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Primary squamous cell carcinoma, breast: A challenging diagnosis.

Cancer Rep (Hoboken) 2021 May 5:e1391. Epub 2021 May 5.

Department of Endocrine surgery, King George's Medical University, Lucknow, India.

Background: Primary squamous cell carcinoma of the breast is an extremely rare malignancy constituting less than 0.1% of all breast cancers with very few cases reported in literature. It is an aggressive, triple-hormone negative tumor, and its appropriate management is still debated. Read More

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Sarcopenia as a predictor of initial administration dose of afatinib in patients with advanced non-small cell lung cancer.

Thorac Cancer 2021 May 5. Epub 2021 May 5.

Department of Medical Oncology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.

Background: Sarcopenia has recently emerged as a new condition with increasing importance in lung cancer patients. The aim of this study was to investigate the influence of sarcopenia on tolerance and efficacy of afatinib.

Methods: We retrospectively evaluated 35 patients with epidermal growth factor receptor (EGFR) mutant advanced non-small cell lung cancer (NSCLC) treated with first-line afatinib. Read More

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Safety and diagnostic efficacy of gadoteridol for magnetic resonance imaging of the brain and spine in children 2 years of age and younger.

Pediatr Radiol 2021 May 5. Epub 2021 May 5.

Duke University School of Medicine, Durham, NC, USA.

Background: Neonates and young children require efficacious magnetic resonance imaging (MRI) examinations but are potentially more susceptible to the short- and long-term adverse effects of gadolinium-based contrast agents due to the immaturity of their body functions.

Objective: To evaluate the acute safety and diagnostic efficacy of gadoteridol (ProHance) for contrast-enhanced MRI of the central nervous system (CNS) in children ≤2 years of age.

Materials And Methods: One hundred twenty-five children ≤2 years old (including 57 children <6 months old) who underwent contrast-enhanced MRI of the CNS with gadoteridol at 0. Read More

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Clinical experience of a specialized urticaria outpatient clinic from a Portuguese UCARE.

Eur Ann Allergy Clin Immunol 2021 May 5. Epub 2021 May 5.

Department of Immunoallergology, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte EPE, Lisbon, Portugal.

Summary: Chronic urticaria (CU) is a frequent disease, with a prevalence of at least 1%. It is characterized by pruritic wheals, angioedema or both for a period longer than 6 weeks. Identify the demographic, clinical, laboratory and therapeutic profile of patients treated in a Portuguese Urticaria Center of Reference and Excellence (UCARE) and compare it with international series. Read More

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Cerebral Venous Thrombosis in Acute Lymphoblastic Leukemia with Severe COVID-19: a Case Report.

SN Compr Clin Med 2021 Apr 30:1-5. Epub 2021 Apr 30.

Department of Medicine, Command Hospital, Kolkata, India.

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has brought an unprecedented upheaval in our health-care systems. Amongst the many challenges posed by the disease, increased risk of thromboembolism has presented a distinct new front for increased mortality and morbidity. While there are multiple documented evidences for the same, the exact mechanism, knowledge of groups at-risk, and mitigation strategies are evolving. Read More

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Diagnosis of pseudoprogression following lomustine-temozolomide chemoradiation in newly diagnosed glioblastoma patients using FET PET.

Clin Cancer Res 2021 May 4. Epub 2021 May 4.

Dept. of Neurology, University Hospital Cologne.

Background: The CeTeG/NOA-09 phase-III trial demonstrated a significant survival benefit of lomustine-temozolomide chemoradiation in newly diagnosed glioblastoma patients with methylated O6-methylguanine-DNA methyltransferase promoter. Following lomustine-temozolomide chemoradiation, late and prolonged pseudoprogression may occur. We here evaluated the value of amino acid PET using O-(2-[18F]fluoroethyl)-L-tyrosine (FET) for differentiating pseudoprogression from tumor progression. Read More

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Osteoarthritis: Novel Molecular Mechanisms Increase Our Understanding of the Disease Pathology.

J Clin Med 2021 Apr 30;10(9). Epub 2021 Apr 30.

Center of Experimental Orthopaedics, Saarland University, 66421 Homburg, Germany.

Although osteoarthritis (OA) is the most common musculoskeletal condition that causes significant health and social problems worldwide, its exact etiology is still unclear. With an aging and increasingly obese population, OA is becoming even more prevalent than in previous decades. Up to 35% of the world's population over 60 years of age suffers from symptomatic (painful, disabling) OA. Read More

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Graves' Disease Presenting as Autoimmune Hemolytic Anemia.

Am J Case Rep 2021 Apr 23;22:e930705. Epub 2021 Apr 23.

Hematology and Medical Oncology Unit, Department of Internal Medicine, Dr. Soetomo General Academic Hospital - Faculty of Medicine Airlangga University, Surabaya, Indonesia.

BACKGROUND Atypical manifestations of Graves' disease (GD) such as anemia have been noticed in the last decades. Anemia is present in up to 34% of patients with GD, yielding various anemia types such as GD anemia, pernicious anemia, iron deficiency anemia, and autoimmune hemolytic anemia (AIHA). So far, AIHA is the rarest manifestation of anemia in GD. Read More

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Functional outcomes of pediatric laparoscopic pyeloplasty: post-operative functional recovery is superior in infants compared to older children.

Pediatr Surg Int 2021 May 4. Epub 2021 May 4.

Pediatric Surgery, Pediatric Urology & MAS, Ankura Hospitals for Women and Children, Hyderabad, Telangana, India.

Aim: Laparoscopic pyeloplasty (LP) is less popular and considered less successful in infants compared to older children. There are few reports analyzing the functional results of LP in relation to age of surgery. The aim of this paper is to compare the functional results of LP in infants (group 1) with children over 1 year of age (group 2). Read More

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The clinical value of three-dimensional measurement in the diagnosis of thoracic myelopathy caused by ossification of the ligamentum flavum.

Quant Imaging Med Surg 2021 May;11(5):2040-2051

Second Department of Spine Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Background: Thoracic ossification of the ligamentum flavum (OLF) is a major cause of thoracic myelopathy, which is often accompanied by multiple segmental stenosis or other degenerative spinal diseases. However, in the above situations, it is difficult to determine the exact segment responsible. The objective of this study was to analyze three-dimensional (3D) radiological parameters in order to establish a novel diagnostic method for discriminating the responsible segment in OLF-induced thoracic myelopathy, and to evaluate its superiority compared to the conventional diagnostic methods. Read More

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A highly accurate method for quantifying LVNC cardiomyophaty.

AMIA Annu Symp Proc 2020 25;2020:223-232. Epub 2021 Jan 25.

Computer Engineering, University of Murcia, Spain.

Left ventricular non-compaction (LVNC) is defined by an increase of trabeculations in left ventricular endo-myocardium. Although LVNC can be in isolation, an increase in hypertrabeculation often accompanies genetic cardiomyopthies. Several enhancements are proposed and implemented to improve a software tool for the automatic quantification of the exact hyper-trabeculation degree in the left ventricular myocardium for a population of patients with LVNC cardiomyopathy (QLVTHC-NC). Read More

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January 2021

Mycotoxin profiles of animal feeds in the central part of Thailand: 2015-2020.

Vet World 2021 Mar 23;14(3):739-743. Epub 2021 Mar 23.

Department of Veterinary Public Health, Faculty of Veterinary Medicine, Kasetsart University, Kamphaeng Saen, Nakhon Pathom, Thailand.

Background And Aim: Mycotoxin contamination in animal feeds is of considerable concern because it can affect animal health systems. As a result of contamination in the food chain, humans can indirectly come into contact with mycotoxins. The present study aimed to present mycotoxin contamination patterns in animal feeds from 2015 to 2020 and elucidate associations between the type of feed and the type of ingredient. Read More

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Spontaneous regression of congenital brain tumors: a report of two cases.

Childs Nerv Syst 2021 May 1. Epub 2021 May 1.

Department of Pediatric Neurosurgery, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, 1419733151, Iran.

Background: Vanishing brain tumor is defined as spontaneously disappearing or decreasing of the initial brain mass volume to ≤ 70% before establishing the definitive diagnosis. The condition is rare and can be attributed to different factors. The exact mechanism is under debate, but the increasing rate and accuracy of neuroimaging studies and occurrence of similar scenario in other pathologies rather than brain tumors can be of particular importance in finding vanishing brain lesions. Read More

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How to design a registry for undiagnosed patients in the framework of rare disease diagnosis: suggestions on software, data set and coding system.

Orphanet J Rare Dis 2021 May 1;16(1):198. Epub 2021 May 1.

Frankfurt Reference Centre for Rare Diseases, University Hospital Frankfurt, Goethe University Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.

Background: About 30 million people in the EU and USA, respectively, suffer from a rare disease. Driven by European legislative requirements, national strategies for the improvement of care in rare diseases are being developed. To improve timely and correct diagnosis for patients with rare diseases, the development of a registry for undiagnosed patients was recommended by the German National Action Plan. Read More

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Neurological and cognitive sequelae of Covid-19: a four month follow-up.

J Neurol 2021 May 1. Epub 2021 May 1.

Unit of Occupational Health, Hygiene, Toxicology and Prevention, University Hospital ASST Spedali Civili of Brescia, Piazza Spedali Civili 1, 25123, Brescia, Italy.

Central and peripheral nervous system involvement during acute COVID-19 is well known. Although many patients report some subjective symptoms months after the infection, the exact incidence of neurological and cognitive sequelae of COVID-19 remains to be determined. The aim of this study is to investigate if objective neurological or cognitive impairment is detectable four months after SARS-CoV-2 infection, in a group of patients who had mild-moderate COVID-19. Read More

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Evaluation of a computer-based facial dysmorphology analysis algorithm (Face2Gene) using standardized textbook photos.

Eye (Lond) 2021 Apr 30. Epub 2021 Apr 30.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.

Background: Genetic syndromes often have ocular involvement. Ophthalmologists may have difficulty identifying dysmorphic features in genetic syndrome evaluations. We investigated the sensitivity and specificity of Face2Gene (F2G), a digital image analysis software trained on integrating dysmorphic features, by analysing patient photos from genetics textbooks. Read More

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Lag Time between Onset of First Symptom and Treatment of Retinoblastoma: An International Collaborative Study of 692 Patients from 10 Countries.

Cancers (Basel) 2021 Apr 19;13(8). Epub 2021 Apr 19.

Department of Ophthalmology, University of Washington, Seattle, WA 98195, USA.

Background: The relationship between lag time and outcomes in retinoblastoma (RB) is unclear. In this study, we aimed to study the effect of lag time between onset of symptoms and diagnosis of retinoblastoma (RB) in countries based on their national-income and analyse its effect on the outcomes.

Methods: We performed a prospective study of 692 patients from 11 RB centres in 10 countries from 1 January 2019 to 31 December 2019. Read More

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Mitochondrial Dysfunction and Chronic Inflammation in Polycystic Ovary Syndrome.

Int J Mol Sci 2021 Apr 10;22(8). Epub 2021 Apr 10.

Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Institute of Human Morphology, 3 Tsyurupa Street, 117418 Moscow, Russia.

Polycystic ovarian syndrome (PCOS) is the most common endocrine-metabolic disorder affecting a vast population worldwide; it is linked with anovulation, mitochondrial dysfunctions and hormonal disbalance. Mutations in mtDNA have been identified in PCOS patients and likely play an important role in PCOS aetiology and pathogenesis; however, their causative role in PCOS development requires further investigation. As a low-grade chronic inflammation disease, PCOS patients have permanently elevated levels of inflammatory markers (TNF-α, CRP, IL-6, IL-8, IL-18). Read More

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The Incidence and Nature of Claims against Dentists Related to Periodontal Treatment in Israel during the Years 2005-2019.

Int J Environ Res Public Health 2021 Apr 14;18(8). Epub 2021 Apr 14.

Department of Periodontology and Implant Dentistry, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel.

Background: In recent years, worldwide dental malpractice claims have dramatically increased. The purpose of the present study is to analyze periodontal therapy related claims in Israel that led to legal decisions.

Methods: This retrospective cohort study includes malpractice claims against dental practitioners related to periodontology between 2005 and 2019. Read More

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A Novel Deep Learning Method for Recognition and Classification of Brain Tumors from MRI Images.

Diagnostics (Basel) 2021 Apr 21;11(5). Epub 2021 Apr 21.

Data Science and Cyber Analytics Research Group, Edinburgh Napier University, Edinburgh EH11 4DY, UK.

A brain tumor is an abnormal growth in brain cells that causes damage to various blood vessels and nerves in the human body. An earlier and accurate diagnosis of the brain tumor is of foremost important to avoid future complications. Precise segmentation of brain tumors provides a basis for surgical planning and treatment to doctors. Read More

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Flexible 5-in-1 Microsensor Embedded in the Proton Battery for Real-Time Microscopic Diagnosis.

Membranes (Basel) 2021 Apr 8;11(4). Epub 2021 Apr 8.

Department of Mechanical Engineering, Yuan Ze Fuel Cell Center, Yuan Ze University, Taoyuan 32003, Taiwan.

The proton battery possesses water electrolysis, proton storage and discharging functions simultaneously, and it can be manufactured without expensive metals. Use the principle of proton exchange membrane water electrolysis for charging, store it in the activated carbon on the hydrogen side and use the principle of proton exchange membrane fuel cell for discharge when needed. According to the latest literature, it is difficult to obtain the exact important physical parameters inside the proton battery (e. Read More

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Expression Levels Combined with Flow Cytometry Blast Counts for Risk Stratification of Acute Myeloid Leukemia and Myelodysplastic Syndromes.

Biomedicines 2021 Apr 6;9(4). Epub 2021 Apr 6.

Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Salerno, Italy.

Wilm's tumor 1 (), a zinc-finger transcription factor and an epigenetic modifier, is frequently overexpressed in several hematologic disorders and solid tumors, and it has been proposed as diagnostic and prognostic marker of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). However, the exact role of in leukemogenesis and disease progression remains unclear. In this real-world evidence retrospective study, we investigated prognostic role of WT1-mRNA expression levels in AML and MDS patients and correlations with complete blood counts, flow cytometry counts, and molecular features. Read More

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A Model for Determining Predictors of the MUAC in Acute Malnutrition in Ghana.

Int J Environ Res Public Health 2021 Apr 5;18(7). Epub 2021 Apr 5.

Department of Statistics, Seoul National University, Seoul 08826, Korea.

The issue of malnutrition is perhaps the most important public health determinant of global wellbeing. It is one of the main causes of improper mental and physical development as well as death of many children. The Mid Upper Arm Circumference (MUAC) rapid text setup is able to diagnose malnutrition due to the fact that the human arm contains subcutaneous fat and muscle mass. Read More

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Percutaneous C-Arm Free O-Arm Navigated Biopsy for Spinal Pathologies: A Technical Note.

Diagnostics (Basel) 2021 Apr 1;11(4). Epub 2021 Apr 1.

Department of Orthopaedic Surgery, Shikoku Cancer Center, 160 Ko Minamiumemotomachi, Matsuyama 791-0280, Ehime, Japan.

Background: Percutaneous biopsy under computed tomography (CT) guidance is a standard technique to obtain a definitive diagnosis when spinal tumors, metastases or infections are suspected. However, specimens obtained using a needle are sometimes inadequate for correct diagnosis. This report describes a unique biopsy technique which is C-arm free O-arm navigated using microforceps. Read More

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Detection of HIV mRNA in routine liquid-based cytology specimens of HIV-infected women.

Cytopathology 2021 Apr 29. Epub 2021 Apr 29.

NOVA Medical School, NMS, CHRC, CEDOC, Universidade NOVA de Lisboa, Lisboa, Portugal.

Objective: Human immunodeficiency virus-infected women have a high incidence of HPV infection, and HIV and HPV coinfection is associated with high incidence of cervical intraepithelial lesions and cervical cancer. This study investigated the ability to detect HIV mRNA in routine screening cervical liquid-based cytology (LBC) samples and its correlation with HPV coinfection and cervical intraepithelial lesions.

Methods: Liquid-based cytology samples from 80 HIV-infected women under combined antiretroviral therapy (cART) were studied for detection of HIV and HPV mRNA using Aptima tests and for cytology diagnosis according to the 2014 Bethesda System for Reporting Cervical Cytology. Read More

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Evaluation of the consistency ratios of cervical smear, cervical biopsy and conization results.

Ginekol Pol 2021 Apr 29. Epub 2021 Apr 29.

Kütahya Sağlık Bilimleri Üniversitesi, Evliya Çelebi Yerleşkesi Tavşanlı Yolu 10. Km Kütahya, Turkey.

Objectives: Possible discrepancies between the cervical smear, biopsy histology and loop electrosurgical excision procedure (LEEP) results of the same patient is a matter of debate in the literature. In this study, we investigate the degree to which these results differ, and the clinical reasons for these differences.

Material And Methods: With a retrospective design, cervical smear, cervical biopsy and LEEP results of patients were compared in terms of consistency. Read More

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Post-partum rectus sheath hematoma complication: case report.

AME Case Rep 2021 25;5:16. Epub 2021 Apr 25.

West Virginia University School of Medicine, Morgantown, WV, USA.

Pregnancy, surgery, and trauma are known risk factors for the development of rectus sheath hematomas (RSHs). The exact incidence of RSH during pregnancy is unknown, however this disease carries a risk of complication and even mortality. The role of infection in this condition is less known with only a few reported case studies in medical literature. Read More

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A New Chemiluminescence Immunoassay for Phospholipase A Receptor 1 Autoantibodies Allows Early Identification of Autoantibody Recurrence in Patients With Membranous Nephropathy.

Kidney Int Rep 2021 Apr 13;6(4):928-935. Epub 2021 Jan 13.

Institute for Experimental Immunology, affiliated to EUROIMMUN Medizinische Labordiagnostika AG, Lübeck, Germany.

Background: Circulating autoantibodies against the M-type phospholipase A receptor 1 (PLAR1) are important biomarkers in membranous nephropathy (MN), supporting the diagnosis and the clinical monitoring of patients. Standardized recombinant cell-based indirect immunofluorescence assay (RC-IFA) and enzyme-linked immunosorbent assay (ELISA) are widely established for the detection of anti-PLAR1 autoantibodies (PLAR1-ab). The RC-IFA provides higher sensitivity than the ELISA, but lacks exact graduated quantification of antibody levels. Read More

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Exosomal Non-coding RNAs-Mediated Crosstalk in the Tumor Microenvironment.

Front Cell Dev Biol 2021 12;9:646864. Epub 2021 Apr 12.

Department of Oncology and Central Laboratory, Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.

Exosomes are secreted by different types of cells in tumor microenvironment (TME) and participate in multiple biological processes of tumors. Non-coding RNAs (ncRNAs) enveloped in exosomes and released to the TME are shown to be involved in tumorigenesis and development, as well as act as important intracellular communication mediators. However, the understanding on the exact regulatory functions and substrates of exosomal RNA is still at an early stage. Read More

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Circulating miR-155 and JAK2/STAT3 Axis in Acute Ischemic Stroke Patients and Its Relation to Post-Ischemic Inflammation and Associated Ischemic Stroke Risk Factors.

Int J Gen Med 2021 21;14:1469-1484. Epub 2021 Apr 21.

Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Background: "Micro RNAs and their target genes recently have been identified to play a crucial role in the molecular pathogenesis of post-stroke ischemic cellular injury, which elucidates their new role in ischemic stroke diagnosis and therapy". Thus, we evaluated the relative serum expression of miR-155, an inflammatory micro RNA, and the mRNAs (JAK2/STAT3) in acute ischemic stroke patients and its associations with the inflammatory cytokine TNF-α and different stroke risk factors.

Subjects And Methods: The relative expression of serum miR-155 and mRNAs (JAK2/STAT3) was assessed using RT-PCR, serum TNF-α was measured using ELIZA in 46 acute ischemic stroke patients and 50 control subjects. Read More

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