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Prospective validation of the Kaiser Permanente prostate cancer risk calculator in a contemporary, racially diverse, referral population.

Urol Oncol 2021 May 4. Epub 2021 May 4.

Division of Research, Kaiser Permanente Northern California, Oakland, CA; Department of Medicine, Kaiser Permanente Northern California, Oakland, CA.

Purpose: To prospectively validate a new prostate cancer risk calculator in a racially diverse population.

Materials And Methods: We recently developed, internally validated and published the Kaiser Permanente Prostate Cancer Risk Calculator. This study is a prospective validation of the calculator in a separate, referral population over a 21-month period. Read More

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Are different medical school admission tests associated with the outcomes of a simulation-based OSCE?

BMC Med Educ 2021 May 7;21(1):263. Epub 2021 May 7.

III. Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: Medical school admission procedures have the common goal to select applicants with the greatest potential of becoming successful physicians. Hamburg Medical Faculty selects medical students by grade point average (GPA) and employs a two-step selection process of a natural sciences test (HAM-Nat), in some cases followed by multiple mini-interviews (HAM-Int). Multiple mini-interviews can predict non-cognitive outcomes, while GPA has predictive validity for cognitive outcomes. Read More

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Academic and Nonacademic Predictors of BSN Student Success on the HESI Exit Exam.

Comput Inform Nurs 2021 Apr 29. Epub 2021 Apr 29.

Author Affiliation: Georgia College & State University, Milledgeville.

First-time success rate on the NCLEX-RN examination has significant implications for BSN students, faculty, and schools of nursing. Many nursing programs utilize standardized examinations such as the HESI Exit Exam to quantify student success on knowledge of nursing concepts and to prepare students for success on the NCLEX-RN. Nursing faculty must be able to identify predictors of student success early in the nursing program in order to offer appropriate support and remediation. Read More

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Implementation of a Flipped Active-Learning Approach in a Community College General Biology Course Improves Student Performance in Subsequent Biology Courses and Increases Graduation Rate.

CBE Life Sci Educ 2021 Jun;20(2):ar30

Front Range Community College, Biology Department, Westminster, CO 80031.

Active learning has been shown to improve student learning and engagement in many 4-year institutions; however, large-scale studies on the efficacy of active learning in community colleges are lacking. In this study, we investigate the effects of active learning in a first semester majors' general biology course at a large, suburban community college by designing and implementing a flipped active-learning model in the course. Our study included 33 sections of general biology class, 16 instructors, and ∼800 students. Read More

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Determination of predictors impacting performance on the third-year pharmacy curriculum outcomes assessment at a historically Black college of pharmacy.

Curr Pharm Teach Learn 2021 Jun 10;13(6):652-658. Epub 2021 Feb 10.

Pharmacy Administration, Howard University College of Pharmacy, 2300 4(th) Street, NW, Washington, DC 20059, United States. Electronic address:

Introduction: The Pharmacy Curriculum Outcomes Assessment (PCOA) is a standardized exam developed by the National Association of Boards of Pharmacy (NABP) in 2008 to measure the curriculum in relation to student progress. The purpose of the study was to determine the impact of pre-admissions and pharmacy school variables on third-year student PCOA performance at a Historically Black College or University (HBCU) College of Pharmacy.

Methods: A retrospective analysis was conducted using data from three cohorts of students who took the PCOA in their third professional year from 2015 to 2017. Read More

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Use of an in-house comprehensive exam as a predictor for academic success.

Curr Pharm Teach Learn 2021 Jun 2;13(6):643-651. Epub 2021 Feb 2.

DeBusk College of Osteopathic Medicine, Lincoln Memorial University, 6965 Cumberland Gap Parkway, Harrogate, TN 37752, United States. Electronic address:

Introduction: We created a comprehensive, internally developed, knowledge-based assessment called the Year 1 Comprehensive Abilities Assessment (Y1-CAA) in order to address the unique assessment needs of an accelerated three-year pharmacy program. This study investigated the correlation between the Y1-CAA and performance on a variety of academic factors, including, but not limited to, curricular performance, Pharmacy Curriculum Outcomes Assessment (PCOA) scores, and North American Pharmacist Licensure Examination (NAPLEX) scores.

Methods: The 120 question Y1-CAA was created and benchmarked by the faculty and given to students at the end of the first professional year. Read More

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Failure of IVIG in steroid-responsive autoimmune glial fibrillary acidic protein astrocytopathy: A case report.

Mult Scler Relat Disord 2021 Apr 4;51:102933. Epub 2021 Apr 4.

University of California Irvine (UCI), Department of Neurology, Irvine CA, United States.

Objective: To advocate for high-dose steroids, not intravenous immunoglobulins (IVIG), as first-line treatment for Anti-glial fibrillary acidic protein (GFAP) associated meningoencephalomyelitis.

Background: A novel IgG antibody against GFAP was associated with relapsing autoimmune meningoencephalomyelitis.

Design/methods: Here, we present an investigational case report to highlight continuing challenges in diagnosing and managing Anti-GFAP associated meningoencephalomyelitis. Read More

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Semi-Circumferential Decompression: Total En-Bloc Ligamentum Flavectomy to Treat Lumbar Spinal Stenosis with Two-Level Degenerative Spondylolisthesis.

Spine Surg Relat Res 2021 9;5(2):91-97. Epub 2020 Oct 9.

Department of Orthopaedic Surgery, Capital Corps of Republic of Korea Army, Yongin, Korea.

Introduction: Despite technical developments in decompression without fusion, many studies still assert that instability could be increased in patients with spinal stenosis and lumbar degenerative spondylolisthesis after spinal decompression surgery without fusion. Thus, this study aimed to describe and assess the clinical outcomes of the semi-circumferential decompression (SCD) technique used for microsurgical en-bloc total ligamentum flavectomy with preservation of the facet joint in treating patients who have lumbar spinal stenosis with two-level degenerative spondylolisthesis.

Methods: We retrospectively analyzed the clinical and radiologic outcomes of 14 patients who had spinal stenosis with two-level Meyerding grade I degenerative spondylolisthesis. Read More

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October 2020

Detection of severe pulmonary hypertension based on computed tomography pulmonary angiography.

Int J Cardiovasc Imaging 2021 Apr 7. Epub 2021 Apr 7.

Department of Radiology, Tel Aviv Medical Center, Tel Aviv, Affiliated to the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Pulmonary hypertension (PH) is often diagnosed late in the disease course. As many patients may undergo computed tomography pulmonary angiography (CTPA) for exclusion of pulmonary embolism (PE), we aimed to create a model that can detect the existence of PH and grade its severity. Consecutive patients who underwent CTPA which was negative for PE, and echocardiography study within 24 h, were included. Read More

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Outcomes of robotically assisted laparoscopic lateral suspension (RALLS) with mesh for anterior and apical prolapse.

J Robot Surg 2021 Apr 5. Epub 2021 Apr 5.

Urogynecology Unit, Division of Gynecology, Department of Pediatrics, Gynecology and Obstetrics, Geneva University Hospitals, 30 boulevard de la Cluse, 1211, Geneva 14, Switzerland.

Abdominal sacral colpopexy/hysteropexy is the gold standard for the treatment of vaginal apex support. However, dissection of the promontory may expose to potentially life-threatening complications. To avoid this risk, laparoscopic lateral suspension with mesh is an alternative. Read More

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Primary intraosseous malignant peripheral nerve sheath tumor of the mandible: An unusual presentation mimicking a benign lesion.

Oral Oncol 2021 Mar 30:105266. Epub 2021 Mar 30.

Laboratory of Morphology and Experimental Pathology, Institute of Technology and Research, Tiradentes University (UNIT), Aracaju, Brazil.

The malignant peripheral nerve sheath tumor (MPNST) is a rare, aggressive malignant tumor that usually develops in the context of neurofibromatosis type 1. In the oral cavity, these tumors are excelling rare, especially in intraosseous sites. Herein, we report an unusual presentation of intraosseous MPNST affecting the mandible posterior region in a 28-year-old male without neurofibromatosis type 1 discovered as an incidental find on imaging exam. Read More

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A Smart Tendon Hammer System for Remote Neurological Examination.

Front Robot AI 2021 16;8:618656. Epub 2021 Mar 16.

Biorobotics and Human Modeling Laboratory, Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, United States.

The deep tendon reflex exam is an important part of neurological assessment of patients consisting of two components, reflex elicitation and reflex grading. While this exam has traditionally been performed in person, with trained clinicians both eliciting and grading the reflex, this work seeks to enable the exam by novices. The COVID-19 pandemic has motivated greater utilization of telemedicine and other remote healthcare delivery tools. Read More

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Reversible HER2 antibody-drug conjugate-induced ocular toxicity.

Can J Ophthalmol 2021 Mar 13. Epub 2021 Mar 13.

Moran Eye Center, University of Utah, Salt Lake City, Utah.

Purpose: To report 3 cases of reversible epitheliopathy induced by A166-a human epidermal growth factor receptor (HER2)-targeted antibody-drug conjugate (ADC) therapy for resistant HER2 tumours.

Methods: Advanced HER2 tumour patients were enrolled in A166 phase I/II clinical trial using Bayesian logistic regression model dose escalation. Key exclusion criteria were ≥grade 2 (G2) corneal pathology, severe organ disease, and other cancer therapy within 4 weeks. Read More

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Midline Suboccipital Subtonsillar Approach in Semisitting Position for Resection of Jugular Tubercle Meningioma: 2-Dimensional Operative Video.

J Neurol Surg B Skull Base 2021 Feb 26;82(Suppl 1):S48-S50. Epub 2020 Nov 26.

Department of Neurological Surgery, Eberhard-Karls-University, University Hospital Tübingen, Germany.

We present a case of a large jugular tubercle meningioma that was removed through a midline suboccipital subtonsillar approach in semisitting position. The patient is a 49-year-old woman with chronic, medication-resistant cephalgias but devoid of any subjective focal neurological deficit. On magnetic resonance imaging (MRI), an extra-axial lesion, originating from the left jugular tubercle was discovered. Read More

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February 2021

Introducing Family Medicine Clerkship to Medical Students' Curriculum at a Saudi Medical University: An Impact Study.

J Prim Care Community Health 2021 Jan-Dec;12:21501327211002100

Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Background: Family Medicine was introduced as a major undergraduate clinical rotation in 2016 after the medical college at Imam Abdulrahman Bin Faisal University revised its curriculum.

Objective: Assessing how students' medical knowledge has improved post Family Medicine introduction to the revised medical school curriculum.

Study Design: This was a cross-sectional epidemiological study among fifth year clinical medical students (n = 219). Read More

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The effects of long-term extracurricular scientific research on the medical students: Insight from Jinan University Medical School.

Biochem Mol Biol Educ 2021 Mar 8. Epub 2021 Mar 8.

Division of Histology and Embryology, International Joint Laboratory for Embryonic Development & Prenatal Medicine, Medical College, Jinan University, Guangzhou, China.

The benefits and long-term effects of extracurricular scientific research on undergraduate students in many countries have been intensively investigated, but it remains obscure for Chinese medical students. In this study, we investigated the outcome of 60 medical students who have participated in extracurricular scientific research at Jinan University Medical School over a period of 7 years (2011-2018). The results revealed that these students have contributed to 31 biomedical science articles in reputable academic journals, as first- or co-authors. Read More

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Pharmacokinetics of UGN-101, a mitomycin-containing reverse thermal gel instilled via retrograde catheter for the treatment of low-grade upper tract urothelial carcinoma.

Cancer Chemother Pharmacol 2021 Mar 7. Epub 2021 Mar 7.

Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA.

Purpose: To evaluate the pharmacokinetic properties of UGN-101, a mitomycin-containing reverse thermal gel used as primary chemoablative treatment for low-grade upper tract urothelial carcinoma (UTUC), in a subset of patients participating in a phase 3 clinical trial.

Methods: Pharmacokinetic parameters (C, T, AUC, λz, t, and AUC) were evaluated in six participants (male or female, ≥ 18 years) with biopsy-proven, low-grade UTUC who received the first of 6 once-weekly instillations of UGN-101 to the renal pelvis and calyces via retrograde ureteral catheter. Plasma samples were collected prior to instillation and 30 min, 1, 2, 3, 4, 5, and 6 h post-instillation. Read More

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Requests for radiologic imaging: Prevalence and determinants of inadequate quality according to RI-RADS.

Eur J Radiol 2021 Apr 25;137:109615. Epub 2021 Feb 25.

Medical Imaging Center, Department of Radiology, Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, the Netherlands. Electronic address:

Purpose: To determine the prevalence and determinants of radiologic imaging requests that are of inadequate quality according to the Reason for exam Imaging Reporting and Data System (RI-RADS).

Methods: This study included a random sample of 673 radiologic examinations performed at a tertiary care center. The quality of each imaging request was graded according to RI-RADS. Read More

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Attacked and Shaken by a Dog: A Cause of Traumatic Brain and Carotid Injury in an Infant.

Pediatr Neurosurg 2021 1;56(2):140-145. Epub 2021 Mar 1.

Department of Neurosurgery, Virginia Commonwealth University, Richmond, Virginia, USA.

Background: Posttraumatic carotid artery dissection (PTCAD) is a common injury in motor vehicle accidents and other extension and rotation injuries, but rarely developed from being shaken vigorously.

Case Description: A 7-day-old infant presented to our facility after being attacked by a large dog. Initial examination revealed multiple puncture wounds and lacerations with visible dura. Read More

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A slow-growing anterior maxillary mass.

Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Jan 29. Epub 2021 Jan 29.

Division of Maxillofacial Oncology and Reconstructive Surgery, John Peter Smith Hospital, Fort Worth, Texas.

A 43-year-old-male with no medical conditions presented to his dentist with a left maxillary swelling present for 1 year. His physical exam revealed a 2-cm × 2-cm, poorly demarcated, firm mass in the left anterior maxilla causing mobility of the associated teeth. He had a bluish discoloration of the anterior maxillary mucosa. Read More

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January 2021

Success for All? A Call to Re-examine How Student Success Is Defined in Higher Education.

CBE Life Sci Educ 2021 03;20(1):es3

Department of Ecology and Evolutionary Biology, University of Tennessee, Knoxville, TN 37996.

A central focus in science education is to foster the success of students who identify as Black, Indigenous, and people of color (BIPOC). However, representation and achievement gaps relative to the majority still exist for minoritized students at all levels of science education and beyond. We suggest that majority groups defining the definitions and measures of success may exert "soft power" over minoritized student success. Read More

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Nasal angiofibroma treatment outcome using intensity-modulated radiation therapy in a dog.

Vet Radiol Ultrasound 2021 Feb 26. Epub 2021 Feb 26.

University of Missouri Veterinary Health Center, Columbia, Missouri, USA.

A 6-year-old dog presented with a modified Adams stage 3 angiofibroma of the right nasal cavity, causing fluid accumulation along the right frontal sinus. Treatment consisted of step-and-shoot intensity-modulated radiation therapy in 12 daily treatments of 3.5 Gy, for a total dose of 42 Gy to 95% of the planning target volume. Read More

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February 2021

Academic Success Experiences: Promoting Research Motivation andSelf-Efficacy Beliefs among Medical Students.

Teach Learn Med 2021 Feb 25:1-11. Epub 2021 Feb 25.

Center for Innovation in Medical Education, Leiden University Medical Center, Leiden, The Netherlands.

Theory: Medicine is facing a physician-scientist shortage. Medical training could contribute to developing physician-scientists by stimulating student research involvement, as previous studies showed this is related to research involvement in professional practice. Motivation for research and research self-efficacy beliefs are related to student research involvement. Read More

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February 2021

A Low-Grade Appendiceal Mucinous Neoplasia and Neuroendocrine Appendiceal Collision Tumor: A Case Report and Review of the Literature.

Am J Case Rep 2021 Feb 23;22:e927876. Epub 2021 Feb 23.

Department of Emergency, Policlinico Tor Vergata Hospital, Rome, Italy.

BACKGROUND Incidental appendiceal neoplasms account for 1-2% of appendectomies. Mucinous neoplasms and carcinoids are the most frequent lesions, with an incidence of 0.6% and 0. Read More

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February 2021

COL5A2 as a potential clinical biomarker for gastric cancer and renal metastasis.

Medicine (Baltimore) 2021 Feb;100(7):e24561

Emergency Department, Weifang People's Hospital.

Background: Gastric cancer, characterized by insidious onset and multiple metastasis, is almost incurable and has poor prognosis, and also one of the leading causes of treatment failure and death in patients with gastric cancer (GC). However, the prognosis of collagen type V alpha2 chain (COL5A2) in GC and renal metastasis is unknown.

Methods: Recruited 148 patients who underwent GC. Read More

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February 2021

Pre- and Post-partum Concentrations of Interleukin 1α, Interleukin 8, and α1-Acid Glycoprotein in Vaginal Fornix and Endometrium of Dairy Cows With Clinical Cervicitis.

Front Vet Sci 2020 2;7:605773. Epub 2021 Feb 2.

Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC, Canada.

Innate immunity is the principal sensor responsible of the local immune response to control mucosal bacterial contamination of the reproductive tract after parturition, triggering a pro-inflammatory process in the mucosa of the uterus, the vaginal and the cervix. However, knowledge about the inflammation process and outcome of the cervix in dairy cows is scarce even though it plays an important anatomic and functional role between the vagina and the uterus. The objective of the present study was to describe the cellular and humoral local innate immune response during clinical cervicitis (CC) in the uterus and vaginal fornix in pre- and post-partum periods of dairy cows. Read More

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February 2021

Kaposi Sarcoma of the Medial Foot in an MSM, HIV-Negative Man: A Fifth Clinical Variant.

J Clin Aesthet Dermatol 2020 Oct 1;13(10):42-44. Epub 2020 Oct 1.

Dr. Swali is a Resident Physician, PGY-2, with the Department of Dermatology at the University of Nebraska Medical Center in Omaha, Nebraska.

Kaposi sarcoma (KS) is a low-grade vascular neoplasm with four well-documented clinical types: classic, African (endemic), acquired immunodeficiency syndrome (AIDS)-associated (epidemic), and iatrogenic, as well as a fifth recently described variant, men having sex with men (MSM) without human immunodeficiency virus (HIV) infection. Often distinguishable on clinical exam, KS lesions are typically found on the skin and mucosa of immunocompromised individuals, though numerous published reports have demonstrated the ability of KS to present in immunocompetent individuals. Here, we present the case of a 66-year-old, HIV-negative MSM with violaceous, non-blanching macules and patches of the medial foot referred to dermatology by his primary care physician. Read More

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October 2020

Diagnostic Accuracy of the Magnetic Resonance Imaging in Adult Post-Ganglionic Brachial Plexus Traumatic Injuries: A Systematic Review and Meta-Analysis.

Brain Sci 2021 Jan 30;11(2). Epub 2021 Jan 30.

Department of Diagnosis and Treatment Services, Radiodiagnostics, "Maggiore della carità" Hospital, University of Piemonte Orientale (UPO), Via Solaroli 17, 28100 Novara, Italy.

Background: Traumatic brachial plexus injuries are rare but serious consequences of major traumas. Pre-ganglionic lesions are considered irreparable, while post-ganglionic injuries can be potentially treated if an early diagnosis is available. Pre-surgical diagnosis is important to distinguish low-grade from high-grade lesions and to identify their location. Read More

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January 2021

Relationship between admission criteria and academic performance in basic science courses in health science colleges in KAU.

BMC Med Educ 2021 Feb 8;21(1):94. Epub 2021 Feb 8.

Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Background: At King Abdulaziz University, medical and health science schools depend on admission exams (aptitude and achievement) and preparatory year scores in their students' selection. However, with the growing number of applicants and the drastic changes in teaching and assessment in these colleges, continuous assessment and development of admission criteria are needed. In this study, we aimed to evaluate the correlation of admission exam scores, in addition to the preparatory year Grade Point Average (GPA), with academic performance in the basic science subjects such as Clinical Biochemistry and Clinical Pharmacology in health science colleges. Read More

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February 2021

Editorial Commentary: The Pivot Shift and Lachman Examinations: Teammates With Distinct Roles.

Arthroscopy 2021 02;37(2):682-685

New York, New York.

The pivot shift and Lachman examinations are "teammates" with complementary but distinct roles in the successful diagnosis and treatment of anterior cruciate ligament rupture and injury to the surrounding soft-tissue envelope of the knee. The Lachman test measures anterior tibial translation in response to an applied anterior tibial load. This test assesses the integrity of the native or reconstructed anterior cruciate ligament and the secondary medial restraints including the medial meniscus and medial collateral ligament. Read More

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February 2021