au system revealed three new phases, which were characterized with respect to their structural and electronic properties as well as thermal stability: LaAu (ThFe type, space group 6, Pearson code 20) appears to be metastable. It can be obtained by slow crystallization from a stoichiometric melt. Read More

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Direct next-generation sequencing analysis using endometrial liquid-based cytology specimens for rapid cancer genomic profiling.

Diagn Cytopathol 2021 Jul 28. Epub 2021 Jul 28.

Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Background: Genomic examination of cytology specimens is often performed on cell blocks or conventional smears rather than on liquid-based cytology (LBC) specimens. Since LBC specimens preserve high-quality DNA, cancer genome profiling using next-generation sequencing (NGS) is also attainable from residual LBC specimens. One of the advantages of using LBC specimens for NGS is that it allows direct extraction of DNA from residual specimens, avoiding a sacrifice of smear slides and minimizing genomic profiling processing time. Read More

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Intentional Replantation of a Second Premolar with Internal Resorption and Root Fracture: A Case Report.

J Contemp Dent Pract 2021 May 1;22(5):562-567. Epub 2021 May 1.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China, e-mail:

Aim: This case aims to detail intentional replantation as a last resort to save an otherwise hopeless premolar with perforated internal resorption and root fracture.

Background: Internal root resorption, progressive destruction of intraradicular dentin, is a condition that sometimes renders a tooth non-restorable. In the rare cases reported where severe internal resorption leads to root fracture, extraction of the tooth seemed to be a common treatment of choice, and a few literatures had reported endodontic surgery as an alternative treatment option. Read More

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Ethics review, reflective equilibrium and reflexivity.

Julie Morton

Nurs Ethics 2021 Jul 28:9697330211003252. Epub 2021 Jul 28.

University of Salford, UK.

Background: Research Ethics Committees (RECs) or their equivalent review applications for prospective research with human participants. Reviewers use universally agreed principles to make decisions about whether prospective health and social care research is ethical. Close attention to understanding how reviewers go about their decision-making work and consider principles in practice is limited. Read More

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Novel Homozygous Truncating Variant Widens the Spectrum of Early-Onset Multisystemic SYNE1 Ataxia.

Cerebellum 2021 Jul 28. Epub 2021 Jul 28.

Department of Neurology, University of Copenhagen, Rigshospitalet, Inge Lehmanns Vej 8, 2100, Copenhagen, Denmark.

Pathogenic variants in the SYNE1 gene are associated with a phenotypic spectrum spanning from late-onset, slowly progressive, relatively pure ataxia to early-onset, fast progressive multisystemic disease. Since its first description in 2007 as an adult-onset ataxia in French Canadian families, subsequent identification of patients worldwide has widened the clinical spectrum and increased the number of identified pathogenic variants. We report a 20-year-old Faroese female with early-onset progressive gait problems, weakness, dysphagia, slurred speech, orthostatic dizziness, and urge incontinence. Read More

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Anomalous Origin of a Right Coronary Artery from the Pulmonary Artery in a Middle-Aged Woman.

JACC Case Rep 2020 Mar 18;2(3):464-467. Epub 2020 Mar 18.

Cardiovascular Department, North Texas Heart Center, Dallas, Texas.

A 53-year-old female patient presented for evaluation of a murmur. The examination revealed a 2/6 systolic ejection murmur in the left upper sternal border. Transthoracic echocardiography with color Doppler showed increased blood flow around the apex of the right ventricle. Read More

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Lawn Mower Versus Left Ventricular Assist Device: A Case of Traumatic Coronary Injury.

JACC Case Rep 2020 Mar 18;2(3):406-410. Epub 2020 Mar 18.

Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina.

A 77-year-old man with history of ischemic cardiomyopathy and left ventricular assist device (LVAD) presented with abdominal pain after a lawn mower accident. Examination and imaging revealed a displaced LVAD driveline and a pericardial hematoma secondary to traumatic coronary artery injury. The patient was treated with coronary artery coil embolization. Read More

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Calcified Nodules in the Superficial Femoral Artery Confirmed by Intravascular Ultrasound, Angioscopy, and Histology.

JACC Case Rep 2020 Oct 21;2(12):1862-1866. Epub 2020 Oct 21.

Division of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan.

An 84-year-old man was admitted to the authors' hospital for the treatment of intermittent claudication. Angiography revealed an exophytic calcified nodules in the distal superficial femoral artery. Angioscopy also revealed abundant exophytic atherosclerotic calcification. Read More

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October 2020

Lidocaine injections and neck corset wearing improve dropped head syndrome in Parkinson's disease and related disorders.

Clin Park Relat Disord 2019 26;1:82-85. Epub 2019 Oct 26.

Department of Neurology, National Center Hospital, Parkinson's Disease & Movement Disorders Center, National Center of Neurology and Psychiatry, Japan.

Background: Patients with Parkinson's disease and related disorders (PDRD) may exhibit dropped head syndrome (DHS), which does not yet have an effective treatment.

Objectives: To evaluate the effect of combining lidocaine injection into the bilateral scalene muscles and neck corset wearing on dropped head syndrome.

Methods: We performed needle electromyography assessments of the scalene, sternocleidomastoid (SCM), levator scapulae, splenius capitis, and trapezius muscles. Read More

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October 2019

Ulnar nerve compression secondary to migration of pyrocarbon implant following right wrist arthroplasty.

J Surg Case Rep 2021 Jul 22;2021(7):rjab296. Epub 2021 Jul 22.

Department of Plastic Surgery, Queen Victoria Hospital, Holtye Road, East Grinstead, RH193DZ, UK.

A 50-year-old, right-hand dominant woman presented with a seven-month history of stiffness, pain and swelling on the ulnar side of her right wrist. She had undergone right wrist arthroplasty with a Pyrocarbon Amandys implant seven months previously for post-traumatic degenerative arthritis. She had an uneventful initial recovery until developing carpal tunnel syndrome, for which she underwent carpal tunnel release 5 months after her arthroplasty. Read More

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Siblings with Glutaric Aciduria Type 1 with Atypical Phenotype with Novel Pathogenic Variant in GCDH Gene.

J Pediatr Neurosci 2021 Jan-Mar;16(1):75-78. Epub 2021 Jun 25.

Department of Neuroradiology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India.

Glutaric aciduria type 1 (GA1) is caused by a deficiency of the enzyme glutaryl CoA dehydrogenase. It generally presents with developmental delay, dystonia, and large head. We are reporting siblings of GA1, presenting with an atypical phenotype with novel pathogenic variant. Read More

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A Rare Cause of Autistic Regression in a Boy with Down Syndrome: Hashimoto Encephalopathy.

J Pediatr Neurosci 2021 Jan-Mar;16(1):65-68. Epub 2021 Jun 25.

Pediatric Neurology Clinic, Istanbul, Turkey.

Background: Hashimoto encephalopathy (HE) is a rare condition associated with autoimmune thyroid disease. We aimed to report the youngest patient with Down syndrome and HE with an unusual presentation.

Case Report: Six years and six months old boy with Down syndrome admitted due to loss of speech. Read More

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Sarcoidosis involvement of the diaphragm leading to right diaphragmatic elevation: a case report.

Sarcoidosis Vasc Diffuse Lung Dis 2021 28;38(2):e2021011. Epub 2021 Jun 28.

Department of Pneumology, Cologne Merheim Hospital, Kliniken der Stadt Köln gGmbH, Faculty of Health/School of Medicine, Witten/Herdecke University, Cologne, Germany.

A 69-year-old male Caucasian presenting with dyspnea on exertion related to unilateral diaphragmatic dysfunction as caused by sarcoidosis is described. First, right diaphragmatic elevation was unexplained, while the patient presented with a restrictive pattern in lung function testing using bodyplethysmography and with reduced global and diaphragmatic respiratory muscle strength as evidenced by respiratory pressures. Subsequently, surgical diaphragm plication was performed, unfortunately, without any clinical improvement. Read More

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Clinical and histopathological studies on neurodegeneration and dysautonomia in buffalo calves during foot-and-mouth disease outbreaks in Egypt.

Vet World 2021 Jun 23;14(6):1622-1630. Epub 2021 Jun 23.

Department of Animal Medicine, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.

Background And Aim: Signs of dysautonomia were frequently observed in calves that died during foot-and-mouth disease (FMD) virus (FMDV) outbreaks in Egypt from 2015 to 2018. This study aimed to describe the clinical and histopathological features of the central nervous system in malignant cases of FMD and excluding possible concurrent bacterial, and bovine herpes virus 4 (BHV4) infections or both.

Materials And Methods: In this study, 335 FMDV-infected buffalo calves aged 1-22 months were clinically examined and followed until recovery or death. Read More

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Central retinal artery occlusion in a patient who contracted COVID-19 and review of similar cases.

BMJ Case Rep 2021 Jul 27;14(7). Epub 2021 Jul 27.

Ophthalmology, Private Konyagoz Hospital, Konya, Turkey.

A 54-year-old male patient applied to our clinic with a sudden and painless loss of vision in his right eye. He was suffering from COVID-19. His best-corrected visual acuity of the right eye was finger counting from 30 cm. Read More

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Gastric dysplasia causing gastric outlet obstruction.

BMJ Case Rep 2021 Jul 27;14(7). Epub 2021 Jul 27.

Department of Surgical Oncology, Shri Guru Ram Rai Institute of Medical and Health Sciences, Dehradun, Uttarakhand, India

Gastric dysplasia signifies the presence of atypical cells in the gastric mucosa, which have not invaded beyond the lamina propria, and it rarely leads to tissue growth large enough to cause gastric outlet obstruction (GOO) to the gastric contents. However, GOO is commonly observed as a first clinical manifestation of advanced invasive gastric cancer in developing countries where patients seek medical care late. The present case highlights the treatment journey of a young woman who presented to us with features of GOO. Read More

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Microstructural Characterization of Nb/Inconel 601 Interface Obtained in the Explosive Welding Process.

Microsc Microanal 2021 Jul 28:1-8. Epub 2021 Jul 28.

Institute of Metallurgy and Materials Science, Polish Academy of Sciences, 25 Reymonta St., 30-059 Krakow, Poland.

This work presents the microstructure of the cross-section of a newly developed Nb/Inconel 601 weld with particular attention paid to the continuity, morphology of the interface, and the microstructural changes within its vicinity. Both scanning (SEM) and transmission (TEM) electron microscopy techniques are excellent tools to analyze the microstructure that affects both mechanical and corrosion resistance properties of the obtained product. Grain size examination and their orientation together with the character of grain boundaries by the electron backscattered diffraction (EBSD) technique were performed followed by chemical composition determination across the interface with energy-dispersive X-ray spectroscopy (EDS) in SEM. Read More

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Interaction between cognitive leisure activity and long-chain polyunsaturated fatty acid intake on global cognitive decline in a Japanese longitudinal cohort study: National Institute for Longevity Sciences-Longitudinal Study of Aging.

BMC Geriatr 2021 Jul 27;21(1):443. Epub 2021 Jul 27.

Department of Epidemiology of Aging, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, 474-8511, Obu-City, Aichi, Japan.

Background: There is a growing interest in the significance of adopting a variety of lifestyle habits for maintaining cognitive function among older adults. A lifestyle that is easy to modify, simple, and less burdensome for older people is ideal. We investigated the longitudinal association between global cognitive decline and cognitive leisure activities (CLAs) combined with long-chain polyunsaturated fatty acids (LCPUFAs) intake. Read More

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Secondary pleuropulmonary amoebiasis due to liver abscess rupture: A complication case report in low resource setting.

Int J Surg Case Rep 2021 Jul 21;85:106231. Epub 2021 Jul 21.

Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Electronic address:

Background: Pleuropulmonary amoebiasis caused by complications of amoebic liver abscess (ALA) is rare.

Case Presentation: A 23 years old male, presented with shortness of breath, cough with yellowish phlegm, right chest pain, fever, bulging stomach, yellow eyes, and swelling of both legs. Abdominal ultrasound and CT scan thorax and abdomen revealed right fluidopneumothorax and liver abscess. Read More

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Examining the influence of mental stress on balance perturbation responses in older adults.

Exp Gerontol 2021 Jul 24;153:111495. Epub 2021 Jul 24.

University of Maryland School of Medicine, Department of Physical Therapy and Rehabilitation Science, Baltimore, MD 21201, USA. Electronic address:

Background: Reach-to-grasp responses following balance perturbations are important to fall prevention but are often ineffective in older adults. The ability to shift attention from an ongoing cognitive task to balance related processes has been shown to influence reach-to-grasp effectiveness in older adults. However, the added influence of stress and anxiety - known to negatively affect attention shifting ability - has not yet been explored in relation to recovery from balance perturbations. Read More

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Incidence of malignant transformation in the oviductal fimbria in laying hens, a preclinical model of spontaneous ovarian cancer.

PLoS One 2021 27;16(7):e0255007. Epub 2021 Jul 27.

Department of Cell and Molecular Medicine, Rush University Medical Center, Chicago, Illinois, United States of America.

Ovarian high grade serous carcinoma (HGSC) is a lethal form of ovarian cancer (OVCA). In most cases it is detected at late stages as the symptoms are non-specific during early stages. Emerging information suggests that the oviductal fimbria is a site of origin of ovarian HGSC. Read More

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Unusual presentations of a severe type 2 leprosy reaction mimicking sepsis induced by helminth infection.

PLoS Negl Trop Dis 2021 Jul 27;15(7):e0009453. Epub 2021 Jul 27.

Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

We describe an unusual case of type 2 leprosy reaction (T2R) with septic shock-like features induced by helminth infection in a 31-year-old Moluccan male patient with a history of completed treatment of WHO multidrug therapy (MDT)-multibacillary (MB) regimen 2 years before admission. During the course of illness, the patient had numerous complications, including septic shock, anemia, and disseminated intravascular coagulation (DIC). Nevertheless, antibiotic therapies failed to give significant results, and the source of infection could not be identified. Read More

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Neuropathological effects of chronically implanted, intracortical microelectrodes in a tetraplegic patient.

J Neural Eng 2021 Jul 27;18(4). Epub 2021 Jul 27.

Department of Pathology, Keck USC School of Medicine, Los Angeles, CA, United States of America.

Intracortical microelectrode arrays (MEA) can be used as part of a brain-machine interface system to provide sensory feedback control of an artificial limb to assist persons with tetraplegia. Variability in functionality of electrodes has been reported but few studies in humans have examined the impact of chronic brain tissue responses revealed postmortem on electrode performanceIn a tetraplegic man, recording MEAs were implanted into the anterior intraparietal area and Brodmann's area 5 (BA5) of the posterior parietal cortex and a recording and stimulation array was implanted in BA1 of the primary somatosensory cortex (S1). The participant expired from unrelated causes seven months after MEA implantation. Read More

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